op 1

Camptothecin (CPT) 属于生物碱类天然产物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂 (IC50=679 nM)，具有特异性。Camptothecin 具有抗肿瘤活性，可以诱导细胞凋亡。

1-Chloro-6-(5-(prop-1-ynyl)thiophen-2-yl)hexa-3,5-diyn-2-ol is a natural product from Laggera pterodonta

TOP1210, a narrow spectrum kinase inhibitor, potently inhibits P38α, Src, and Syk kinase activities.

Hop-17(21)-en-3-ol是一种天然产物，属于龙胆科龙胆属，其产品编号为 TN4225，CAS号为 564-14-7。Hop-17(21)-en-3-ol可用作对照参考。

Top1 inhibitor 1 is a potent inhibitor of human topoisomerase I (Top1)(IC50: 29 nM).

TPOP146 is a selective CBP P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).

JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibody blockade prevented cellular retention of JAS239 indicating direct interaction with ChoKα independent of the choline transporters and catabolic choline pathways. In mice bearing orthotopic MCF7 breast xenografts, optical imaging with JAS239 distinguished tumors overexpressing ChoKα from their empty vector counterparts and delineated tumor margins.

Intermediate and building block-boronic acid, heterocyclic compound-pyridine

Intermediate and building block-electrophile, heterocyclic compound-pyridine

3-(2-Iodoethoxy)prop-1-yne 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64472，CAS号为 164118-56-3。

Top1 2-IN-1（compound 23）作为一种口服双重抑制剂，对Top1 2具有有效的抗增殖作用。该化合物能够随着活性氧水平的升高而破坏DNA，进而诱发癌细胞的凋亡和周期停滞。在异种移植模型中，Top1 2-IN-1展现了显著的体内抗肿瘤活性。

Clathrin-IN-1 is a selective clathrin inhibitor that acts by addressing clathrin function in cell physiology with potential applications as an inhibitor of virus and pathogen entry and as a modulator of cell signaling.

OP-145是一种合成抗菌肽及抗菌肽LL-37的衍生物。它对E. coli、P. aeruginosa、C. albicans和A. niger具有活性（MICs分别为2、3、6和18 µM）。含有OP-145的聚乳酸-共-聚乙二醇酸（PLGA）微球能够在骨折部位接种细菌后通过外科股骨骨折所诱导的小鼠骨感染模型中防止生物膜的形成。

TOP1288是一种窄谱激酶抑制剂，抑制P38α、Src和Syk激酶活性，IC50分别为116 nM、24 nM和659 nM。TOP1288还能抑制发炎活检组织和肌成纤维细胞释放炎症细胞因子。

COP1-ATGL modulator 1 (86) 作为具有口服活性的COP1-ATGL调节剂，能够显著提升ATGL蛋白表达量，同时有效降低ATGL的泛素化以及COP1的自泛素化，进而在纳摩尔范围内减少肝细胞中的脂质积累。

2-Chloro-1-(5'-(prop-1-ynyl)-2,2'-bithiophen-5-yl)ethanol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126334。

Heterocyclic compound - pyridine

TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and ocular cytokine levels with efficacy comparable to that of dexamethasone.

DOX−NOP1 is a molecular hybrid covalently joining doxorubicin (DOX) and NOP1. DOX−NOP1 showed similar increased toxicity toward resistant cancer cells and, in addition, lower cardiotoxicity than DOX.

OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.

1-Oleoyl-2-palmitoyl-rac-glycerol (1,2-OP) is a diacylglycerol containing oleic acid at the sn-1 position and palmitic acid at the sn-2 position. It enhances the inhibition of superoxide anion production by cytochalasin B when used at a concentration of 10 μM. The concentration of 1,2-OP decreases from 25.7 to 11.15% during the dry-curing process of Iberian ham.

Palazestrant (OP-1250) 是一种可口服且具有高效性的雌激素受体拮抗剂和选择性ER降解剂，具有抗肿瘤活性。Palazestrant 抑制 17b-estradiol (E2)，抑制 MCF7 和 CAMA-1 细胞增殖，可用于研究乳腺癌。

Limaprost (17α,20-dimethyl-δ2-PGE1) 是PGE1类似物，也是口服具有活性的血管舒张剂。它能够增加血流量以及减少血小板聚集。它具有抗心绞痛的功能，可用于疼痛的缓解，以及用于研究缺血性症状。

1-Palmitoyl-3-oleoyl-rac-glycerol, a diacylglycerol featuring palmitic acid at the sn-1 position and oleic acid at the sn-3 position, serves as a substrate for diacylglycerol acyltransferase (DAGAT) in myotubes.