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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-BOP1 Polyclonal Antibody

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货号 TMAB-03188

Anti-BOP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BOP1。Anti-BOP1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-BOP1 Polyclonal Antibody

Anti-BOP1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-03188

Anti-BOP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BOP1。Anti-BOP1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-BOP1 Polyclonal Antibody is a Rabbit antibody targeting BOP1. Anti-BOP1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis.
抗原信息
免疫原
KLH conjugated synthetic peptide: human BOP1
抗原种属
Human
基因名称
BOP1
基因ID
23246
蛋白名称
Ribosome biogenesis protein BOP1
Uniprot ID
Q14137
功能
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
化学信息
分子量Theoretical: 84 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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