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Anti-Phospho-p107 (Thr369) Polyclonal Antibody 2

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产品编号 TMAB-11075

Anti-Phospho-p107 (Thr369) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-p107 (Thr369)。Anti-Phospho-p107 (Thr369) Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

Anti-Phospho-p107 (Thr369) Polyclonal Antibody 2

Anti-Phospho-p107 (Thr369) Polyclonal Antibody 2

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Rating icon 还可以
产品编号 TMAB-11075

Anti-Phospho-p107 (Thr369) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-p107 (Thr369)。Anti-Phospho-p107 (Thr369) Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-p107 (Thr369) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-p107 (Thr369). Anti-Phospho-p107 (Thr369) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
交叉反应
Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit)
应用WBIHC-PIHC-FrIFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The pocket protein family consists of three structurally and functionally related proteins, Rb (retinoblastoma), p107, and p130. This family of tumor suppressors function to regulate important cellular transcription factors, such as the E2F family. The E2F proteins regulate the expression of genes whose products are important for cell cycle progression. The inactivation Rb is catalyzed by CDK phosphorylation thereby releasing E2F during the G1-S phase cellular progression. Unchecked inactivation of Rb in G1 phase has been indicated as a universal mechanism underlying cellular transformation . While Rb has been the most studied among the pocket proteins, p107 and p130 have also been shown to be key regulators of E2F. Several studies have also provided evidence that p107/p130 provide different functions in E2F regulation than does Rb. Rb, p107, and p130 each contain a conserved 'A/B pocket', which is the target of several viral oncoproteins, namely SV40 large T-antigen and adenovirus E1A. There are two isoforms.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human RBL1 around the phosphorylation site of Thr369
抗原种属
Human
基因名称
RBL1
基因ID
5933
蛋白名称
Retinoblastoma-like protein 1
Uniprot ID
P28749
功能
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
化学信息
分子量Theoretical: 121 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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