购物车
全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-10533

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-COP1 (Ser387)。Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-10533

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-COP1 (Ser387)。Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
资源下载:
产品操作手册

产品介绍

生物活性
产品描述
Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-COP1 (Ser387). Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus speckle. Cytoplasm. In the nucleus, it forms nuclear speckles.
组织特异性Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景COP1 is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumorigenesis.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human COP1 around the phosphorylation site of Ser387
抗原种属
Human
基因名称
COP1
基因ID
64326
蛋白名称
E3 ubiquitin-protein ligase COP1
Uniprot ID
Q8NHY2
功能
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.
化学信息
分子量Theoretical: 80 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
Related Tags: buy Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 | purchase Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 | Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 cost | order Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 | Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 2 molecular weight