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顶部生物活性储存和溶解信息计算器

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody

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Anti-Phospho-COP1 (Ser387) Polyclonal Antibody
产品编号 TMAC-00938
别名 p-COP1 (Ser387), p-COP1 (S387), COP1 (p-Ser387), COP1 (p-S387)

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-COP1 (Ser387)。Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 可用于 WB,ELISA。

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-COP1 (Ser387) Polyclonal Antibody
产品编号 TMAC-00938 别名 p-COP1 (Ser387), p-COP1 (S387), COP1 (p-Ser387), COP1 (p-S387)

Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-COP1 (Ser387)。Anti-Phospho-COP1 (Ser387) Polyclonal Antibody 可用于 WB,ELISA。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-COP1 (Ser387) Polyclonal Antibody is a Rabbit antibody targeting Phospho-COP1 (Ser387). Anti-Phospho-COP1 (Ser387) Polyclonal Antibody can be used in WB,ELISA.
别名p-COP1 (Ser387), p-COP1 (S387), COP1 (p-Ser387), COP1 (p-S387)
Ig Type
IgG
交叉反应
Human,Mouse
应用
WB
ELISA
推荐剂量
WB: 1:500-2000; ELISA: 1:5000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
性状Liquid
缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
研究背景domain:The RING finger domain, in addition to its role in ubiquitination, functions as a structural scaffold to bring two clusters of positive-charged residues within spatial proximity to mimic a bipartite nuclear localization signal (NLS).,function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.,induction:By p53/TP53.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the COP1 family.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 7 WD repeats.,subcellular location:In the nucleus, it forms nuclear speckles.,subunit:Homodimer. Homodimerization is mediated by the coiled coil domain. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Isoform 2 does not interact with CUL4A but still binds to RBX1, suggesting that the interaction may be mediated by another culllin protein. Isoform 1 and isoform 2 interact with CUL5 but not with CUL1, CUL2 not CUL3. Interacts with bZIP transcription factors JUN, JUNB and JUND but not with FOS, ATF2 nor XBP1. Interacts with p53 (TP53).,tissue specificity:Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart.,
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human RFWD2 around the phosphorylation site of Ser387. AA range:353-402
抗原种属
human
Uniprot ID
Q8NHY2
化学信息
分子量Actual: 100 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pCOP1 (Ser387)pCOP1 (S387)COP1 (pSer387)COP1 (pS387)COP1 (phospho-Ser387)COP1 (phospho-S387)

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