β-secretase

BACE-IN-1 是淀粉样前体蛋白 β-分泌酶抑制剂。

DAPM (gamma-Secretase Inhibitor XVI) 是 Notch 通路抑制剂，具有抗癌活性和抗增殖作用，抑制细胞增殖并诱导人结肠癌细胞中 Krüppel 样因子 4 （KLF4） 和 p21 的表达，抑制 Notch 信号传导，可用于研究肾小管腺瘤。

Jagged-1 (188-204) TFA(219127-21-6 free base) 是 JAG-1 蛋白的一个片段。 JAG-1 是 Notch 配体，是一种在皮肤中表达最明显的肽。 JAG-1 诱导表皮成熟。将淹没的角质形成细胞单层暴露于钙浓度升高的 JAG-1 会产生具有 loricrin 表达和 NF-alphaB 激活的分层。

Notch 1 TFA encodes a member of the NOTCH family of proteins.

Z-LLNle-CHO is a cell permeable inhibitor of gamma-secretase. Z-LLNle-CHO induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.

OM99-2 TFA is an eight-residue peptidomimetic compound, functioning as a tight-binding inhibitor of human brain memapsin 2. It exhibits a high affinity for the target with a Ki value of 9.58 nM, making it a promising candidate in the development of BACE1 inhibitors. Due to its potential, OM99-2 presents opportunities for further research in the field of Alzheimer's disease.

OM99-2 is an eight-residue peptidomimetic with a high affinity for human brain memapsin 2, exhibiting a Ki value of 9.58 nM. This compound represents a significant advancement in the development of BACE1 inhibitors and holds potential for the study of Alzheimer's disease.

Z-Phe-Ala-diazomethylketone 直接与 Aβ42 单体及其小型低聚物相结合，能抑制 Aβ42 在溶液中形成的十二聚体以及原纤维的生成，显示出在神经退行性疾病研究中的应用潜力。

Jagged-1 （188-204） 是 JAG-1 蛋白的一个片段。其中 JAG-1 能够诱导单核细胞衍生的人树突状细胞成熟，是一种在培养的和原发性多发性骨髓瘤细胞中高度表达的 Notch 配体。

Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

Notch1 (Notch homolog 1, translocation-associated) 能编码NOTCH家族的蛋白质。作为I型跨膜蛋白，该家族具有共同的结构特征，包括一个由多个表皮生长因子样 (EGF) 重复序列构成的细胞外结构域，以及一个由多种不同结构域类型构成的细胞内结构域。

M-2420 is a fluorogenic substrate designed specifically for the β-secretase site found in the Swedish mutation of the amyloid precursor protein (APP).

Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-secretase processing site (Lys16-Leu17 bond). It also contains the HHQK domain (residues 13-16) re

Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) 是 Amyloid-β 肽的片段，可能用于神经系统疾病的研究。Amyloid β 蛋白片段含有 α-分泌酶加工位点（Lys16-Leu17 键）。它还包含负责与小胶质细胞结合的 HHQK 结构域（残基 13-16）。

GL189 是一种β-分泌酶抑制剂。GL189具有神经保护作用，可用于神经退行性疾病的研究。