nmu

N-Nitroso-N-methylurea 是一种具有烷基化、致癌和致突变特性的亚硝基脲化合物。它靶向多种动物器官，可引起各种癌症和变性疾病，可用于重氮甲烷合成。

NMU-25 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64545。

Hainanmurpanin是一种天然产物，属于芸香科九里香属，其产品编号为 TN4180，CAS号为 95360-22-8。Hainanmurpanin可用作对照参考。

Pifithrin-μ (NSC-303580) 是 p53和 HSP70的抑制剂，具有抗肿瘤和神经保护作用。

Nicotinamide 是维生素 B3 的吡啶核苷形式，可作为烟酰胺腺嘌呤二核苷酸或 NAD+ 的前体，可通过膳食摄入来补充，能预防或治疗黑舌病和糙皮病。

(-)-Blebbistatin ((S)-(-)-Blebbistatin) 是 blebbistatin 的 S 对映异构体。(-)-Blebbistatin 是一种肌球蛋白 II 抑制剂 (IC50=0.5-5 μM)，具有有效性和选择性。(-)-Blebbistatin 可以用于抑制心肌肌球蛋白、非肌肉肌球蛋白II和骨骼肌肌球蛋白。

Glycogen, Mussel 是一种糖酵解的中间产物和高能磷酸盐，它是人类、动物、真菌和细菌的一种能量储存形式。

Blebbistatin ((±)-Blebbistatin) 是一种非肌肉肌球蛋白 II(NMII)选择性和非肌肉肌球蛋白重链9（MYH9）特异性的抑制剂，可促进角膜内皮细胞 (CEC) 的定向迁移并加速伤口愈合，并保留了细胞连接的完整性和屏障功能。

Arctigenin mustard is a tumor-growth inhibiting substance.

CPX-351 (Vyxeos) 是阿糖胞苷和柔红霉素的脂质体封装物，具有潜在的抗肿瘤活性，可用与研究急性髓系白血病。

GSK467 是一种有效的、选择性的 KDM5 (JARID1) 抑制剂，Ki 值为10 nM。

Endotrophin (Mus musculus) 为Col6的裂解产物，其上调可能导致纤维化和炎症基因表达增强。

CPN-351 TFA (compound 9a) 是一种具有选择性的人NMUR1拮抗作用的五肽，其pA2值为7.35。相比于NMUR2，CPN-351 TFA 对人 NMUR1 的拮抗效力高出10倍。该化合物可应用于炎症研究中。

Neuromedin U (rat) acetate 是一种 23 个氨基酸的脑肠肽。 Neuromedin U (NMU) 通过其在中枢神经系统中的同源受体 NMUR2 调节几种重要的生理功能，包括能量平衡、压力反应和伤害感受。

Neuromedin U-23 (NMU-23) is a neuropeptide involved in diverse biological processes, including smooth muscle contraction, energy homeostasis, and nociception.1It is an agonist of neuromedin-U receptor 1 (NMUR1; EC50= 0.17 nM for the human receptor in a calcium mobilization assay using HEK293 cells) and NMUR2 (EC50= ~1.4-2 nM for arachidonic acid release in CHO cells expressing the human receptor).2,3NMU-23 (1 μM) induces contractions in isolated rat colon smooth muscle strips.4It decreases body weight and food intake and increases core body temperature in mice when administered at a dose of 36 μg/animal.5Intrathecal administration of NMU-23 decreases the mechanical pain threshold in the von Frey test in rats.6 1.Mitchell, J.D., Maguire, J.J., and Davenport, A.P.Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin SBr. J. Pharmacol.158(1)87-103(2009) 2.Szekeres, P.G., Muir, A.I., Spinage, L.D., et al.Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3J. Biol. Chem.275(27)20247-20250(2000) 3.Hosoya, M., Moriya, T., Kawamata, Y., et al.Identification and functional characterization of a novel subtype of neuromedin U receptorJ. Biol. Chem.275(38)29528-29532(2000) 4.Brighton, P.J., Wise, A., Dass, N.B., et al.Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissueJ. Pharmacol. Exp. Ther.325(1)154-164(2008) 5.Peier, A., Kosinski, J., Cox-York, K., et al.The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)Endocrinology150(7)3101-3109(2009) 6.Yu, X.H., Cao, C.Q., Mennicken, F., et al.Pro-nociceptive effects of neuromedin U in ratNeuroscience120(2)467-474(2003)

Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery (KDs = 0.26 and 0.11 nM, respectively), eliciting endothelium-independent vasoconstriction.3NMU-25 also suppresses glucose-stimulated insulin secretion in human islets, and this effect is lost in NMU R165W mutants, resulting in early-onset obesity.4 1.Mitchell, J.D., Maguire, J.J., and Davenport, A.P.Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin SBritish Journal of Pharmacology15887-103(2009) 2.Greenwood, H.C., Bloom, S.R., and Murphy, K.G.Peptides and their potential role in the treatment of diabetes and obesityRev.Diabet.Stud.8(3)355-368(2011) 3.Mitchell, J.D., Maguire, J.J., Kuc, R.E., et al.Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular systemCardiovascular Research81353-361(2009) 4.Alfa, R.W., Park, S., Skelly, K.R., et al.Suppression of insulin production and secretion by a decretin hormoneCell Metabolism21(2)323-333(2015)

Neuromedin S (human) 是包含33个氨基酸的神经肽，作为G 蛋白偶联受体 (GPCR) FM-4 TGR-1的内源性配体，在大脑中被鉴定，并对神经调节素 U (NMU) 受体 2 (NMUR2)调节体重稳态具有调控作用。