ly-5

LY5 is an inhibitor of STAT3 that acts by inhibiting cell viability, cell migration, and angiogenesis in medulloblastoma cells.

LY-53857 free base is a bioactive chemical.

LY-510929, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of hyperlipidaemia, metabolic disorders and type 2 diabetes.

LY-580276 is an inhibitor of the type I transforming growth factor beta receptor (TβRI).

LLY-507 是一种有效的、细胞活性的、特异性的蛋白质赖氨酸甲基转移酶 SMYD2 抑制剂。它是一种化学探针，用于解析 SMYD2 在癌症和其他生物过程中的功能。它有抑制 SMYD2 甲基化 p53 肽的能力，IC50小于 15 nM。

LY 517717 是一种具有口服活性的凝血因子 Xa 抑制剂，具有抗血栓活性，可用于研究静脉血栓栓塞（VTE）。

Erteberel (LY500307) 是一种选择性的雌激素受体 β(ERβ) 激动剂，其Ki=1.54 nM，EC50=3.61 nM。具有抗肿瘤作用。

LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor.

Org 24461 is a synaptic and nonsynaptic glycine transporter type-1 inhibitor.

Lubabegron, also known as LY591281; LY488756 fumarate, is a veterinary drug used to reduce ammonia emissions from animals and their waste. Ammonia emissions are a concern in agricultural production because of detrimental effects on the environment, human health, and animal health. Lubabegron was approved by the U.S. Food and Drug Administration in 2018 for use in feedlot cattle. Lubabegron is a beta-adrenergic receptor agonist that has the effect of increasing the breakdown of fats and increasing energy expenditure in cells.

Gly5-Ahx-DM1 是一种转肽酶反应型 Drug-linker,具有创新型高度稳定可降解连接子，DM1 是一种微管蛋白抑制剂，可用于抗体-药物偶联物（ADC）的合成。

LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells.

LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.

LY503430 is a AMPA receptor potentiator with oral activity. LY503430 has both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP.

Lilly 51641 is used as a MAO inhibitor.

LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.

LY518674 (LY-674) 是一种高效、选择性的 PPARα 激动剂，对人 PPARα 作用的 EC50 值为 42 nM。LY518674 能降低甘油三酸酯，增加 HDL-C，可用于研究动脉粥样硬化。

LY550410是一种I型TGF-β受体激酶(type ITGF-β receptor kinase)的小分子ATP竞争性抑制剂，含有异芳香环结构，可有效结合至激酶的活性位点。该化合物通过调节TGF-β信号通路来影响基因表达，进而促进细胞生长，有望在癌症研究中发挥作用。

LY 54761 is a bio-active chemical.

PNU-EDA-Gly5 is a DNA topoisomerase I inhibitor-based oligo-glycine linker-payload used for the synthesis of antibody-drug conjugates (ADCs). It consists of the DNA topoisomerase I inhibitor PNU-159682 and the linker EDA-Gly5.

LY 56110 is a novel nonsteroidal aromatase inhibitor.

Prexasertib (LY2606368) 是一种具有潜在抗肿瘤活性的检查点激酶 1 抑制剂。它可引起双链 DNA 断裂和复制突变，导致细胞凋亡。

LY-2624803 是一种 5-HT2A 受体拮抗剂和组胺受体反向激动剂，可用于改善慢波睡眠。

Izonsteride (LY320236) 是一种选择性强效 5α 还原酶抑制剂，对酶的 I 型和 II 型同工酶具有双重作用。Izonsteride 可用于治疗肿瘤和泌尿生殖系统疾病，可用于研究前列腺癌。