CD161 Protein, Human, Recombinant (N-hFc)

CD161 Protein, Human, Recombinant (N-hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 55-70 KDa and the accession number is Q12918.

规格	价格/CNY		数量
10 μg	￥ 550	5日内发货
50 μg	￥ 1,670	5日内发货
500 μg	￥ 13,800	5日内发货
1 mg	￥ 20,700	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 550

5日内发货

50 μg

￥ 1,670

5日内发货

500 μg

￥ 13,800

5日内发货

1 mg

￥ 20,700

5日内发货

产品描述	CD161 Protein, Human, Recombinant (N-hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 55-70 KDa and the accession number is Q12918.

种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	Q12918
别名	Killer cell lectin-like receptor subfamily B member 1, HNKR-P1a, NKRP1A, KLRB1, CLEC5B, CD161, Natural killer cell surface protein P1A, C-type lectin domain family 5 member B, NKR-P1A
氨基酸序列	Lys68-Ser225
蛋白构建	Lys68-Ser225
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
分子量	55-70 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

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CD161 Protein, Human, Recombinant (N-hFc)

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