C-11

C-11 is a tubulin inhibitor and acts as an ADC cytotoxin with cytotoxicity for carcinoma cell lines.

Mito-apocynin (C11)是一种线粒体靶向抗氧化剂，通过靶向和中和细胞呼吸过程中产生的活性氧（ROS）发挥作用。三苯基溴化鏻已被发现能有效预防线粒体功能障碍，线粒体功能障碍是衰老过程和各种疾病的主要原因。它具有抗炎、抗凋亡和抗氧化活性。

Levetimide C-11 is a radiotracer.

JHU-75528 C-11 can be used as a Radiotracer for PET Imaging of CB1 Cannabinoid Receptors.

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR).References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018). STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR). References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018).

IRES-C11是针对c-MYC基因内部核糖体进入位点(IRES)的特异性翻译抑制剂。IRES-C11通过阻断异源核糖核蛋白A1（一种对c-MYC IRES活性必需的跨作用因子）与其相应IRES之间的相互作用，从而发挥作用。值得注意的是，IRES-C11不抑制BAG-1、XIAP和p53的IRES活性。

LysoPalloT-NH-amide-C3-ph-m-O-C11 是一种GPR174激动剂，其EC50为34 nM。

Thalidomide-5-O-C11-NH2 hydrochloride是一款基于Thalidomide的cereblon配体，能够招募CRBN蛋白。该化合物通过linker与靶向蛋白配体结合，用于构建PROTAC分子，如THAL-SNS-032。

Thalidomide-4-O-C11-NH2 hydrochloride是Thalidomide衍生的cereblon配体，能够募集CRBN蛋白。该化合物能够利用linker与目标蛋白配体结合，进而形成PROTAC分子，如THAL-SNS-032。

Pomalidomide-C11-NH2 hydrochloride 是一款以 Pomalidomide 为基础的 E3 泛素连接酶 cereblon (CRBN) 配体，主要应用于募集 cereblon 蛋白。该化合物能够借助 linker 结构与蛋白质配体相连，从而构建 PROTAC 分子。

Pomalidomide-5-C11-NH2 hydrochloride 是一款基于 Pomalidomide 的 cereblon (CRBN) E3 泛素连接酶配体，能够招募 cereblon 蛋白。通过 linker 结构，该化合物可用于构建 PROTAC，实现其与蛋白质配体的连接。

MBC-11 通过将阿糖胞苷和依替膦酸盐浓缩在疾病部位来靶向癌症的偶联物。MBC-11 可溶用于研究肿瘤诱发的骨病。

Boc-11-aminoundecanoic acid 是一种属于 Alkyl ether 类的 PROTAC linker，可用于 MS432 的合成。

SBC-115076 是前蛋白转化酶枯草杆菌蛋白酶 kexin 9型(PCSK9)抑制剂。其中PCSK9 是一种前蛋白转化酶，在 LDL 受体代谢中的重要物质。

UC-112是凋亡抑制蛋白IAP 新型高效抑制剂，癌细胞IC50值0.7-3.4uM。

MBC-11 trisodium has potential to treat tumor-induced bone disease (TIBD).It is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C.

MBC-11 triethylamine has potential to treat tumor-induced bone disease (TIBD), is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC).

CP-LC-1143 是一种可电离的阳离子氨基脂质，用于递送多种 RNA 类型（mRNA, cRNA, saRNA）。

FAUC-113 is an antagonist of Dopamine D4 receptor.

AC-119 is a bamifylline metabolite in human plasma. It has been shown to induce apoptosis in cancer cells while having no effect on health cells in humans.

LNC-119 is an aminosteroid.

CC-115 是一种双重 mTOR DNA-PK 的抑制剂，IC50分别为 21 nM 和 13 nM，可阻断mTORC1和mTORC2信号通路。

SBC-110736 是一种蛋白转化酶枯草杆菌蛋白酶 9 型 (PCSK9) 抑制剂。

SLEC-11 可在E-钙粘蛋白缺陷细胞中作为合成致死(SL)的先导化合物出现，具有治疗胃癌的潜力。