195
12
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42
Cat. No. | Product Name | ||
---|---|---|---|
L7500 | 凝血与抗凝化合物库 | 144 compounds | |
144 个化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9845 | Thrombin inhibitor 5 | ||
Thrombin inhibitor 5 (compound 385) 是一种凝血酶抑制剂,IC50范围为 0.1 μM~1 μM,可用于静脉血栓栓塞的研究。 | |||
T7674 |
Thrombin Receptor Activator for Peptide
|
Protease-activated Receptor | GPCR/G Protein |
Thrombin Receptor Activator for Peptide 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。 | |||
T19580 |
Thrombin (MW 37kDa)
凝血酶,Thrombin |
Thrombin | Proteases/Proteasome |
Thrombin (MW 37kDa) 是一种 Na+激活的胰蛋白酶样别构丝氨酸蛋白酶。它能够利用凝血酶识别序列对融合蛋白进行位点特异性切割,并可用于消化 GST 标记的蛋白。 | |||
T7625 |
TRAP-6
PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA) |
Protease-activated Receptor | GPCR/G Protein |
TRAP-6 (Thrombin Receptor Activator Peptide 6) 是一种多肽片段,是选择性的蛋白酶激活受体 1 (PAR1) 激动剂,通过凝血酶受体激活人血小板。 | |||
T17091 | Thrombin Inhibitor 2 | Others | Others |
Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor. Thrombin Inhibitor 2 has antithrombotic activity. | |||
T10081 | Thrombin inhibitor 1 | Thrombin | Proteases/Proteasome |
Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM). | |||
T7496 |
Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Thrombin Receptor Activator for Peptide |
Protease-activated Receptor | GPCR/G Protein |
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。 | |||
T36553 |
Thrombin Receptor Peptide Ligand (trifluoroacetate salt)
|
||
Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 μM to inhibit platelet aggregation in vitro). It inhibits α-thrombin and platelet aggregation induced by thrombin receptor activating peptide in vitro when used at a concentration of 32 μM but does not affect platelet aggregation induced by ADP or collagen. It also inhibits thrombin- and TRAP-induced proliferation of vascular smooth muscle cells (VSMCs). Thrombin receptor peptide ligand (100 μmol/kg bolus, i.v... | |||
T36777 |
Thrombin Receptor Agonist Peptide (trifluoroacetate salt)
|
||
Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor. It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma. TRAP-14 (100 μM) increases the cytosolic calcium concentration in isolated guinea pig pulmonary smooth muscle cells 5-fold over baseline. It increases pulmonary arterial pressure in isolated guinea pig lung when used at a concentration of 1 μM, which is comparable to the effect induced by 10 nM α... | |||
T72448 |
Thrombin inhibitor 6
|
||
Thrombin inhibitor6为高效的凝血酶抑制剂,IC50值为1 nM,表现出显著的抗凝作用。 | |||
T80512 |
Thrombin receptor peptide ligand
|
Thrombin | Proteases/Proteasome |
Thrombin receptor peptide ligand为凝血酶受体的一种拮抗肽,用于抗血栓治疗。 | |||
TP2234 |
coagulation factor II (thrombin) B chain fragment [Homo sapiens]
|
Others | Others |
Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble | |||
T3757 |
NQ301
|
Thrombin; Platelet aggregation | Others; Proteases/Proteasome |
NQ301 是一种抗血栓剂,能够抑制胶原蛋白激发的兔血小板聚集,IC50=10 mg/mL。 | |||
T7137 |
I-191
|
Protease-activated Receptor | GPCR/G Protein |
I-191 是选择性有效的蛋白酶激活受体 2 拮抗剂。 | |||
T1986 |
Atopaxar
E5555,ER-172594-00 |
Protease-activated Receptor | GPCR/G Protein |
Atopaxar (E5555) 是一种高效、可口服的,选择性的,可逆的凝血酶受体蛋白酶激活受体-1 (PAR-1) 拮抗剂。它是一种抗血小板剂,能干扰血小板信号,可用于动脉粥样硬化血栓性疾病的研究。 | |||
TQ0012 |
AZ3451
|
Protease-activated Receptor | GPCR/G Protein |
AZ3451 是蛋白酶激活受体 2 的变构拮抗剂,IC50值为 23 nM。 | |||
T12870 |
SCH79797 dihydrochloride
|
Apoptosis; Others; Protease-activated Receptor | Apoptosis; GPCR/G Protein; Others |
SCH79797 dihydrochloride 是一种有效的特异性蛋白酶激活受体 1 (PAR1) 拮抗剂,IC50 为 70 nM,Ki 为 35 nM。SCH79797 dihydrochloride 具有抗增殖和促凋亡作用。 | |||
T6594 |
MNS
|
Syk; Src; p97 | Angiogenesis; Tyrosine Kinase/Adaptors; Ubiquitination |
MNS 是一种酪氨酸激酶抑制剂和广谱抗血小板药物,是一种 β-硝基苯乙烯衍生物。它完全抑制 U46619 (IC50:2.1 μM)、ADP (IC50:4.1 μM)、花生四烯酸 (IC50:5.8 μM)、胶原 (IC50:7.0 μM)和凝血酶 (IC50:12.7 μM)诱导的血小板聚集,并抑制 Src (IC50:27.3 μM)、Syk (IC50:2.8 μM) 和 FAK (IC50:97.6 μM)。 | |||
TP1046 |
SLIGRL-NH2
Protease-Activated Receptor-2 Activating Peptide |
Protease-activated Receptor | GPCR/G Protein |
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) 为一种蛋白酶激活受体-2 (PAR-2) 激动剂,具有诱导非组胺能性瘙痒的功能。 | |||
T2370 |
AC-55541
AOB2796 |
Proteasome; Protease-activated Receptor | GPCR/G Protein; Proteases/Proteasome; Ubiquitination |
AC-55541 (AOB2796) 是高选择性的蛋白酶激活受体 2(PAR2)激动剂,pEC50为6.7。它在 PI 水解测定和 Ca2+动态测定中的pEC50值为 5.9 和 6.6,在体内表现出伤害感受器活性。 | |||
T22246 |
Argatroban Monohydrate
阿加曲班一水合物,阿加曲班 |
Thrombin | Proteases/Proteasome |
Argatroban Monohydrate 是一种 thrombin 选择性抑制剂。 | |||
T6295 |
Dabigatran
BIBR 953,BIBR 953ZW,达比加群 |
Thrombin | Proteases/Proteasome |
Dabigatran (BIBR 953ZW) 是一种口服抗凝剂,是一种可逆的,竞争性的直接凝血酶 (thrombin) 抑制剂,Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。 | |||
T6370 |
AEBSF hydrochloride
AEBSF HCl,Pefabloc SC |
Thrombin; Serine Protease; Influenza Virus | Microbiology/Virology; Proteases/Proteasome |
AEBSF hydrochloride (Pefabloc SC) 是一种丝氨酸蛋白酶的不可逆抑制剂。 | |||
T5519 |
Bivalirudin
BG-8967,比伐卢定,Hirulog-1 |
Thrombin | Proteases/Proteasome |
Bivalirudin (BG-8967) 是一种直接凝血酶(thrombin)抑制剂,是一种肽类抗凝剂,可在侵入性心脏病,特别是在经皮冠状动脉介入中用于抗凝。 | |||
T1893 |
Parmodulin 2
ML 161 |
Protease-activated Receptor | GPCR/G Protein |
Parmodulin 2 (ML 161) 是一种蛋白酶激活受体 1(PAR1) 变构抑制剂,IC50为 0.26 μM。它是蛋白酶激活受体 1 (PAR1) 介导的血小板活化的抑制剂,可以抑制体外血小板聚集和体内血小板血栓形成。 | |||
T0389 |
Dabigatran etexilate
达比加群酯,BIBR 1048 |
Thrombin | Proteases/Proteasome |
Dabigatran etexilate (BIBR 1048) 是一种 Dabigatran 前药,具有口服活性。它具有抗凝作用,能够预防心房颤动引起的静脉血栓栓塞和中风。 | |||
T7013 |
Vorapaxar
SCH 530348,MK-5348,沃拉帕沙 |
Protease-activated Receptor | GPCR/G Protein |
Vorapaxar (MK-5348) 是抗血小板药物,是一种选择性、口服活性和竞争性的凝血酶受体蛋白酶激活受体(PAR-1)拮抗剂,Ki 值为 8.1 nM。它靠剂量依赖性抑制凝血酶受体激活肽 (TRAP) 诱导的血小板聚集。 | |||
T0155 |
Argatroban
MCI-9038,阿加曲班,MD-805,Argipidine |
Thrombin | Proteases/Proteasome |
Argatroban (MCI-9038) 是一种选择性的凝血酶抑制剂。 | |||
T22323 |
Enoxaparin sodium
|
Thrombin | Proteases/Proteasome |
Enoxaparin sodium 是一种低分子量肝素 (LMWH),已获得美国 FDA 批准,可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用,并抑制凝血因子 XIa、IXa、Xa 和 IIa(凝血酶),从而防止血栓形成。 | |||
T5133 |
Dabigatran Etexilate Mesylate
甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate |
Thrombin | Proteases/Proteasome |
Dabigatran Etexilate Mesylate (BIBR 1048MS) 是一种口服具有活性的 Dabigatran 前药,具有抗凝作用,能够预防心房颤动引起的静脉血栓栓塞和中风。 | |||
T17265 |
Ximelagatran
EXANTA,H 376-95,H37695,希美加群,H 376/95,H-37695,H 37695 |
Thrombin | Proteases/Proteasome |
Ximelagatran (H 376-95) 是一种口服活性凝血酶抑制剂,可选择性的、竞争性的抑制游离和凝块结合的凝血酶。它是一种抗凝药物,具有快速起效的抗凝作用,可预测的,剂量依赖性的药代动力学和药效学。 | |||
T3098 |
Vorapaxar sulfate
SCH 530348 sulfate,Zontivity,vorapaxar monosulfate,沃拉帕沙 |
Protease-activated Receptor | GPCR/G Protein |
Vorapaxar sulfate (Zontivity) 是一种选择性、口服活性和竞争性的凝血酶受体蛋白酶激活受体(PAR-1)拮抗剂,Ki 值为 8.1 nM。它剂量依赖性抑制凝血酶受体激活肽 (TRAP) 诱导的血小板聚集,是抗血小板药物。 | |||
T8917 |
PAR-2-IN-1
IUN76750,8-(叔丁基)-6-氯咪唑并[1,2-B]吡啶-2-羧酸甲酯 |
Protease-activated Receptor | GPCR/G Protein |
PAR-2-IN-1 (IUN76750) 是一种 PAR-2 信号通路抑制剂,具有抗炎和抗癌作用。 | |||
T7513 |
Protease-Activated Receptor-2, amide
蛋白酶活化的受体-2,酰胺,SLIGKV-NH2,H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2 |
Protease-activated Receptor | GPCR/G Protein |
Protease-Activated Receptor-2, amide (SLIGKV-NH2) 是 PAR2 的激动剂,IC50为 10.4 M。 | |||
TP1065 |
PAR-4 Agonist Peptide, amide TFA
PAR-4-AP (TFA),AY-NH2 (TFA) |
Protease-activated Receptor | GPCR/G Protein |
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) 是一种蛋白酶激活受体 4 (PAR-4) 激动剂,对 PAR-1 或 PAR-2 均无影响,其作用可被 PAR-4 拮抗剂阻断。 | |||
T1986L |
Atopaxar Hydrobromide
|
Protease-activated Receptor | GPCR/G Protein |
Atopaxar hydrobromide 是可口服的,高效选择性的可逆凝血酶受体蛋白酶激活受体-1 拮抗剂。它是一种抗血小板剂,能干扰血小板信号,用于动脉粥样硬化血栓性疾病的研究。 | |||
T10951 |
Dabigatran ethyl ester hydrochloride
N-[[2-[[[4-(氨基亚氨甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-(2-吡啶基)-BETA-丙氨酸乙酯盐酸盐 |
Others; Thrombin | Others; Proteases/Proteasome |
Dabigatran ethyl ester hydrochloride 是一种核糖基二氢烟酰胺脱氢酶抑制剂,IC50=0.8 μM,也是一种凝血酶的抑制剂。 | |||
T2368 |
Edoxaban Tosylate Monohydrate
DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban,依度沙班对甲苯磺酸盐一水化合物 |
Factor Xa; Thrombin | Metabolism; Proteases/Proteasome |
Edoxaban Tosylate Monohydrate (DU-176b tosylate Monohydrate) 是口服具有活力的 factor Xa 选择性抑制剂。它是一种抗凝剂,可用于预防中风,是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂,对 FXa 的选择性超过 10000 倍。它具有抗血栓形成的特性,可用于血栓栓塞性疾病的研究。 | |||
T4186 |
AC-264613
AC264613 |
Protease-activated Receptor | GPCR/G Protein |
AC-264613 是一种选择性蛋白酶激活受体 (PAR-2) 激动剂,pEC50为 7.5。 | |||
T40711 |
H-D-Phe-Pip-Arg-pNA dihydrochloride
S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride |
Others | Others |
H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, H-D-Phe-Pip-Arg-pNA dihydrochloride is employed for the quantification of antithrombin-heparin cofactor (AT-III). The AT-III assay utilizing this substrate is characterized by its sensitivity, accuracy, and ease of implementation. | |||
T7380 |
Protease-Activated Receptor-4
蛋白酶活化的受体-4 |
Protease-activated Receptor | GPCR/G Protein |
Protease-Activated Receptor-4 是蛋白酶激活受体 4 激动剂,具有抗血小板治疗。 | |||
T7573 |
TFLLR-NH2
TFLLR-NH2(2TFA) |
Protease-activated Receptor | GPCR/G Protein |
TFLLR-NH2 是选择性的一种PAR1激动剂,EC50值为1.9 μM。 | |||
T7623 |
PAR-4 Agonist Peptide, amide
AY-NH2,PAR-4 Agonist Peptide, amide(2TFA),PAR-4-AP |
Protease-activated Receptor | GPCR/G Protein |
PAR-4 Agonist Peptide, amide (AY-NH2) 是蛋白酶激活受体 4 (PAR-4) 的激动剂,对 PAR-1 或 PAR-2 均无影响,其作用可被 PAR-4 拮抗剂阻断。 | |||
T22676 |
Prothrombin (474-477) [Mus musculus]
|
Others | Others |
Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to | |||
T8362 |
Benzamidine hydrochloride
Benzamidine HCl,苄脒盐酸盐 |
Serine/threonin kinase; Serine Protease | Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome |
Benzamidine hydrochloride (Benzamidine HCl) 是可逆的胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 竞争性抑制剂,对 uPA、类胰蛋白酶、胰蛋白酶和 Xa 因子作用的Ki 分别为 97 µM、20 µM、21 µM 和 110 µM。 | |||
T25364L |
Efegatran sulfate
LY294468 sulfate,GYKI-14766 sulfate,LY 294468 sulfate,LY-294468 sulfate |
Thrombin | Proteases/Proteasome |
Efegatran sulfate (LY294468 sulfate) 是一种有效的凝血酶抑制剂,可用于治疗血栓类疾病。 | |||
T9892 |
JAMM protein inhibitor 2
Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]- |
Others | Others |
JAMM protein inhibitor 2 (Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-) 是 JAMM 蛋白酶的抑制剂,可用于抗癌的研究。 对thrombin、Rpn11 和 MMP2 的 IC50 分别为 10 μM、46 μM 和 89 μM。 | |||
T37034 |
H-Gly-Arg-pNA dihydrochloride
H-Gly-Arg-Pna 2HCl |
||
H-Gly-Arg-pNA dihydrochloride (H-Gly-Arg-Pna 2HCl) 属于多肽类,可与1,2凝血酶结合,可通过 405 纳米波长的比色检测进行定量,作为凝血酶活性的测量指标。 | |||
TP1143L |
Fibrinopeptide A, human acetate
Fibrinopeptide A, human acetate(25422-31-5 free base),Human fibrinopeptide A acetate |
Others | Others |
Fibrinopeptide A, human acetate (Human fibrinopeptide A acetate)(25422-31-5 free base) 是一种 16 个残基的短多肽,由凝血酶从纤维蛋白原上切割下来。纤维蛋白肽 A (FPA) 由纤维蛋白原蛋白的 N 末端 Aα 区域在被凝血酶切割后产生。 | |||
T36951 |
N-(p-Tosyl)-GPR-pNA acetate
|
Others | Others |
N-(p-Tosyl)-GPR-pNA acetate 是凝血酶的比色底物,可作为凝血酶活性的量度。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3839 |
Cycloolivil
Isoolivil,环橄榄树脂素 |
Free radical scavengers; Others; Platelet aggregation | Others; oxidation-reduction |
Cycloolivil (Isoolivil) 是一种天然多酚化合物,在橄榄树中具有显着的自由基清除活性。 Cycloolivil 具有抗氧化活性,它可以预防与血小板过度聚集相关的血栓并发症,是开发抗聚集治疗策略的基础。 | |||
T3793 |
(20R)-Ginsenoside Rh1
20(R)-Ginsenoside Rh1,人参皂苷 R-RH1,人参皂苷R-RH1 |
Others | Others |
(20R)-Ginsenoside Rh1 (20(R)-Ginsenoside Rh1) 是 Ginsenoside Rh1 的 R 型异构体,分离自 Panax Ginseng 中,能够阻碍凝血酶诱导的纤维蛋白原向纤维蛋白的转化。 | |||
T3781 |
Jujuboside B
酸枣仁皂苷 B,酸枣仁皂苷B |
Others | Others |
Jujuboside B 是一种提取自Zizyphus jujuba 中的活性成分,对血小板聚集具有抑制作用。 | |||
TN1054 |
Loureirin C
龙血素C,龙血素 C |
Others | Others |
Loureirin C 在体外能有效抑制凝血酶的活性。它具有抗菌,抗痉挛,抗炎,止痛,抗糖尿病和抗肿瘤作用。 | |||
T3S0601 |
Buddlejasaponin IVb
醉鱼草皂苷IVb,Saikosaponin 1b |
Others | Others |
Buddlejasaponin IVb (Saikosaponin 1b) 是一种三萜皂苷,从Clinopodium chinense (Benth.) O. Kuntze 中分离得到,能够缩短凝血时间,具有止血作用。 | |||
TN3831 |
(-)-Denudatin B
Denudatin B |
ATPase; Potassium Channel; Calcium Channel; PAFR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
(-)-Denudatin B (Denudatin B) 源自 Magnolia fargesii。 (-)-Denudatin B 通过抑制胶原蛋白和凝血酶诱导的磷酸肌醇分解,在高浓度下具有非特异性抗血小板作用。 | |||
T5S0896 |
Loureirin A
龙血素 A,龙血素A |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Loureirin A 是一种黄酮类物质,从龙血树中分离得到,能够降低Akt 的磷酸化,具有抗血小板聚集作用。 | |||
T5S2358 |
Dehydrocorydaline
Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
TN4917 |
Rosenonolactone
|
Others | Others |
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin. | |||
T36532 |
SCH 38519
|
||
SCH 38519 is an isochromanequinone fungal metabolite originally isolated from Thermomonospora. It inhibits aggregation induced by thrombin , as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 μg/ml, respectively). It inhibits the growth of various Gram-negative and Gram-positive bacteria (mean MICs = 122.1 and 0.92 μg/ml, respectively). | |||
TN4860 |
Pueroside B
|
COX; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2 | |||
TN6014 |
Norcepharadione B
鱼腥草 |
||
Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05025 |
Thrombin Receptor Protein, Human, Recombinant (His)
TR,PAR1,HTR,coagulation factor II (thrombin) recept... |
Human | HEK293 Cells |
Thrombin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10.2 kDa and the accession number is A0A024RAP7. | |||
TMPY-04996 |
Coagulation Factor II Protein, Rat, Recombinant (His)
coagulation factor II (thrombin) |
Rat | HEK293 Cells |
Coagulation Factor II Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.5 kDa and the accession number is A6HND0. | |||
TMPY-01791 |
Coagulation Factor II Protein, Mouse, Recombinant (His)
Cf-2,coagulation factor II (thrombin),Cf2,FII |
Mouse | HEK293 Cells |
Coagulation Factor II Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.3 kDa and the accession number is P19221. | |||
TMPJ-00649 |
CPB2 Protein, Human, Recombinant (His)
CPB2,CPU,TAFI,pCPB,Carboxypeptidase B2,Plasma Carboxypeptida... |
Human | HEK293 Cells |
Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the plasma as a plasminogen-bound zymogen. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides, such as kinins or anaphylatoxins, in the circulation regulating their activities. CPB2 also down-regulates fibrinolysis by removing C-terminal lysine residu... | |||
TMPH-00038 |
Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc)
|
Agkistrodon contortrix | E. coli |
Thrombin-like snake venom serine protease that cleaves beta chain of fibrinogen (FGB), releasing fibrinopeptide B. Has a coagulant activity activating blood coagulation factors V (F5) and XIII (F13A1). Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.4 kDa and the accession number is P82981. | |||
TMPJ-00243 |
Serpin B6 Protein, Human, Recombinant (E. coli, His)
CAP,PI6,SERPINB6,Placental Thrombin Inhibitor,Cytop... |
Human | E. coli |
Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. In addition, Serpin B6 may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and se... | |||
TMPY-00916 |
Antithrombin III Protein, Human, Recombinant (His)
AT3D,THPH7,ATIII,AT3,Serpin C1,MGC22579,serpin peptidase inh... |
Human | HEK293 Cells |
Antithrombin III Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.5 kDa and the accession number is A0A024R944. | |||
TMPH-01974 |
Prothrombin Protein, Human, Recombinant (His)
|
Human | P. pastoris (Yeast) |
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Prothrombin Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 67.3 kDa and the accession number is P00734. | |||
TMPY-02471 |
Antithrombin III Protein, Cynomolgus, Recombinant (His)
SerpinC1,serpin peptidase inhibitor, clade C (antithromb... |
Cynomolgus | HEK293 Cells |
Antithrombin III Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.2 kDa. | |||
TMPH-01975 |
Prothrombin Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Prothrombin Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-01101 |
Coagulation factor X/F10 Protein, Human, Recombinant (His)
FXA,FX,coagulation factor X,coagulation factor 10 |
Human | Baculovirus Insect Cells |
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema... | |||
TMPY-02185 |
Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)
Coagulation factor 13,coagulation factor XIII, B polypeptide... |
Human | HEK293 Cells |
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have en... | |||
TMPH-01578 |
KRT18 Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. | |||
TMPJ-00452 |
Serpin A1a Protein, Mouse, Recombinant (His)
Alpha-1-antitrypsin 1-1, Alpha-1 protease inhibitor 1, Alpha... |
Mouse | HEK293 Cells |
Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. | |||
TMPH-00768 |
SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc)
|
Gloydius ussuriensis | E. coli |
Thrombin-like snake venom serine protease. Has a coagulant activity. Acts on alpha-chains of fibrinogen (FGA) generating fibrinopeptide A. SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.7 kDa and the accession number is Q91053. | |||
TMPJ-00796 |
Serpin E2 Protein, Human, Recombinant (His)
PN-1,PI-7,Protease nexin 1,PI7,GDN,Peptidase inhibitor 7,Ser... |
Human | HEK293 Cells |
Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown tha... | |||
TMPJ-01069 |
Serpin A1e Protein, Mouse, Recombinant (His)
Dom5,α-1-antitrypsin 1-5,Serpina1e,Spi1-5,Serine protease in... |
Mouse | HEK293 Cells |
Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein ... | |||
TMPJ-00605 |
GPVI Protein, Mouse, Recombinant (His)
Glycoprotein 6,GP6,glycoprotein VI (platelet),GPVI,GPIV,MGC1... |
Mouse | HEK293 Cells |
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregation and thrombin generation. GPVI is also a secondary receptor required for platelet spreading on laminin. GPVI associates with the Fc receptor gamma -chain via charged aa in the TM domains of GPVI (arginine) and the FcR gamma (aspartic acid). Collagen binding by the GPVI Ig-like... | |||
TMPK-01043 |
VEGFC Protein, Human, Recombinant (His & Avi)
Flt4-L,血管内皮生长因子,VEGFC,VRP,VEGF-C |
Human | HEK293 Cells |
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet enhancement of lymphatic growth after wounding is dependent on the release of VEGFC, but not VEGFD, a finding consistent with high expression of VEGFC in both platelets and avian thrombocytes. VEGFC Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells w... | |||
TMPH-00213 |
Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc)
Platelet aggregation activation inhibitor,Disintegrin colomb... |
Bothrops atrox | E. coli |
Inhibits fibrinogen interaction with platelets. Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Also inhibits T24 and SK-Mel-28 cell adhesion to fibronectin with IC(50) of 4.4 uM and 33 nM, respectively. Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted... | |||
TMPH-00215 |
SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc)
|
Bothrops jararaca | E. coli |
Thrombin-like snake venom serine protease that clots fibrinogen by releasing fibrinopeptide A from the alpha chain of fibrinogen (FGA), induces platelet aggregation through its interaction with GPIb (GP1BA/GP1BB), and activates factor VIII (F8). SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.0 kDa and the accession number is P81661. | |||
TMPH-01577 |
KRT18 Protein, Human, Recombinant (E. coli, His)
|
Human | E. coli |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. KRT18 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 52.0 kDa and the accession number is P05783. | |||
TMPJ-00490 |
Serpin A5 Protein, Human, Recombinant (His)
Plasminogen Activator Inhibitor 3,Acrosomal Serine Protease ... |
Human | HEK293 Cells |
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes o... | |||
TMPH-02778 |
Mcpt4 Protein, Mouse, Recombinant (E. coli, His)
|
Mouse | E. coli |
Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. Mcpt4 Protein, Mouse, Recombinant (E. c... | |||
TMPJ-01124 |
PDIA6 Protein, Human, Recombinant (His)
Thioredoxin Domain-Containing Protein 7,P5,ERP5,TXNDC7,Prote... |
Human | HEK293 Cells |
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA... | |||
TMPY-03604 |
VAMP3 Protein, Human, Recombinant (His)
vesicle-associated membrane protein 3,CEB |
Human | E. coli |
VAMP3, also known as cellubrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Because of VAMP3 gene's high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, VAMP3 was shown to be the human equivalent ... | |||
TMPK-01044 |
VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated
血管内皮生长因子,Flt4-L,VRP,VEGF-C,VEGFC |
Human | HEK293 Cells |
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet enhancement of lymphatic growth after wounding is dependent on the release of VEGFC, but not VEGFD, a finding consistent with high expression of VEGFC in both platelets and avian thrombocytes. VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mam... | |||
TMPY-02242 |
Serpin B6 Protein, Human, Recombinant (His)
DKFZp686I04222,PTI,SPI3,PI-6,RP1-90J20.6,serpin peptidase in... |
Human | Baculovirus Insect Cells |
SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6 / PI-6 is ex... | |||
TMPJ-00707 |
Coagulation factor X/F10 Protein, Mouse, Recombinant (His)
Stuart factor,Coagulation factor X,F10 |
Mouse | HEK293 Cells |
Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin K-dependent plasma protease that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. The two chains of F10 are formed from a single-chain precursor by the excision of two Arg residues. A single-chain precursor is initiall... | |||
TMPJ-01282 |
Serpin B12 Protein, Human, Recombinant (His)
SERPINB12,Serine Protease Inhibitor-clade B12,Serpin B12 |
Human | HEK293 Cells |
Serpin B12 is a member of the serpin family. Serpins are the largest and most diverse family of serine protease inhibitors. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. Serpin B12 is expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine. Serpins are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysi... | |||
TMPJ-00301 |
Coagulation Factor X Protein, Human, Recombinant (hFc)
Stuart-Prower factor,Stuart factor,Coagulation factor X |
Human | HEK293 Cells |
F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways activate Factor X to Xa, which consists of light (residues 41‑179) and heavy (residues 235‑488) chains linked by a disulfide bond. Coagulation factor X is initially synthesized in the liver. The two chains are formed from a single-chain precursor by the excision of two Arg residue... | |||
TMPJ-00505 |
Serpin A1 Protein, Human, Recombinant (aa 25-418, His)
Alpha-1-Antiproteinase,α-1-Antiproteinase,SERPINA1,Serpin A1... |
Human | HEK293 Cells |
Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants re... | |||
TMPY-01718 |
Serpin B12 Protein, Mouse, Recombinant (His)
2300003F07Rik,4833409F13Rik,serpin peptidase inhibitor, clad... |
Mouse | Baculovirus Insect Cells |
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. Mouse SerpinB12 is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. It ... | |||
TMPJ-00734 |
KNG1 Protein, Human, Recombinant (His)
KNG1,High Molecular Weight Kininogen,BDK,HMWK,KNG,Williams-F... |
Human | HEK293 Cells |
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation... | |||
TMPJ-00193 |
TREML1 Protein, Human, Recombinant (hFc)
TLT-1,Trem-Like Transcript 1 Protein,TLT1,Triggering Recepto... |
Human | HEK293 Cells |
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain, and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic... | |||
TMPJ-01083 |
Serpin E2 Protein, Mouse, Recombinant (His)
Pi7,Protease nexin I,Spi4,Pn1,Serine protease-inhibitor 4,PI... |
Mouse | HEK293 Cells |
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronic pancreatitis tissue samples. Ser... | |||
TMPJ-00857 |
Thrombomodulin Protein, Mouse, Recombinant (His)
Fetomodulin,Thbd,BDCA-3,Thrombomodulin,CD141,TM |
Mouse | HEK293 Cells |
Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits ... | |||
TMPY-00821 |
HGFA Protein (pro form), Human, Recombinant (His)
MGC138397,HGFA,RP11-529E1.2,肝细胞生长因子,MGC138395 |
Human | HEK293 Cells |
HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is clea... | |||
TMPJ-00535 |
F13A Protein, Human, Recombinant (His)
F13A1,Coagulation Factor XIII A Chain,Transglutaminase A Cha... |
Human | HEK293 Cells |
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium io... | |||
TMPY-01840 |
TLT-1/TREML1 Protein, Human, Recombinant (His)
PRO3438,TLT-1,triggering receptor expressed on myeloid cells... |
Human | HEK293 Cells |
Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) do... | |||
TMPH-02832 |
Serpin A5 Protein, Mouse, Recombinant (His)
|
Mouse | Baculovirus Insect Cells |
Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin comple... | |||
TMPY-02014 |
Coagulation factor VII/F7 Protein, Human, Recombinant (His)
coagulation factor VII (serum prothrombin conversio... |
Human | HEK293 Cells |
Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is ... |