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66

抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
TP1483L Abl Cytosolic Substrate acetate

Abl Cytosolic Substrate acetate(168202-46-8 free base)

Others Others
Abl Cytosolic Substrate acetate(168202-46-8 free base) 是 Abelson 酪氨酸激酶 (Abl) 的底物。
TP1483 Abl Cytosolic Substrate

Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl ).
T22043 BCATc Inhibitor 2

Others Others
BCATc Inhibitor 2 是选择性分支链氨基转移酶抑制剂,可用于神经退行性疾病的研究。能够抑制 rBCATc (IC50:0.2 μM),hBCATc (IC50:0.8 μM)、 rBCATm (IC50:3.0 μM)。其中BCATc 也称为 BCAT1,存在于细胞质基质中的亚型。
T6500 Ferrostatin-1

Ferrostatin 1,Ferrostatin-1 (Fer-1)

Ferroptosis; Antifungal Apoptosis; Microbiology/Virology
Ferrostatin-1 (Fer-1) 是一种铁死亡抑制剂,具有强效性和选择性。Ferrostatin-1 有效抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 还具抗氧化和抗真菌活性。
T8356 FPL 62064

Lipoxygenase; COX Immunology/Inflammation; Metabolism; Neuroscience
FPL 62064 是 5-脂氧合酶和COX 双重抑制剂,具有抗炎活性,对 RBL-1 胞质 5-脂氧合酶和前列腺素合成酶 (环氧化酶) 的IC50值分别为 3.5 和 3.1 μM。
TQ0105 CAY10650

Phospholipase Metabolism
CAY10650 是高效的胞浆磷脂酶A2α抑制剂,IC50=12 nM,能够抑制脂滴形成和 PGE2 分泌。
T0380 Bicalutamide

比卡鲁胺,ICI-176334

Androgen Receptor; Autophagy Autophagy; Endocrinology/Hormones
Bicalutamide (ICI-176334) 是一种具有口服活性的非甾体雄激素受体拮抗剂,可研究前列腺癌。
T5481 TRi-1

Others Others
TRi-1 是不可逆的胞质硫氧还蛋白还原酶1 的特异性抑制剂(IC50:12 nM)。它有抗肿瘤作用,且线粒体毒性很小。
TP1545L1 FFAGLDD amine salt

Others Others
FFAGLDD amine salt 是MMP9选择性裂解肽,用于多柔比星(DOX)的胞浆递送,实现时间和空间可控的缓慢药物递送和释放。
T11149 Ecopladib

PLA 725

Phospholipase Metabolism
Ecopladib (PLA 725) 是一种胞浆磷脂酶 A2α (phospholipase A2α) 抑制剂,在 GLU micelle 和大鼠全血细胞中,IC50 值分别为 0.15 μM 和 0.11 μM。
T10927 Cyt-PTPε Inhibitor-1

Cyt-PTP|A Inhibitor-1

Phosphatase; Src Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
Cyt-PTPε Inhibitor-1 (A Inhibitor-1) 是胞质蛋白酪氨酸磷酸酶 ε 的抑制剂。 Cyt-PTPε Inhibitor-1 阻断 c-Src 的去磷酸化并表现出抗破骨活性。
T13613 ChX710

STING Immunology/Inflammation
ChX710可以引发 I 型干扰素对细胞溶质 DNA 的反应,其特异性细胞干扰素刺激基因 (ISG) 诱导 ISRE 启动子序列和干扰素调节因子 (IRF) 3 的磷酸化。
T77616 VU533

Nape-Pld activator

Phospholipase Metabolism
VU533 (Nape-Pld activator) 是一种NAPE-PLD 激活剂,其 EC50 值为0.30 µM。VU533 可以提高 NAPE-PLD 活性,增加巨噬细胞的胞葬作用。VU533 可用于与心脏代谢相关的疾病。
T13072 Taltirelin acetate

TA-0910 acetate

Thyroid hormone receptor(THR) Endocrinology/Hormones
Taltirelin acetate (TA-0910 acetate) 是促甲状腺激素释放激素受体(TRH-R)超激动剂(IC50:910 nM),能够刺激细胞溶质Ca2+浓度增加 (Ca2+释放) ,其EC50值为 36 nM。
T6040 Aloxistatin

E64d,Loxistatin,阿洛司他丁,E64c ethyl ester

SARS-CoV; Cysteine Protease Microbiology/Virology; Proteases/Proteasome
Aloxistatin (E64d) 是一种不可逆的、可透过膜的溶酶体和细胞溶质半胱氨酸蛋白酶抑制剂,能够抑制完整血小板中的钙蛋白酶活性。它是一种半胱氨酸蛋白酶抑制剂,具有血小板聚集抑制活性。
T61338 MS023 dihydrochloride

MS023 2HCl

Histone Methyltransferase Chromatin/Epigenetic
MS023 dihydrochloride (MS023 2HCl) 是一种具有选择性、细胞活性和高效性的人I 型蛋白精氨酸甲基转移酶 (PRMTs)抑制剂,具有抗肿瘤活性,抑制 PRMT1,PRMT3,PRMT4,PRMT6和PRMT8,增加离体培养的 MuSC 的增殖能力,可用于研究乳腺癌。
T35868 BCAT-IN-2

Others Others
BCAT-IN-2 是一种具有口服活性和选择性的线粒体支链氨基转移酶(BCATm)抑制剂,抑制 BCATm 和 BCATc,可用于肥胖症和血脂异常。
T24089 GK470

GK 470,GK-470

GK470 is a group IVA cytosolic phospholipase A2 inhibitor.
T25546 Isoproterenol tartrate, (-)-

L-Isoproterenol D-bitartrate,Isoproterenol D-bitartrate, L-,Isolevin

Isoproterenol tartrate, (-)- is a beta-Adrenoceptor agonist agent that increases cytosolic cAMP.
T26693 AVX-001

FP-025,AKH-217,AKH217,AVX001,FP025

AVX-001, a cytosolic phospholipase A2 (cPLA2) inhibitor, is used potentially for the treatment of psoriasis.
T13606 cGAMP

3',3'-cGAMP,Cyclic GMP-AMP

Others Others
cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.
T69046 AK-106

AK-106, also known as AK106-001616, is a selective inhibitor of cytosolic phospholipase A2 (cPLA2) inhibitor. AK-106 has been shown to have analgesic activites similar to non-steroidal anti-inflammatory drugs (NSAIDs).
T26523 Abroquinone A

Abroquinone A, a natural isoflavanquinone, has been shown to block cytosolic phospholipase A(2) and 5-lipoxygenase activation in neutrophils, it may have pharmaceutical potential as an antiallergic agent.
T82922 BAPTA-TMFM

BAPTA-TMFM为研究胞质游离钙行为专用的荧光螯合指示剂。
T37502 sn-Glycerol 3-phosphate lithium

sn-Glycerol 3-phosphate lithium is synthesized via the cytosolic glycerol 3-phosphate dehydrogenase pathway. This process involves the conversion of dihydroxyacetone phosphate to sn-Glycerol 3-phosphate using NADH, which is generated during glycolysis.
T61650 CXCR4 antagonist 9

CXCR4 antagonist 9 (Compound 2) is a potent CXCR4 antagonist displaying an IC50 of 15 nM. It effectively inhibits the cytosolic calcium increase induced by CXCL12, with an IC50 value of 1.3 nM [1].
T71913 Bourgeonal

Bourgeonal is an agonist of human testicular olfactory receptor hOR17-4. It increases cytosolic calcium levels in human spermatozoa, acts as a chemoattractant, and increases swimming speed in sperm chemotaxis assays in a concentration-dependent manner.
T35640 trans-carboxy Glimepiride

trans-carboxy Glimepiride is a metabolite of the sulfonylurea glimepiride .1It is formed from glimepiride in a two-step process mediated by the cytochrome P450 (CYP) isoform CYP2C9 and cytosolic enzymes. 1.Noh, K., Kim, E., Jeong, T.C., et al.Simultaneous determination of glimepiride and its metabolites in human plasma by liquid chromatography coupled to a tandem mass spectrometryArch. Pharm. Res.34(12)2073-2078(2011)
T81894 Lys-Phe-Glu-Arg-Gln

Lys-Phe-Glu-Arg-Gln 促进无血清培养条件下人二倍体成纤维细胞胞浆蛋白的降解作用。
T37556 CAY10502

Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway. CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits ...
T40566 2′-O-(2-Methoxyethyl)guanosine

2′-O-(2-Methoxyethyl)guanosine,2'-O-MOE-rG

2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a modified nucleoside, can be enzymatically converted from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside by adenosine deaminase. However, this compound is not readily phosphorylated by cytosolic nucleoside kinases, and it cannot be incorporated into cellular DNA or RNA.
T7590 Taltirelin

TA-0910,他替瑞林

Thyroid hormone receptor(THR) Endocrinology/Hormones
Taltirelin (TA-0910) 是促甲状腺激素释放激素受体(TRH-R)超激动剂(IC50:910 nM),能够刺激细胞溶质 Ca2+浓度增加 (Ca2+释放) (EC50:36 nM)。
TP1545 FFAGLDD

Others Others
FFAGLDD 是 MMP9 选择性切割肽,用于多柔比星 (DOX) 的胞浆递送,实现时间和空间控制的缓慢药物递送和释放。
T61363 CXCR4 antagonist 8

CXCR4 antagonist 8 (Compound 3) is a potent inhibitor of CXCR4. It demonstrates an IC50 value of 57 nM in CXCR4 antagonism. In addition, it effectively inhibits the increase in cytosolic calcium induced by CXCL12 with an IC50 value of 0.24 nM. Furthermore, Compound 3 shows efficacy in the inhibition of CXCL12/CXCR4-mediated cell migration [1].
T61447 CXCR2 antagonist 4

CXCR2 antagonist 4 (compound 7) is a highly potent antagonist that inhibits CXCR2 with an IC50 value of 0.13 μM. It also effectively inhibits the cytosolic calcium increase induced by CXCL8, with an IC50 value of 27 μM. CXCR2 antagonist 4 shows promising potential for anticancer research [1].
T37842 ASB 14780

Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor (IC50 = 20 nM). Selective for cPLA2α over secreted PLA2α (sPLA2α; exhibits no inhibition at 10 μM). Inhibits cPLA2α-dependent inflammatory responses in vitro in guinea pig and human whole-blood assays. Improves diet-induced liver injury and CCl4-induced hepatic fibrosis in vivo. Orally bioavailable.
T40750 12,14-Dichlorodehydroabietic acid

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity. It effectively inhibits GABA-dependent chloride influx in the mammalian brain, functioning as a non-competitive antagonist of GABA A receptors. Moreover, 12,14-Dichlorodehydroabietic acid induces an elevation in cytosolic free calcium levels and promotes the release of neurotransmitters.
TP1296 Foxy-5 TFA(881188-51-8 free base)

Foxy-5 (TFA)

Foxy-5 is a peptide that mimics the WNT5A protein and is expected to reduce the mobility of the cancer cells. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial c
T37652 5(S),6(R)-DiHETE

5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM.
T37824 MCT4-IN-1

MCT4-IN-1

MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MCT4-IN-1 has the potential for MCT4 transporter inhibition research[1].
T37616 Leukotriene A4 methyl ester

Leukotriene A4 methyl ester

白三烯A4甲酯可在大鼠肝脏中主要碱性胞质谷胱甘肽转移酶的催化下转化为白三烯C4单甲酯,可用于代谢相关研究。
T77131 Clervonafusp alfa

Clervonafusp alfa (VAL-1221) 作为一种融合蛋白,针对胞浆及溶酶体糖原进行靶向。该化合物结合了穿透细胞的抗体Fab部分与重组人酸性葡萄糖苷酶 (rhGAA),通过核苷转运体ENT-2进入细胞质,再利用甘露糖-6-磷酸受体(M6PRs)导向溶酶体。主要应用于晚发型庞贝病的研究领域。
T61419 CXCR4 antagonist 5

CXCR4 antagonist 5 (compound 23), a potent CXCR4 antagonist, exhibits high inhibition efficacy against CXCR4 with an IC50 value of 8.8 nM. It effectively suppresses CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and hinders CXCR4/CXCL12-mediated chemotaxis. Moreover, Compound 23 demonstrates favorable physicochemical properties and in vitro safety profiles, exhibiting only marginal to moderate inhibition of CYP isozymes and hERG [1].
T37303 5-OxoETE

5-KETE,5-OxoETE

5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.[1] It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.[2] 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils via a specific G protein-coupled receptor.[3],[4],[5],[6]
T61420 CXCR4 antagonist 6

CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM. It effectively inhibits the cytosolic calcium flux induced by CXCL12, achieving an IC50 of 0.25 nM. Moreover, CXCR4 antagonist 6 demonstrates significant mitigation of cell migration mediated by the CXCL12/CXCR4 interaction. Notably, this compound exhibits remarkable efficacy in a mouse model of cancer metastasis [1].
T36369 3,6-diacetoxy Phthalonitrile

3,6-diacetoxy Phthalonitrile is a fluorescent probe for monitoring intracellular pH by flow cytometry in living cells. It rapidly crosses cell membranes and is cleaved by cytosolic esterases to form the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH), which is excited at UV wavelengths. DCH can be excited at 351 nm, with pH-dependent emission in the range of 450-476 nm (pH 5.0-10.0) using a potassium-based buffer.
T21681 AACOCF3

Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane

Phospholipase Metabolism
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Moreover, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. Given its diverse applications, AACOCF3 ...
T80771 WRR139

WRR139为肽乙烯基砜类化合物,涉及诸如炎症与癌症等病症的生物学路径。该化合物同时作用于胞质酶N-聚糖酶1(NGLY1)与Nrf1,表现为抑制剂身份。WRR139可提升Carfilzomib对癌细胞的细胞毒效应。
TP1565L Foxy-5 acetate

Foxy-5 acetate(881188-51-8 free base)

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
Foxy-5 acetate 是 Wnt 5A 的激动剂,Wnt 5A 是 Wnt 家族的非经典成员。 Foxy-5 acetate 损害上皮癌细胞的迁移和侵袭,触发细胞溶质游离钙信号传导,而不影响 β-连环蛋白活化。
T81675 NICE-01

AP1867-PEG2-JQ1,AP-PEG2-JQ1

NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1)是一款具有双功能的化合物,它通过特异性结合到细胞内特定亚细胞区室中的蛋白质,并以BRD4蛋白的核定位含溴结构域作为诱导,实现将胞浆中的货物输送至细胞核。

化合物

Abl Cytosolic Substrate acetate
Cat.No: TP1483L
Synonym: Abl Cytosolic Substrate acetate(168202-46-8 free base)
Target: Others
Abl Cytosolic Substrate
Cat.No: TP1483
Synonym:
Target:
BCATc Inhibitor 2
Cat.No: T22043
Synonym:
Target: Others
Ferrostatin-1
Cat.No: T6500
Synonym: Ferrostatin 1,Ferrostatin-1 (Fer-1)
Target: Ferroptosis, Antifungal
FPL 62064
Cat.No: T8356
Synonym:
Target: Lipoxygenase, COX
CAY10650
Cat.No: TQ0105
Synonym:
Target: Phospholipase
Bicalutamide
Cat.No: T0380
Synonym: 比卡鲁胺,ICI-176334
Target: Androgen Receptor, Autophagy
TRi-1
Cat.No: T5481
Synonym:
Target: Others
FFAGLDD amine salt
Cat.No: TP1545L1
Synonym:
Target: Others
Ecopladib
Cat.No: T11149
Synonym: PLA 725
Target: Phospholipase
Cyt-PTPε Inhibitor-1
Cat.No: T10927
Synonym: Cyt-PTP|A Inhibitor-1
Target: Phosphatase, Src
ChX710
Cat.No: T13613
Synonym:
Target: STING
VU533
Cat.No: T77616
Synonym: Nape-Pld activator
Target: Phospholipase
Taltirelin acetate
Cat.No: T13072
Synonym: TA-0910 acetate
Target: Thyroid hormone receptor(THR)
Aloxistatin
Cat.No: T6040
Synonym: E64d,Loxistatin,阿洛司他丁,E64c ethyl ester
Target: SARS-CoV, Cysteine Protease
MS023 dihydrochloride
Cat.No: T61338
Synonym: MS023 2HCl
Target: Histone Methyltransferase
BCAT-IN-2
Cat.No: T35868
Synonym:
Target: Others
GK470
Cat.No: T24089
Synonym: GK 470,GK-470
Target:
Isoproterenol tartrate, (-)-
Cat.No: T25546
Synonym: L-Isoproterenol D-bitartrate,Isoproterenol D-bitartrate, L-,Isolevin
Target:
AVX-001
Cat.No: T26693
Synonym: FP-025,AKH-217,AKH217,AVX001,FP025
Target:
cGAMP
Cat.No: T13606
Synonym: 3',3'-cGAMP,Cyclic GMP-AMP
Target: Others
AK-106
Cat.No: T69046
Synonym:
Target:
Abroquinone A
Cat.No: T26523
Synonym:
Target:
BAPTA-TMFM
Cat.No: T82922
Synonym:
Target:
sn-Glycerol 3-phosphate lithium
Cat.No: T37502
Synonym:
Target:
CXCR4 antagonist 9
Cat.No: T61650
Synonym:
Target:
Bourgeonal
Cat.No: T71913
Synonym:
Target:
trans-carboxy Glimepiride
Cat.No: T35640
Synonym:
Target:
Lys-Phe-Glu-Arg-Gln
Cat.No: T81894
Synonym:
Target:
CAY10502
Cat.No: T37556
Synonym:
Target:
2′-O-(2-Methoxyethyl)guanosine
Cat.No: T40566
Synonym: 2′-O-(2-Methoxyethyl)guanosine,2'-O-MOE-rG
Target:
Taltirelin
Cat.No: T7590
Synonym: TA-0910,他替瑞林
Target: Thyroid hormone receptor(THR)
FFAGLDD
Cat.No: TP1545
Synonym:
Target: Others
CXCR4 antagonist 8
Cat.No: T61363
Synonym:
Target:
CXCR2 antagonist 4
Cat.No: T61447
Synonym:
Target:
ASB 14780
Cat.No: T37842
Synonym:
Target:
12,14-Dichlorodehydroabietic acid
Cat.No: T40750
Synonym:
Target:
Foxy-5 TFA(881188-51-8 free base)
Cat.No: TP1296
Synonym: Foxy-5 (TFA)
Target:
5(S),6(R)-DiHETE
Cat.No: T37652
Synonym:
Target:
MCT4-IN-1
Cat.No: T37824
Synonym: MCT4-IN-1
Target:
Leukotriene A4 methyl ester
Cat.No: T37616
Synonym: Leukotriene A4 methyl ester
Target:
Clervonafusp alfa
Cat.No: T77131
Synonym:
Target:
CXCR4 antagonist 5
Cat.No: T61419
Synonym:
Target:
5-OxoETE
Cat.No: T37303
Synonym: 5-KETE,5-OxoETE
Target:
CXCR4 antagonist 6
Cat.No: T61420
Synonym:
Target:
3,6-diacetoxy Phthalonitrile
Cat.No: T36369
Synonym:
Target:
AACOCF3
Cat.No: T21681
Synonym: Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane
Target: Phospholipase
WRR139
Cat.No: T80771
Synonym:
Target:
Foxy-5 acetate
Cat.No: TP1565L
Synonym: Foxy-5 acetate(881188-51-8 free base)
Target: Wnt/beta-catenin
NICE-01
Cat.No: T81675
Synonym: AP1867-PEG2-JQ1,AP-PEG2-JQ1
Target:
Cat. No. Product Name Target Signaling Pathways
T19343L Glycerol 3-phosphate biscyclohexylammonium salt

Endogenous Metabolite Metabolism
Glycerol 3-phosphate biscyclohexylammonium salt 是胞质甘油 3-磷酸脱氢酶途径中产生的,即利用 NADH 还原二羟丙酮磷酸的过程。
TN2215 Taurochenodeoxycholic acid sodium

牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠

Apoptosis; Endogenous Metabolite Apoptosis; Metabolism
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡,具有抗炎和免疫调节作用。
TL0008 Gigantol

Wnt/beta-catenin; Glucosidase Cytoskeletal Signaling; Metabolism; Stem Cells
Gigantol 是一种联苄基化合物,从几种药用兰花中获得,是一种Wnt/β-catenin 通路抑制剂,具有抗肿瘤活性。
T37977 Succinyladenosine

Succinyladenosine is a biochemical marker of adenylosuccinase (ASL) deficiency. It is formed through the dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase [1].
T19253 Cyclic ADP-​ribose

cADPR

Calcium Channel Membrane transporter/Ion channel; Metabolism
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release
T37687 Cyclic ADP-ribose ammonium

Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum, while also facilitating extracellular influx through the opening of TRPM2 channels [1][2][3].
TN6458 Acetylshikonin

Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
T35895 Ingenol 3,20-dibenzoate

Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].
TN5221 (-)-Variabilin

Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...
T73717 cGAMP diammonium

cGAMP (Cyclic GMP-AMPP) diammonium 是一种内源性第二信使,通过触发干扰素的产生来响应胞浆 DNA。它通过激活干扰素基因刺激因子(STING),启动信号级联,进而导致I型干扰素及其他免疫介质的生成。
TN2511 Britannilactone diacetate

1,6-O,O-Diacetylbritannilactone

IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro
T36954 Nemorosone

Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Glycerol 3-phosphate biscyclohexylammonium salt
Cat.No: T19343L
Synonym:
Target: Endogenous Metabolite
Taurochenodeoxycholic acid sodium
Cat.No: TN2215
Synonym: 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠
Target: Apoptosis, Endogenous Metabolite
Gigantol
Cat.No: TL0008
Synonym:
Target: Wnt/beta-catenin, Glucosidase
Succinyladenosine
Cat.No: T37977
Synonym:
Target:
Cyclic ADP-​ribose
Cat.No: T19253
Synonym: cADPR
Target: Calcium Channel
Cyclic ADP-ribose ammonium
Cat.No: T37687
Synonym:
Target:
Acetylshikonin
Cat.No: TN6458
Synonym:
Target:
Ingenol 3,20-dibenzoate
Cat.No: T35895
Synonym:
Target:
(-)-Variabilin
Cat.No: TN5221
Synonym:
Target:
cGAMP diammonium
Cat.No: T73717
Synonym:
Target:
Britannilactone diacetate
Cat.No: TN2511
Synonym: 1,6-O,O-Diacetylbritannilactone
Target: IL Receptor, PARP, ROS, MAPK, Caspase, JAK, JNK, STAT
Nemorosone
Cat.No: T36954
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPH-00096 APX2, cytosolic Protein, Arabidopsis thaliana, Recombinant (His)

APX1b,APX2,L-ascorbate peroxidase 2, cytosolic,L-as...

Arabidopsis thaliana E. coli
APX2, cytosolic Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is Q1PER6.
TMPY-02062 SULT1A1 Protein, Human, Recombinant (His)

HAST1/HAST2,PST,P-PST,ST1A1,STP,sulfotransferase family,

Human E. coli
Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroids and neurotransmitters, and certain xenobiotics, including N-hydroxy-2-acetylaminoflourine and phenolic compounds, like alpha-naphthol. SULTs may be involved in the individual genetic disposition, species differences, and organotropisms for toxicological effects of chemicals. Pa...
TMPY-01478 HSP90 alpha Protein, Human, Recombinant

Hsp89,Hsp90,HSPCAL1,heat shock protein 90kDa alpha (cyto...

Human E. coli
HSP90 alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.6 kDa and the accession number is K9JA46.
TMPJ-00769 TK1 Protein, Human, Recombinant (His)

cytosolic,Thymidine kinase,TK1

Human HEK293 Cells
Thymidine kinase 1(TK1) belongs to the thymidine kinase family. It is located in the cytoplasm, and phosphorylated on Ser-13 in mitosis during post-translational modification. Two forms of this protein have been identified in animal cells, one in cytosol TK1 and one in mitochondria TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Activity of the cytosolic enzyme...
TMPJ-01302 ACAT2 Protein, Human, Recombinant (His)

ACTL,Acetyl-CoA transferase-like protein,Acetyl-CoA acetyltr...

Human E. coli
ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus.
TMPJ-00955 MDH1 Protein, Human, Recombinant (His)

Cytosolic Malate Dehydrogenase,MDH1,MDHA,Diiodophen...

Human E. coli
Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted up...
TMPH-01198 ENGASE Protein, Human, Recombinant (His & SUMO)

Cytosolic endo-beta-N-acetylglucosaminidase,ENGASE

Human E. coli
ENGASE Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-01617 SULT1B1 Protein, Human, Recombinant (His)

sulfotransferase family, cytosolic, 1B, member 1,SU...

Human E. coli
Sulfotransferase family cytosolic 1B member 1, also known as Sulfotransferase 1B1, Sulfotransferase 1B2, Thyroid hormone sulfotransferase, SULT1B1 and ST1B2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1B1 is highly expressed in the liver, perip...
TMPJ-00484 SHMT1 Protein, Human, Recombinant (His)

Serine Methylase,Glycine Hydroxymethyltransferase,Serine Hyd...

Human HEK293 Cells
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to ...
TMPH-00477 NDK, cytosolic Protein, Dictyostelium discoideum, Recombinant (His & V5)

Dictyostelium discoideum E. coli
NDK, cytosolic Protein, Dictyostelium discoideum, Recombinant (His & V5) is expressed in E. coli.
TMPH-03520 ACP Protein, S. aureus, Recombinant (His & SUMO)

acpP,Cytosolic-activating factor,Fatty acid synthas...

Staphylococcus aureus E. coli
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced. ACP Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 24.5 kDa and the accession number is P0A001.
TMPY-03619 p67phox Protein, Human, Recombinant (His & GST)

P67-PHOX,P67PHOX,neutrophil cytosolic factor 2,NCF-...

Human Baculovirus Insect Cells
p67phox Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 87.6 kDa and the accession number is AAH01606.1.
TMPH-00093 GAPC1, cytosolic Protein, Arabidopsis thaliana, Recombinant (His & Myc)

Arabidopsis thaliana E. coli
GAPC1, cytosolic Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.4 kDa and the accession number is P25858.
TMPY-03660 p67phox Protein, Human, Recombinant

NCF-2,NOXA2,P67-PHOX,P67PHOX,neutrophil cytosolic f...

Human Baculovirus Insect Cells
p67phox Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 30 kDa and the accession number is AAH01606.1.
TMPH-00572 ACP Protein, E. coli, Recombinant (His & SUMO)

acpP,Fatty acid synthase acyl carrier protein,Cytosolic<...

E. coli E. coli
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
TMPH-03519 ACP Protein, S. aureus, Recombinant (His)

Cytosolic-activating factor,Fatty acid synthase acy...

Staphylococcus aureus P. pastoris (Yeast)
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced. ACP Protein, S. aureus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 10.5 kDa and the accession number is P0A001.
TMPY-04480 UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)

CMPK,UMPK,UMK,CK,UMP-CMPK,CMK,cytidine monophosphate (UMP-CM...

Human Baculovirus Insect Cells
CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid bi...
TMPH-03518 ACP Protein, S. aureus, Recombinant (GST)

acpP,Fatty acid synthase acyl carrier protein,Acyl carrier p...

Staphylococcus aureus E. coli
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced. ACP Protein, S. aureus, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 35.5 kDa and the accession number is P0A001.
TMPY-06846 HSP90 alpha Protein, Mouse, Recombinant (His)

AL024080,Hspca,hsp4,Hsp86-1,heat shock protein 90kDa α (...

Mouse Baculovirus Insect Cells
HSP90 alpha Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.19 kDa and the accession number is NP_032328.2.
TMPJ-01096 SLP-76 Protein, Human, Recombinant (His)

LCP2,SH2 domain-containing leukocyte protein of 76 kDa,SLP-7...

Human E. coli
Lymphocyte cytosolic protein 2(LCP2)contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation ...
TMPH-01199 CNDP2 Protein, Human, Recombinant (E. coli, His)

HEL-S-13,CPGL,Threonyl dipeptidase,PEPA,CNDP dipeptidase 2,C...

Human E. coli
CNDP2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli.
TMPY-01587 SULT2A1 Protein, Human, Recombinant (His)

hSTa,HST,ST2,ST2A1,STD,DHEAS,ST2A3,sulfotransferase family, ...

Human E. coli
Hydroxysteroid sulfotransferase ( SULT2A1 ) is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar amon...
TMPH-01277 ENOX2 Protein, Human, Recombinant

ENOX2,APK1 antigen,Cytosolic ovarian carcinoma anti...

Human E. coli
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biol...
TMPY-02893 NT5C3A/NT5C3 Protein, Human, Recombinant

P5N1,P5N-1,hUMP1,NT5C3,cN-III,PSN1,UMPH1,UMPH,POMP,5'-nucleo...

Human E. coli
NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but...
TMPH-01278 ENOX2 Protein, Human, Recombinant (His & Myc)

Cytosolic ovarian carcinoma antigen 1,Ecto-NOX disu...

Human E. coli
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biol...
TMPJ-00908 LMW-PTP Protein, Human, Recombinant (His)

Low Molecular Weight Cytosolic Acid Phosphatase,Adi...

Human E. coli
Low Molecular Weight Phosphotyrosine Protein Phosphatase (LMW-PTP) is a member of the low molecular weight phosphotyrosine protein phosphatase family. LMW-PTP serves as an acid phosphatase and a protein tyrosine phosphatase (PTPase) by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. LMW-PTP can be detected in all human tissues, including adipocytes. LMW-PTP is a cytosolic enzyme that regulate cell proliferation and growth of leiomyomas during dephosphorylation of t...
TMPY-06845 HSP90 alpha Protein, Human, Recombinant (His)

EL52,HSP89A,heat shock protein 90kDa alpha (cytosolic

Human Baculovirus Insect Cells
HSP90 alpha Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.06 kDa and the accession number is NP_005339.3.
TMPJ-01351 XPNPEP1 Protein, Human, Recombinant (His)

Xaa-Pro Aminopeptidase 1,X-Prolyl Aminopeptidase 1 Soluble,A...

Human E. coli
X-Prolyl Aminopeptidase (XPNPEP1) is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate proline residue. Because of its specificity toward proline, it has been suggested that X-Prolyl Aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides, and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments, thereby compleme...
TMPY-02483 ATP citrate lyase/ACLY Protein, Human, Recombinant (His)

ATPCL,ACL,ATP citrate lyase,CLATP

Human Baculovirus Insect Cells
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, show...
TMPY-02245 SNAP-25 Protein, Human, Recombinant (His)

synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ106...

Human E. coli
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp...
TMPH-03603 KcsA Protein, S. coelicolor, Recombinant (His)

Streptomyces coelicolor E. coli
Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel. KcsA Protein, S. coelicolor, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 23.7 kDa and the accession number is P0A333.
TMPH-01024 Calbindin Protein, Human, Recombinant (His)

Vitamin D-dependent calcium-binding protein, avian-type,D-28...

Human P. pastoris (Yeast)
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Calbindin Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P05937.
TMPK-00876 G-CSFR/CD114 Protein, Mouse, Recombinant (His)

CD114,G CSF R,G-CSF-R,G-CSF R,CSF3R,GCSFR,Csfgr

Mouse HEK293 Cells
The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal.
TMPY-03047 Stathmin 1 Protein, Human, Recombinant (His)

SMN,OP18,stathmin 1,LAP18,C1orf215,PP17,Lag,PP19,PR22

Human E. coli
Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and prom...
TMPY-04477 CKMT1A Protein, Human, Recombinant (His)

creatine kinase, mitochondrial 1A,CKMT,CKMT1A,CKMT1

Human Baculovirus Insect Cells
CKMT1A belongs to the ATP:guanido phosphotransferase family. It contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. CKMT1A gene is one of two genes that encodes the ubiquitous mitochondrial creatine kinase (CKMT1). CKMT1 is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK (CKMT2) and ubiquitous MtCK, enco...
TMPK-01386 TK1 Potein, Canine, Recombinant (His)

thymidine kinase-1,EC 2.7.1.21,Thymidine kinase

Canine E. coli
Thymidine kinase 1 (TK1) catalyzes the initial phosphorylation of thymidine in the salvage pathway synthesis of dTTP, an essential building block of DNA. TK1 is a cytosolic enzyme with its highest level during the S-phase of the cell cycle.
TMPH-01211 DGUOK Protein, Human, Recombinant (His & SUMO)

Deoxyguanosine kinase, mitochondrial,Deoxyadenosine kinase, ...

Human E. coli
Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents.
TMPY-01579 GBA3 Protein, Human, Recombinant (His)

glucosidase, beta, acid 3 (gene/pseudogene),GBA3,MGC126878,K...

Human Baculovirus Insect Cells
Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in r...
TMPY-02847 Moesin Protein, Human, Recombinant (aa 1-346, His)

moesin,HEL70

Human E. coli
Moesin is a member of the ERM family which includes ezrin and radixin. ERM proteins, highly related members of the larger protein 4.1 superfamily, can exist in an active or inactive conformation. It seems that ERM proteins function as cross-linkers between plasma membranes and actin-based cytoskeletons. The sole Drosophila ERM protein, moesin, functions to promote cortical actin assembly and apical-basal polarity. As a result, cells lacking moesin lose epithelial characteristics and adopt invasi...
TMPJ-00540 PEPD Protein, Human, Recombinant

PRD,Imidodipeptidase,PEPD,PeptidaseD,Prolinedipeptidase,Xaa-...

Human E. coli
PEPD belongs to the peptidase M24B family of Eukaryotic-type prolidase subfamily. PEPD is a cytosolic dipeptidase that hydrolyzes dipeptides with proline or hydroxyproline at the carboxy terminus. It is important in collagen metabolism because of the high levels of imino acids. Defects in PEPD are a cause of prolidase deficiency which is an autosomal recessive disorder associated with iminodipeptiduria.
TMPY-04623 PRRG2 Protein, Human, Recombinant (mFc)

PRGP2,proline rich Gla (G-carboxyglutamic acid) 2,PRRG2

Human HEK293 Cells
The genes encoding a family of proteins termed proline-rich gamma-carboxyglutamic acid (PRRG) proteins were identified and characterized more than a decade ago. These novel membrane proteins have an extracellular gamma-carboxyglutamic acid (Gla) protein domain and cytosolic WW binding motifs. Several of the PRRG-interacting proteins are essential for a variety of physiologic processes.
TMPJ-00656 SULT1C2 Protein, Human, Recombinant (His)

Sulfotransferase 1C1,humSULTC2,SULT1C1,Sulfotransferase 1C2,...

Human E. coli
Sulfotransferase 1C2 (SULT1C2) is a cytosolic enzyme member of the Sulfotransferase 1 family. Human SULT1C2 is primarily expressed in the adult stomach, kidney and thyroid gland, and in the fetal kidney and liver. SULT1C2 catalyzes the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. SULT1C2 may be involved in the activation of carcinogenic hyroxylamines. It shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
TMPJ-01054 PAFAHB Protein, Human, Recombinant (His)

PAFAH Subunit Beta,PAF-AH 30 kDa Subunit,Platelet-Activating...

Human E. coli
Platelet-Activating Factor Acetylhydrolase IB Subunit β (PAFAHB) is a cytoplasmic hydrolase. PAFAHB is a member of the GDSL lipolytic enzyme family. It also belongs to Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily. Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma), PAFAHB is a catalytic subunit. PAFAHB inactivates PAF by removing the acetyl group at the sn-2 position.
TMPH-01276 ENOX1 Protein, Human, Recombinant (His)

Ecto-NOX disulfide-thiol exchanger 1,ENOX1,cNOX,cCNOX

Human E. coli
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.
TMPY-03392 CKAP1/TBCB Protein, Human, Recombinant (His)

CKAPI,tubulin folding cofactor B,CG22,CKAP1

Human E. coli
Tubulin-folding cofactor B, also known as TBCB, belongs to the TBCB family. It contains 1 CAP-Gly domain and can be detected in most tissues. TBCB binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway. The cytoskeleton is composed of 3 structural elements: actin filaments, microtubules, and intermediate filaments. TBCB is involved in regulation of tubulin heterodimer dissociation. It may function as a negative regulator of axonal growth.
TMPJ-01192 ELAPOR1 Protein, Human, Recombinant (His)

ELAPOR1,Endosome-Lysosome Associated Apoptosis And Autophagy...

Human HEK293 Cells
Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated with breast and endometrial cancers,but its mechanism of action remains unknown.May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. That EIG121 is a good endometrial biomarker associated with a hyperestrogenic state and estr...
TMPY-00587 GABARAP Protein, Human, Recombinant (His & MBP)

GABARAP-a,GABA(A) receptor-associated protein,ATG8A,MM46

Human E. coli
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in vivo by delaying cell death and its associated immune-related response. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases. GABARAPs as the first known direct interaction partners of Nef that are essential...
TMPY-01734 CA13 Protein, Human, Recombinant (His)

carbonic anhydrase XIII,FLJ37995,CAXIII,MGC59868

Human E. coli
The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. The CAXIII is a member of th...
TMPY-04103 COLEC10 Protein, Cynomolgus, Recombinant (hFc)

collectin sub-family member 10 (C-type lectin)

Cynomolgus HEK293 Cells
COLEC1 is a member of the C-lectin family. Members of this family possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. COLEC10 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 ...
TMPJ-00690 PGDS Protein, Human, Recombinant

Glutathione-Requiring Prostaglandin D Synthase,PGDS,Glutathi...

Human E. coli
Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macrophages, and placenta, and it exists in the form of homodimer in living body. HPGDS is a cytosolic enzyme that isomerizes PGH(2). HPGDS is a bifunctional enzyme that catalyzes both the conversion of PGH2 to PGD2 and also shows low glutathione-peroxidase activity towards cumenehydrop...
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重组蛋白

APX2, cytosolic Protein, Arabidopsis thaliana, Recombinant (His)
Cat.No: TMPH-00096
Species: Arabidopsis thaliana
Expression System: E. coli
SULT1A1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02062
Species: Human
Expression System: E. coli
HSP90 alpha Protein, Human, Recombinant
Cat.No: TMPY-01478
Species: Human
Expression System: E. coli
TK1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00769
Species: Human
Expression System: HEK293 Cells
ACAT2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01302
Species: Human
Expression System: E. coli
MDH1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00955
Species: Human
Expression System: E. coli
ENGASE Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01198
Species: Human
Expression System: E. coli
SULT1B1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01617
Species: Human
Expression System: E. coli
SHMT1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00484
Species: Human
Expression System: HEK293 Cells
NDK, cytosolic Protein, Dictyostelium discoideum, Recombinant (His & V5)
Cat.No: TMPH-00477
Species: Dictyostelium discoideum
Expression System: E. coli
ACP Protein, S. aureus, Recombinant (His & SUMO)
Cat.No: TMPH-03520
Species: Staphylococcus aureus
Expression System: E. coli
p67phox Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-03619
Species: Human
Expression System: Baculovirus Insect Cells
GAPC1, cytosolic Protein, Arabidopsis thaliana, Recombinant (His & Myc)
Cat.No: TMPH-00093
Species: Arabidopsis thaliana
Expression System: E. coli
p67phox Protein, Human, Recombinant
Cat.No: TMPY-03660
Species: Human
Expression System: Baculovirus Insect Cells
ACP Protein, E. coli, Recombinant (His & SUMO)
Cat.No: TMPH-00572
Species: E. coli
Expression System: E. coli
ACP Protein, S. aureus, Recombinant (His)
Cat.No: TMPH-03519
Species: Staphylococcus aureus
Expression System: P. pastoris (Yeast)
UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04480
Species: Human
Expression System: Baculovirus Insect Cells
ACP Protein, S. aureus, Recombinant (GST)
Cat.No: TMPH-03518
Species: Staphylococcus aureus
Expression System: E. coli
HSP90 alpha Protein, Mouse, Recombinant (His)
Cat.No: TMPY-06846
Species: Mouse
Expression System: Baculovirus Insect Cells
SLP-76 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01096
Species: Human
Expression System: E. coli
CNDP2 Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-01199
Species: Human
Expression System: E. coli
SULT2A1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01587
Species: Human
Expression System: E. coli
ENOX2 Protein, Human, Recombinant
Cat.No: TMPH-01277
Species: Human
Expression System: E. coli
NT5C3A/NT5C3 Protein, Human, Recombinant
Cat.No: TMPY-02893
Species: Human
Expression System: E. coli
ENOX2 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01278
Species: Human
Expression System: E. coli
LMW-PTP Protein, Human, Recombinant (His)
Cat.No: TMPJ-00908
Species: Human
Expression System: E. coli
HSP90 alpha Protein, Human, Recombinant (His)
Cat.No: TMPY-06845
Species: Human
Expression System: Baculovirus Insect Cells
XPNPEP1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01351
Species: Human
Expression System: E. coli
ATP citrate lyase/ACLY Protein, Human, Recombinant (His)
Cat.No: TMPY-02483
Species: Human
Expression System: Baculovirus Insect Cells
SNAP-25 Protein, Human, Recombinant (His)
Cat.No: TMPY-02245
Species: Human
Expression System: E. coli
KcsA Protein, S. coelicolor, Recombinant (His)
Cat.No: TMPH-03603
Species: Streptomyces coelicolor
Expression System: E. coli
Calbindin Protein, Human, Recombinant (His)
Cat.No: TMPH-01024
Species: Human
Expression System: P. pastoris (Yeast)
G-CSFR/CD114 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-00876
Species: Mouse
Expression System: HEK293 Cells
Stathmin 1 Protein, Human, Recombinant (His)
Cat.No: TMPY-03047
Species: Human
Expression System: E. coli
CKMT1A Protein, Human, Recombinant (His)
Cat.No: TMPY-04477
Species: Human
Expression System: Baculovirus Insect Cells
TK1 Potein, Canine, Recombinant (His)
Cat.No: TMPK-01386
Species: Canine
Expression System: E. coli
DGUOK Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01211
Species: Human
Expression System: E. coli
GBA3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01579
Species: Human
Expression System: Baculovirus Insect Cells
Moesin Protein, Human, Recombinant (aa 1-346, His)
Cat.No: TMPY-02847
Species: Human
Expression System: E. coli
PEPD Protein, Human, Recombinant
Cat.No: TMPJ-00540
Species: Human
Expression System: E. coli
PRRG2 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-04623
Species: Human
Expression System: HEK293 Cells
SULT1C2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00656
Species: Human
Expression System: E. coli
PAFAHB Protein, Human, Recombinant (His)
Cat.No: TMPJ-01054
Species: Human
Expression System: E. coli
ENOX1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01276
Species: Human
Expression System: E. coli
CKAP1/TBCB Protein, Human, Recombinant (His)
Cat.No: TMPY-03392
Species: Human
Expression System: E. coli
ELAPOR1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01192
Species: Human
Expression System: HEK293 Cells
GABARAP Protein, Human, Recombinant (His & MBP)
Cat.No: TMPY-00587
Species: Human
Expression System: E. coli
CA13 Protein, Human, Recombinant (His)
Cat.No: TMPY-01734
Species: Human
Expression System: E. coli
COLEC10 Protein, Cynomolgus, Recombinant (hFc)
Cat.No: TMPY-04103
Species: Cynomolgus
Expression System: HEK293 Cells
PGDS Protein, Human, Recombinant
Cat.No: TMPJ-00690
Species: Human
Expression System: E. coli
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