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16
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35914 |
Epitinib succinate
HMPL-813 succinate |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Epitinib succinate (HMPL-813 succinate) 是一种具有口服活性和脑渗透性的 EGFR 酪氨酸激酶抑制剂,可用于癌症研究。 | |||
T6188 |
Desvenlafaxine succinate hydrate
O-Desmethylvenlafaxine succinate hydrate,WY 45233 Succinate,琥珀酸去甲文拉法辛,Desvenlafaxine Succinate |
5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Desvenlafaxine succinate hydrate (WY 45233 Succinate) 是 Venlafaxine 主要代谢物的丁二酸盐形式,在人多巴胺转运体上显示弱的结合亲和力。它是具有口服活性的、能透过血脑屏障的5-HT 和 去甲肾上腺素再摄取的抑制剂,对 hSERT 和 hNET 的IC50值分别为47.3 nM 和531.3 nM。 | |||
T15732 |
Ribociclib succinate
LEE011 琥珀酸盐,瑞博西尼琥珀酸盐,LEE011 succinate |
CDK | Cell Cycle/Checkpoint |
Ribociclib succinate (LEE011 succinate) 是一种高度特异性的CDK4/6抑制剂,IC50值分别为 10 nM 和 39 nM。它对细胞周期蛋白 B/CDK1 复合物的效力低 1000 倍。 | |||
T13083L |
Tafenoquine Succinate
他非诺喹琥珀酸盐,WR 238605 (Succinate) |
Others | Others |
Tafenoquine Succinate (WR 238605 (Succinate)),一种8-氨基喹啉类化合物,作用为抗疟疾预防剂。 | |||
T64914 |
Vitamin E succinate
D-α-Tocopherol Succinate |
Apoptosis | Apoptosis |
Vitamin E succinate (D-α-Tocopherol Succinate) 是一种具有抗氧化作用的生育酚,属于维生素 E 类化合物。Vitamin E succinate 具有抗肿瘤活性,可诱导细胞凋亡,可用于辅助治疗癌症和合成 INVITE (一种生物偶联物)。 | |||
T22367 |
Methylprednisolone succinate
Methylprednisolone hemisuccinate,Methylprednisolone hydrogen succinate,甲基泼尼松龙琥珀酸酯 |
Glucocorticoid Receptor | Endocrinology/Hormones |
Methylprednisolone succinate (Methylprednisolone hemisuccinate) 是合成的糖皮质激素,常用作抗炎剂。 | |||
T2296 |
Trelagliptin succinate
曲格列汀琥珀酸盐,琥珀酸曲格列汀,SYR-472 succinate,SYR472 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Trelagliptin succinate (SYR-472 succinate) 是一种有效的,具有口服活性的DPP-4抑制剂,IC50=4 nM。它可以改善体内血糖控制,能够用于2 型糖尿病(T2DM) 的研究。 | |||
T6958 |
Prucalopride Succinate
琥珀酸普芦卡必利,R-108512,琥珀酸普卡比利,Resolor Succinate |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Prucalopride Succinate (Resolor Succinate) 是5-HT4受体选择高亲和性激动剂,对5-HT4a 和5-HT4b 的 Ki 值分别为 2.5 和 8 nM。 | |||
T1412 |
Loxapine succinate
Daxolin,Loxapac,Cloxazepin,Loxapine succinate salt,丁二酸洛沙平,琥珀酸洛沙平 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Loxapine succinate (Loxapac) 是D2/D4多巴胺受体,5-羟色胺受体抑制剂,用于精神分裂症。 | |||
T16091 |
MK-0812 Succinate
|
Others; CCR | Immunology/Inflammation; Microbiology/Virology; Others |
MK-0812 Succinate 是一种选择性CCR2拮抗剂。 | |||
T67915 |
Succinate/succinate receptor antagonist 1
|
Others | Others |
Succinate/succinate receptor antagonist 1 是一种有效的琥珀酸受体拮抗剂。Succinate/succinate receptor antagonist 1 中断牙龈组织中的琥珀酸信号,抑制琥珀酸受体 1 (SucnRl Antagonist 1) 的激活,对琥珀酸受体 1的 IC50 值为 20 μΜ。Succinate/succinate receptor antagonist 1 可用于治疗牙周病。 | |||
T28226 |
Octahydroaminoacridine succinate
|
Others | Others |
Octahydroaminoacridine succinate 是一种乙酰胆碱酯酶抑制剂,可用于治疗阿尔茨海默病。 | |||
T5696 |
Dimethyl succinate
|
Others | Others |
Dimethyl succinate 存在于坚果中。琥珀酸二甲酯存在于烤榛子中。琥珀酸二甲酯是一种调味成分。 | |||
T7875 |
Emoxypine Succinate
|
Others | Others |
Emoxypine Succinate 是一种抗氧化剂。 | |||
T1115 |
Doxylamine succinate
琥珀酸多西拉敏,Decapryn |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂,具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应,可防止组胺引起的皮肤和粘膜疼痛和瘙痒。 | |||
T0111 |
Solifenacin succinate
YM905,索非那新琥珀酸盐 |
AChR | Neuroscience |
Solifenacin succinate (YM905) 是毒蕈碱受体拮抗剂,对 M1、M2和M3受体的pKi 值分别为 7.6、6.9 和 8.0。 | |||
T11326 |
Frovatriptan succinate hydrate
Frovelan,夫罗曲坦琥珀酸盐水合物 ,Frova |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Frovatriptan succinate hydrate (Frova) 是一种有效、高亲和力、选择性和口服活性的 5-HT1B、HT1D 受体激动剂和中等有效的 5-HT7 受体激动剂,pKi 值分别为 8.6、8.4 和 6.7。它可有效治疗各种偏头痛,包括恶心、呕吐、畏光和畏声等相关症状。 | |||
T0203 |
Sumatriptan succinate
舒马普坦琥珀酸盐,GR 43175,琥珀酸舒马曲坦 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Sumatriptan succinate (GR 43175) 是一种5-HT1受体激动剂,可作用于偏头疼的急性治疗。 | |||
T39105 |
Ibiglustat succinate
GZ402671succinate,Venglustat succinate,Ibiglustat succinate,SAR402671succinate |
||
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS). It is utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease. | |||
T67509 |
Cholesteryl Hemisuccinate
Cholesterol hydrogen succinate |
Apoptosis; DNA/RNA Synthesis; Topoisomerase | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) 是一种经常使用在极性溶液中具有高溶解度的胆固醇类似物 ,具有保肝、抗癌和抑制肿瘤生长的作用。Cholesteryl Hemisuccinate 抑制对乙酰氨基酚 的肝毒性,并防止 AAP 诱导的肝细胞凋亡 和坏死 。Cholesteryl Hemisuccinate 抑制 DNA 聚合酶 和 DNA 拓扑异构酶 ,从而抑制 DNA 复制和修复以及细胞分裂。 | |||
T24702 |
Rabacfosadine succinate
VDC-1101 succinate,GS-9219 succinate,VDC 1101 succinate VDC1101 succinate,GS-9219-01 |
||
Rabacfosadine succinate is the acyclic nucleoside phosphonate PMEG double prodrug. | |||
T34120L |
PQ1 Succinate
PQ 1 Succinate,PQ-1 Succinate |
||
PQ1 Succinate, a gap junction enhancer, acts by restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells. | |||
T11824 |
Lanraplenib succinate
GS-9876 succinate |
Syk | Angiogenesis; Tyrosine Kinase/Adaptors |
Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib succinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. | |||
T40065 |
ALK2-IN-4 succinate
ALK2-IN-4 succinate |
||
ALK2-IN-4 succinate is a robust and effective inhibitor of ALK2. | |||
T0294 |
6α-Methylprednisolone 21-hemisuccinate sodium salt
Asmacortone,Methylprodnisolone Sodium Succinate,甲强龙琥珀酸钠,Metypresol,Methylprednisolone sodium succinate,Corticel,6-Methylprednisolone succinate sodium |
Glucocorticoid Receptor; Glucagon Receptor | Endocrinology/Hormones; GPCR/G Protein |
6α-Methylprednisolone 21-hemisuccinate sodium salt (Asmacortone) 是一种糖皮质激素,是一种有效的抗炎剂,半衰期比 Prednisolone 长。 | |||
T21407 |
Frovatriptan Succinate
Frovatriptan succinate hydrate,NCGC00183880-01,Frovatriptan Succinate monohydrate,KB-295988 |
||
Frovatriptan Succinate is a synthetic triptan with 5-HT1B/1D receptors agonist activity. It is indicated for the acute treatment of migraine. | |||
T31679L |
Esreboxetine succinate
PNU-165442G,(S,S)-Reboxetine succinate |
||
Ereboxetine succinate, a selective norepinephrine reuptake inhibitor, is an even more selective (+)-(S, S)- enantiomer of reboxetine. It is currently being developed for the treatment of neuropathic pain and fibromyalgia. | |||
T15731 |
Ribociclib succinate hydrate
LEE011 succinate hydrate |
CDK | Cell Cycle/Checkpoint |
Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B/CDK1 complex. | |||
T70975 |
Carsatrin succinate
|
||
Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbi... | |||
T68272 |
Batefenterol Succinate
|
||
Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. | |||
T70125 |
Pemrametostat succinate
|
||
Pemrametostat succinate is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) that potently inhibits tumor growth in vitro and in vivo in animal models. | |||
T70328 |
HDM-201 succinate
|
||
HDM-201 succinate is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. | |||
T71897 |
Vatalanib succinate
|
||
Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor. | |||
T11297 |
FF-10101 succinate
|
Others | Others |
FF-10101 succinate is a potent FLT3 inhibitor. | |||
T12419 |
PF-04634817 succinate
|
COX | Immunology/Inflammation; Neuroscience |
PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM. | |||
T22901 |
L-703,664 succinate
|
Others | Others |
L-703,664 succinate is a 5-HT1D receptor agonist. | |||
T19436 |
Monooctyl succinate
|
Others | Others |
Monooctyl succinate can be used as a surfactants and a potential fragrance releaser. | |||
T6684 |
Succinylcholine Chloride Dihydrate
choline chloride succinate,Succinyldicholine dichloride,Suxamethonium Chloride Dihydrate,司可林 |
AChR | Neuroscience |
Succinylcholine Chloride Dihydrate (Succinyldicholine dichloride) 是一种烟碱型 AChR 激动剂,也可作为去极化神经肌肉阻滞剂。 | |||
T70858 |
Nemiralisib succinate
|
||
Nemiralisib succinate is a potent and selective PI3Kδ inhibitor. | |||
T69323 | Dexamethasone sodium succinate | ||
Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regul... | |||
T38416 | Adenosine 5'-succinate | ||
Adenosine 5'-succinate is a compound closely related to adenosine monophosphate (AMP) that demonstrates strong inhibitory properties against taste receptor activation of transducin caused by Denatonium benzoate. | |||
T28088 |
MP-10 succinate
MP10,MP 10 |
||
MP-10 succinate is a potent and specific inhibitor of PDE10A. | |||
T71587 |
Fluoxetine succinate ester
|
||
Fluoxetine succinate ester is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. | |||
T32608 |
Lavoltidine succinate
AH 23844A,AH23844A,AH-23844A |
||
Lavoltidine succinate is a biochemical. | |||
T0270L |
Hydrocortisone sodium succinate
Cortop,Arcocort,Corlan,A-hydroCort,Buccalsone,Emi-Corlin |
||
Hydrocortisone sodium succinate is a glucocorticoid which is used to alleviate allergic reactions, particularly those of the skin and gums. | |||
T40971 |
Dehydroandrographolide succinate potassium sodium salt
|
||
Dehydroandrographolide succinate (potassium sodium salt), derived from the herbal medicine Andrographis paniculata (Burm f) Nees, is a versatile compound highly utilized for the treatment of viral pneumonia and viral upper respiratory tract infections due to its potent immunostimulatory, anti-infective, and anti-inflammatory properties. | |||
T18107 | m-PEG-Succinimidyl Succinate (MW 5000) | Others | Others |
m-PEG-Succinimidyl Succinate (MW 5000) is a polyethylene glycol (PEG)-based linker featuring succinimidyl succinate functionality, primarily applied in the synthesis of proteolysis-targeting chimeras (PROTACs)[1]. | |||
T4994 |
Tocofersolan
Vitamin E-TPGS,Tocophersolan,TPGS,D-α-Tocopherol polyethylene glycol 1000 succinate,托可索仑,维生素E聚乙二醇琥珀酸酯 |
Others | Others |
Tocofersolan (TPGS) 是合成的 α-生育酚的聚乙二醇衍生物。 | |||
T72749 |
E7090 succinate
|
||
E7090 succinate 是具有口服活性的、选择性的、有效的 FGFR1/2/3抑制剂,其对 FGFR1/2/3/4 的 IC50值分别为 0.71 nM、0.50 nM、1.2 nM 和120 nM。 | |||
T28291 |
Palbociclib-Succinic acid
Palbociclib-hemi Succinic acid,Palbociclib-Succinate, |
||
Palbociclib-Succinic acid is a Palbociclib- derivative with a succinic acid linker. The carboxy group of Palbociclib-Succinic acid can be used to conjugate with other molecules such as peptides, proteins, or polymers. Palbociclib-Succinic acid is a useful |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8073 |
Disodium succinate
丁二酸二钠,Sodium succinate |
Others | Others |
Disodium succinate (Sodium succinate) 是 Succinic acid 的盐形式。Succinic acid 是无氧代谢的发酵产物,也是三羧酸循环的中间产物。 | |||
T8258 |
Chloramphenicol succinate sodium
Chloramphenicol sodium succinate,琥珀酸钠氯霉素,氯霉素琥珀酸钠 |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Chloramphenicol succinate sodium 是 Chloramphenicol 的前药,具有血液学毒性。它是琥珀酸脱氢酶的竞争底物和抑制剂。 | |||
T8096 |
Diethyl succinate
|
Others | Others |
Diethyl succinate 能够在生理 pH 下使用并穿过生物膜,掺入组织培养物中的细胞中,通过 TCA 循环进行代谢。它不具有毒性,可用于香料和调味剂中。 | |||
T2S0257 |
Dehydroandrographolide succinate
|
Others; Influenza Virus | Microbiology/Virology; Others |
Dehydroandrographolide succinate 是从中药穿心莲中提取的一种天然产物,具有免疫刺激、抗感染和抗炎作用,有潜力研究病毒性肺炎和病毒性上呼吸道感染。 | |||
T25240 |
Chloramphenicol succinate
Paraxin succinate,Kemicetine succinate,CPSA |
||
Chloramphenicol succinate is an inactive precursor of chloramphenicol. It is used for parenteral administration of chloramphenicol. | |||
T3667 |
Kalii Dehydrographolidi Succinas
Ddhads,穿琥宁,Dehydroandrographolide Succinate Potasium Salt |
Others | Others |
Kalii Dehydrographolidi Succinas (Dehydroandrographolide Succinate Potasium Salt) 从中药穿心莲中提取得到,具有免疫刺激、抗感染和抗炎作用,对病毒性肺炎和病毒性上呼吸道感染具有潜在的研究价值。 | |||
T1341 |
Nortropine
Nortropenol,去甲托品醇 |
AChR | Neuroscience |
Nortropine (Nortropenol) 是托品碱分解和反应生成琥珀酸的中间体,可从Convolvulus subhirsutus 生物碱中分离得到。 | |||
T0474 |
Erythromycin ethylsuccinate
EES,琥乙红霉素 |
ribosome; HIV Protease; Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
Erythromycin ethylsuccinate (EES) 是一种由红链霉菌产生的大环内酯类抗生素,有潜力用于多种细菌感染。它具有抗 HIV-1病毒活性。 | |||
T4948 |
Potassium 2-hydroxy-2-methylsuccinate
(±)-柠苹酸钾 一水合物,(±)-Potassium citramalate monohydrate,(±)-2-Hydroxy-2-methylsuccinic acid dipotassium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Potassium 2-hydroxy-2-methylsuccinate ((±)-2-Hydroxy-2-methylsuccinic acid dipotassium salt) 是内源性代谢产物的一种。 | |||
T5695 |
Dimethyl malonate
|
Others | Others |
Dimethyl malonate 是一种琥珀酸脱氢酶抑制剂。 | |||
T3009 |
3-Nitropropanoic acid
3-NP acid,Bovinocidin,3-NP,3-硝基丙酸,β-Nitropropionic acid |
Apoptosis; Dehydrogenase; Antibacterial | Apoptosis; Metabolism; Microbiology/Virology |
3-Nitropropanoic acid (Bovinocidin) 是一种琥珀酸脱氢酶的不可逆抑制剂。它对分枝杆菌有很强的抗菌活性,MIC 值为 3.3μM。 | |||
T4764 |
5-Methoxy-5-oxopentanoic acid
戊二酸单乙酯,mono-Methyl glutarate,METHYL HYDROGEN GLUTARATE |
Others; Endogenous Metabolite | Metabolism; Others |
5-Methoxy-5-oxopentanoic acid (mono-Methyl glutarate) 是内源性代谢产物的一种。 | |||
TN1546 |
Dactylorhin A
|
NO Synthase | Immunology/Inflammation |
Dactylorhin A 是一种琥珀酸衍生物酯,分离自 Gymnadenia conopsea 根茎中。它对 RAW 264.7 巨噬细胞产生 NO 有中等程度的抑制作用。 | |||
T5291 |
Malonic acid
Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid |
Others | Others |
Malonic acid (propanedioic acid) 是竞争性抑制剂的典型例子:它作用于呼吸电子传递链中的琥珀酸脱氢酶(复合物 II)。发现丙二酸与丙二酰辅酶A 脱羧酶缺乏有关,这是一种先天性代谢错误。 | |||
T4838 |
(S)-Malic acid
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸,是水果酸甜味的来源,常用作食品添加剂。 | |||
T11274 |
Ferulenol
|
Others | Others |
Ferulenol, a sesquiterpene prenylated coumarin derivative, exhibits potent antimycobacterial activity and haemorrhagic action. This compound selectively targets succinate ubiquinone reductase within the ubiquinone cycle as its specific mode of inhibition. |