succinate

ALK2-IN-4 succinate is a robust and effective inhibitor of ALK2.

Hydrocortisone sodium succinate is a glucocorticoid which is used to alleviate allergic reactions, particularly those of the skin and gums.

Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib succinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.

PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.

Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B/CDK1 complex.

MK-0812 Succinate 是一种选择性CCR2拮抗剂。

m-PEG-Succinimidyl Succinate (MW 5000) is a polyethylene glycol (PEG)-based linker featuring succinimidyl succinate functionality, primarily applied in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Succinate dehydrogenase-IN-4 (Compound 4b) 是一种琥珀酸脱氢酶抑制剂，IC50为3.38 μM。它对Physalospora piricola 和Colletotrichum orbiculare 显示出抗真菌活性，EC50分别为16.33 μM和18.06 μM。

Succinate dehydrogenase-IN-5 (Compound M8) 是一种琥珀酸脱氢酶 (succinate dehydrogenase) 抑制剂，主要通过干扰真菌的能量代谢与生长，对Rhizoctonia solani、Sclerotinia sclerotiorum、Botrytis cinerea 和 Fusarium graminearum 展示抑制效能，EC50< 0.3 μg/mL。

Succinate dehydrogenase-IN-7 (Compound 2f) 是琥珀酸脱氢酶抑制剂 (IC50= 2.51 μM)，并且具有杀菌活性。

Succinate dehydrogenase-IN-6 (Compound E23) 是一种琥珀酸脱氢酶 (SDH) 抑制剂，在立枯丝核菌 (Rhizoctonia solani) 中的IC50为11.76 μM。它能够破坏真菌细胞膜，展现广谱抗真菌活性，可抑制R. solani、V. dahliae、A. solani和C. gloeosporioides，EC50分别为0.41、0.27、1.15和0.27 μg/mL。在水稻和斑马鱼中没有明显毒性表现 (LC50> 12.5 μg/mL)。

Succinate dehydrogenase-IN-9 (Compound Iik) 是一种琥珀酸脱氢酶抑制剂，具有IC50为3.6 μM的效果。它对多种真菌表现出强效抑制活性，例如抑制S. sclerotiorum的EC50为1.14 μg/mL。此外，Succinate dehydrogenase-IN-9 还能增强硝酸还原酶活性，从而促进植物生长。

Succinate dehydrogenase-IN-8 (compound i19) 是一种高效的琥珀酸脱氢酶 (SDH) 抑制剂。作为茚氨基酸衍生物，它在体外对立枯丝核菌 (EC50= 0.1843 mg/L)、灰葡萄孢菌 (EC50=0.4829 mg/L) 和核盘菌 (EC50=0.1349 mg/L) 展现了强大的抗真菌活性。

Paclitaxel-2′-succinate NHS ester 为一种紫杉醇衍生物，琥珀酸连接基中的羧基被 NHS 酯活化。NHS 酯基对氨基或羟基具高度反应性，可与其他分子（如肽、蛋白质、抗体、酶或聚合物）结合。Paclitaxel-2′-succinate NHS ester 可用于纳米药物开发及癌症治疗研究。

Succinate dehydrogenase-IN-10 (Compound B5) 是一种 RsSDH (R. solani中的Succinate dehydrogenase) 抑制剂，IC50为0.12 μM。它对R. solani（EC50为0.002 μg/mL）和P. pachyrhizi表现出抗真菌活性。

Succinate dehydrogenase-IN-11 (Compound A12) 是一种琥珀酸脱氢酶抑制剂，IC50为 3.58 μM，具有抗真菌作用。在体外，Succinate dehydrogenase-IN-11 对 R. solani、B. cinerea、F. graminearum 和 S. sclerotiorum 具有活性；在体内，对 R. solani、P. pachyrhizi 和 P. sorghi 也具有防治效果。此化合物可用于抗真菌研究。

Frovatriptan Succinate is a synthetic triptan with 5-HT1B/1D receptors agonist activity. It is indicated for the acute treatment of migraine.

L-703,664 succinate is a 5-HT1D receptor agonist.

Rabacfosadine succinate is the acyclic nucleoside phosphonate PMEG double prodrug.

MP-10 succinate is a potent and specific inhibitor of PDE10A.

Ereboxetine succinate, a selective norepinephrine reuptake inhibitor, is an even more selective (+)-(S, S)- enantiomer of reboxetine. It is currently being developed for the treatment of neuropathic pain and fibromyalgia.

PQ1 Succinate, a gap junction enhancer, acts by restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells.

Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS). It is utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.