gp-4

PGP-4008 是一种具有选择性和有效性的 P-糖蛋白 (Pgp) 抑制剂,通过与Doxorubicin联合给药来抑制肿瘤生长。

CGP-42112 acetate是一种有效的血管紧张素受体 AT2 激动剂,抑制 LPS 产生的蛋白激酶 A 活性的增加。

CGP-42112 is an agonist of the Angiotensin-II subtype 2 receptor (AT2 R).

CGP-42454A is a bio-active chemical.

CGP-47292 is a metabolite of the novel antiepileptic compound CGP 33,101.

CGP-49823 is a non-peptide tachykinin NK1 receptor antagonist.

CGP-42456A - Benazepril Related Compound A, it is an Impurity. Benazepril is a prodrug which is metabolized by the liver into its active form benazeprilat via cleavage of the drug's ester group. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. Benazeprilat has much greater ACE inhibitory activity than does Benazepril. It is indicated for the treatment of hypertension.

Staurosporine (AM-2282) 是一种蛋白激酶抑制剂，对 PKC、PKA、c-Fgr、Phosphorylase kinase 和 TAOK2 均有抑制活性 (IC50=6 15 2 3 3000 nM)，具有 ATP 竞争性和非选择性。Staurosporine 也可以诱导凋亡。

CGP48369 是一种有效的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂，具有降血压作用，可增强自发性高血压大鼠冠状动脉的内皮依赖性松弛。

Diclofenac sodium (GP 45840) 是一种非选择性抗炎剂，是 COX 抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM，0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。

Theaflavin 3,3'-digallate 是一种寨卡病毒蛋白酶抑制剂，IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制，可抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚，有抗肿瘤作用。

CGP 46381 is a GABAB receptor antagonist.

Cgp 44099 is a potent plasma renin inhibitor from all subprimate species.

CGP 44532 a GABAB receptor agonist.

CGP 47656 is an agonist of GABAB receptor.

CGP 43182 is an effective inhibitor of group IIA secretory phospholipase A2 (Group IIA sPLA2) activity in vitro, which can be used to prevent the synergistic effect of pro-inflammatory genes stimulated by cytokines mediated by NFkappaB.

CGP 43487 is an N-methyl-D-aspartic acid (NMDA) receptor antagonist. CGP 43487, a competitive NMDA receptor antagonist, significantly increased the convulsive threshold.

Cgp 43902A is a bio-active chemical.

CGP 45688 is an oral active non-steroidal aromatase inhibitor with anti-tumor and endocrine effects on rat breast tumors.

CGP 45715A (irukostat) is a potent peptide-leukotriene antagonist used to treat respiratory diseases by antagonizing the bronchial constriction, mucus secretion, and inflammatory effects of these leukotrienes.

Cgp 47072 is a bisphosphonate, used in the treatment of bone diseases, particularly where there is uncontrolled bone resorption.

CGP 47645 (Leflurozole) is an oral active non-steroidal aromatase inhibitor and antitumor agent with anti-tumor and endocrine effects.

Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα β γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1 2的IC50值范围为 22 到500 nM 之间。

Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.