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CD68 Protein, Human, Recombinant (aa 1-319, His)

产品编号 TMPY-02972

别名: SCARD1, LAMP4, GP110, CD68 molecule

CD68 Protein, Human, Recombinant (aa 1-319, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 32.99 kDa and the accession number is P34810-1.

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CD68 Protein, Human, Recombinant (aa 1-319, His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货
1 mg	￥ 24,900		5日内发货

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生物活性	Testing in progress
产品描述	CD68 Protein, Human, Recombinant (aa 1-319, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 32.99 kDa and the accession number is P34810-1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	C-His
蛋白编号	P34810-1
别名	SCARD1, LAMP4, GP110, CD68 molecule
蛋白构建	The Human CD68 () was expressed, with a C-terminal polyhistidine tag.
蛋白纯度	> 98 % as determined by SDS-PAGE
分子量	32.99 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, pH 7.4, 10% gly. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Macrosialin, also known as CD68 and Gp11, is a single-pass type I membrane protein which belongs to theLAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

参考文献

1. Strobl H. et al., 1995, Br J Haematol. 90 (4): 774-82. 2. Ogawa Y. et al., 1995, Pathol Int. 45 (9): 698-701. 3. Sadovnikova E. et al., 2002,Leukemia. 16 (10): 2019-26. 4. Gottfried E. et al., 2008, Scand J Immunol. 67 (5): 453-63. 5. Strojnik T. et al., 2009, Anticancer Res. 29 (8): 3269-79.

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Keywords

CD68 Protein, Human, Recombinant (aa 1-319, His) SCARD1 LAMP-4 LAMP4 GP-110 LAMP 4 SCARD 1 SCARD-1 GP110 CD68 molecule GP 110 recombinant recombinant-proteins proteins protein

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