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Search Results for " acetylcholinesterase "

158

抑制剂 & 化合物

73

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Cat. No.	Product Name	Target	Signaling Pathways
T76130	Acetylcholinesterase
	Acetylcholinesterase(ACHE; EC 3.1.1.7), 即乙酰胆碱酯酶，是一种胆碱能酶，主要存在于神经肌肉接头和胆碱能类型的化学突触中，常用于生化研究。Acetylcholinesterase 可以催化乙酰胆碱和其他一些充当神经递质的胆碱酯分解或水解为乙酸和胆碱。Acetylcholinesterase 主要作用是终止突触之间的神经元传递和信号传导，以防止 ACh 扩散和附近受体的激活。
T1635	Fenchlorphos Ronnel,Dermafos,皮蝇磷	AChE; Parasite	Microbiology/Virology; Neuroscience
	Fenchlorphos (Dermafos) 是一种有机磷酸盐杀虫剂，是乙酰胆碱酯酶的抑制剂，能够引起线粒体功能障碍。
T4478	CID 16020046 C390-0219	Cannabinoid Receptor	GPCR/G Protein
	CID 16020046 (C390-0219) 是一种选择性 GPR55 拮抗剂，在酵母中抑制 GPR55 组成型活性，IC50 为 0.15 μM。它抑制 GPR55 介导的 Ca2+信号传导和 GPR55 介导的 ERK1/2 磷酸化，可降低内皮细胞的伤口愈合，参与血小板功能的调节。
T20539	Pirimiphos-methyl R 33986,甲基嘧啶磷,AI3-27699,Caswell No. 334B,PP511,Actelic	AChE; Parasite	Microbiology/Virology; Neuroscience
	Pirimiphos-methyl (AI3-27699) 是一种速效有机磷杀虫剂和杀螨剂，对目标生物的乙酰胆碱酯酶有抑制作用。甲基嘧啶磷常用于农粮贮藏过程中甲虫、鼻甲虫、飞蛾和蝽蛄的防治。
T25944	Phenoxyacetone 苯氧乙酮,NSC-1876,NSC 1876,NSC1876	Others	Others
	Phenoxyacetone (NSC-1876) 可抑制乙酰胆碱酯酶。
T62360	AChE-IN-26	AChE	Neuroscience
	AChE-IN-26 (compound 4a) 是一种 AChE (acetylcholinesterase) 抑制剂 (IC50: 0.42 μM)。AChE-IN-26 能够用于研究阿尔兹海默症。
T28226	Octahydroaminoacridine succinate	Others	Others
	Octahydroaminoacridine succinate 是一种乙酰胆碱酯酶抑制剂，可用于治疗阿尔茨海默病。
T1111	Pralidoxime Chloride 2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)	AChE	Neuroscience
	Pralidoxime Chloride (2-PAM chloride) 是一种肟类化合物，对中毒乙酰胆碱酯酶具有恢复作用，可用于有机磷中毒的研究。
Fr12799	AChE-IN-23
	AChE-IN-23 (compound 3h) 是乙酰胆碱酯酶 (AChE) 抑制剂(IC50=48.3 μM)。
T23131	PE 154	AChE	Neuroscience
	PE 154是一种强效的 acetylcholinesterase (AChE) 和 butyrylcholinesterase (BChE) 荧光抑制剂，IC50 分别为 280 pM 和 16 nM。PE 154 在组织化学分析中常用来标记 β 淀粉样蛋白斑块。
T7500	Isoxazole 1,2-oxazole,异恶唑	AChR	Neuroscience
	Isoxazole (1,2-oxazole) 是乙酰胆碱酯酶 (AChE) 的抑制剂。异恶唑的配体结合并抑制 Sxc-反转运蛋白。
T77352	ACHE Inhibitor 12
	ACHE Inhibitor 12 对乙酰胆碱酯酶具有抑制作用，IC50值为0.38 µM。
T80671	ACHE-IN-38 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one	Antifungal	Microbiology/Virology
	ACHE-IN-38 是一种有效的Acetylcholinesterase 抑制剂，可用于合成具有抗炎、抗肿瘤和抗菌活性的化合物。
T8907	Minaprine dihydrochloride 米那卜林二盐酸盐	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Minaprine dihydrochloride 是一种可逆的单胺氧化酶 MAO-A 抑制剂，对乙酰胆碱酯酶有微弱抑制，是一种抗抑郁类化合物。
T1612	Neostigmine methyl sulfate Normastigmin,甲基硫酸新斯的明,甲硫酸新斯的明,Hodostin,Syntostigmin	AChR; AChE	Neuroscience
	Neostigmine methyl sulfate (Syntostigmin) 是一种乙酰胆碱酯酶的可逆抑制剂, 不能透过血脑屏障。
T8631	pyridostigmine Regonol,Mestinon-SR,UNII-19QM69HH21,PyridostigmineBromine,Pyridostigminum	Others	Others
	Pyridostigmine(Regonol) 是一种乙酰胆碱酯酶抑制剂，可通过增加突触后运动终板的乙酰胆碱来治疗重症肌无力。
T9355	2-Thiomorpholinoethanol	Others	Others
	2-Thiomorpholinoethanol 是一种吗啉的衍生物，通过抑制乙酰胆碱酯酶（AChE），增加体内乙酰胆碱的量，从而影响神经系统。
T4631	NSC 4810	Others	Others
	NSC 4810 是一种酰胺类生物活性化合物，它在体内已被用作细胞色素P450酶的底物，在体外被用作乙酰胆碱酯酶的底物。
T7041	Donepezil E2020,Donepezilo,Aricept,多奈哌齐	AChE	Neuroscience
	Donepezil (Aricept) 是一种AChE 抑制剂，对牛 AChE 和人 AChE 的IC50分别为 8.12 nM 和 11.6 nM。
T83616	SEW06622	BACE; AChE	Neuroscience
	SEW06622 是一种有效的乙酰胆碱酯酶(AChE)和β-分泌酶-1(BACE-1)抑制剂，是治疗阿尔茨海默病的潜在候选化合物。
T68084	Icopezil	AChE	Neuroscience
	Icopezil是一种小分子乙酰胆碱酯酶在（AChE）抑制剂，可用于治疗神经系统疾病，可用于研究阿尔茨海默病。
T4466	Pitofenone hydrochloride Baralgin Ketone Hydrochloride,Pitophenone hydrochloride,吡托非农盐酸盐	AChE	Neuroscience
	Pitofenone hydrochloride (Pitophenone hydrochloride) 是一种能够抑制乙酰胆碱酯酶活性的解痉化合物，对于来自牛红细胞和电鳗的乙酰胆碱酯酶的Ki 分别为 36 和 45 μM。
T19084	1-Naphthyl acetate	AChE	Neuroscience
	1-Naphthyl acetate 是一种有吸引力的生色底物，用于检测红细胞乙酰胆碱酯酶的活性。它具有检测有机磷农药中毒的潜力。
T14194	β-NETA α-NETA	AChE	Neuroscience
	β-NETA(α-NETA) 是胆碱乙酰转移酶(ChA；IC50=76 μM) 和胆碱酯酶 (ChE;IC50=40 µM)的非竞争性抑制剂，对乙酰胆碱酯的作用微弱 (AChE;IC50=1 mM)。
T4174	NSC 191412	Others	Others
	NSC 191412 能与多种酶和受体相互作用，包括乙酰胆碱酯酶和神经递质多巴胺的受体，是这些酶和受体的激动剂或激活剂。
T1345	1,1-Bis(Methylthio)-2-Nitroethylene	Others	Others
	1,1-Bis(Methylthio)-2-Nitroethylene （1,1-BMNE）具有多种生化和生理作用。它可以抑制参与药物和其他化合物代谢的酶的活性，如细胞色素P450和乙酰胆碱酯酶。
T60739L	Y13g dihydrochloride Y13g 2HCl(T60739 Free base)	IL Receptor; AChE	Immunology/Inflammation; Neuroscience
	Y13g dihydrochloride 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂（这两个靶点阿尔茨海默症 (AD) 进展的有关）。Y13g dihydrochloride 逆转 STZ 诱导的记忆缺陷，并表现出与正常动物相似的组织病理学。
T50064	2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate	KLF	MAPK
	2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate 是一种用于增强认知功能的促神经药物，通过增加大脑中乙酰胆碱的合成和释放以及通过抑制乙酰胆碱酯酶对乙酰胆碱的分解而发挥作用。
T50041	N-(4-methoxyphenyl)prop-2-enamide N-(4-Methoxyphenyl)acrylamide,N-(4-甲氧苯基)丙烯酰基酰胺	Others	Others
	N-(4-methoxyphenyl)prop-2-enamide (N-(4-Methoxyphenyl)acrylamide) 是一种用作分子结构单元的丙烯酰胺类化合物。它可以抑制乙酰胆碱酯酶，增加突触间隙中的乙酰胆碱水平；也可以抑制多巴胺的分解，导致大脑中多巴胺水平的升高。
T1682	Methacholine Chloride 醋甲胆碱,Mecholyl chloride,氯化乙酰甲胆碱,Acetyl-β-methylcholine chloride	AChR	Neuroscience
	Methacholine Chloride (Acetyl-β-methylcholine chloride) 是副交感神经系统中的毒蕈碱-3 受体激动剂。它可用于测量气道高反应性，作为评估哮喘样症状和正常静息呼气流速的诊断辅助手段。它直接作用于平滑肌上的乙酰胆碱受体，引起收缩和气道狭窄。
T2319	Acotiamide monohydrochloride trihydrate Acotiamide hydrochloride,YM-443 HCl,盐酸阿考替胺,Z-338 HCl	AChE	Neuroscience
	Acotiamide monohydrochloride trihydrate (Z-338 HCl) 是一种首创的、具有口服活性的胃肠动力药。它通过促毒蕈碱受体拮抗作用和乙酰胆碱酯酶(AChE)抑制作用增强肠神经元释放的乙酰胆碱，从而增强胃排空和胃部适应性，有潜力用于功能性消化不良的研究。
T26597	Allyxycarb Hydrol
	Allyxycarb is an acetylcholinesterase inhibitor.
T27105	Cyclophostin
	Cyclophostin is an irreversible inhibitor of acetylcholinesterase (AChE).
T70973	Zifrosilone
	Zifrosilone is an acetylcholinesterase inhibitor.
T28041	Mimopezil ZT-1 LA,Debio-9902-SR,Debio-9902,ZT-1
	Mimopezil is an acetylcholinesterase (AChE) inhibitor.
T70572	CHF-2060
	CHF-2060 is a novel acetylcholinesterase inhibitor.
T70117	Cyclanoline (free base)
	Cyclanoline (free base) is an acetylcholinesterase inhibitor
T71780	Diisopropylamine dichloroacetate
	Diisopropylamine dichloroacetate stimulates smooth muscle & strongly inhibits acetylcholinesterase activity.
T19810	Pirimicarb
	Pirimicarb is an insecticide that inhibits acetylcholinesterase in selective species.
T20940	Chlorpyrifos-methyl M-3196,M 3196
	Chlorpyrifos-methyl inhibits acetylcholinesterase by acting on the nervous system of insects.
T71258	Dehydrodeoxy donepezil
	Dehydrodeoxy donepezil is an inhibitor of acetylcholinesterase (AChE)
T71802	1-Bromopinacolone
	1-Bromopinacolone is an active site-directed covalent inhibitor for acetylcholinesterase
T21219	Isatin-O Isatin-3-oxime
	Isatin-O acts as a neutral BBB crossing reactivator for acetylcholinesterase inhibited by paraoxon and is also an anticonvulsant.
T70640	SCR1693
	SCR1693 is a dual acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB).
T38288	Profenofos
	Profenofos is an acetylcholinesterase-inhibiting organophosphorus pesticide on field crops, vegetables, and fruit crops [1]. [1]. Madhulika Kushwaha, et al. Kushwaha, M., et al.. Profenofos, an Acetylcholinesterase-Inhibiting Organophosphorus Pesticide: A Short Review of Its Usage, Toxicity, and Biodegradation. J Environ Qual.2016 Sep;45(5):1478-1489.
T80442	Fasciculin-II Fas-2
	Fasciculin-II (Fas-2) 是一种针对 acetylcholinesterase (AChE) 的高效抑制剂。
T70474	Gallamine
	Gallamine is an allosteric antagonist at muscarinic M2 acetylcholine receptors and an inhibitor of acetylcholinesterase.
T70236	Isonitrosoacetone
	Isonitrosoacetone is an acetylcholinesterase reactivator.
T69233	Ganstigmine
	Ganstigmine is an acetylcholinesterase inhibitor for Alzheimer's disease.
T70697	(+)-Donepezil
	(+)-Donepezil is an isomer of Donepezil -- a nootropic acting as an inhibitor of acetylcholinesterase.

化合物

Acetylcholinesterase

Cat.No: T76130

Cat.No: T1635

Synonym: Ronnel,Dermafos,皮蝇磷

Target: AChE, Parasite

Cat.No: T4478

Synonym: C390-0219

Target: Cannabinoid Receptor

Pirimiphos-methyl

Cat.No: T20539

Synonym: R 33986,甲基嘧啶磷,AI3-27699,Caswell No. 334B,PP511,Actelic

Target: AChE, Parasite

Cat.No: T25944

Synonym: 苯氧乙酮,NSC-1876,NSC 1876,NSC1876

Target: Others

Cat.No: T62360

Target: AChE

Octahydroaminoacridine succinate

Cat.No: T28226

Target: Others

Pralidoxime Chloride

Cat.No: T1111

Synonym: 2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)

Target: AChE

Cat.No: Fr12799

Cat.No: T23131

Target: AChE

Cat.No: T7500

Synonym: 1,2-oxazole,异恶唑

Target: AChR

ACHE Inhibitor 12

Cat.No: T77352

Cat.No: T80671

Synonym: 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one

Target: Antifungal

Minaprine dihydrochloride

Cat.No: T8907

Synonym: 米那卜林二盐酸盐

Target: MAO, Monoamine Oxidase

Neostigmine methyl sulfate

Cat.No: T1612

Synonym: Normastigmin,甲基硫酸新斯的明,甲硫酸新斯的明,Hodostin,Syntostigmin

Target: AChR, AChE

Cat.No: T8631

Synonym: Regonol,Mestinon-SR,UNII-19QM69HH21,PyridostigmineBromine,Pyridostigminum

Target: Others

2-Thiomorpholinoethanol

Cat.No: T9355

Target: Others

Cat.No: T4631

Target: Others

Cat.No: T7041

Synonym: E2020,Donepezilo,Aricept,多奈哌齐

Target: AChE

Cat.No: T83616

Target: BACE, AChE

Cat.No: T68084

Target: AChE

Pitofenone hydrochloride

Cat.No: T4466

Synonym: Baralgin Ketone Hydrochloride,Pitophenone hydrochloride,吡托非农盐酸盐

Target: AChE

1-Naphthyl acetate

Cat.No: T19084

Target: AChE

Cat.No: T14194

Synonym: α-NETA

Target: AChE

Cat.No: T4174

Target: Others

1,1-Bis(Methylthio)-2-Nitroethylene

Cat.No: T1345

Target: Others

Y13g dihydrochloride

Cat.No: T60739L

Synonym: Y13g 2HCl(T60739 Free base)

Target: IL Receptor, AChE

2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate

Cat.No: T50064

Target: KLF

N-(4-methoxyphenyl)prop-2-enamide

Cat.No: T50041

Synonym: N-(4-Methoxyphenyl)acrylamide,N-(4-甲氧苯基)丙烯酰基酰胺

Target: Others

Methacholine Chloride

Cat.No: T1682

Synonym: 醋甲胆碱,Mecholyl chloride,氯化乙酰甲胆碱,Acetyl-β-methylcholine chloride

Target: AChR

Acotiamide monohydrochloride trihydrate

Cat.No: T2319

Synonym: Acotiamide hydrochloride,YM-443 HCl,盐酸阿考替胺,Z-338 HCl

Target: AChE

Cat.No: T26597

Synonym: Hydrol

Cat.No: T27105

Cat.No: T70973

Cat.No: T28041

Synonym: ZT-1 LA,Debio-9902-SR,Debio-9902,ZT-1

Cat.No: T70572

Cyclanoline (free base)

Cat.No: T70117

Diisopropylamine dichloroacetate

Cat.No: T71780

Cat.No: T19810

Chlorpyrifos-methyl

Cat.No: T20940

Synonym: M-3196,M 3196

Dehydrodeoxy donepezil

Cat.No: T71258

1-Bromopinacolone

Cat.No: T71802

Cat.No: T21219

Synonym: Isatin-3-oxime

Cat.No: T70640

Cat.No: T38288

Cat.No: T80442

Synonym: Fas-2

Cat.No: T70474

Isonitrosoacetone

Cat.No: T70236

Cat.No: T69233

Cat.No: T70697

Cat. No.	Product Name	Target	Signaling Pathways
TN1899	Lycoramine	AChE	Neuroscience
	Lycoramine 是一种加兰他敏的二氢衍生物，从Lycoris radiate 中分离得到，是一种乙酰胆碱酯酶抑制剂。
TN2298	Vincosamide 喜果苷	AChE	Neuroscience
	Vincosamide 是一种来自Psychotria leiocarpa 提取物的生物碱，具有抑制乙酰胆碱酯酶 (AChE) 作用，具有抗炎活性。
Fr14127	Coumaran 2,3-Dihydrobenzofuran,2,3-二氢苯并呋喃	Endogenous Metabolite; AChE	Metabolism; Neuroscience
	Coumaran (2,3-Dihydrobenzofuran) 是一种提取自L. camara 的 (AChE) 抑制剂。2,3-Dihydrobenzofuran 能够用作生物农药。
TN6786	O-Desmethyl Galanthamine Sanguinine,O-去甲基加兰他敏	AChE	Neuroscience
	O-Desmethyl Galanthamine (Sanguinine) 是一种加兰他敏型生物碱，是一种乙酰胆碱酯酶 (AChE) 抑制剂，其IC50=1.83 μM。
T6S0653	Linarin Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷	TNF; AChE	Apoptosis; Neuroscience
	Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂，从薄荷花提取物中分离得到。
T0086	Galanthamine hydrobromide Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏	AChR; AChE	Neuroscience
	Galanthamine hydrobromide (Galantamine hydrobromide) 是一种长效的中枢活性 AChE 抑制剂，IC50为 410 nM。它是神经元烟碱型 ACh 受体的变构增强剂，IC50值为 0.35 µM，可用于阿尔茨海默症的研究。
T2S1200	Sinapine	Antioxidant; P-gp; AChE	Membrane transporter/Ion channel; Neuroscience; oxidation-reduction
	Sinapine 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T3392	Sinapine thiocyanate	P-gp; AChE	Membrane transporter/Ion channel; Neuroscience
	Sinapine thiocyanate 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T4852	Trimyristin Trimyristoylglycerol,Tritetradecanoin,三肉豆蔻酸甘油酯,Glyceryl trimyristate,甘油三肉豆蔻酸酯,1,2,3-Tritetradecanoylglycerol	Phosphatase; Endogenous Metabolite; AChE	Metabolism; Neuroscience
	Trimyristin (Tritetradecanoin) 是一种 Myristica fragransHoutt 的有效成分，能够显著抑制乙酰胆碱酯酶 (AChE)，酸性和碱性磷酸酶 (ACP/ALP) 特性。它对 AChE，ACP 和 ALP 的 IC50分别为 0.11、0.16 和 0.18 mM。
T6S2356	Corynoline 紫蓳灵,堇醇灵碱,(+)-Corynoline	Nrf2; AChE	Immunology/Inflammation; Neuroscience
	Corynoline ((+)-Corynoline) 是可逆和非竞争性的乙酰胆碱酯酶抑制剂，IC50=30.6 μM。它可激活 Nrf2，具有抗炎作用。
T4S1725	Galanthamine Galantamine,加兰他敏	Apoptosis; AChE	Apoptosis; Neuroscience
	Galanthamine (Galantamine) 是一种乙酰胆碱酯酶抑制剂，IC50为 500 nM。
T2846	Isoimperatorin	Antibacterial; AChE	Microbiology/Virology; Neuroscience
	Isoimperatorin 是 Angelica dahurica 根的甲醇提取物，是一种抗炎剂，有效抑制乙酰胆碱酯酶，IC50为 74.6 μM。
TN6919	Methyl tridecanoate	Beta Amyloid; AChE	Neuroscience
	Methyl tridecanoate 能够适度抑制 β-淀粉样蛋白聚集，弱抑制乙酰胆碱酯酶。
TN1091	Dehydronuciferine	AChE	Neuroscience
	Dehydronuciferine 是一种乙酰胆碱酯酶抑制剂，其 IC50=25 μg/mL，是从 Nelumbo nucifera Gaertn 的叶子中分离得到。
T2984	Scopoletin Chrysatropic acid,东莨菪内酯,Esculetin 6-methyl ether,Gelseminic acid,6-Methylesculetin	Apoptosis; AChR; AChE	Apoptosis; Neuroscience
	Scopoletin (Esculetin 6-methyl ether) 是一种源自东莨菪根的植物生长因子，可抑制乙酰胆碱酯酶。
T9862	Pseudocoptisine chloride 盐酸异黄连碱,Isocoptisine chloride	AChE	Neuroscience
	Pseudocoptisine chloride (Isocoptisine chloride) 是从 Corydalis Tuber 中分离出来的，具有抗炎和抗健忘的作用。 Pseudocoptisine chloride 抑制乙酰胆碱酯酶 (AChE) 活性 (IC50 = 12.8 μM)。
TN1589	Dihydrowithaferin A	AChE	Neuroscience
	Dihydrowithaferin A 是一种从 Withania somnifera 中分离出来的 withanolide，具有抗乙酰胆碱酯酶 (AChE) 的活性。饮食中的Dihydrowithaferin A 可以预防或减少肿瘤的生长。
TN1305	Ethoxysanguinarine 乙氧基血根碱,6-Ethoxydihydrosanguinarine	Apoptosis; AChR	Apoptosis; Neuroscience
	Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) 是存在于龙葵中的一种苯并菲啶生物碱天然产物，通过抑制蛋白磷酸酶 2A，可抑制结直肠癌细胞活力，诱导细胞凋亡。
T13301	Violanthin	AChE	Neuroscience
	Violanthin 是一种从胡椒Piper bavinum 中分离出来，具有抗氧化和抗菌作用。它能够抑制乙酰胆碱酯酶，IC50=79.80 μM。
T3819	Ursolic acid acetate 熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid	AChE	Neuroscience
	Ursolic acid acetate (Acetylursolic acid) 分离于 Ficus microcarpa 的气根中，对 KB 细胞显示细胞毒性(IC50:8.4 μM)。
T5855	Edrophonium chloride	AChE	Neuroscience
	Edrophonium chloride 是一种乙酰胆碱酯酶抑制剂，可通过特异性结合其催化位点来防止神经递质乙酰胆碱的分解。
TN1124	Neoeriocitrin	AChE	Neuroscience
	Neoeriocitrin 是一种有效的乙酰胆碱酯酶抑制剂，分离于自百日草，在 MC3T3-E1 中显示出对增殖和成骨分化的活性。
TN2230	Soyasaponin Ba 大豆皂苷 BA,大豆皂苷Ba	Others	Others
	Soyasaponin Ba 是一种大豆皂苷，分离自菜豆类，可用作醛糖还原酶抑制剂。
T11351	Galanthamine N-Oxide	AChE	Neuroscience
	Galanthamine N-Oxide 是分离于Zephyranthes concolor 的球茎中的一种生物碱。它抑制电鳗乙酰胆碱酯酶，EC50=26.2 μM。它是TcAChE，hAChE 和 hBChE 酶活性位点中底物调节的显著抑制剂。
TN3466	Atherosperminine	cAMP; Calcium Channel; AChR; Parasite	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Atherosperminine 是一种天然生物碱，在体外表现出抗疟原虫活性，IC50为 5.80 μM。它具有DPPH 自由基清除活性，其IC50值为 29.56 µg/mL。它对气管有非特异性的弛缓作用。它是一种良好的还原剂，具有螯合金属的能力。
TN1030	N-p-trans-Coumaroyltyramine N-反式对香豆酰基酪胺,N-反式-对香豆酰酪胺	AChE; Parasite	Microbiology/Virology; Neuroscience
	N-p-trans-Coumaroyltyramine 是从蓼属植物中分离出的肉桂酰苯乙酰胺，是一种乙酰胆碱酯酶抑制剂，IC50 为 122 μM。它具有抗锥虫活性，对T. brucei rhodesiense 作用的 IC50值为 13.3 µM。
TN4368	Kaempferol-3,7-di-O-β-glucoside Kaempferol 3,7-di-O-glucoside	Glucosidase; Amylase	Metabolism
	Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) 是一种来自 Morettia philaena 的黄酮醇，对 α-淀粉酶 (α-amylase)、α-葡萄糖苷酶 (α-glucosidase) 和乙酰胆碱酯酶 (Acetylcholinesterase) 具有抑制作用。Kaempferol-3,7-di-O-β-glucoside 具有神经保护活性，可减缓分化神经元细胞 SH-SY5Y 免受 Amyloid β 肽诱导的损伤。Kaempferol-3,7-di-O-β-glucoside 可用于研究阿尔茨海默氏症类的神经系统疾病。
T9076	Spinosad	Others	Others
	Spinosad 是在土壤细菌 S. spinosa 中发现的一种杀虫剂，是大环内酯多杀菌素 A 和多杀菌素 D 的混合物，可作为昆虫烟碱乙酰胆碱酯酶受体 (nAChRs) 的激动剂。它具有优良的环境和哺乳动物毒理学特征，以及杀灭幼虫的活性。
T3767	Polygalacic acid Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸	MMP; AChR; AChE	Neuroscience; Proteases/Proteasome
	Polygalacic acid (Virgaureagenin G) 是一种从远志 Polygala tenuifolia Willd 根中分离出来的三萜，可抑制 MMP 表达。它对认知障碍有显著的神经保护作用，PA 通过抑制乙酰胆碱酯酶活性，增加胆碱乙酰转移酶活性，提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。它可以用于骨关节炎相关研究。
T3026	(-)-Huperzine A HupA,石杉碱,Huperzine A,石杉碱甲	Apoptosis; AChR; AChE; iGluR	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	(-)-Huperzine A (HupA) 是从中国梅花苔中分离得到的一种生物碱，具有神经保护活性。它是高特异性可逆的，具有血脑屏障渗透性的一种乙酰胆碱酯酶抑制剂，其IC50值为 82 nM。它也是 N-甲基-D-天冬氨酸受体的非竞争性拮抗剂，可研究神经退行性疾病，如阿尔茨海默病。
T5S2360	Corydaline Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline	P450; Virus Protease; Opioid Receptor; AChE	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱，是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运，促进胃的调节，具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。
T5S2254	Swertianolin Bellidifolin-8-O-Glucoside,当药醇苷	Others; HBV; Antibacterial; AChE	Microbiology/Virology; Neuroscience; Others
	Swertianolin (Bellidifolin-8-O-Glucoside) 是从Gentianella Acuta 分离得到的一种黄酮，具有抗 HBV 和抗菌活性，可抑制乙酰胆碱酯酶。
T2S1635	3-Isomangostin	MTH1	DNA Damage/DNA Repair
	3-Isomangostin 可从莽吉柿壳中提取的一种天然产物，是一种乙酰胆碱酯酶选择性抑制剂，也是一种有效的人醛糖还原酶抑制剂，IC50 为 3.48 uM。它抑制 MutT 同源物 1 (MTH1)，IC50 为 52 nM。它具有清除自由基、抗疟原虫和抗癌的活性。
T2S1792	Lycobetaine 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐	Antibacterial	Microbiology/Virology
	Lycobetaine (Ungeremine) 是一种潜在的抗罗克福尔青霉和黑曲霉的生物杀菌剂。它对柱状黄杆菌有很强的抗菌活性。它有效地靶向哺乳动物以及细菌I 型和II 型拓扑异构酶。它显示出强烈的乙酰胆碱酯酶抑制活性（IC(50) 值为 0.35 microM）。它具有抗原生动物活性，在体外试验中对Trypanosoma brucei rhodesiense、T. cruzi 表现出良好的活性。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
T27104	Cyclopenin NSC 114538,NSC-114538,NSC604989,NSC 604989,NSC-604989,NSC114538
	Cyclopenin is an inhibitor of acetylcholinesterase (AChE; IC50 = 2.04 μM for human recombinant AChE).
TN5940	Lycoclavanol 14-Serratene-3,21,24-triol
	Lycoclavanol exhibits acetylcholinesterase inhibition activity.
T72794	Millmerranone A
	Millmerranone A 具有抑制乙酰胆碱酯酶的特性。
TN2505	1,5-Diphenylpentan-1-one	AChR	Neuroscience
	1,5-Diphenylpentan-1-one shows poor insecticidal and acetylcholinesterase inhibitory activities.
T40512	Echimidine N-oxide
	Echimidine N-oxide, a pyrrolizidine alkaloid, exhibits significant inhibitory activity against acetylcholinesterase (AChE) with an IC50 value of 0.347 mM.
TN6009	Pseudopalmatine
	Pseudopalmatine exhibits antiplasmodial activity. It also shows anti-acetylcholinesterase (AChE) activity, with IC50 values of 1.8uM.
TN6050	Macusine B
	Macusine B is a dual inhibitor, has almost equal inhibitory activity on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
TN3570	Calyxamine B	Others	Others
	Calyxamine B has inhibitory activity on acetylcholinesterase, the effect is comparable to the natural inhibitors.
T75455	Paecilomide
	Paecilomide，吡啶酮生物碱，是一种乙酰胆碱酯酶 (acetylcholinesterase) 抑制剂。
TN1559	Dehydrodicentrine	AChR	Neuroscience
	Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.
TN3875	Dipterocarpol	P450; AChR	Metabolism; Neuroscience
	Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory activity with the IC50 value of 8.28 uM.
T28122	Myrtenal NSC-54384,NSC 54384,NSC54384,Benihinal
	Myrtenal is a natural monoterpene. It is found to attenuate diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades. Myrtenal also inhibits acetylcholinesterase
T21438	Physostigmine Physostol,Antilirium,Eserine,毒扁豆碱,Esromiotin,Ezerin
	Physostigmine is a potent and reversible inhibitor of cholinesterase. It is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE).
T80009	Osmanthuside B
	Osmanthuside B，从Pseuderanthemum carruthersii (Seem.) Guill. var.atropurpureum (Bull.) Fosb 中分离得到，展现出较弱的乙酰胆碱酯酶抑制活性。
TN2504	1,5-Dihydroxyxanthone	EGFR; AChR	Angiogenesis; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzym
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天然产物

Cat.No: TN1899

Target: AChE

Cat.No: TN2298

Synonym: 喜果苷

Target: AChE

Cat.No: Fr14127

Synonym: 2,3-Dihydrobenzofuran,2,3-二氢苯并呋喃

Target: Endogenous Metabolite, AChE

O-Desmethyl Galanthamine

Cat.No: TN6786

Synonym: Sanguinine,O-去甲基加兰他敏

Target: AChE

Cat.No: T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷

Target: TNF, AChE

Galanthamine hydrobromide

Cat.No: T0086

Synonym: Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏

Target: AChR, AChE

Cat.No: T2S1200

Target: Antioxidant, P-gp, AChE

Sinapine thiocyanate

Cat.No: T3392

Target: P-gp, AChE

Cat.No: T4852

Synonym: Trimyristoylglycerol,Tritetradecanoin,三肉豆蔻酸甘油酯,Glyceryl trimyristate,甘油三肉豆蔻酸酯,1,2,3-Tritetradecanoylglycerol

Target: Phosphatase, Endogenous Metabolite, AChE

Cat.No: T6S2356

Synonym: 紫蓳灵,堇醇灵碱,(+)-Corynoline

Target: Nrf2, AChE

Cat.No: T4S1725

Synonym: Galantamine,加兰他敏

Target: Apoptosis, AChE

Cat.No: T2846

Target: Antibacterial, AChE

Methyl tridecanoate

Cat.No: TN6919

Target: Beta Amyloid, AChE

Dehydronuciferine

Cat.No: TN1091

Target: AChE

Cat.No: T2984

Synonym: Chrysatropic acid,东莨菪内酯,Esculetin 6-methyl ether,Gelseminic acid,6-Methylesculetin

Target: Apoptosis, AChR, AChE

Pseudocoptisine chloride

Cat.No: T9862

Synonym: 盐酸异黄连碱,Isocoptisine chloride

Target: AChE

Dihydrowithaferin A

Cat.No: TN1589

Target: AChE

Ethoxysanguinarine

Cat.No: TN1305

Synonym: 乙氧基血根碱,6-Ethoxydihydrosanguinarine

Target: Apoptosis, AChR

Cat.No: T13301

Target: AChE

Ursolic acid acetate

Cat.No: T3819

Synonym: 熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid

Target: AChE

Edrophonium chloride

Cat.No: T5855

Target: AChE

Cat.No: TN1124

Target: AChE

Cat.No: TN2230

Synonym: 大豆皂苷 BA,大豆皂苷Ba

Target: Others

Galanthamine N-Oxide

Cat.No: T11351

Target: AChE

Atherosperminine

Cat.No: TN3466

Target: cAMP, Calcium Channel, AChR, Parasite

N-p-trans-Coumaroyltyramine

Cat.No: TN1030

Synonym: N-反式对香豆酰基酪胺,N-反式-对香豆酰酪胺

Target: AChE, Parasite

Kaempferol-3,7-di-O-β-glucoside

Cat.No: TN4368

Synonym: Kaempferol 3,7-di-O-glucoside

Target: Glucosidase, Amylase

Cat.No: T9076

Target: Others

Polygalacic acid

Cat.No: T3767

Synonym: Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸

Target: MMP, AChR, AChE

(-)-Huperzine A

Cat.No: T3026

Synonym: HupA,石杉碱,Huperzine A,石杉碱甲

Target: Apoptosis, AChR, AChE, iGluR

Cat.No: T5S2360

Synonym: Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

Cat.No: T5S2254

Synonym: Bellidifolin-8-O-Glucoside,当药醇苷

Target: Others, HBV, Antibacterial, AChE

Cat.No: T2S1635

Target: MTH1

Cat.No: T2S1792

Synonym: 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐

Target: Antibacterial

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: T27104

Synonym: NSC 114538,NSC-114538,NSC604989,NSC 604989,NSC-604989,NSC114538

Cat.No: TN5940

Synonym: 14-Serratene-3,21,24-triol

Millmerranone A

Cat.No: T72794

1,5-Diphenylpentan-1-one

Cat.No: TN2505

Target: AChR

Echimidine N-oxide

Cat.No: T40512

Pseudopalmatine

Cat.No: TN6009

Cat.No: TN6050

Cat.No: TN3570

Target: Others

Cat.No: T75455

Dehydrodicentrine

Cat.No: TN1559

Target: AChR

Cat.No: TN3875

Target: P450, AChR

Cat.No: T28122

Synonym: NSC-54384,NSC 54384,NSC54384,Benihinal

Cat.No: T21438

Synonym: Physostol,Antilirium,Eserine,毒扁豆碱,Esromiotin,Ezerin

Cat.No: T80009

1,5-Dihydroxyxanthone

Cat.No: TN2504

Target: EGFR, AChR

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01742	Acetylcholinesterase Protein, Mouse, Recombinant (His) Acre,Chrne,acetylcholinesterase (Yt blood group)	Mouse	HEK293 Cells
	Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). ACHE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. It is an externally oriented membrane-bound enzyme and ...
TMPJ-00695	CuTA Protein, Human, Recombinant (His) C6orf82,Brain Acetylcholinesterase Putative Membran...	Human	E. coli
	Protein CutA (CUTA) posseses a signal peptide and is widely expressed in brain. CUTA mayforms part of a complex of membrane proteins attached to acetylcholinesterase (AChE). CUTA takes part in cellular tolerance to a broad range of divalent cations other than copper. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found.
TMPH-03234	Acetylcholinesterase Protein, Rat, Recombinant (His) AChE,EC:3.1.1.7	Rat	E. coli
	Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Acetylcholinesterase Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 68.9 kDa and the accession number is P37136.

重组蛋白

Acetylcholinesterase Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01742

Species: Mouse

Expression System: HEK293 Cells

CuTA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00695

Species: Human

Expression System: E. coli

Acetylcholinesterase Protein, Rat, Recombinant (His)

Cat.No: TMPH-03234

Species: Rat

Expression System: E. coli

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