c-terminal

Oxytocin C-terminal tripeptide Acetate 是 Oxytocin 的 C-末端三肽。Oxytocin 是哺乳动物的神经垂体激素，催产素受体的配体。

Fas C-Terminal Tripeptide Acetate 显示出对 Fas/FAP-1 结合的抑制活性。

Amyloid precursor c-terminal peptide has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. APP is best known as the precursor molecule whose proteolysis generates beta-amyloid (Aβ), a 37 to 49 amino acid peptide whose am

Z-VAD(OMe)-FMK 是一种具有不可逆特性的pan-caspase抑制剂。Z-VAD(OMe)-FMK 还是泛素 C 端水解酶 L1 (UCHL1) 的抑制剂，它通过靶向 UCHL1 活性位点进行不可逆修饰。

740 Y-P acetate (740YPDGFR acetate) 是一个有效的且具有细胞渗透性的 PI3K 激活剂。740 Y-P acetate 倾向和含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白结合，但不能单独结合 GST。

(Iso)-Z-VAD(OMe)-FMK 是 Z-VAD(OMe)-FMK 的异构体，Z-VAD(OMe)-FMK 是一种具有不可逆特性的 pan-caspase 抑制剂。Z-VAD(OMe)-FMK 还是泛素 C 端水解酶 L1 (UCHL1) 的抑制剂，通过靶向 UCHL1 活性位点进行不可逆修饰。

Cytochrome c - pigeon (88-104) Acetate (Cytochrome c - pigeon ) 对 COOH 末端序列 88-1041 内的肽具有特异性。

gamma-preprotachykinin amide (72-92) acetate 是一种 21 个氨基酸的肽，属于速激肽 (TK) 家族，在其 C 末端序列中包括神经激肽 A (NKA)。它对中枢 NK-2 受体的亲和力高于 NKA；它对 NK-1 受体的亲和力较低，但是，它有效地刺激唾液分泌，这是由 NK-1 受体激活介导的。

Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate)(736171-62-3 free base) 是一组含有四肽重复 (TPR) 的蛋白质，已显示与 70 kDa 热休克同源蛋白 (hsc70) 的 C 末端结构域相互作用。在本研究中，含 TPR 的蛋白质，包括 hsc70 相互作用蛋白 (CHIP)、TPR1 和人富含谷氨酰胺的 TPR 含蛋白 (hSGT) 的 C 端，对 DnaJ 和 hsc70 对荧光素酶重折叠的影响进行了调查。

Tetragastrin is the C-terminal tetrapeptide of gastrin. It has the same physiological and pharmacological activity as gastrin.

Beta-Lipotropin (1-10), porcine Acetate (Beta-Lipotropin ) 被发现在其 C 末端序列中包含这些肽的一级结构。

Ac-Endothelin-1 (16-21), human acetate 是内皮素家族的主要肽，已被证明在血管和非血管组织中具有多种生物活性。 C-末端片段是 ET 家族肽中高度保守的序列，已显示可区分称为 ETA 和 ETB 的两种 ET 受体亚型，因为它仅激活后者。

Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4). It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 μM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial cells (HUVECs) by 80% after 12 hours in an in vitro wound closure assay. NPY (3-36) corresponds to residues 3-36 of the human and rat protein sequence.

Obestatin is a 23 amino acid peptide hormone with a conserved C-terminal glycine residue and amidation site that is formed by cleavage of the ghrelin and obestatin prepropeptide.1It binds to the orphan receptor GPR39 (Kd= 1 nM) and stimulates cAMP production in CHO and HEK293 cells overexpressing human GPR39. Obestatin inhibits contraction of isolated mouse jejunum muscle strips induced by ghrelin .In vivo, obestatin (12.5-1,000 nmol/kg) suppresses food intake in a time- and dose-dependent manner and reduces body weight gain and gastric emptying in mice. Obestatin (0.22 g per animal) also reduces food intake and glucose response without affecting plasma insulin responses in fasted high-fat diet fed mice.2 1.Zhang, J.V., Ren, P.C., Avsian-Kretchmer, O., et al.Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intakeScience310(5750)996-999(2005) 2.Subasinghage, A.P., Green, B.D., Flatt, P.R., et al.Metabolic and structural properties of human obestatin {1-23} and two fragment peptidesPeptides31(9)1697-1705(2010)

Epsilon-V1-2 是蛋白激酶 C ε（PKCε）的特异性抑制剂。Epsilon-V1-2 被用于卵巢衰老、人颗粒细胞凋亡、脑缺血-再灌注损伤、脑发育、肝细胞胰岛素信号转导以及缺血条件下神经元细胞死亡等相关研究。研究表明，Epsilon-V1-2 能够有效降低 PKCε 的活性，从而促进对线粒体动力学、钙超载、AKT 激活、脑萎缩、胰岛素抵抗及铁死亡等调控通路的深入解析。Epsilon-V1-2 在卒中、SHORT 综合征、肝脂肪变性及脑损伤等疾病模型中显示出显著的治疗相关性。

Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52) . In vitro, adrenomedullin (22-52) reduces basal corticosterone production in a mixture of rat adrenocortical and adrenomedulllary cells. It also reverses increases in ACTH-stimulated corticosterone production induced by adrenomedullin (1-52). Adrenomedulin (22-52) (0.5 and 5 μg/kg/min) has no effect on basal regional cerebral blood flow but reverses increases in regional cerebral blood flow induced by rat adrenomedullin in rats. Unlike adrenomedullin (1-52), adrenomedullin (22-52) has no effect on mesenteric arterial perfusion pressure in cats.

Chemokine-like receptor 1 (CMKLR1) agonist (EC50 = 42 nM). Corresponds to C-terminal of full length mouse Chemerin, amino acids 148 - 156.

CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 uM) and inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 uM), an effect that can be reversed by naloxone. Unlike sulfated CCK (27-33), the non-sulfated form does not reduce exploratory behavior in mice when administered at doses up to 1 uMol/kg.

YGFGG, C-terminal pentapeptide fragment of the osteogenic growth peptide (OGP), (H-8640), showed the full spectrum of OGP-like bioactivities. It has attracted considerable interest as bone anabolic agent and hematopoietic stimulator.

GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it effectively inhibits mitochondrial permeability transition (MPT). This compound exhibits anti-diabetic properties and demonstrates cardioprotection effects[1].

Onilcamotide, a cancer vaccine derived from the C-terminal peptide of the RhoC protein, exhibits potential immunomodulating and antineoplastic activities.

Apelin-12 is a highly potent C-terminal fragment of a polypeptide that exhibits a strong affinity towards the orphan receptor APJ. It plays a role in maintaining body fluid balance and regulating feeding control in the central nervous system. Additionally, Apelin-12 functions as an inhibitor of HIV-1 entry through the APJ receptor and demonstrates neuroprotective properties.

OVA (329-337) is a 9-aa core epitope (329–337) located in the C-terminal end of the OVA peptide.

TAME (Tosyl-Arginine Methyl Este) 是后期促进复合体 (APC/C 或 APC) 的抑制剂， 通过与 APC 激活剂细胞分裂周期 20 （Cdc20） 的 C 末端异亮氨酸-精氨酸尾部竞争 APC 结合来抑制 APC 依赖性蛋白水解。TAME 与 APC 结合并阻止其被 Cdc20 和 Cdh1 激活.