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AKR1A1 Protein, Human, Recombinant (His)

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货号 TMPY-02461

别名 HEL-S-6, DD3, ARM, ALR, ALDR1, aldo-keto reductase family 1, member A1 (aldehyde reductase)

Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fold which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases. AKR1A1 is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.

AKR1A1 Protein, Human, Recombinant (His)
其他形式的 “AKR1A1 Protein, Human, Recombinant (His)”:
GFER Protein, Human, Recombinant (His)
GFER Protein, Human, Recombinant (HEK293, His)
AKR1B1 Protein, Human, Recombinant (His)

AKR1A1 Protein, Human, Recombinant (His)

一键复制产品信息
Rating icon 还可以
SPR兼容缓冲液
货号 TMPY-02461 别名 HEL-S-6, DD3, ARM, ALR, ALDR1, aldo-keto reductase family 1, member A1 (aldehyde reductase)

Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fold which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases. AKR1A1 is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.

规格价格库存数量
5 μg
¥ 797
6-8日内发货
10 μg
¥ 1,320
6-8日内发货
20 μg
¥ 2,180
5日内发货
50 μg
¥ 4,380
5日内发货
100 μg
¥ 7,450
5日内发货
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纯度: > 90 % as determined by SDS-PAGE
颜色: 白色
性状: Lyophilized powder
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资源下载:
COA重组蛋白用户指南

产品介绍

生物活性
产品描述
Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fold which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases. AKR1A1 is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.
生物活性
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景
Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fold which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases. AKR1A1 is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.
种属
Human
表达系统
E. coli
标签N-His
蛋白编号P14550
蛋白构建A DNA sequence encoding the human AKR1A1 (P14550) (Met 1-Tyr 325) was expressed, with a polyhistidine tag at the N-terminus. Predicted N terminal: Met
蛋白纯度
> 90 % as determined by SDS-PAGE
蛋白性状Lyophilized powder
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名HEL-S-6, DD3, ARM, ALR, ALDR1, aldo-keto reductase family 1, member A1 (aldehyde reductase)
内毒素Please contact us for more information.
化学信息
分子量39 kDa (predicted); 39 kDa (reducing conditions)
储存&溶解度
运输方式In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
存储

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剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.

关键词

DD-3DD 3ALDR-1ALDR 1aldo-keto reductase family 1, member A1aldehyde reductase
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