antimicrobial activity

Cyclo-L-Trp-L-Trp 是一种广谱抗真菌剂。它还诱导组蛋白的高度乙酰化。

LL-37, Human acetate(154947-66-7 free base) 是一种 37 个残基、两亲性、cathelicidin 衍生的抗菌肽，具有广谱的抗菌活性。

Dermaseptin acetate 是一种从青蛙皮肤中分离出来的肽，在微摩尔浓度下表现出对细菌、真菌和原生动物的有效抗菌活性。

SPR741 acetate 是衍生自多粘菌素 B 的阳离子肽，通过增加革兰氏阴性细菌外膜的通透性来抑制严重的革兰氏阴性细菌感从而展现出对革兰氏阴性菌的抗菌活性。SPR741 acetate 常与抗生素联合使用来治疗一些疾病。

rCRAMP (rat) acetate 是一种与cathelin 相关的抗菌肽，在大鼠脑肽/蛋白质提取物中表现出抗菌活性。

Magainin 1 acetate 是一种抗菌肽。它对许多革兰氏阴性和革兰氏阳性细菌表现出抗生素活性。

Alamethicin 是从 Trichoderma viride 中分离得到的一种通道形成抗生素肽，具有潜在的抗菌活性，抑制甲烷生成并促进生物电化学系统中的乙酰生成。

Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.

Golotimod (SCV 07) 是一种具有抗菌活性的二肽，具有免疫调节活性，能显著提高抗结核治疗的疗效，诱导胸腺和脾脏细胞增殖，调节巨噬细胞功能，抑制 STAT3 信号传导。Golotimod 可用于研究复发性生殖器单纯疱疹病毒 2 （HSV-2）感染和口腔黏膜炎。

P-113 is a peptide with antimicrobial activity.

β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but not of resistantM. tuberculosisRM22 when used at a concentration of 128 μg/ml.3,4It blocks human and mouse Kv1.3 voltage-gated potassium channels (IC50s = 11.8 and 13.2 μM, respectively).5Overexpression of β-defensin-1 in the human oral squamous cell carcinoma (OSCC) cell lines HSC-3, UM-1, and SCC-9 increases migration and invasion but not proliferation.6 1.Lehrer, R.I.Primate defensinsNat. Rev. Microbiol.2(9)727-738(2004) 2.Schroeder, B.O., Ehmann, D., Precht, J.C., et al.Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptideMucosal Immunol.8(3)661-671(2015) 3.Ouhara, K., Komatsuzawa, H., Yamada, S., et al.Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cellsJ. Antimicrob. Chemother.55(6)888-896(2005) 4.Fattorini, L., Gennaro, R., Zanetti, M., et al.In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosisPeptides25(7)1075-1077(2004) 5.Feng, J., Xie, Z., Yang, W., et al.Human beta-defensin 1, a new animal toxin-like blocker of potassium channelToxicon113(2016) 6.Han, Q., Wang, R., Sun, C., et al.Human beta-defensin-1 suppresses tumor migration and invasion and is an independent predictor for survival of oral squamous cell carcinoma patientsPLoS One9(3)e91867(2014)

Lactoferricin B (4-14), bovine (TFA), is a peptide derived from bovine lactoferrin, specifically consisting of residues 4-14. This compound exhibits broad-spectrum antimicrobial activity against various microorganisms[1].

CAP18 (rabbit) is a 37 amino acid antimicrobial peptide derived from rabbit granulocytes. It exhibits extensive antimicrobial activity against both Gram-positive (IC50, 130-200 nM) and Gram-negative (IC50, 20-100 nM) bacteria. Thus, CAP18 (rabbit) holds promise for the study and advancement of bacterial sepsis research.

Temporin L, a potent antimicrobial peptide, exhibits activity against Gram-negative bacteria and yeast strains, as well as demonstrating antiendotoxin properties.

Omiganan is a cationic antimicrobial peptide with activity against both gram-positive and gram-negative bacteria, as well as Candida spp. isolates. This compound, serving as an analogue of indolicidin, is utilized for research purposes related to alcohol nose and acne.

Poly-L-lysine hydrochloride 作为一种非特异性附着因子，通过增强细胞膜上存在的负电离子与培养基质表面之间的静电相互作用，在促进细胞对固体基质的附着方面起着关键作用。Poly-L-lysine hydrochloride 是一种多肽，在低浓度时表现出促进液-液相分离（LLPS）的能力，而在高浓度时抑制 LLPS。由于其阳离子肽的性质，Poly-L-lysine hydrochloride 抗菌活性。这些特性使它成为增强细胞粘附力、调节相分离动力学和展示抗菌活性的重要成分。

rCRAMP (rat), the rat cathelin-related antimicrobial peptide, plays a crucial role in the antibacterial activity found in rat brain peptide/protein extracts. As a potential key player in the innate immune system of the rat central nervous system, rCRAMP (rat) serves to enhance immune response.

Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by epithelial surfaces, circulatory cells, and cells of the reproductive tract. It exhibits antimicrobial activity against a wide range of sperm bacteria.

IDR-1 is an antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines.

Defensin HNP-1, human acetate是一种主要存在于中性粒细胞中的抗菌肽和人α -防御素，对细菌和病毒具有广谱抗菌活性，可以触发NF-κB和IRF1从而增加IFN-α，能够诱导肿瘤细胞凋亡，抑制血管内皮细胞功能，介导感染免疫等等。

Micronomicin sulfate (Gentamicin C2b sulfate) 是一种氨基糖苷类抗生素，具有抗菌活性，抑制甲型流感病毒的神经氨酸酶 N1。

HLF1-11，一种人乳铁蛋白衍生肽，是一种广谱抗菌剂。HLF1-11 抑制MPO(human) 的活性。HLF1-11 还使GM-CSF 驱动的单核细胞向巨噬细胞分化，并增强其免疫反应。

Murepavadin TFA是一种高效的 14 氨基酸环状肽类抗生素，对铜绿假单胞菌（Pseudomonas aeruginosa）具有高度特异性和强效的抗菌活性，其 MIC50 和 MIC90 均为 0.12 mg/L。该化合物通过与脂多糖转运蛋白 D 的靶向相互作用发挥作用，是研究细菌耐药机制、抗菌特异性以及新型抗生素开发策略的重要研究化合物。

Beta-defensin 1, pig 是一种在猪舌黏膜中主要发现的抗菌肽，对包括大肠杆菌、鼠伤寒沙门氏菌、单核细胞增生性李斯特菌、金黄色葡萄球菌、百日咳博德特氏菌和白色念珠菌在内的多种细菌显示出活性。