Name: WLBU2
Brand: TargetMol
SKU: TP3849
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

产品介绍

生物活性

产品描述

WLBU2 is an engineered cationic antimicrobial peptide (eCAP) designed to overcome the sensitivity issues of natural antimicrobial peptides (AMPs) in various environments. WLBU2 exhibits rapid bactericidal activity and has a minimum inhibitory concentration (MIC) value of ≤ 10 μM against numerous Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococci, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, and Escherichia coli. It effectively prevents biofilm formation by Pseudomonas aeruginosa and retains its activity in mucus-rich, low pH, and high salt conditions, without adverse effects on human respiratory epithelial cells. Additionally, WLBU2 is applicable for studying cystic fibrosis (CF) and Pseudomonas aeruginosa infections.

体外活性

WLBU2在非生物表面（5-90 μM, 24 小时）和人囊性纤维化气道上皮细胞（CFAECs）（10-100 μM, 5 小时）上有效防止铜绿假单胞菌的生物膜形成。在高盐条件（100 mM Nacl）和低 pH（6.5-7.0）条件下，WLBU2（50 μM, 5 小时）依然能够在CFAECs中保持其预防生物膜的活性。此外，WLBU2（20 μM, 5 小时）与Tobramycin、ciprofloxacin、Ceftazidime和Meropenem联合使用时显示出协同作用，但与Colistin无明显协同。WLBU2对肺炎克雷伯菌的最低抑菌浓度（MIC）为7.943 μM，对鲍曼不动杆菌临床分离株的MIC为7.484 μM，与其各自的最低杀菌浓度（MBC）相同，表明WLBU2具备杀菌效力。