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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Di-O-methylhonokiol

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纯度: 99.84%

货号 TN7231Cas号 68592-18-7

别名 和厚朴酚二甲醚, Honokiol dimethyl ether

Di-O-methylhonokiol (Honokiol dimethyl ether) 是Magnolia grandiflora L 的酚类成分，具有抗微生物活性，对革兰氏阳性和抗酸细菌和真菌具有显著的抗氧化活性。

Di-O-methylhonokiol
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Di-O-methylhonokiol

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Rating icon 很棒

纯度: 99.84%

货号 TN7231 别名 和厚朴酚二甲醚, Honokiol dimethyl etherCas号 68592-18-7

Di-O-methylhonokiol (Honokiol dimethyl ether) 是Magnolia grandiflora L 的酚类成分，具有抗微生物活性，对革兰氏阳性和抗酸细菌和真菌具有显著的抗氧化活性。

规格价格库存数量
1 mg
¥ 795
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5 mg
¥ 1,990
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10 mg
¥ 3,150
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25 mg
¥ 4,970
现货
50 mg
¥ 6,990
现货
1 mL x 10 mM (in DMSO)
¥ 1,790
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产品介绍

Di-O-methylhonokiol AI Summary
Di-O-methylhonokiol shows diverse bioactivities and potential therapeutic effects. It promotes neurite growth in rat cortical neurons, with notable activity at concentrations of 0.1 µM and 1 µM, and enhances neurite length by about 111 µM. The compound exhibits inhibitory effects on inflammatory enzymes, including 45% inhibition of COX1 in ram seminal vesicle and 47.8% inhibition of COX2 in sheep placental vesicle at an 8 µM concentration, with IC50 values of 11400.0 nM and 7700.0 nM, respectively. It also inhibits 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes, with a 27.8% inhibition and an IC50 value of 15000.0 nM. In addition, Di-O-methylhonokiol modulates the GABAAalpha1beta2 receptor by potentiating GABA-induced chloride current, exhibiting an EC50 of 42100.0 nM and maximal potentiation of 368% at 30 µM concentration. The compound has a high octanol-water partition coefficient (log P) of around 5.69, indicating higher hydrophobicity and potential for good membrane permeability. It shows antiproliferative activity against various human and mouse cell lines, including HUVEC, HepG2, LL/2, MCF7, CNE2Z, and I10 cells, with IC50 values indicating limited potency, generally above 100,000.0 nM. Di-O-methylhonokiol also demonstrates significant inhibition of LPS-induced COX2-mediated PGF1 production and NO production in mouse RAW264.7 cells, displaying cytotoxicity at higher concentrations. Furthermore, it acts as a CB2 receptor ligand with a Ki value of 1375.0 nM, showcasing its moderate affinity for this receptor. Overall, Di-O-methylhonokiol demonstrates a broad spectrum of bioactivities, including inflammation modulation, receptor activity modulation, and limited antiproliferative effects, with moderate hydrophobicity and potential membrane permeability..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Di-O-methylhonokiol (Honokiol dimethyl ether), a phenolic component of Magnolia grandiflora L, exhibits antimicrobial activity and significant antioxidant activity against Gram-positive and acid-resistant bacteria and fungi.
别名和厚朴酚二甲醚, Honokiol dimethyl ether
化学信息
分子量294.39
分子式C20H22O2
CAS No.68592-18-7
SmilesO(C)C1=C(C=C(CC=C)C=C1)C2=CC(CC=C)=C(OC)C=C2
密度no data available
储存&溶解度
存储store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 2.95 mg/mL (10.02 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.3969 mL16.9843 mL33.9685 mL169.8427 mL
5 mM0.6794 mL3.3969 mL6.7937 mL33.9685 mL
10 mM0.3397 mL1.6984 mL3.3969 mL16.9843 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Di-O-methylhonokiolAntioxidant
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