Name: Murepavadin TFA
Brand: TargetMol
SKU: T75996
Price: 1220 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,220

现货

5 mg

¥ 2,880

现货

10 mg

¥ 4,330

现货

25 mg

¥ 6,900

现货

50 mg

¥ 9,490

现货

生物活性

产品描述	Murepavadin TFA is a highly potent 14–amino acid cyclic peptide antibiotic that exhibits strong and specific antibacterial activity against Pseudomonas aeruginosa, with MIC50 and MIC90 values both measured at 0.12 mg/L, functioning through targeted interaction with the lipopolysaccharide transport protein D, and serving as a valuable research compound for studying bacterial resistance mechanisms, antimicrobial specificity, and novel antibiotic development strategies.
体内活性	方法：在使用 XDR（广泛耐药）细菌分离株的临床前感染模型中，皮下注射给予 Murepavadin TFA（0–100 mg/kg）。结果：Murepavadin TFA 在临床前动物感染模型中表现出抗菌活性[1]。
别名	莫瑞伐定三氟乙酸盐, POL7080 TFA, POL 7080 TFA, Murepavadin TFA

化学信息

分子量	1667.83
分子式	C₇₃H₁₁₂N₂₂O₁₆.C₂HF₃O₂
CAS No.	3053070-05-3
Smiles	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC4=CNC5=CC=CC=C54)[C@@H](C)O)CO)C)CCN)CCN)CC6=CNC7=CC=CC=C76)CCN)CCN)CCCN)CCN.C(=O)(C(F)(F)F)O
Sequence	Cyclo[Ala-Ser-dPro-Pro-Thr-Trp-Ile-Dab-Orn-dDab-Dab-Trp-Dab-Dab].CH3CO2H
Sequence Short	Cyclo(AS-{d-Pro}-PTWI-{Dab}-{Orn}-{d-Dab}-{Dab}-W-{Dab}-{Dab})

储存&溶解度

存储

溶解度信息

H2O: 40.00 mg/mL (23.98 mM), Sonication is recommended.

溶液配制表

H2O

Murepavadin TFA