GSK-3

Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over 100 different proteins in a variety of different pathways. In mammals GSK-3 is encoded by two paralogous genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B). GSK-3 has recently been the subject of much research because it has been implicated in a number of diseases, including Type II diabetes (diabetes mellitus type 2), Alzheimer's disease, inflammation, cancer, and bipolar disorder.

Cat. No.	Product Name	CAS No.	Purity
T22180	3F8 化合物3F8	159109-11-2	98%
T22180	3F8 是一种具有选择性的 GSK-3β抑制剂，可用作 GSK3 相关疾病的新工具和潜在治疗候选化合物，可用于研究神经系统疾病和癌症。
T35556	GSK-3β inhibitor 8 GSK-3β抑制剂8	1139875-74-3	98%
T35556	GSK-3β inhibitor 8是具有有效和选择性的 GSK-3β 抑制剂，IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物，负调控 Wnt 信号通路，刺激 β 细胞增殖。
T61360	ARN25068 化合物ARN25068	2649882-80-2	98%
T61360	ARN25068是三种蛋白激酶(GSK-3β、FYN和DYRK1A)的亚微摩尔抑制剂，可用于治疗tau相关神经系统疾病。
T72048	CDK8-IN-12 化合物CDK8-IN-12	2613307-67-6	98%
T72048	CDK8-IN-12 是一种具有选择性、有效性和口服活性的 CDK8 抑制剂（Ki ： 14 nM），是一种抗癌剂。CDK8-IN-12 对 GSK-3α、GSK-3β、PCK-θ 具有抑制作用，Ki 分别为 13 nM、4 nM、109 nM。CDK8-IN-12对 MV4-11 细胞显示出抗增殖活性。
T15204	EHT 1610 化合物EHT 1610	1425945-60-3	98%
T15204	EHT 1610 是双特异性酪氨酸磷酸化调节酶 (DYRK) 的强效抑制剂，对 DYRK1A 和 DYRK1B 有抑制作用，的 IC50 分别为 0.36 nM 和 0.59 nM。EHT 1610 对白血病具有抑制效应，可调节细胞周期，诱导细胞凋亡。
T69188	Aloisine B 化合物Aloisine B	496864-14-3	98%
T69188	Aloisine B is a potent and selective CDK and GSK-3 inhibitor. Highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50 750.0 nM...
T11468	GSK-3 inhibitor 1 化合物 T11468	603272-51-1	98%
T11468	GSK-3 inhibitor 1 is a GSK-3 inhibitor.
TN4424	Lecanoric acid 化合物 TN4424	480-56-8	98%
TN4424	Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased d...
TN4263	Isoangustone A 化合物 TN4263	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN3319	9-Hydroxycanthin-6-one 化合物 TN3319	138544-91-9	98%
TN3319	9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
T10172	5-Iodo-indirubin-3'-monoxime 5-碘靛红-3'-单肟	331467-03-9	98%
T10172	5-Iodo-indirubin-3'-monoxime 是一种 GSK-3β、CDK5/P25和CDK1/cyclin B 抑制剂，IC50值分别为 9、20 和 25 nM，与 ATP 竞争性地结合酶的催化位点。
T2S0606	Bakkenolide A 蜂斗菜内酯A	19906-72-0	98%
T2S0606	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T10786	Charantin 化合物 T10786	57126-62-2	98%
T10786	Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit G...
TN4637	Neogrifolin 化合物 TN4637	23665-96-5	98%
TN4637	Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS ...
T6139	A-674563 化合物A-674563	552325-73-2	98%
T6139	A674563 是一种口服有效，选择性的Akt1抑制剂，Ki=11 nM。
TN2995	4,10-Aromadendranediol 化合物 TN2995	70051-38-6	98%
TN2995	4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN2775	2-Methoxystypandrone 化合物 TN2775	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TMA0291	Dehydroglyasperin D 化合物 TMA0291	517885-72-2	98%
TMA0291	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN4046	Excisanin A 化合物 TN4046	78536-37-5	98%
TN4046	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T11960	MBM-55 化合物MBM-55	2083622-09-5	98%
T11960	MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂，IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。