首页 工具
登录
购物车
GSK-3

GSK-3

Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over 100 different proteins in a variety of different pathways. In mammals GSK-3 is encoded by two paralogous genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B). GSK-3 has recently been the subject of much research because it has been implicated in a number of diseases, including Type II diabetes (diabetes mellitus type 2), Alzheimer's disease, inflammation, cancer, and bipolar disorder.
TargetMol
1 2 3 4 5 6
Cat. No. Product Name CAS No. Purity Chemical Structure
T79693 PIMPC
化合物 PIMPC
2250244-44-9 98%
TargetMol Chemical Structure PIMPC
PIMPC为具抗氧化及金属螯合性能之化合物,新型糖原合成酶激酶3(GSK-3)抑制剂,潜在抗阿尔茨海默病作用。
T80124 C-Peptide 1 (rat)
化合物 C-Peptide 1 (rat)
41475-27-8 98%
TargetMol Chemical Structure C-Peptide 1 (rat)
C-Peptide 1 (rat) 为肽类化合物,作为β-catenin/GSK-3β激活剂,具有调节Wnt/β-catenin信号通路的功能,常用于癌症研究领域。
T82243 HAChE-IN-5
化合物 hAChE-IN-5
98%
TargetMol Chemical Structure hAChE-IN-5
hAChE-IN-5(化合物49)是一种同时针对hAChE和hBuChE的有效抑制剂,其IC50值均为0.17 μM。此外,hAChE-IN-5对GSK3β同样展现出良好的抑制活性,IC50值为0.21 μM。作为tau蛋白聚集和Aβ1-42自聚集的抑制剂,hAChE-IN-5能够结合PAS,进而阻止Aβ依赖的神经毒性。...
TN4263 Isoangustone A
化合物 TN4263
129280-34-8 98%
TargetMol Chemical Structure Isoangustone A
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN3319 9-Hydroxycanthin-6-one
化合物 TN3319
138544-91-9 98%
TargetMol Chemical Structure 9-Hydroxycanthin-6-one
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
T10172 5-Iodo-indirubin-3'-monoxime
5-碘靛红-3'-单肟
331467-03-9 98%
TargetMol Chemical Structure 5-Iodo-indirubin-3'-monoxime
5-Iodo-indirubin-3'-monoxime 是一种 GSK-3β、CDK5/P25和CDK1/cyclin B 抑制剂,IC50值分别为 9、20 和 25 nM,与 ATP 竞争性地结合酶的催化位点。
T2S0606 Bakkenolide A
蜂斗菜内酯A
19906-72-0 98%
TargetMol Chemical Structure Bakkenolide A
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T10786 Charantin
化合物 T10786
57126-62-2 98%
TargetMol Chemical Structure Charantin
Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit G...
TN4637 Neogrifolin
化合物 TN4637
23665-96-5 98%
TargetMol Chemical Structure Neogrifolin
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS ...
TN2995 4,10-Aromadendranediol
化合物 TN2995
70051-38-6 98%
TargetMol Chemical Structure 4,10-Aromadendranediol
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN2775 2-Methoxystypandrone
化合物 TN2775
85122-21-0 98%
TargetMol Chemical Structure 2-Methoxystypandrone
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
TMA0291 Dehydroglyasperin D
化合物 TMA0291
517885-72-2 98%
TargetMol Chemical Structure Dehydroglyasperin D
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN4046 Excisanin A
化合物 TN4046
78536-37-5 98%
TargetMol Chemical Structure Excisanin A
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T35556 GSK-3β inhibitor 8
GSK-3β抑制剂8
1139875-74-3 98%
TargetMol Chemical Structure GSK-3β inhibitor 8
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII)是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。
T11960 MBM-55
化合物MBM-55
2083622-09-5 99.98%
TargetMol Chemical Structure MBM-55
MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂,IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
T1260 Cromolyn sodium
色甘酸钠
15826-37-6 99.95%
TargetMol Chemical Structure Cromolyn sodium
Cromolyn sodium (FPL-670) 是一种GSK-3β抑制剂,IC50为 2.0 µM,有抗过敏作用。
T1881 AR-A014418
化合物AR-A014418
487021-52-3 99.94%
TargetMol Chemical Structure AR-A014418
AR-A014418 (GSK 3β inhibitor VIII) 是选择性的,ATP 竞争性的 GSK3β抑制剂 ,其 IC50=104 nM,Ki=38 nM。
T6940 PHA-767491 hydrochloride
化合物PHA767491 HCl
942425-68-5 99.92%
TargetMol Chemical Structure PHA-767491 hydrochloride
PHA-767491 hydrochloride (CAY-10572 hydrochloride) 是一种Cdc7-Dbf4(DDK)/Cdk9的双重抑制剂,IC50值分别为 10 nM 和 34 nM。
T1965 Bikinin
化合物Bikinin
188011-69-0 99.91%
TargetMol Chemical Structure Bikinin
Bikinin (Abrasin) 是一种非甾体类的,ATP 竞争性的,植物性 GSK-3/Shaggy-like kinases 抑制剂,可激活 BR 信号通路。
T1917 GSK 3 Inhibitor IX
化合物6-BIO
667463-62-9 99.9%
TargetMol Chemical Structure GSK 3 Inhibitor IX
GSK 3 Inhibitor IX (6-BIO) 是一种选择性可逆的,ATP 竞争性的 GSK-3α/β和 CDK1-cyclinB 复合体抑制剂,能够抑制 (GSK-3α/β)/CDK1/CDK5 的活性,IC50值分别为 5 nM/320 nM/83 nM。
PIMPC
T79693
PIMPC为具抗氧化及金属螯合性能之化合物,新型糖原合成酶激酶3(GSK-3)抑制剂,潜在抗阿尔茨海默病作用。
C-Peptide 1 (rat)
T80124
C-Peptide 1 (rat) 为肽类化合物,作为β-catenin/GSK-3β激活剂,具有调节Wnt/β-catenin信号通路的功能,常用于癌症研究领域。
hAChE-IN-5
T82243
hAChE-IN-5(化合物49)是一种同时针对hAChE和hBuChE的有效抑制剂,其IC50值均为0.17 μM。此外,hAChE-IN-5对GSK3β同样展现出良好的抑制活性,IC50值为0.21 μM。作为tau蛋白聚集和Aβ1-42自聚集的抑制剂,hAChE-IN-5能够结合PAS,进而阻止Aβ依赖的神经毒性。...
Isoangustone A
TN4263
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
9-Hydroxycanthin-6-one
TN3319
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
5-Iodo-indirubin-3'-monoxime
T10172
5-Iodo-indirubin-3'-monoxime 是一种 GSK-3β、CDK5/P25和CDK1/cyclin B 抑制剂,IC50值分别为 9、20 和 25 nM,与 ATP 竞争性地结合酶的催化位点。
Bakkenolide A
T2S0606
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
Charantin
T10786
Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit G...
Neogrifolin
TN4637
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS ...
4,10-Aromadendranediol
TN2995
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
Dehydroglyasperin D
TMA0291
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
Excisanin A
TN4046
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
GSK-3β inhibitor 8
T35556
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII)是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。
MBM-55
T11960
MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂,IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
Cromolyn sodium
T1260
Cromolyn sodium (FPL-670) 是一种GSK-3β抑制剂,IC50为 2.0 µM,有抗过敏作用。
AR-A014418
T1881
AR-A014418 (GSK 3β inhibitor VIII) 是选择性的,ATP 竞争性的 GSK3β抑制剂 ,其 IC50=104 nM,Ki=38 nM。
PHA-767491 hydrochloride
T6940
PHA-767491 hydrochloride (CAY-10572 hydrochloride) 是一种Cdc7-Dbf4(DDK)/Cdk9的双重抑制剂,IC50值分别为 10 nM 和 34 nM。
Bikinin
T1965
Bikinin (Abrasin) 是一种非甾体类的,ATP 竞争性的,植物性 GSK-3/Shaggy-like kinases 抑制剂,可激活 BR 信号通路。
GSK 3 Inhibitor IX
T1917
GSK 3 Inhibitor IX (6-BIO) 是一种选择性可逆的,ATP 竞争性的 GSK-3α/β和 CDK1-cyclinB 复合体抑制剂,能够抑制 (GSK-3α/β)/CDK1/CDK5 的活性,IC50值分别为 5 nM/320 nM/83 nM。
1 2 3 4 5 6
TargetMol Loading
联系我们
400-820-0310

上海市静安区江场三路238号8楼