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GSK-3

GSK-3

Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over 100 different proteins in a variety of different pathways. In mammals GSK-3 is encoded by two paralogous genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B). GSK-3 has recently been the subject of much research because it has been implicated in a number of diseases, including Type II diabetes (diabetes mellitus type 2), Alzheimer's disease, inflammation, cancer, and bipolar disorder.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T22180 3F8
化合物3F8
159109-11-2 98%
3F8 是一种具有选择性的 GSK-3β抑制剂,可用作 GSK3 相关疾病的新工具和潜在治疗候选化合物,可用于研究神经系统疾病和癌症。
T35556 GSK-3β inhibitor 8
GSK-3β抑制剂8
1139875-74-3 98%
GSK-3β inhibitor 8是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。
T61360 ARN25068
化合物ARN25068
2649882-80-2 98%
ARN25068是三种蛋白激酶(GSK-3β、FYN和DYRK1A)的亚微摩尔抑制剂,可用于治疗tau相关神经系统疾病。
T72048 CDK8-IN-12
化合物CDK8-IN-12
2613307-67-6 98%
CDK8-IN-12 是一种具有选择性、有效性和口服活性的 CDK8 抑制剂(Ki : 14 nM),是一种抗癌剂。CDK8-IN-12 对 GSK-3α、GSK-3β、PCK-θ 具有抑制作用,Ki 分别为 13 nM、4 nM、109 nM。CDK8-IN-12对 MV4-11 细胞显示出抗增殖活性。
T15204 EHT 1610
化合物EHT 1610
1425945-60-3 98%
EHT 1610 是双特异性酪氨酸磷酸化调节酶 (DYRK) 的强效抑制剂,对 DYRK1A 和 DYRK1B 有抑制作用,的 IC50 分别为 0.36 nM 和 0.59 nM。EHT 1610 对白血病具有抑制效应,可调节细胞周期,诱导细胞凋亡。
T69188 Aloisine B
化合物Aloisine B
496864-14-3 98%
Aloisine B is a potent and selective CDK and GSK-3 inhibitor. Highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50 750.0 nM...
T11468 GSK-3 inhibitor 1
化合物 T11468
603272-51-1 98%
GSK-3 inhibitor 1 is a GSK-3 inhibitor.
TN4424 Lecanoric acid
化合物 TN4424
480-56-8 98%
Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased d...
TN4263 Isoangustone A
化合物 TN4263
129280-34-8 98%
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN3319 9-Hydroxycanthin-6-one
化合物 TN3319
138544-91-9 98%
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
T10172 5-Iodo-indirubin-3'-monoxime
5-碘靛红-3'-单肟
331467-03-9 98%
5-Iodo-indirubin-3'-monoxime 是一种 GSK-3β、CDK5/P25和CDK1/cyclin B 抑制剂,IC50值分别为 9、20 和 25 nM,与 ATP 竞争性地结合酶的催化位点。
T2S0606 Bakkenolide A
蜂斗菜内酯A
19906-72-0 98%
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T10786 Charantin
化合物 T10786
57126-62-2 98%
Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit G...
TN4637 Neogrifolin
化合物 TN4637
23665-96-5 98%
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS ...
T6139 A-674563
化合物A-674563
552325-73-2 98%
A674563 是一种口服有效,选择性的Akt1抑制剂,Ki=11 nM。
TN2995 4,10-Aromadendranediol
化合物 TN2995
70051-38-6 98%
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN2775 2-Methoxystypandrone
化合物 TN2775
85122-21-0 98%
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
TMA0291 Dehydroglyasperin D
化合物 TMA0291
517885-72-2 98%
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN4046 Excisanin A
化合物 TN4046
78536-37-5 98%
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T11960 MBM-55
化合物MBM-55
2083622-09-5 98%
MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂,IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
3F8
T22180
3F8 是一种具有选择性的 GSK-3β抑制剂,可用作 GSK3 相关疾病的新工具和潜在治疗候选化合物,可用于研究神经系统疾病和癌症。
GSK-3β inhibitor 8
T35556
GSK-3β inhibitor 8是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。
ARN25068
T61360
ARN25068是三种蛋白激酶(GSK-3β、FYN和DYRK1A)的亚微摩尔抑制剂,可用于治疗tau相关神经系统疾病。
CDK8-IN-12
T72048
CDK8-IN-12 是一种具有选择性、有效性和口服活性的 CDK8 抑制剂(Ki : 14 nM),是一种抗癌剂。CDK8-IN-12 对 GSK-3α、GSK-3β、PCK-θ 具有抑制作用,Ki 分别为 13 nM、4 nM、109 nM。CDK8-IN-12对 MV4-11 细胞显示出抗增殖活性。
EHT 1610
T15204
EHT 1610 是双特异性酪氨酸磷酸化调节酶 (DYRK) 的强效抑制剂,对 DYRK1A 和 DYRK1B 有抑制作用,的 IC50 分别为 0.36 nM 和 0.59 nM。EHT 1610 对白血病具有抑制效应,可调节细胞周期,诱导细胞凋亡。
Aloisine B
T69188
Aloisine B is a potent and selective CDK and GSK-3 inhibitor. Highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50 750.0 nM...
GSK-3 inhibitor 1
T11468
GSK-3 inhibitor 1 is a GSK-3 inhibitor.
Lecanoric acid
TN4424
Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased d...
Isoangustone A
TN4263
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
9-Hydroxycanthin-6-one
TN3319
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
5-Iodo-indirubin-3'-monoxime
T10172
5-Iodo-indirubin-3'-monoxime 是一种 GSK-3β、CDK5/P25和CDK1/cyclin B 抑制剂,IC50值分别为 9、20 和 25 nM,与 ATP 竞争性地结合酶的催化位点。
Bakkenolide A
T2S0606
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
Charantin
T10786
Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit G...
Neogrifolin
TN4637
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS ...
A-674563
T6139
A674563 是一种口服有效,选择性的Akt1抑制剂,Ki=11 nM。
4,10-Aromadendranediol
TN2995
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
Dehydroglyasperin D
TMA0291
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
Excisanin A
TN4046
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
MBM-55
T11960
MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂,IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
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