ly5

LY5 is an inhibitor of STAT3 that acts by inhibiting cell viability, cell migration, and angiogenesis in medulloblastoma cells.

LY518674 (LY-674) 是一种高效、选择性的 PPARα 激动剂，对人 PPARα 作用的 EC50 值为 42 nM。LY518674 能降低甘油三酸酯，增加 HDL-C，可用于研究动脉粥样硬化。

LY550410是一种I型TGF-β受体激酶(type ITGF-β receptor kinase)的小分子ATP竞争性抑制剂，含有异芳香环结构，可有效结合至激酶的活性位点。该化合物通过调节TGF-β信号通路来影响基因表达，进而促进细胞生长，有望在癌症研究中发挥作用。

Gly5-Ahx-DM1 是一种转肽酶反应型 Drug-linker,具有创新型高度稳定可降解连接子，DM1 是一种微管蛋白抑制剂，可用于抗体-药物偶联物（ADC）的合成。

LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.

LY503430 is a AMPA receptor potentiator with oral activity. LY503430 has both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP.

LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.

PNU-EDA-Gly5 is a DNA topoisomerase I inhibitor-based oligo-glycine linker-payload used for the synthesis of antibody-drug conjugates (ADCs). It consists of the DNA topoisomerase I inhibitor PNU-159682 and the linker EDA-Gly5.

LY 517717 是一种具有口服活性的凝血因子 Xa 抑制剂，具有抗血栓活性，可用于研究静脉血栓栓塞（VTE）。

Erteberel (LY500307) 是一种选择性的雌激素受体 β(ERβ) 激动剂，其Ki=1.54 nM，EC50=3.61 nM。具有抗肿瘤作用。

Sivelestat (ONO5046) 是一种选择性的中性粒细胞弹性蛋白酶抑制剂，其 IC50值为 44 nM，Ki 值为 200 nM。它有潜力研究 COVID-19 的急性肺损伤、急性呼吸窘迫综合征或弥散性血管内凝血。

Fenoprofen (LILLY-5385) 是一种非甾体抗炎化合物，也是黑皮质素受体的变构增强剂，增加 ERK1/2 的激活，抑制生物膜的形成，改变生物膜结构，可用于治疗急性疼痛和慢性关节炎。

LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells.

Sivelestat sodium (EI 546 sodium) 是一种高效性的人类中性粒细胞弹性蛋白酶的抑制剂， 通过激活 PI3K/AKT/mTOR 信号通路改善脓毒症诱导的心肌功能障碍，可用于研究急性肺损伤/急性呼吸窘迫综合征。

Aranotin 是一种从金黄色蜘蛛中分离的真菌毒素，具有对抗脊髓灰质炎病毒、柯萨奇病毒、犀牛和副流感病毒等 RNA 病毒的活性。Aranotin 通过阻碍 RNA 依赖性RNA 聚合酶的活性来抑制病毒RNA 的合成。

Lilly 51641 is used as a MAO inhibitor.

LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor.

LY 56110 is a novel nonsteroidal aromatase inhibitor.

LY-510929, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of hyperlipidaemia, metabolic disorders and type 2 diabetes.

LY 54761 is a bio-active chemical.

LY-53857 free base is a bioactive chemical.

Naveglitazar (LY 519818, LY 9818) is a peroxisome proliferator-activated receptor (PPAR) modulator, which has entered phase II clinical trials for the treatment of type 2 diabetes.

Tasisulam is an anti-cancer compound that induces apoptosis through the intrinsic pathway, leading to the release of cytochrome c and caspase-dependent cell death. Additionally, tasisulam inhibits mitotic progression and triggers vascular normalization.

Telaprevir (Incivek) 是一种选择性可逆的HCV NS3-4A 蛋白酶抑制剂，作用于基因 1型 (H 株) NS3 蛋白酶结构域和 NS4A 辅因子肽，Ki 为 7 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。