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Search Results for " cmk "

Targets Recommended: Others

23

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10845	CMK	Others	Others
	CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.
T36347	Ac-YVAD-CMK Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK	IL Receptor; Caspase; Immunology/Inflammation related; Pyroptosis	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) 是一种选择性的、不可逆的Caspase-1抑制剂，并能抑制焦亡作用、IL-1β和IL-18。Ac-YVAD-CMK 显示出神经保护和抗炎的能力。
T36819	Ac-FLTD-CMK	Caspase	Apoptosis; Proteases/Proteasome
	Ac-FLTD-CMK 是由消皮素 D (GSDMDD) 衍生的抑制剂，具有对炎症性 caspases 特异性的抑制作用。Ac-FLTD-CMK 对 Ac-FLTD-CMK 对 caspases-1、caspases-4和 caspases-11有抑制作用，IC50分别为为 46.7 nM、 1.49 μM 和 329 nM。 Ac-FLTD-CMK 对 caspases-1、caspases-4、 caspases-11均表现出有效性，但对凋亡相关的 caspase-3 无效。
T39526	Decanoyl-RVKR-CMK TFA DecRVKRcmk TFA,Decanoyl-RVKR-CMK TFA
	Decanoyl-RVKR-CMK (DecRVKRcmk) TFA effectively hinders the processing of over-expressed gp160 and suppresses HIV-1 replication.
T80745	Z-Ala-Ala-Asp-CMK Z-AAD-CMK	Caspase	Apoptosis; Proteases/Proteasome
	Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) 是选择性granzyme B 抑制剂。
T76251L	Ac-FEID-CMK TFA	Pyroptosis	Apoptosis; Immunology/Inflammation
	Ac-FEID-CMK TFA 是一种选择性斑马鱼 GSDMEb 衍生肽抑制剂，可减少感染性休克的死亡率和肾损伤。Ac-FEID-CMK TFA 在体内可抑制焦亡，缓解败血性 AKI (急性肾损伤)，抑制 caspy2 介导的非典型炎症小体通路发挥作用。
T36338	AAF-CMK (trifluoroacetate salt)
	Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 μM.
TP2038	Decanoyl-RVKR-CMK
	Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in
T72281	Caspase-9 Inhibitor III Ac-LEHD-cmk
	Caspase-9 Inhibitor III (Ac-LEHD-cmk) 是一种 caspase-9抑制剂。Caspase-9 Inhibitor III 对局部缺血-重新灌注诱导的心肌损伤表现出保护作用。
T72111	Ala-Ala-Pro-Val-chloromethylketone AAPV-CMK
	Ala-Ala-Pro-Val-chloromethylketone 是不可逆的 NE 抑制剂，适用于慢性炎症性气道疾病研究。
T73412	AAF-CMK
	AAF-CMK为一种TPPII（tripeptidylpeptidase II）抑制剂，具备抗肿瘤活性与诱导细胞凋亡能力，适用于白血病研究。
T78633	MeOSuc-AAPV-CMK Elastase Inhibitor III
	MeOSuc-AAPV-CMK (Elastase Inhibitor III) 为一种特定抗体，不仅抑制白细胞弹性蛋白酶，也能够抑制组织蛋白酶 G 及蛋白酶 3。此外，MeOSuc-AAPV-CMK 可有效阻断白细胞弹性蛋白酶对脂联素进行裂解的作用。
T80553	MeOSuc-AAPA-CMK
	MeOSuc-AAPA-CMK为一种针对人中性粒细胞弹性蛋白酶 (elastase) 的高效抑制剂。
T81822	MeOSuc-AAPF-CMK MeOSuc-Ala-Ala-Pro-Phe-CH₂Cl
	MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH2Cl) 是蛋白酶 K 抑制剂，具有较高效能。
T80659	Z-YVAD-CMK	Caspase	Apoptosis; Proteases/Proteasome
	Z-YVAD-CMK为一种针对caspase-1及caspase-3的抑制剂。
T76251	Ac-FEID-CMK
	Ac-FEID-CMK 是一种有效的斑马鱼特异性GSDMEb 衍生肽抑制剂。Ac-FEID-CMK 可减轻感染性休克的死亡率和肾损伤。Ac-FEID-CMK 在体内可抑制焦亡，减轻败血性 AKI (急性肾损伤)。Ac-FEID-CMK 可抑制 caspy2 介导的非典型炎症小体通路。
T82592	DEC-RVRK-CMK Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
	DEC-RVRK-CMK为一种小型合成抗病毒化合物，具不可逆性及细胞渗透性，作为竞争性弗林蛋白酶抑制剂，该化合物对寨卡病毒(ZIKV)和日本脑炎病毒(JEV)显示出显著的抗病毒活性。
T80660	Z-DEVD-CMK
	Z-DEVD-CMK为众多组织蛋白酶(cathepsins)的不可逆抑制剂，其作用主要在体外环境中。
T80743	Z-APF-CMK
	Z-APF-CMK为特异性CRNSP (Ca2+-调节的核支架蛋白酶) 抑制剂。
T80101	Z-GGF-CMK	Proteasome	Proteases/Proteasome; Ubiquitination
	Z-GGF-CMK为一种针对ClpP1P2及蛋白酶体的蛋白酶抑制剂，其在HepG2细胞上展现出细胞毒性，具有125 μM的CC50值。
T75706	Ac-DEVD-CMK TFA
	Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA 是一种选择性且不可逆的caspase-3抑制剂。Ac-DEVD-CMK TFA 显着抑制由高水平葡萄糖或 3,20-dibenzoate (IDB) 诱导的凋亡。Ac-DEVD-CMK TFA 可以用于多种实验方法以抑制细胞凋亡。
T82703	CMKLR1 antagonist 1
	CMKLR1 antagonist 1 (compound S-26d) 为口服型趋化因子样受体 1 (CMKLR1) 拮抗剂，其在hCMKLR1感染的CHO细胞中表现出pIC50值达7.44。该化合物适用于银屑病和代谢性疾病的研究。
TQ0061	CHZ868	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	CHZ868 是II型 JAK 抑制剂，具有潜在的抗肿瘤活性，可逆转 I 型 JAK 抑制剂的持续存在，可用于研究白血病。

化合物

Cat.No: T10845

Target: Others

Cat.No: T36347

Synonym: Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK

Target: IL Receptor, Caspase, Immunology/Inflammation related, Pyroptosis

Cat.No: T36819

Target: Caspase

Decanoyl-RVKR-CMK TFA

Cat.No: T39526

Synonym: DecRVKRcmk TFA,Decanoyl-RVKR-CMK TFA

Z-Ala-Ala-Asp-CMK

Cat.No: T80745

Synonym: Z-AAD-CMK

Target: Caspase

Ac-FEID-CMK TFA

Cat.No: T76251L

Target: Pyroptosis

AAF-CMK (trifluoroacetate salt)

Cat.No: T36338

Decanoyl-RVKR-CMK

Cat.No: TP2038

Caspase-9 Inhibitor III

Cat.No: T72281

Synonym: Ac-LEHD-cmk

Ala-Ala-Pro-Val-chloromethylketone

Cat.No: T72111

Synonym: AAPV-CMK

Cat.No: T73412

MeOSuc-AAPV-CMK

Cat.No: T78633

Synonym: Elastase Inhibitor III

MeOSuc-AAPA-CMK

Cat.No: T80553

MeOSuc-AAPF-CMK

Cat.No: T81822

Synonym: MeOSuc-Ala-Ala-Pro-Phe-CH₂Cl

Cat.No: T80659

Target: Caspase

Cat.No: T76251

Cat.No: T82592

Synonym: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone

Cat.No: T80660

Cat.No: T80743

Cat.No: T80101

Target: Proteasome

Ac-DEVD-CMK TFA

Cat.No: T75706

CMKLR1 antagonist 1

Cat.No: T82703

Cat.No: TQ0061

Target: JAK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02234	CXCL9 Protein, Human, Recombinant MIG,CMK,Humig,chemokine (C-X-C motif) ligand 9,SCYB...	Human	E. coli
	CXCL9 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.9 kDa and the accession number is Q07325.
TMPY-02203	CXCL9 Protein, Mouse, Recombinant BB139920,Scyb9,MuMIG,crg-10,CMK,chemokine (C-X-C mo...	Mouse	E. coli
	CXCL9 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.3 kDa and the accession number is P18340.
TMPY-04480	UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His) CMPK,UMPK,UMK,CK,UMP-CMPK,CMK,cytidine monophosphat...	Human	Baculovirus Insect Cells
	CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid bi...
TMPH-00603	Cytidylate kinase Protein, E. coli, Recombinant (His & SUMO) Cytidine monophosphate kinase,CMP kinase,ycaF,Cytidylate kin...	E. coli	E. coli
	ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors.
TMPJ-01084	CXCL9 Protein, Human, Recombinant (His) Monokine Induced by Interferon-γ,Gamma-Interferon-Induced Mo...	Human	HEK293 Cells
	Chemokine (C-X-C Motif) Ligand 9 (CXCL9) belongs to the intercrine alpha (chemokine CXC) family. It is secreted by interferon stimulated monocytes, macrophages and endothelial cells, which elicits chemotactic functions by interacting with the chemokine receptor CXCR3. CXCL9 acts as a Th1 (type 1 helper T) cell chemoattractant and plays a role in the growth, activation and movement of cells associated with immune and inflammatory responses, and in tumour growth inhibition. It is closely related t...
TMPH-03265	CMKLR2 Protein, Rat, Recombinant (His) Chemerin chemokine-like receptor 2,Gpr1,Chemokine-like recep...	Rat	E. coli
	Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway.
TMPH-01082	CMKLR1 Protein, Human, Recombinant (His) CMKLR1,G-protein coupled receptor ChemR23,G-protein...	Human	E. coli
	CMKLR1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 45.1 kDa and the accession number is Q99788.

重组蛋白

CXCL9 Protein, Human, Recombinant

Cat.No: TMPY-02234

Species: Human

Expression System: E. coli

CXCL9 Protein, Mouse, Recombinant

Cat.No: TMPY-02203

Species: Mouse

Expression System: E. coli

UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04480

Species: Human

Expression System: Baculovirus Insect Cells

Cytidylate kinase Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00603

Species: E. coli

Expression System: E. coli

CXCL9 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01084

Species: Human

Expression System: HEK293 Cells

CMKLR2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03265

Species: Rat

Expression System: E. coli

CMKLR1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01082

Species: Human

Expression System: E. coli

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