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Anti-CCR5 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 CCR5。Anti-CCR5 Polyclonal Antibody 可用于 WB。
Anti-CCR5 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 CCR5。Anti-CCR5 Polyclonal Antibody 可用于 WB。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,160 | 5日内发货 | |
100 μL | ¥ 1,965 | 5日内发货 | |
200 μL | ¥ 2,780 | 5日内发货 |
产品描述 | Anti-CCR5 Polyclonal Antibody is a Rabbit antibody targeting CCR5. Anti-CCR5 Polyclonal Antibody can be used in WB. |
别名 | IDDM22, CMKBR5, CKR-5, CKR5, CD195, CCR-5, CC-CKR-5, CCCKR5 |
Ig Type | IgG |
交叉反应 | Human |
验证活性 | Sample: Lane 1: Human THP-1 cell lysates Lane 2: Human U937 cell lysates Primary: Anti-CCR-5 (TMAB-00325) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 43 kDa |
应用 | |
推荐剂量 | WB: 1:500-2000 |
抗体种类 | Polyclonal |
宿主来源 | Rabbit |
亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
组织特异性 | Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. |
构建方式 | Polyclonal Antibody |
纯化方式 | Protein A purified |
性状 | Liquid |
缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
浓度 | 1 mg/mL |
研究背景 | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. |
免疫原 | KLH conjugated synthetic peptide: human CCR-5 |
抗原种属 | Human |
基因名称 | CCR5 |
基因ID | |
蛋白名称 | C-C chemokine receptor type 5 |
Uniprot ID | |
研究领域 | GPCR,Chemokines,HIV-related,Beta Chemokine Rec. (CCR),Macrophage / Inflamm.,Host Virus Interaction,Alzheimer's disease,GPCR |
功能 | Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. |
分子量 | Theoretical: 40 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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