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Anti-CCR2/CD192 Antibody (3O968)
还可以产品编号 TMAY-00161
Anti-CCR2/CD192 Antibody (3O968) 是一种 Mouse 抗体，靶向 CCR2/CD192。Anti-CCR2/CD192 Antibody (3O968) 可用于 FCM。
Anti-CCR2/CD192 Antibody (3O968)
Anti-CCR2/CD192 Antibody (3O968)
还可以产品编号 TMAY-00161
Anti-CCR2/CD192 Antibody (3O968) 是一种 Mouse 抗体，靶向 CCR2/CD192。Anti-CCR2/CD192 Antibody (3O968) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-CCR2/CD192 Antibody (3O968) is a Mouse antibody targeting CCR2/CD192. Anti-CCR2/CD192 Antibody (3O968) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 3O968 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD192 expression on human whole blood monocytes. Cells were stained with purified anti-Human CD192, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the center region of the Human CCR2/CD192. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The C-C motif chemokine receptor-2 (CCR2) is a G protein-coupled receptor (GPCR), made up of a carboxy-terminus, extracellular amino terminus, and a hydrophobic transmembrane domain consisting of 7 amino acid segments that mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. CCR2 is expressed on monocytes, immature dendritic cells, and T-cell subpopulations, and mediates their migration towards endogenous CCL2. CCR2 is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis. In mice, CCR2 deficiency reduced macrophage content, increased adiponectin expression, ameliorated hepatic steatosis, and improved systemic glucose homeostasis and insulin sensitivity. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. Furthermore, CCR2 mRNA was highly expressed in prostate cancer (PCa) metastatic tissues compared with benign prostate tissues according to real-time RT-PCR3, suggesting that CCR2 may contribute to PCa development. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | A synthetic peptide corresponding to the center region of the Human CCR2/CD192 |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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