Anti-CCR6 Antibody (1O55)

Name: Anti-CCR6 Antibody (1O55)
Brand: TargetMol
SKU: TMAH-00158
Rating: 4.5 (1 reviews)

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产品编号 TMAH-00158

别名 STRL22, GPR-CY4, GPRCY4, GPR29, DRY-6, DRY6, DCR2, CMKBR6, CKR-L3, CKRL3, CD196, CCR-6, CC-CKR-6, C-C CKR-6, BN-1

Anti-CCR6 Antibody (1O55) 是一种抗体，靶向 CCR6。Anti-CCR6 Antibody (1O55) 可用于 ELISA。

Anti-CCR6 Antibody (1O55)

还可以

产品编号 TMAH-00158 别名 STRL22, GPR-CY4, GPRCY4, GPR29, DRY-6, DRY6, DCR2, CMKBR6, CKR-L3, CKRL3, CD196, CCR-6, CC-CKR-6, C-C CKR-6, BN-1

Anti-CCR6 Antibody (1O55) 是一种抗体，靶向 CCR6。Anti-CCR6 Antibody (1O55) 可用于 ELISA。

规格	价格	库存	数量
50 μL	¥ 1,310	5日内发货
100 μL	¥ 2,195	5日内发货

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产品描述	Anti-CCR6 Antibody (1O55) is an antibody targeting CCR6. Anti-CCR6 Antibody (1O55) can be used in ELISA.
别名	STRL22, GPR-CY4, GPRCY4, GPR29, DRY-6, DRY6, DCR2, CMKBR6, CKR-L3, CKRL3, CD196, CCR-6, CC-CKR-6, C-C CKR-6, BN-1
Ig Type	Human IgG1
克隆号	1O55
交叉反应	Human
验证活性	The Binding Activity of Human CCR6 with Anti-CCR6 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR6 at 10 μg/mL can bind Anti-CCR6 recombinant antibody. The EC50 is 44.79-56.10 ng/mL. The VLPs is negative control.
应用	ELISA
抗体种类	Monoclonal
亚细胞定位	Cell membrane; Multi-pass membrane protein. Cell surface.
构建方式	Recombinant Antibody
纯化方式	Affinity-chromatography
性状	Liquid
缓冲液	Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景	Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma. CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells. Positively regulates sperm motility and chemotaxis via its binding to CCL20.