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Anti-CXCR3 Polyclonal Antibody
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产品编号 TMAB-00508
别名 Mig-R, MigR, IP10-R, GPR9, CMKAR3, CKR-L2, CD183, CD182
Anti-CXCR3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CXCR3。Anti-CXCR3 Polyclonal Antibody 可用于 WB。
Anti-CXCR3 Polyclonal Antibody
Anti-CXCR3 Polyclonal Antibody
还可以产品编号 TMAB-00508 别名 Mig-R, MigR, IP10-R, GPR9, CMKAR3, CKR-L2, CD183, CD182
Anti-CXCR3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CXCR3。Anti-CXCR3 Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,960 | 5日内发货 | |
| 200 μL | ¥ 2,780 | 5日内发货 |
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产品介绍
生物活性
抗原信息
化学信息
| 产品描述 | Anti-CXCR3 Polyclonal Antibody is a Rabbit antibody targeting CXCR3. Anti-CXCR3 Polyclonal Antibody can be used in WB. |
| 疾病造模方案 | |
| 别名 | Mig-R, MigR, IP10-R, GPR9, CMKAR3, CKR-L2, CD183, CD182 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Rabbit,GuineaPig) |
| 验证活性 | Sample: Lane 1: Mouse Blood cell tissue lysates Lane 2: Rat Blood cell tissue lysates Primary: Anti-CXCR3 (TMAB-00508) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 40 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]. |
| 免疫原 | KLH conjugated synthetic peptide: human CXCR3 |
| 抗原种属 | Human |
| 基因名称 | CXCR3 |
| 基因ID | |
| 蛋白名称 | C-X-C chemokine receptor type 3 |
| Uniprot ID | |
| 研究领域 | Chemokines,Alpha Chemokine Rec. (CXCR),Calcium Signaling,GPCR |
| 功能 | Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3 mediates the activity of CXCL11. |
| 分子量 | Theoretical: 41 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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