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Anti-CCR1/CD191 Polyclonal Antibody

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产品编号 TMAB-00321

别名 SCYAR1, MIP1aR, HM145, CMKR1, CMKBR1, CKR-1, CKR1, CD191, CCR-1

Anti-CCR1/CD191 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CCR1/CD191。Anti-CCR1/CD191 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

Anti-CCR1/CD191 Polyclonal Antibody

Anti-CCR1/CD191 Polyclonal Antibody

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产品编号 TMAB-00321 别名 SCYAR1, MIP1aR, HM145, CMKR1, CMKBR1, CKR-1, CKR1, CD191, CCR-1

Anti-CCR1/CD191 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CCR1/CD191。Anti-CCR1/CD191 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-CCR1/CD191 Polyclonal Antibody is a Rabbit antibody targeting CCR1/CD191. Anti-CCR1/CD191 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
别名SCYAR1, MIP1aR, HM145, CMKR1, CMKBR1, CKR-1, CKR1, CD191, CCR-1
Ig Type
IgG
交叉反应
Human (predicted:Mouse,Rat)
验证活性
Tissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min;
Incubation: Anti-CCR1 Polyclonal Antibody, Unconjugated (TMAB-00321) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining.
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Multi-pass membrane protein.
组织特异性Widely expressed in different hematopoietic cells.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human CCR-1
抗原种属
Human
基因名称
CCR1
基因ID
1230
蛋白名称
C-C chemokine receptor type 1
Uniprot ID
P32246
研究领域
Beta Chemokine Rec. (CCR),SARS Coronavirus
功能
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
化学信息
分子量Theoretical: 40 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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