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CCR4 Protein-VLP, Human, Recombinant (His)

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货号 TMPH-01065

别名 K5-5, CMKBR4, CD194, CCR-4, CCR4, CC-CKR-4, C-C CKR-4, C-C chemokine receptor type 4

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 43.2 kDa and the accession number is P51679.

CCR4 Protein-VLP, Human, Recombinant (His)
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CCR4 Protein-VLP, Human, Recombinant (His)

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货号 TMPH-01065 别名 K5-5, CMKBR4, CD194, CCR-4, CCR4, CC-CKR-4, C-C CKR-4, C-C chemokine receptor type 4

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 43.2 kDa and the accession number is P51679.

规格价格库存数量
5 μg
¥ 1,730
20日内发货
10 μg
¥ 2,920
20日内发货
20 μg
¥ 4,930
20日内发货
50 μg
¥ 7,930
20日内发货
100 μg
¥ 11,800
20日内发货
200 μg
¥ 19,900
20日内发货
500 μg
¥ 39,800
20日内发货
1 mg
¥ 67,300
20日内发货
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产品介绍

生物活性
产品描述
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 43.2 kDa and the accession number is P51679.
生物活性
Measured by its binding ability in a functional ELISA. Immobilized Human CCR4 at 10 μg/mL can bind Anti-CCR4 recombinant antibody, the EC 50 is 362.3-630.8 ng/mL.
研究背景
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
种属
Human
表达系统
HEK293 Cells
标签C-10xHis (This tag can be tested only under denaturing conditions)
蛋白编号P51679
氨基酸序列MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
蛋白构建1-360 aa
缓冲液PBS, pH 7.4, 6% trehalose
复溶方法A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名K5-5, CMKBR4, CD194, CCR-4, CCR4, CC-CKR-4, C-C CKR-4, C-C chemokine receptor type 4
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量43.2 kDa (predicted)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

计算器

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剂量转换

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技术支持

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关键词

K55CMKBR 4CD 194CCR 4CC-CKR4C-C CKR4
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