AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Cat. No.	Product Name	CAS No.	Purity
T20232	Kazinol B 小构树醇B	99624-27-8	98%
T20232	Kazinol B 是一氧化氮（NO）产生的抑制剂，是一种具有二甲基吡喃环的异戊烯化黄烷。Kazinol B 通过激活胰岛素-Akt 信号途径和AMPK，增强葡萄糖摄取，从而改善胰岛素敏感性。Kazinol B 刺激脂肪素的基因表达和分泌，可用于研究糖尿病。
TN3042	4-Hydroxycinnamamide 化合物 TN3042	194940-15-3	98%
TN3042	4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN5013	Shizukaol D 化合物 TN5013	142279-42-3	98%
TN5013	Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be...
T10105	3α-Hydroxymogrol 3α-羟基罗汉果醇	1343402-73-2	98%
T10105	3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.
T11570	HL271 化合物 T11570	1422365-52-3	98%
T11570	HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
T22460	XMD-17-51 化合物XMD-17-51	1628614-50-5	98%
T22460	XMD-17-51 是一种有效且高度选择性的 NUAK1 抑制剂。
TN4382	Kazinol A 化合物 TN4382	99624-28-9	98%
TN4382	Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
T10312	Ampkinone 化合物 T10312	1233082-79-5	98%
T10312	Ampkinone is an indirect AMPK activator.
TL0014	Pinusolide 化合物 TL0014	31685-80-0	98%
TL0014	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T14149	AICAR phosphate 化合物 T14149	681006-28-0	98%
T14149	AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proinf...
TN1868	Ligupurpuroside A 紫茎女贞苷 A	147396-01-8	98%
TN1868	Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
T1456	Doxorubicin（Doxorubicin hydrochloride is in stock）阿霉素	23214-92-8	98%
T1456	Doxorubicin 是一种有细胞毒性的蒽环类抗生素，具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II，IC50分别为0.8 μM 和2.67 μM，从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬。
T16113	ML753286 化合物 T16113	1699720-89-2	98%
T16113	ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
TN1870	Ligupurpuroside C 紫茎女贞苷 C	1194056-33-1	98%
TN1870	Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
T16166	N-[(4-Aminophenyl)methyl]adenosine N-[(4-氨基苯基)甲基]腺苷	95523-13-0	98%
T16166	N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase).
TN1670	Ganodermanondiol 灵芝酮二醇	107900-76-5	98%
TN1670	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
TN5431	Icariside E4 化合物Icariside E4	126253-42-7	98%
TN5431	Icariside E4是一种从小叶榆中提取得到天然化合物，通过AMPK 磷酸化和抑制HepG1细胞中MID1IP2的低脂化作用。Icariside E4具有抗伤害，抗氧化，抗阿尔茨海默氏症和抗炎作用，抑制了SREBP-1c，肝脏X 受体-α（LXR）和FASN 在HepG2细胞中从头脂肪生成的表达。Icarisi...
T13371	YM-53601 free base 化合物 T13371	182959-28-0	98%
T13371	YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
T3881	Vaccarin 王不留行黄酮苷	53452-16-7	98%
T3881	Vaccarin 是从王不留行中提取的一种黄酮糖苷，可显著促进伤口愈合以及伤口部位的内皮和成纤维细胞增殖。它通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。
T5552	Methyl cinnamate 肉桂酸甲酯	103-26-4	98%
T5552	Methyl cinnamate 是花椒的有效成分，也是一种天然香料。它是一种防止食品褐变的酪氨酸酶抑制剂，具有抗菌活性。它通过由 CaMKK2-AMPK 信号途径介导的机制具有抗脂活性。