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AMPK

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
TargetMol
1 2 3 4 5 6
Cat. No. Product Name CAS No. Purity Chemical Structure
T60675 AMPK activator 2
AMPK激活剂2
2410961-69-0 99.86%
TargetMol Chemical Structure AMPK activator 2
AMPK activator 2 是一种含氟氯胍衍生物,具有潜在的抗癌活性,可上调 AMPK 信号通路并下调 mTOR/4EBP1/p70S6K,对人类癌细胞系 (UMUC3、T24、A549) 的增殖和迁移有抑制作用。
T20232 Kazinol B
小构树醇B
99624-27-8 98%
TargetMol Chemical Structure Kazinol B
Kazinol B 是一氧化氮(NO)产生的抑制剂,是一种具有二甲基吡喃环的异戊烯化黄烷。Kazinol B 通过激活胰岛素-Akt 信号途径和AMPK,增强葡萄糖摄取,从而改善胰岛素敏感性。Kazinol B 刺激脂肪素的基因表达和分泌,可用于研究糖尿病。
TN3042 4-Hydroxycinnamamide
化合物 TN3042
194940-15-3 98%
TargetMol Chemical Structure 4-Hydroxycinnamamide
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
T79232 MARK4 inhibitor 2
化合物 MARK4 inhibitor 2
98%
TargetMol Chemical Structure MARK4 inhibitor 2
MARK4 inhibitor 2作为MARK4的高效抑制剂,展现出对微管亲和调节激酶 4 (MARK4) 的Km值为6.3×10^7,及IC50为0.82 μM的特异性。它能够抑制癌细胞生长,适用于癌症的科学研究。
T82165 HTH-02-006
化合物 HTH-02-006
98%
TargetMol Chemical Structure HTH-02-006
HTH-02-006,一种NUAK2抑制剂(IC50 = 126 nM),能够降低HuCCT-1细胞中磷酸化MYPT1水平,并抑制YAP驱动的细胞增殖、肝肿大和肿瘤发生,同时具备抗纤维化保护效果。
T83125 AMPK-α1β1γ1 activator 1
化合物 AMPK-α1β1γ1 activator 1
1943510-86-8 98%
TargetMol Chemical Structure AMPK-α1β1γ1 activator 1
AMPK-α1β1γ1激活剂1 (M1) 是一个衍生于Indole-3-carcinoma的酰基葡萄糖醛酸代谢AMPK激活剂,专一性地针对人类β1亚型,表现出38.1nM的EC50值。该化合物能够直接结合至人AMPK α1β1γ1亚型,适用于糖尿病肾病的相关研究。
T83127 AMPK activator 13
化合物 AMPK activator 13
98%
TargetMol Chemical Structure AMPK activator 13
AMPK activator13作为AMPK激活剂,通过激活AMPK通路有效抑制3T3-L1细胞的有丝分裂克隆扩增,并增加细胞线粒体耗氧量,适用于肥胖研究。
TN5013 Shizukaol D
化合物 TN5013
142279-42-3 98%
TargetMol Chemical Structure Shizukaol D
Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be...
T10105 3α-Hydroxymogrol
3α-羟基罗汉果醇
1343402-73-2 98%
TargetMol Chemical Structure 3α-Hydroxymogrol
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.
T11570 HL271
化合物 T11570
1422365-52-3 98%
TargetMol Chemical Structure HL271
HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
T22460 XMD-17-51
化合物XMD-17-51
1628614-50-5 98%
TargetMol Chemical Structure XMD-17-51
XMD-17-51 是一种有效且高度选择性的 NUAK1 抑制剂。
TN4382 Kazinol A
化合物 TN4382
99624-28-9 98%
TargetMol Chemical Structure Kazinol A
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
T10312 Ampkinone
化合物 T10312
1233082-79-5 98%
TargetMol Chemical Structure Ampkinone
Ampkinone is an indirect AMPK activator.
TL0014 Pinusolide
化合物 TL0014
31685-80-0 98%
TargetMol Chemical Structure Pinusolide
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
TN1868 Ligupurpuroside A
紫茎女贞苷 A
147396-01-8 98%
TargetMol Chemical Structure Ligupurpuroside A
Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
T1456 Doxorubicin
阿霉素
23214-92-8 98%
TargetMol Chemical Structure Doxorubicin
Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素,具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II,IC50分别为0.8 μM 和2.67 μM,从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬 。
T16113 ML753286
化合物 T16113
1699720-89-2 98%
TargetMol Chemical Structure ML753286
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
TN1870 Ligupurpuroside C
紫茎女贞苷 C
1194056-33-1 98%
TargetMol Chemical Structure Ligupurpuroside C
Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
TN1670 Ganodermanondiol
灵芝酮二醇
107900-76-5 98%
TargetMol Chemical Structure Ganodermanondiol
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
TN5431 Icariside E4
化合物Icariside E4
126253-42-7 98%
TargetMol Chemical Structure Icariside E4
Icariside E4是一种从小叶榆中提取得到天然化合物, 通过AMPK 磷酸化和抑制HepG1细胞中MID1IP2的低脂化作用。Icariside E4具有抗伤害,抗氧化,抗阿尔茨海默氏症和抗炎作用,抑制了SREBP-1c,肝脏X 受体-α(LXR)和FASN 在HepG2细胞中从头脂肪生成的表达。Icarisi...
AMPK activator 2
T60675
AMPK activator 2 是一种含氟氯胍衍生物,具有潜在的抗癌活性,可上调 AMPK 信号通路并下调 mTOR/4EBP1/p70S6K,对人类癌细胞系 (UMUC3、T24、A549) 的增殖和迁移有抑制作用。
Kazinol B
T20232
Kazinol B 是一氧化氮(NO)产生的抑制剂,是一种具有二甲基吡喃环的异戊烯化黄烷。Kazinol B 通过激活胰岛素-Akt 信号途径和AMPK,增强葡萄糖摄取,从而改善胰岛素敏感性。Kazinol B 刺激脂肪素的基因表达和分泌,可用于研究糖尿病。
4-Hydroxycinnamamide
TN3042
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
MARK4 inhibitor 2
T79232
MARK4 inhibitor 2作为MARK4的高效抑制剂,展现出对微管亲和调节激酶 4 (MARK4) 的Km值为6.3×10^7,及IC50为0.82 μM的特异性。它能够抑制癌细胞生长,适用于癌症的科学研究。
HTH-02-006
T82165
HTH-02-006,一种NUAK2抑制剂(IC50 = 126 nM),能够降低HuCCT-1细胞中磷酸化MYPT1水平,并抑制YAP驱动的细胞增殖、肝肿大和肿瘤发生,同时具备抗纤维化保护效果。
AMPK-α1β1γ1 activator 1
T83125
AMPK-α1β1γ1激活剂1 (M1) 是一个衍生于Indole-3-carcinoma的酰基葡萄糖醛酸代谢AMPK激活剂,专一性地针对人类β1亚型,表现出38.1nM的EC50值。该化合物能够直接结合至人AMPK α1β1γ1亚型,适用于糖尿病肾病的相关研究。
AMPK activator 13
T83127
AMPK activator13作为AMPK激活剂,通过激活AMPK通路有效抑制3T3-L1细胞的有丝分裂克隆扩增,并增加细胞线粒体耗氧量,适用于肥胖研究。
Shizukaol D
TN5013
Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be...
3α-Hydroxymogrol
T10105
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.
HL271
T11570
HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
XMD-17-51
T22460
XMD-17-51 是一种有效且高度选择性的 NUAK1 抑制剂。
Kazinol A
TN4382
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
Ampkinone
T10312
Ampkinone is an indirect AMPK activator.
Pinusolide
TL0014
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
Ligupurpuroside A
TN1868
Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
Doxorubicin
T1456
Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素,具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II,IC50分别为0.8 μM 和2.67 μM,从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬 。
ML753286
T16113
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
Ligupurpuroside C
TN1870
Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
Ganodermanondiol
TN1670
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
Icariside E4
TN5431
Icariside E4是一种从小叶榆中提取得到天然化合物, 通过AMPK 磷酸化和抑制HepG1细胞中MID1IP2的低脂化作用。Icariside E4具有抗伤害,抗氧化,抗阿尔茨海默氏症和抗炎作用,抑制了SREBP-1c,肝脏X 受体-α(LXR)和FASN 在HepG2细胞中从头脂肪生成的表达。Icarisi...
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