75
19
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20958 |
Hexazinone
|
Others | Others |
Hexazinone 是三嗪家族的广谱除草剂。 Hexazinone 通过与光系统 II 中电子传递链的 D-1 醌蛋白结合来抑制光合作用。 | |||
T5117 |
Hexaflumuron
|
Others | Others |
Hexazinone 是一种三嗪家族的非选择性除草剂。它能够同光系统 II 电子传递链的 D-1 醌蛋白结合,抑制光合作用的发生。 | |||
T23280 |
Ruthenium Red
钌红,Ammoniated ruthenium oxychloride |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Ruthenium Red (Ammoniated ruthenium oxychloride) 是一种 L 型钙电流 (ICa) 阻断剂,是一种聚阳离子染料,广泛用于电子显微镜 (EM) 下细胞、组织和营养细菌的观察。它能与磷脂和脂肪酸反应强烈,并与酸性粘多糖结合。 | |||
T40732 |
TMPD dihydrochloride
|
||
TMPD dihydrochloride 是酶促转化氧化还原的活性底物和用于还原血红素过氧化物酶的电子供体。 | |||
T22381 |
Antimalarial agent 14
4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone |
Others | Others |
Antimalarial agent 14 (NSC-102533) 是一种生物活性化学品。 | |||
T19714 |
Fenpyroximate
|
Others | Others |
Fenpyroximate 是一种有效的杀螨剂。 | |||
T13151L |
THK5351
|
Others | Others |
THK5351 是一种参与PET成像的示踪剂,参与阿尔茨海默病和认知障碍的电子发射断层扫描成像。 | |||
T7092 |
NADPH tetrasodium salt
|
Others; Ferroptosis; Endogenous Metabolite | Apoptosis; Metabolism; Others |
NADPH tetrasodium salt 是电子受体烟酰胺腺嘌呤二核苷酸磷酸的还原形式,在各种生物反应中充当电子供体。NADPH tetrasodium salt 也是一种内源性铁死亡抑制剂。 | |||
T19374 |
INT
Iodonitrotetrazolium chloride,p-Iodonitrotetrazolium Violet,碘硝基氯化四氮唑蓝 |
Others | Others |
INT (Iodonitrotetrazolium chloride) 能够通过脱氢酶比色法,测定电子受体。 | |||
T40515 |
Metamitron
|
||
Metamitron 是一种光合电子传递链抑制剂,可用作化学稀释剂。 | |||
T4172 |
Methoxy-PMS
1-Methoxyphenazine methosulfate,1-Methoxy PMS |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Methoxy-PMS (1-Methoxyphenazine methosulfate) 是一个稳定的电子传递中介,是一种活性氧生成的诱导剂。 | |||
T21275 |
Azoxystrobin
HSDB 7017,ICI-A 5504,Bankit,ICIA-5504,Amistar |
Antifungal | Microbiology/Virology |
Azoxystrobin (Bankit) 是一种广谱杀菌剂。 Azoxystrobin 通过阻断细胞色素 b 和 c1 之间的电子转移来诱导 ROS 产生、细胞凋亡和线粒体呼吸。 | |||
T0412 |
Idebenone
艾地苯醌,CV-2619 |
Apoptosis; Antioxidant; Mitochondrial Metabolism | Apoptosis; Metabolism; oxidation-reduction |
Idebenone (CV-2619) 是一种线粒体保护剂,具有神经保护功效,可用于研究阿尔茨海默病、亨廷顿舞蹈病,可透过血脑屏障,诱导细胞凋亡。 | |||
T5337 |
IACS-010759
IACS-10759,IACS 10759,IACS10759 |
Apoptosis; Others; Mitochondrial Metabolism | Apoptosis; Metabolism; Others |
IACS-010759 是一种口服有效的线粒体氧化磷酸化复合物 I 抑制剂。它在依赖 OXPHOS 的脑癌和急性髓性白血病模型中抑制增殖并诱导细胞凋亡,有研究复发/难治性 AML 和实体瘤潜力。 | |||
T8940 |
KUN56321
3H-Naphth[1,2-d]imidazole, 2-(4-bromophenyl)-3-phenyl- |
Others | Others |
KUN56321 (3H-Naphth[1,2-d]imidazole, 2-(4-bromophenyl)-3-phenyl-) 是一种发光剂。 KUN56321的应用包括:真空蒸镀将 KUN56321薄膜涂布在 ITO 玻璃的空穴传输层或电子传输层上。将空穴传输层或电子传输层蒸镀在薄膜上,preppg。蒸发金属电极。 KUN56321 展示了提高发光效率和降低 org 驱动电压的能力。发光器件和显示器件。 | |||
T5363 |
Tempo
2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy |
Free radical scavengers; Reactive Oxygen Species; DNA/RNA Synthesis; Mitochondrial Metabolism | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Tempo (2,2,6,6-Tetramethylpiperidinooxy) 可用作自由基清除剂、有机合成中的试剂和电子自旋共振光谱中的结构探针。它可在催化循环中使超氧化物歧化,也可诱导DNA 链断裂。 | |||
T21343 |
PTZ-343
PTZ-343 sodium,PTZ 343,吩噻嗪-10-基-丙基磺酸钠盐 |
Others | Others |
PTZ-343 是一种鲁米诺的强效发光增强剂 (enhancer)。它极大的增强了过氧化物酶催化的鲁米诺化学发光氧化反应 (>80%) 的光输出。 | |||
T5114 |
Pyridaben
|
Calcium Channel; Parasite | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Pyridaben 是一种METI 杀螨剂,可抑制复合物 I 处的线粒体电子转运。它对多种螨虫具有活性,通过滤纸接触给药,在 25 mg/mL、100 mg/mL 和 200 mg/mL 的剂量下,分别诱导 100% 的C. malaccensis,D. farina 和T. putrescentia 死亡率。 | |||
T1546 |
Nitazoxanide
NSC 697855,硝唑尼特 |
Others; Influenza Virus; Parasite; Autophagy | Autophagy; Microbiology/Virology; Others |
Nitazoxanide (NSC-697855) 是一种广谱驱虫剂,对感染动物和人类的各种蠕虫、原生动物和肠道细菌都具有作用活性。 它在无菌培养中抑制Giardia lamblia 滋养体增殖,IC50为 2.4 μM。它可研究寄生虫性胃肠炎,具有抗病毒特性。 | |||
T22739 |
DMPO
5,5-二甲基-1-吡咯啉-N-氧化物,5,5-Dimethyl-1-pyrroline N-oxide |
Others | Others |
DMPO (5,5-Dimethyl-1-pyrroline N-oxide) 是一种细胞渗透性亲水自旋诱捕剂,可用于超氧化物检测。 | |||
T36958 |
BODIPY 505/515
|
||
BODIPY 505/515 是一种亲脂性荧光探针,可定位到细胞内的脂质体,已被用于标记脂滴。BODIPY 505/515 已被用于电子显微镜、外荧光显微镜、共聚焦显微镜以及各种藻类物种的流式细胞仪应用中。 | |||
T72083 |
Octadecyl Rhodamine B chloride
|
||
Octadecyl Rhodamine B chloride 也被叫做RBOE, 是一种极性敏感染料,常作为一种发色基团与其他化合物一起使用,可用于给细胞膜染色,在有机分子组装、膜结构及蛋白质结构域中的电子能量转移中都有应用。 | |||
T26168 |
Rufigallol
AI3 00865,AI3-00865,AI300865 |
||
Rufigallol (AI3-00865) 是一种具有六个羟基的电子缺失的盘状分子,是诱导非平面AIE 分子形成DLC 的良好单元,是一种蒽醌衍生物。Rufigallol 诱导获得了DLC 特性,而TPE 基团的引入使分子结构在聚集状态下具有良好的荧光。Rufigallol 在体外的显著的协同抗疟作用,在体内与维生素C 和酮类化合物一起使用具有协同作用并显示出抗疟活性。 | |||
T37807 |
JTV 519 fumarate
|
||
Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID:17313373 |Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID:17994112 |... | |||
T12049 |
MitoTam bromide, hydrobromide
MitoTam bromide hydrobromide |
Others | Others |
MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor. | |||
T24401 |
L-erythro-Chloramphenicol
L(+)-erythro-Chloramphenicol |
||
L-erythro-Chloramphenicol functions as a potent inhibitor of electron transport. | |||
T22772 |
EUK 118
|
Others | Others |
EUK 118 is an inhibitor of superoxide-mediated reduction of an electron acceptor. | |||
T70935 | Phenoxan | ||
Phenoxan is isolated from Polyangium; inhibits electron transport at NADH-ubiquinone oxidoreductase. | |||
T22773 |
EUK 124
|
Others | Others |
EUK 124 is an inhibitor of superoxide-mediated reduction of an electron acceptor. | |||
T27444 |
GSK 932121
GSK-932121,GSK932121 |
||
GSK 932121 is a potent antimalarial agent. GSK 932121 inhibits selectively the electron-transport chain in P. falciparum at the cytochrome bc1 level (complex III). | |||
T28626 |
Rutamycin
Oligomycin D,A272,A 272,A-272 |
||
Rutamycin is a macrolide antibiotic of the oligomycin group obtained from Streptomyces rutgersensis. It inhibits various ATPases and uncouples oxidative phosphorylation from electron transport. | |||
T34472 |
S1QEL
S-1QEL,S1 QEL,S 1QEL,S1QEL1.1,S1-QEL |
||
S1QEL is a suppressor of mitochondrial respiratory complex I site IQ electron leak which suppresses superoxide and/or H2O2 production without altering oxidative phosphorylation. | |||
T36792 |
DNP-INT
|
||
DNP-INT is a quinone analog that inhibits electron transport in plants by competitively inhibiting plastoquinol oxidation by binding at the Qo site of cytochrome b6f (Kd = 1.4 nM). It inhibits electron flow from water to NADP or methylviologen by 50 and 100% when used at concentrations of 0.5 or 5 μM, respectively. | |||
T34424 |
RSU 1164
RSU-1164,RSU1164 |
||
RSU 1164 is an electron affinic agent that contains a nitro group and a weakly basic alkylating aziridine moiety. | |||
T27516 | GW844520 | ||
GW844520 is a potent and selective inhibitor of the cytochrome bc1 complex of mitochondrial electron transport in P. falciparum. | |||
T29792 | AK-135 | ||
AK-135 is a derivative of 1,4-naphthoquinone (Menadione). AK-135 has been shown to restore the electron flow in defective respiratory chain (hypoxia or rotenone) systems more effectively than Menadione. | |||
T19385 | ITIC-4F | CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
ITIC-4F, an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor, exhibits wide applicability in high-efficiency binary and ternary single-junction as well as tandem polymer solar cells (PSCs). | |||
T41141 |
Fullerene-C60
Fullerene-C60 |
||
Fullerene-C60, a carbon nanocompound, is considered a potential agent for photodynamic therapy owing to its distinctive physicochemical properties. It investigates the dynamics of intramolecular electron and energy transfer. | |||
T37913 | Picoxystrobin | ||
Picoxystrobin, a prominent primary strobilurin fungicide, is extensively utilized for efficient plant disease management. By obstructing electron transfer at the Qo center of cytochrome b and c1, picoxystrobin effectively halts mitochondrial respiration[1]. | |||
T21079 |
Decafluorobenzophenone
Perfluorobenzophenone |
||
Decafluorobenzophenone is used in the synthesis of fluorinated acridones and acridines. Decafluorobenzophenone alcoholic solution generates radical anion and ketyl which can be studied by electron spin resonance spectra. It undergoes photolysis to form ke | |||
T37519 |
Diquat (bromide)
|
||
Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administration has been used to induce oxidative stressin vitroand in animal models.2,3,4It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.2Form... | |||
T80905 |
UHDBT
|
||
UHDBT为一种作用于细胞色素bc1复合体Qo位点的抑制剂,适用于电子传递研究。 | |||
T34084 |
Plastoquinone
Q 254,Q-254,Q254 |
||
Plastoquinone is a polyunsaturated side-chain quinone derivative which is an important link in the electron transport chain of green plants during the photosynthetic conversion of light energy by photophosphorylation into the potential energy of chemical | |||
T19386 |
ITIC
|
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its high glass transition temperature (Tg) of 180 °C. Furthermore, ITIC, which is an indacenodithienothiophene-based postfullerene electron acceptor, displays a distinct crystallization behavior, differing substantially from that of fullerenes. | |||
T38825 |
Glyco-diosgenin
|
||
Glyco-diosgenin serves as a synthetic surfactant and detergent utilized in the extraction of proteins from membranes. This compound finds application in studies related to the structure and function of proteins, as well as in single-particle cryo-electron microscopy (cryoEM) studies specifically targeted at membrane proteins. | |||
T35948 |
4-carboxy TEMPO
|
||
4-carboxy TEMPO is a nitroxide and spin label. Nitroxides such as 4-carboxy TEMPO react with reactive oxygen species (ROS) and can be used with electron spin resonance (ESR) spectroscopy to monitor ROS production in vivo., It has also been used to study flavin-photosensitized damage in inner mitochondrial membranes. | |||
T36203 |
Menaquinone 9
MK-9,Vitamin K2(45),Menaquinone 9 |
||
Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain. In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats. | |||
T83130 |
AMCPy
|
||
AMCPy 是一款有效的 EPR 脑成像剂,其优秀的亲脂性使其能够穿透 BBB。 | |||
T60791 | Antitubercular agent-11 | ||
Antitubercular agent-11 (Compound 1e) 是一种具有较大供电子基团 (Bu-t)的抗结核剂,其 MIC 值为 0.060 μg/mL。 | |||
T37583 |
XTT (sodium salt hydrate)
|
||
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.3 1.Berridge, M.V., Tan, A.S., and Herst, P.M.Tetrazolium dyes as tools in cell biology: New insights into their cellular reductionBiotechnol. Ann. Rev.11127-152(2005) 2.Berridge, M.V., and Tan, A.S.Trans-plas... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8433 |
HQNO
|
Mitochondrial Metabolism | Metabolism |
HQNO 是一种电子传递链抑制剂,对 complex III 的Kd 值为 64 nM,由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。 | |||
T5573 |
Coenzyme Q9
辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式,是电子传递链中的一种双亲分子组分,具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降,改善左心室功能,减少心肌梗死面积和心肌细胞凋亡。 | |||
T0928 |
L-Ascorbic acid
维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate |
Apoptosis; Calcium Channel; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB |
L-Ascorbic acid (Vitamin C) 属于天然产物,是一种强效的还原剂和抗氧化剂。L-Ascorbic acid 具有抗细菌感染、解毒反应和胶原蛋白形成的作用。L-Ascorbic acid 被用于治疗坏血病。 | |||
T22446 |
NADP disodium salt
Disodium NADP,Triphosphopyridine nucleotide disodium salt,beta-烟酰胺腺嘌呤二核苷酸磷酸二钠盐 |
Others | Others |
NADP disodium salt (Disodium NADP) 是一种氧化还原辅助因子,是一种烟酰胺腺嘌呤二核苷酸。它是代谢中电子转移的关键辅因子,可以被交替氧化 (NADP+) 和还原 (NADPH)。 | |||
T5300 |
Ammonium formate
甲酸铵,Formic acid ammonium salt |
Others | Others |
Ammonium formate (Formic acid ammonium salt) 是最简单的羧酸。它通过抑制细胞色素氧化酶活性(电子传递链的末端电子受体)来负责代谢性酸中毒和破坏线粒体电子传递和能量产生。 | |||
T2796 |
Coenzyme Q10
Ubiquinone-10,辅酶Q10,CoQ10 |
Ferroptosis; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Coenzyme Q10 (CoQ10)是来自藤仓赤霉菌的一种天然产物,在线粒体呼吸链中充当电子载体。 | |||
T21494 |
Oligomycin
|
HIF | Angiogenesis; Chromatin/Epigenetic |
Oligomycin 是一种抗真菌抗生素,是 H+-ATP 合成酶的抑制剂。Oligomycin 能够阻断氧化磷酸化和电子传递链。Oligomycin 对缺氧性肿瘤细胞 HIF-1alpha 表达具有抑制作用。 | |||
T1609 |
NAD+
烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD |
NADPH; Endogenous Metabolite | Metabolism |
NAD+ (β-Nicotinamide Adenine Dinucleotide) 即烟酰胺腺嘌呤二核苷酸,是转递氢离子的辅酶。 | |||
T2970 |
Rotenone
Rotenon,鱼藤酮,Paraderil,Barbasco,Rotocide,Dactinol |
Apoptosis; Dehydrogenase; Mitochondrial Metabolism; p53; Autophagy | Apoptosis; Autophagy; Metabolism |
Rotenone (Rotocide) 属于天然产物,是一种植物杀虫剂。Rotenone 是一种线粒体电子传递复合物 I 抑制剂,可以促进线粒体产生活性氧,并诱导细胞凋亡。 | |||
T5693 |
Pyrroloquinoline quinone disodium salt
吡咯喹啉醌二钠盐,Methoxatin disodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Pyrroloquinoline quinone disodium salt (Methoxatin disodium salt) 一种阴离子型氧化还原循环原醌,作为氧化还原辅助因子。它是从嗜甲基细菌的培养物中分离的,也存在于哺乳动物的组织。它是哺乳动物的必需营养素,对免疫功能很重要。 | |||
T5291 |
Malonic acid
Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid |
Others | Others |
Malonic acid (propanedioic acid) 是竞争性抑制剂的典型例子:它作用于呼吸电子传递链中的琥珀酸脱氢酶(复合物 II)。发现丙二酸与丙二酰辅酶A 脱羧酶缺乏有关,这是一种先天性代谢错误。 | |||
TN6565 |
Maculosidin
|
||
Maculosidine affect the PS I electron acceptors on leaf discs, it can inhibit ATP synthesis, basal, phosphorylating and uncoupled electron transport acting as Hill reaction inhibitors on spinach chloroplasts. | |||
TN4418 | Lasiodiplodin | ATPase; TNF | Apoptosis; Membrane transporter/Ion channel |
Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron transport chain. | |||
T17037 | Tenuazonic acid | Others | Others |
Tenuazonic acid is a putative nonhost-selective mycotoxin isolated from Alternaria alternate. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosyste | |||
T82926 | Bacteriopheophytin | ||
Bacteriopheophytin是细菌脱镁叶绿素的一种,由细菌叶绿素去除镁中心并由两个氢原子取代形成。在紫色细菌的反应中心(RC)中,它作为电子受体参与电子转移过程。 | |||
T81158 |
Siderin
|
||
Siderin作为一种Photosystem II抑制剂,有效地阻断了离体菠菜光合过程中ATP的合成及叶绿体电子传递,因此被用于植物光合作用的研究。 | |||
T75699 | Coenzyme Q6 | ||
Coenzyme Q6 (Ubiquinone 30),一种异戊二烯化的苯醌脂质,主要在呼吸电子传输链中发挥作用,并作为脂质抗氧化剂,具备抗氧化性能,能够防止自由基生成和氧化损伤。 | |||
TN1208 |
2-Amino-3-carboxy-1,4-naphthoquinone
|
NADPH-oxidase | Immunology/Inflammation |
2-Amino-3-carboxy-1,4-naphthoquinone 是电子转移介质,可改变同型发酵乳酸菌的葡萄糖代谢,可作为双歧杆菌生长刺激剂,它通过NAD(P)H 介导的氧化作用影响双歧杆菌的终产物形态。 | |||
T4448 | NADP | ||
NADP,也称为烟酰胺腺嘌呤二核苷酸磷酸,是各种代谢过程中电子转移所必需的重要氧化还原辅因子。 它在促进细胞能量产生和维持细胞内氧化还原平衡方面发挥着关键作用。 |