Me-Tet-PEG4-Maleimide, an ADC Linker, incorporates four PEG units and features a Tetrazine group capable of engaging in a specific inverse electron demand Diels-Alder reaction (iEDDA) with TCO group-containing compounds. Additionally, its maleimide group (-Maleimide) is susceptible to degradation in aqueous environments, a characteristic that has been explored in drug delivery research.