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Nitric Oxide (NO) is a free radical gas that is involved in a variety of biological processes including regulation vascular tone, neuronal signaling, and host defense. Nitroxyl (HNO) is the one electron reduced form of nitric oxide. Piloty's acid is one of the best known and most widely used HNO donors. Under basic conditions Piloty's acid decomposes to HNO and benzenesulfinate anion. The rate of HNO release at pH 7 is very slow (t = 5,500 minutes) making its use most effective above pH 8.0. The half-life of Piloty's acid decreases with an increase in pH to 561, 90, and 33 minutes at pH 8.0, 9.0, and 10.0, respectively. Piloty's acid also inhibits yeast aldehyde dehydrogenase with an IC50 or 48 μM.
Nitric Oxide (NO) is a free radical gas that is involved in a variety of biological processes including regulation vascular tone, neuronal signaling, and host defense. Nitroxyl (HNO) is the one electron reduced form of nitric oxide. Piloty's acid is one of the best known and most widely used HNO donors. Under basic conditions Piloty's acid decomposes to HNO and benzenesulfinate anion. The rate of HNO release at pH 7 is very slow (t = 5,500 minutes) making its use most effective above pH 8.0. The half-life of Piloty's acid decreases with an increase in pH to 561, 90, and 33 minutes at pH 8.0, 9.0, and 10.0, respectively. Piloty's acid also inhibits yeast aldehyde dehydrogenase with an IC50 or 48 μM.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 mg | 待估 | 35日内发货 | |
1 g | 待估 | 35日内发货 | |
5 g | 待估 | 35日内发货 | |
10 g | 待估 | 35日内发货 |
Piloty's Acid 相关产品
产品描述 | Nitric Oxide (NO) is a free radical gas that is involved in a variety of biological processes including regulation vascular tone, neuronal signaling, and host defense. Nitroxyl (HNO) is the one electron reduced form of nitric oxide. Piloty's acid is one of the best known and most widely used HNO donors. Under basic conditions Piloty's acid decomposes to HNO and benzenesulfinate anion. The rate of HNO release at pH 7 is very slow (t = 5,500 minutes) making its use most effective above pH 8.0. The half-life of Piloty's acid decreases with an increase in pH to 561, 90, and 33 minutes at pH 8.0, 9.0, and 10.0, respectively. Piloty's acid also inhibits yeast aldehyde dehydrogenase with an IC50 or 48 μM. |
分子量 | 173.19 |
分子式 | C6H7NO3S |
CAS No. | 599-71-3 |
密度 | 1.342 g/cm3 (Estimated) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | DMF: 30 mg/mL (173.22 mM), Sonication is recommended. DMSO: 20 mg/mL (115.48 mM), Sonication is recommended. Ethanol: 30 mg/mL (173.22 mM), Sonication is recommended. PBS (pH7.2): 2 mg/mL (11.55 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
PBS (pH7.2)/DMSO/DMF/Ethanol
DMSO/DMF/Ethanol
|
以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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