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| Cat. No. | Product Name | ||
|---|---|---|---|
| L2191 | 抗乳腺癌化合物库 | 1965 compounds | |
| 1965 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究； | |||
| L9410 | 共价抑制剂库 | 941 compounds | |
| 941 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发； | |||
| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T11159 | EGFR-IN-2 | EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
| EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor. | |||
| T62776 | EGFR/HER2-IN-2 | ||
| EGFR/HER2-IN-2 (Compound ZINC35560729) 是一种 EGFR 和 HER2 双重抑制剂，作用于 EGFR (IC50: 5.02 μM) 和 HER2 (IC50: 0.83 μM)。 | |||
| T63532 | EGFR/HER2/TS-IN-2 | ||
| EGFR/HER2/TS-IN-2 是 EGFR (IC50: 0.173 μM)、HER2 (IC50: 0.125 μM) 和 TS (IC50: 1.12 μM) 的有效抑制剂。EGFR/HER2/TS-IN-2 对 MDA-MB-231 癌细胞表现出细胞毒性作用 (IC50: 1.69 μM)。 | |||
| T63357 | EGFR/HER2/CDK9-IN-2 | ||
| EGFR/HER2/CDK9-IN-2 是 EGFR/HER2/CDK9 的有效抑制剂，他们的 IC50s 值分别为 145.35、129.07 和 117.13 nM，表现出明显的抗肿瘤作用。 | |||
| T74833 | EGFR T790M/L858R-IN-2 | ||
| EGFRT790M/L858R-IN-2 是一种有效的选择性EGFRT790M/L858R 抑制剂，对 EGFRT790M/L858R 和EGFRWT 的IC50值分别为 3.5, 1290 nM。EGFRT790M/L858R-IN-2 降低 p-EGFR、P-AKT、P-ERK1/2 的表达。EGFRT790M/L858R-IN-2 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 G1 期。EGFRT790M/L858R-IN-2 具有抗癌活性。 | |||
| T12130 | Mutated EGFR-IN-2 | EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
| Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR. | |||
| T6619 |
Desmethyl Erlotinib hydrochloride
去甲厄洛替尼,OSI-420,OSI420,CP-473420,DesMethyl Erlotinib (CP-473420) HCl,Desmethyl Erlotinib,OSI 420 |
Drug Metabolite; EGFR | Angiogenesis; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors |
| OSI420 是 Erlotinib 的活性代谢物。Erlotinib 是 EGFR 酪氨酸激酶抑制剂。 | |||
| T4S0544 |
Furanodienone
莪术呋喃二烯酮,呋喃二烯酮 |
HER; Apoptosis | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
| Furanodienone 是来源于姜黄根茎的一种主要生物活性成分，可诱导细胞凋亡。 | |||
| T16328 |
Nitroaspirin
2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016 |
COX; Apoptosis | Apoptosis; Immunology/Inflammation; Neuroscience |
| Nitroaspirin 是一氧化氮供体和阿司匹林的硝基衍生物，与 Aspirin 结合可抑制环氧合酶=，可作为 COX-1 的直接和不可逆抑制剂。 它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡，具有抗血栓和抗血小板特性。 | |||
| T2116 |
AEE788
NVP-AEE 788 |
Apoptosis; EGFR; c-Fms; FLT; Bcr-Abl | Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
| AEE788是EGFR 和ErbB2的抑制剂，IC50值分别为2和6 nM。它已用于研究癌症、多形性胶质母细胞瘤以及脑和中枢神经系统肿瘤治疗的试验。 | |||
| T6479 |
Dovitinib lactate hydrate
多韦替尼,Dovitinib (TKI258) Lactate,TKI258,Dovitinib Lactate |
VEGFR; FGFR; c-Kit; PDGFR; FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
| Dovitinib Lactate 是一种多靶点的酪氨酸激酶抑制剂，抑制 FLT3，c-Kit，FGFR1/3，VEGFR1/2/3和 PDGFRα/β的 IC50值分别为 1，2，8/9，10/13/8，27/210 nM。 | |||
| T2988 |
(-)-Epigallocatechin Gallate
(-)-表没食子儿茶素没食子酸酯,EGCG,Epigallocatechol Gallate |
Ferroptosis; Autophagy; Endogenous Metabolite; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
| (-)-Epigallocatechin Gallate 是茶类黄酮，具有强大的抗氧化，抗炎和抗癌作用。它可抑制EGFR 信号传导，有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c 氧化酶来诱导氧化磷酸化。 | |||
| T63798 | EGFR-IN-32 | ||
| EGFR-IN-32 是 EGFR 的有效抑制剂。其中表皮生长因子受体 (EGFR) 的过度表达和突变已被证实会造成细胞无法控制的生长，并与大多数癌症疾病（尤其是 NSCLC ）的进展有关。EGFR-IN-32 对 EGFR 突变相关疾病表现出研究潜力 (信息来源于专利 WO2021185297A1，化合物 2)。 | |||
| T61696 | EGFR-IN-57 | ||
| EGFR-IN-57 (Compound 25a) 是一种有效的、具有口服活性的EGFR-TK 抑制剂，IC50值为 0.054 μM。EGFR-IN-57 也抑制VEGFR-2、CK2α、topoisomerase IIβ和tubulin polymerization，IC50值分别为 0.087、0.171、0.13 和 3.61 μM。EGFR-IN-57 诱导细胞 G2/M 和 pre-G1 期周期阻滞，诱导癌细胞凋亡 (apoptosis)。 | |||
| T8525 |
EGFR-IN-16
AG473 |
EGFR; FGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
| EGFR-IN-16 是一种EGFR 抑制剂，对 EGFR 和 HER-2 的pIC50分别为4.85和4.74。 | |||
| T64030 | EGFR-IN-31 | ||
| EGFR-IN-31 是 EGFR 的有效抑制剂。其中表皮生长因子受体 (EGFR) 的过度表达和突变已被证实会造成细胞无法控制的生长，且与大多数癌症疾病（尤其是 NSCLC ）的进展有关。EGFR-IN-31 对 EGFR 突变相关疾病表现出研究潜能 (信息来源于专利 WO2021185298A1，化合物 2)。 | |||
| T11385 | Gefitinib N-oxide | Others | Others |
| Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib. | |||
| T63178 | EGFR-IN-39 | ||
| EGFR-IN-39 是一种丙烯酰胺衍生物，是一种 EGFR 的有效抑制剂。EGFR-IN-39 是一种低毒副作用的抗肿瘤药物。其中表皮生长因子受体 (EGFR) 的过度表达和突变已被明确证实会造成细胞生长无法控制，且与大多数癌症疾病（尤其是 NSCLC）的进展有关。EGFR-IN-33 具有潜力进行 EGFR 突变相关疾病的研究 (详细信息请参考专利 WO2021185348A1，化合物 2)。 | |||
| T63895 | EGFR-IN-62 | ||
| EGFR-IN-62 是 EGFR 激酶的有效抑制剂，对 L858R/T790 M、WT 和 L858R/T790 M/C797S 的 IC50 值分别为10 nM、29 nM 和2 42 nM。EGFR-IN-62 可将 A549 和/或 H1975细胞周期阻滞在 G1/G0 期，并诱导凋亡和运动抑制，有效的抑制 A549 细胞 (IC50: 2.53 μM) 和 H1975 细胞 (IC50: 1.56 μM) 的增殖。 | |||
| T76697 | Panitumumab (anti-EGFR) | ||
| Panitumumab (anti-EGFR) 是一种全人源IgG2抗EGFR 单克隆抗体，具有抗肿瘤活性。Panitumumab (anti-EGFR) 抑制肿瘤细胞增殖、存活和血管生成。Panitumumab (anti-EGFR) 可用于癌症研究，例如结肠癌。 | |||
| T61191 | EAI001 | ||
| EAI001 is a highly effective, selective allosteric inhibitor of mutant epidermal growth factor receptor (EGFR), specifically targeting EGFR L858R/T790M. With an impressive IC50 value of 24 nM, EAI001 proves to be a powerful tool in cancer research [1] [2]. | |||
| T73627 | Gefitinib N-oxide hydrochloride | ||
| Gefitinib N-oxide hydrochloride 是 Gefitinib 的 N-oxide 衍生物。Gefitinib 是一种有效的 (EGFR) 抑制剂，在 NR6wtEGFR 细胞中 IC50值为 2-37 nM。 | |||
| T63769 | EGFR-IN-60 | ||
| EGFR-IN-60 是一种有效的、口服具有活力的、安全的抗肿瘤剂。EGFR-IN-60 能够明显抑制 EGFRWT (IC50: 83 nM)、EGFRT790M (IC50: 26 nM)、EGFRL858R (IC50: 53 nM) 和 JAK3 (IC50: 69 nM)。EGFR-IN-60 能够抑制携带 EGFRT790M 突变的 H1975 细胞 (IC50: 1.32 μM) ，并抑制过表达 EGFRWT 的 A431 细胞 (IC50: 4.96 μM)。EGFR-IN-60 能够提高 Bax/Bcl-2 比率，进而诱导细胞凋亡诱导并导致细胞死亡。 | |||
| T35915 |
Erlotinib-13C6
Erlotinib-13C6 |
||
| Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]... | |||
| T11384 |
Gefitinib-d8
ZD1839 D8,Gefitinib D8 |
Others | Others |
| Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib. | |||
| T72890 | VEGFR-2-IN-30 | ||
| VEGFR-2-IN-30 是一种 VEGFR-2 抑制剂 (IC50: 66 nM)。VEGFR-2-IN-30 还抑制 PDGFR、EGFR 和 FGFR1，IC50s 分别为 180、98、82 nM。VEGFR-2-IN-30 将癌细胞阻滞在 S 期并诱导早期和晚期细胞凋亡 (apoptosis)。 | |||
| T74367 | SC209 | ||
| SC209 是个 ADC 细胞毒素，源于专利 WO2021247798, 用于合成抗 EGFR 抗体-活性分子偶联 ADC。SC209 是 STRO-002 的代谢物。 | |||
| T14101 | Acid-PEG3-C2-Boc | Others | Others |
| Acid-PEG3-C2-Boc is a compound used as a linker in the synthesis of PROTACs to facilitate the degradation of EGFR and the inhibition of mTOR[1][2]. It is classified as a PEG- and alkyl/ether-based PROTAC linker. | |||
| T1181L | Gefitinib hydrochloride | ||
| Gefitinib hydrochloride (ZD1839 hydrochloride) 是一种有效，选择性和具有口服活性的EGFR 酪氨酸激酶抑制剂，IC50为 33 nM。Gefitinib hydrochloride 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM)，并阻断 EGF 刺激的肿瘤细胞中EGFR 自磷酸化。Gefitinib hydrochloride 也诱导细胞自噬 (autophagy)，具有抗肿瘤活性。 | |||
| T76890 | Petosemtamab | ||
| Petosemtamab (MCLA 158) 是一种抗 EGFR(Kd: 0.22 nM) 和抗 LGR5(Kd: 0.86 nM) 单克隆抗体 (mAb)。Petosemtamab 导致 LGR5+ 癌细胞中的 EGFR 信号传导阻断和受体降解。Petosemtamab 可用于头颈部鳞状细胞癌 (HNSCC)、转移性结直肠癌 (CRC) 等实体瘤的研究。 | |||
| T62621 | Pan-HER-IN-2 | ||
| pan-HER-IN-2 (Compound C6) 是一种口服具有活力的、可逆的广谱 HER 抑制剂，能够作用于 EGFR (IC50: 0.72 nM)、HER4 (IC50: 2.0 nM)、EGFRT790M (IC50: 8.2 nM) / L858R (IC50: 75.1 nM)。pan-HER-IN-2 可以诱导细胞凋亡 (apoptosis)，具有抗肿瘤作用。 | |||
| T69055 | PD153035 nitrate | ||
| PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also... | |||
| T63205 | HSP90-IN-13 | ||
| HSP90-IN-13 (compound 5k) 是一种高效的HSP90广谱性抑制剂，IC50为 25.07 nM。HSP90-IN-13 对 EGFR、VEGFR-2 和 Topoisomerase-2 具有多靶点活性。HSP90-IN-13 将 MCF-7 细胞周期阻滞在 G2/M 期，并通过线粒体介导途径诱导细胞凋亡 (apoptosis)。 | |||
| T76812 | Intetumumab | ||
| Intetumumab (CNTO 95) 是一种有效的抗EGFR 单克隆抗体，是糖工程增强抗体依赖性细胞毒性 (ADCC)。Intetumumab 可用于癌症的研究。 | |||
| T36102 | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | ||
| 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds.1,2,3It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.4,5 | |||
| TN5100 | Taspine | Akt; ERK; EGFR; MAPK; VEGFR; BCL | Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
| Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful angiogenesis activity. Taspine exhibi | |||
| T35855 | AAA | ||
| AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension... | |||
| T22610 |
BMS 599626 dihydrochloride (714971-09-2 free base)
BMS 599626 dihydrochloride |
Others | Others |
| BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor. BMS-599626 inhibited HER4 (IC50: 190 nM). In Sal2, N87, and GEO tumor cells, BMS-599626 inhibited phosphorylation of HER1 and HER2 in a dose-dependent way and inhibited cell pr | |||
| T35897 | ASK120067 | ||
| ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT... | |||
| TMPY-03125 | SHP2 Protein, Mouse, Recombinant (His Tag) | ||
| SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participat... | |||
| T37594 | Pericosine A | ||
| Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable t... | |||
| T36648 | Tucatinib hemiethanolate | ||
| Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-fold selective for HER2 versus EGFR in cell-based assays. Tucatinib selectively inhibits the receptor tyrosine kinase HER2 relative to EGFR[1].Tucatinib blocks proliferation and the phosphorylation of HER2 and its downstream effector, Akt in HER2 overexpressing cell lines. In the ... | |||
| T70431 | TX-1123 | ||
| TX-1123 是一种有效的蛋白酪氨酸激酶 (PTK) 抑制剂，针对于 Src、eEF2-K、PKA 和 EGFR-K/PKC。TX-1123 是一种环氧合酶 (COX) 抑制剂，对 COX2 和 COX1 的 IC50值分别为 1.16 μM 和 15.7 μM。TX-1123 具有低线粒体毒性。TX-1123 可用于癌症研究。 | |||
| TMPY-03569 | Betacellulin Protein, Human, Recombinant (hFc Tag) | ||
| Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of abou... | |||
| TMPY-06597 | Betacellulin Protein, Rhesus, Recombinant (hFc Tag) | ||
| Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of abou... | |||
| TMPY-01323 | Betacellulin Protein, Mouse, Recombinant (His & hFc Tag) | ||
| Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of abou... | |||
| TMPY-00008 | CXCL1 Protein, Rat, Recombinant | ||
| The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol... | |||
| TMPY-00433 | CXCL1 Protein, Mouse, Recombinant | ||
| The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol... | |||
| TMPY-02180 | CXCL1 Protein, Human, Recombinant (His & NusA Tag) | ||
| The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol... | |||
| TMPY-02868 | CXCL1 Protein, Human, Recombinant | ||
| The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol... | |||
| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T4S0544 |
Furanodienone
莪术呋喃二烯酮,呋喃二烯酮 |
HER; Apoptosis | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
| Furanodienone 是来源于姜黄根茎的一种主要生物活性成分，可诱导细胞凋亡。 | |||
| T2988 |
(-)-Epigallocatechin Gallate
(-)-表没食子儿茶素没食子酸酯,EGCG,Epigallocatechol Gallate |
Ferroptosis; Autophagy; Endogenous Metabolite; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
| (-)-Epigallocatechin Gallate 是茶类黄酮，具有强大的抗氧化，抗炎和抗癌作用。它可抑制EGFR 信号传导，有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c 氧化酶来诱导氧化磷酸化。 | |||
| TN5100 | Taspine | Akt; ERK; EGFR; MAPK; VEGFR; BCL | Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
| Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful angiogenesis activity. Taspine exhibi | |||
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