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Targets Recommended: EGFR

51

抑制剂 & 化合物

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化合物库

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Cat. No. Product Name
L2191 抗乳腺癌化合物库

1965 compounds
1965 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究;
L9410 共价抑制剂库

941 compounds
941 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发;

化合物库

抗乳腺癌化合物库
L2191
Compounds: 1965
共价抑制剂库
L9410
Compounds: 941
Cat. No. Product Name Target Signaling Pathways
T11159 EGFR-IN-2

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.
T62776 EGFR/HER2-IN-2

EGFR/HER2-IN-2 (Compound ZINC35560729) 是一种 EGFR 和 HER2 双重抑制剂,作用于 EGFR (IC50: 5.02 μM) 和 HER2 (IC50: 0.83 μM)。
T63532 EGFR/HER2/TS-IN-2

EGFR/HER2/TS-IN-2EGFR (IC50: 0.173 μM)、HER2 (IC50: 0.125 μM) 和 TS (IC50: 1.12 μM) 的有效抑制剂。EGFR/HER2/TS-IN-2 对 MDA-MB-231 癌细胞表现出细胞毒性作用 (IC50: 1.69 μM)。
T63357 EGFR/HER2/CDK9-IN-2

EGFR/HER2/CDK9-IN-2EGFR/HER2/CDK9 的有效抑制剂,他们的 IC50s 值分别为 145.35、129.07 和 117.13 nM,表现出明显的抗肿瘤作用。
T74833 EGFR T790M/L858R-IN-2

EGFRT790M/L858R-IN-2 是一种有效的选择性EGFRT790M/L858R 抑制剂,对 EGFRT790M/L858R 和EGFRWT 的IC50值分别为 3.5, 1290 nM。EGFRT790M/L858R-IN-2 降低 p-EGFR、P-AKT、P-ERK1/2 的表达。EGFRT790M/L858R-IN-2 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 G1 期。EGFRT790M/L858R-IN-2 具有抗癌活性。
T12130 Mutated EGFR-IN-2

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.
T6619 Desmethyl Erlotinib hydrochloride

去甲厄洛替尼,OSI-420,OSI420,CP-473420,DesMethyl Erlotinib (CP-473420) HCl,Desmethyl Erlotinib,OSI 420

Drug Metabolite; EGFR Angiogenesis; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
OSI420 是 Erlotinib 的活性代谢物。Erlotinib 是 EGFR 酪氨酸激酶抑制剂。
T4S0544 Furanodienone

莪术呋喃二烯酮,呋喃二烯酮

HER; Apoptosis Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Furanodienone 是来源于姜黄根茎的一种主要生物活性成分,可诱导细胞凋亡。
T16328 Nitroaspirin

2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016

COX; Apoptosis Apoptosis; Immunology/Inflammation; Neuroscience
Nitroaspirin 是一氧化氮供体和阿司匹林的硝基衍生物,与 Aspirin 结合可抑制环氧合酶=,可作为 COX-1 的直接和不可逆抑制剂。 它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白,显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡,具有抗血栓和抗血小板特性。
T2116 AEE788

NVP-AEE 788

Apoptosis; EGFR; c-Fms; FLT; Bcr-Abl Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors
AEE788是EGFR 和ErbB2的抑制剂,IC50值分别为2和6 nM。它已用于研究癌症、多形性胶质母细胞瘤以及脑和中枢神经系统肿瘤治疗的试验。
T6479 Dovitinib lactate hydrate

多韦替尼,Dovitinib (TKI258) Lactate,TKI258,Dovitinib Lactate

VEGFR; FGFR; c-Kit; PDGFR; FLT Angiogenesis; Tyrosine Kinase/Adaptors
Dovitinib Lactate 是一种多靶点的酪氨酸激酶抑制剂,抑制 FLT3,c-Kit,FGFR1/3,VEGFR1/2/3和 PDGFRα/β的 IC50值分别为 1,2,8/9,10/13/8,27/210 nM。
T2988 (-)-Epigallocatechin Gallate

(-)-表没食子儿茶素没食子酸酯,EGCG,Epigallocatechol Gallate

Ferroptosis; Autophagy; Endogenous Metabolite; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism Apoptosis; Autophagy; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
(-)-Epigallocatechin Gallate 是茶类黄酮,具有强大的抗氧化,抗炎和抗癌作用。它可抑制EGFR 信号传导,有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c 氧化酶来诱导氧化磷酸化。
T63798 EGFR-IN-32

EGFR-IN-32EGFR 的有效抑制剂。其中表皮生长因子受体 (EGFR) 的过度表达和突变已被证实会造成细胞无法控制的生长,并与大多数癌症疾病(尤其是 NSCLC )的进展有关。EGFR-IN-32EGFR 突变相关疾病表现出研究潜力 (信息来源于专利 WO2021185297A1,化合物 2)。
T61696 EGFR-IN-57

EGFR-IN-57 (Compound 25a) 是一种有效的、具有口服活性的EGFR-TK 抑制剂,IC50值为 0.054 μM。EGFR-IN-57 也抑制VEGFR-2、CK2α、topoisomerase IIβ和tubulin polymerization,IC50值分别为 0.087、0.171、0.13 和 3.61 μM。EGFR-IN-57 诱导细胞 G2/M 和 pre-G1 期周期阻滞,诱导癌细胞凋亡 (apoptosis)。
T8525 EGFR-IN-16

AG473

EGFR; FGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR-IN-16 是一种EGFR 抑制剂,对 EGFR 和 HER-2 的pIC50分别为4.85和4.74。
T64030 EGFR-IN-31

EGFR-IN-31 是 EGFR 的有效抑制剂。其中表皮生长因子受体 (EGFR) 的过度表达和突变已被证实会造成细胞无法控制的生长,且与大多数癌症疾病(尤其是 NSCLC )的进展有关。EGFR-IN-31 对 EGFR 突变相关疾病表现出研究潜能 (信息来源于专利 WO2021185298A1,化合物 2)。
T11385 Gefitinib N-oxide

Others Others
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.
T63178 EGFR-IN-39

EGFR-IN-39 是一种丙烯酰胺衍生物,是一种 EGFR 的有效抑制剂。EGFR-IN-39 是一种低毒副作用的抗肿瘤药物。其中表皮生长因子受体 (EGFR) 的过度表达和突变已被明确证实会造成细胞生长无法控制,且与大多数癌症疾病(尤其是 NSCLC)的进展有关。EGFR-IN-33 具有潜力进行 EGFR 突变相关疾病的研究 (详细信息请参考专利 WO2021185348A1,化合物 2)。
T63895 EGFR-IN-62

EGFR-IN-62EGFR 激酶的有效抑制剂,对 L858R/T790 M、WT 和 L858R/T790 M/C797S 的 IC50 值分别为10 nM、29 nM 和2 42 nM。EGFR-IN-62 可将 A549 和/或 H1975细胞周期阻滞在 G1/G0 期,并诱导凋亡和运动抑制,有效的抑制 A549 细胞 (IC50: 2.53 μM) 和 H1975 细胞 (IC50: 1.56 μM) 的增殖。
T76697 Panitumumab (anti-EGFR)

Panitumumab (anti-EGFR) 是一种全人源IgG2EGFR 单克隆抗体,具有抗肿瘤活性。Panitumumab (anti-EGFR) 抑制肿瘤细胞增殖、存活和血管生成。Panitumumab (anti-EGFR) 可用于癌症研究,例如结肠癌。
T61191 EAI001

EAI001 is a highly effective, selective allosteric inhibitor of mutant epidermal growth factor receptor (EGFR), specifically targeting EGFR L858R/T790M. With an impressive IC50 value of 24 nM, EAI001 proves to be a powerful tool in cancer research [1] [2].
T73627 Gefitinib N-oxide hydrochloride

Gefitinib N-oxide hydrochloride 是 Gefitinib 的 N-oxide 衍生物。Gefitinib 是一种有效的 (EGFR) 抑制剂,在 NR6wtEGFR 细胞中 IC50值为 2-37 nM。
T63769 EGFR-IN-60

EGFR-IN-60 是一种有效的、口服具有活力的、安全的抗肿瘤剂。EGFR-IN-60 能够明显抑制 EGFRWT (IC50: 83 nM)、EGFRT790M (IC50: 26 nM)、EGFRL858R (IC50: 53 nM) 和 JAK3 (IC50: 69 nM)。EGFR-IN-60 能够抑制携带 EGFRT790M 突变的 H1975 细胞 (IC50: 1.32 μM) ,并抑制过表达 EGFRWT 的 A431 细胞 (IC50: 4.96 μM)。EGFR-IN-60 能够提高 Bax/Bcl-2 比率,进而诱导细胞凋亡诱导并导致细胞死亡。
T35915 Erlotinib-13C6

Erlotinib-13C6

Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...
T11384 Gefitinib-d8

ZD1839 D8,Gefitinib D8

Others Others
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.
T72890 VEGFR-2-IN-30

VEGFR-2-IN-30 是一种 VEGFR-2 抑制剂 (IC50: 66 nM)。VEGFR-2-IN-30 还抑制 PDGFR、EGFR 和 FGFR1,IC50s 分别为 180、98、82 nM。VEGFR-2-IN-30 将癌细胞阻滞在 S 期并诱导早期和晚期细胞凋亡 (apoptosis)。
T74367 SC209

SC209 是个 ADC 细胞毒素,源于专利 WO2021247798, 用于合成抗 EGFR 抗体-活性分子偶联 ADC。SC209 是 STRO-002 的代谢物。
T14101 Acid-PEG3-C2-Boc

Others Others
Acid-PEG3-C2-Boc is a compound used as a linker in the synthesis of PROTACs to facilitate the degradation of EGFR and the inhibition of mTOR[1][2]. It is classified as a PEG- and alkyl/ether-based PROTAC linker.
T1181L Gefitinib hydrochloride

Gefitinib hydrochloride (ZD1839 hydrochloride) 是一种有效,选择性和具有口服活性的EGFR 酪氨酸激酶抑制剂,IC50为 33 nM。Gefitinib hydrochloride 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM),并阻断 EGF 刺激的肿瘤细胞中EGFR 自磷酸化。Gefitinib hydrochloride 也诱导细胞自噬 (autophagy),具有抗肿瘤活性。
T76890 Petosemtamab

Petosemtamab (MCLA 158) 是一种抗 EGFR(Kd: 0.22 nM) 和抗 LGR5(Kd: 0.86 nM) 单克隆抗体 (mAb)。Petosemtamab 导致 LGR5+ 癌细胞中的 EGFR 信号传导阻断和受体降解。Petosemtamab 可用于头颈部鳞状细胞癌 (HNSCC)、转移性结直肠癌 (CRC) 等实体瘤的研究。
T62621 Pan-HER-IN-2

pan-HER-IN-2 (Compound C6) 是一种口服具有活力的、可逆的广谱 HER 抑制剂,能够作用于 EGFR (IC50: 0.72 nM)、HER4 (IC50: 2.0 nM)、EGFRT790M (IC50: 8.2 nM) / L858R (IC50: 75.1 nM)。pan-HER-IN-2 可以诱导细胞凋亡 (apoptosis),具有抗肿瘤作用。
T69055 PD153035 nitrate

PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also...
T63205 HSP90-IN-13

HSP90-IN-13 (compound 5k) 是一种高效的HSP90广谱性抑制剂,IC50为 25.07 nM。HSP90-IN-13 对 EGFR、VEGFR-2 和 Topoisomerase-2 具有多靶点活性。HSP90-IN-13 将 MCF-7 细胞周期阻滞在 G2/M 期,并通过线粒体介导途径诱导细胞凋亡 (apoptosis)。
T76812 Intetumumab

Intetumumab (CNTO 95) 是一种有效的抗EGFR 单克隆抗体,是糖工程增强抗体依赖性细胞毒性 (ADCC)。Intetumumab 可用于癌症的研究。
T36102 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds.1,2,3It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.4,5
TN5100 Taspine

Akt; ERK; EGFR; MAPK; VEGFR; BCL Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful angiogenesis activity. Taspine exhibi
T35855 AAA

AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension...
T22610 BMS 599626 dihydrochloride (714971-09-2 free base)

BMS 599626 dihydrochloride

Others Others
BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor. BMS-599626 inhibited HER4 (IC50: 190 nM). In Sal2, N87, and GEO tumor cells, BMS-599626 inhibited phosphorylation of HER1 and HER2 in a dose-dependent way and inhibited cell pr
T35897 ASK120067

ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...
TMPY-03125 SHP2 Protein, Mouse, Recombinant (His Tag)

SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participat...
T37594 Pericosine A

Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable t...
T36648 Tucatinib hemiethanolate

Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-fold selective for HER2 versus EGFR in cell-based assays. Tucatinib selectively inhibits the receptor tyrosine kinase HER2 relative to EGFR[1].Tucatinib blocks proliferation and the phosphorylation of HER2 and its downstream effector, Akt in HER2 overexpressing cell lines. In the ...
T70431 TX-1123

TX-1123 是一种有效的蛋白酪氨酸激酶 (PTK) 抑制剂,针对于 Src、eEF2-K、PKA 和 EGFR-K/PKC。TX-1123 是一种环氧合酶 (COX) 抑制剂,对 COX2 和 COX1 的 IC50值分别为 1.16 μM 和 15.7 μM。TX-1123 具有低线粒体毒性。TX-1123 可用于癌症研究。
TMPY-03569 Betacellulin Protein, Human, Recombinant (hFc Tag)

Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of abou...
TMPY-06597 Betacellulin Protein, Rhesus, Recombinant (hFc Tag)

Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of abou...
TMPY-01323 Betacellulin Protein, Mouse, Recombinant (His & hFc Tag)

Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of abou...
TMPY-00008 CXCL1 Protein, Rat, Recombinant

The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol...
TMPY-00433 CXCL1 Protein, Mouse, Recombinant

The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol...
TMPY-02180 CXCL1 Protein, Human, Recombinant (His & NusA Tag)

The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol...
TMPY-02868 CXCL1 Protein, Human, Recombinant

The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized rol...

化合物

EGFR-IN-2
T11159
synonym:
Target: EGFR
EGFR/HER2-IN-2
T62776
synonym:
Target:
EGFR/HER2/TS-IN-2
T63532
synonym:
Target:
EGFR/HER2/CDK9-IN-2
T63357
synonym:
Target:
EGFR T790M/L858R-IN-2
T74833
synonym:
Target:
Mutated EGFR-IN-2
T12130
synonym:
Target: EGFR
Desmethyl Erlotinib hydrochloride
T6619
synonym: 去甲厄洛替尼,OSI-420,OSI420,CP-473420,DesMethyl Erlotinib (CP-473420) HCl,Desmethyl Erlotinib,OSI 420
Target: Drug Metabolite, EGFR
Furanodienone
T4S0544
synonym: 莪术呋喃二烯酮,呋喃二烯酮
Target: HER, Apoptosis
Nitroaspirin
T16328
synonym: 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016
Target: COX, Apoptosis
AEE788
T2116
synonym: NVP-AEE 788
Target: Apoptosis, EGFR, c-Fms, FLT, Bcr-Abl
Dovitinib lactate hydrate
T6479
synonym: 多韦替尼,Dovitinib (TKI258) Lactate,TKI258,Dovitinib Lactate
Target: VEGFR, FGFR, c-Kit, PDGFR, FLT
(-)-Epigallocatechin Gallate
T2988
synonym: (-)-表没食子儿茶素没食子酸酯,EGCG,Epigallocatechol Gallate
Target: Ferroptosis, Autophagy, Endogenous Metabolite, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism
EGFR-IN-32
T63798
synonym:
Target:
EGFR-IN-57
T61696
synonym:
Target:
EGFR-IN-16
T8525
synonym: AG473
Target: EGFR, FGFR
EGFR-IN-31
T64030
synonym:
Target:
Gefitinib N-oxide
T11385
synonym:
Target: Others
EGFR-IN-39
T63178
synonym:
Target:
EGFR-IN-62
T63895
synonym:
Target:
Panitumumab (anti-EGFR)
T76697
synonym:
Target:
EAI001
T61191
synonym:
Target:
Gefitinib N-oxide hydrochloride
T73627
synonym:
Target:
EGFR-IN-60
T63769
synonym:
Target:
Erlotinib-13C6
T35915
synonym: Erlotinib-13C6
Target:
Gefitinib-d8
T11384
synonym: ZD1839 D8,Gefitinib D8
Target: Others
VEGFR-2-IN-30
T72890
synonym:
Target:
SC209
T74367
synonym:
Target:
Acid-PEG3-C2-Boc
T14101
synonym:
Target: Others
Gefitinib hydrochloride
T1181L
synonym:
Target:
Petosemtamab
T76890
synonym:
Target:
pan-HER-IN-2
T62621
synonym:
Target:
PD153035 nitrate
T69055
synonym:
Target:
HSP90-IN-13
T63205
synonym:
Target:
Intetumumab
T76812
synonym:
Target:
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
T36102
synonym:
Target:
Taspine
TN5100
synonym:
Target: Akt, ERK, EGFR, MAPK, VEGFR, BCL
AAA
T35855
synonym:
Target:
BMS 599626 dihydrochloride (714971-09-2 free base)
T22610
synonym: BMS 599626 dihydrochloride
Target: Others
ASK120067
T35897
synonym:
Target:
SHP2 Protein, Mouse, Recombinant (His Tag)
TMPY-03125
synonym:
Target:
Pericosine A
T37594
synonym:
Target:
Tucatinib hemiethanolate
T36648
synonym:
Target:
TX-1123
T70431
synonym:
Target:
Betacellulin Protein, Human, Recombinant (hFc Tag)
TMPY-03569
synonym:
Target:
Betacellulin Protein, Rhesus, Recombinant (hFc Tag)
TMPY-06597
synonym:
Target:
Betacellulin Protein, Mouse, Recombinant (His & hFc Tag)
TMPY-01323
synonym:
Target:
CXCL1 Protein, Rat, Recombinant
TMPY-00008
synonym:
Target:
CXCL1 Protein, Mouse, Recombinant
TMPY-00433
synonym:
Target:
CXCL1 Protein, Human, Recombinant (His & NusA Tag)
TMPY-02180
synonym:
Target:
CXCL1 Protein, Human, Recombinant
TMPY-02868
synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4S0544 Furanodienone

莪术呋喃二烯酮,呋喃二烯酮

HER; Apoptosis Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Furanodienone 是来源于姜黄根茎的一种主要生物活性成分,可诱导细胞凋亡。
T2988 (-)-Epigallocatechin Gallate

(-)-表没食子儿茶素没食子酸酯,EGCG,Epigallocatechol Gallate

Ferroptosis; Autophagy; Endogenous Metabolite; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism Apoptosis; Autophagy; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
(-)-Epigallocatechin Gallate 是茶类黄酮,具有强大的抗氧化,抗炎和抗癌作用。它可抑制EGFR 信号传导,有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c 氧化酶来诱导氧化磷酸化。
TN5100 Taspine

Akt; ERK; EGFR; MAPK; VEGFR; BCL Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful angiogenesis activity. Taspine exhibi

天然产物

Furanodienone
T4S0544
synonym: 莪术呋喃二烯酮,呋喃二烯酮
Target: HER, Apoptosis
(-)-Epigallocatechin Gallate
T2988
synonym: (-)-表没食子儿茶素没食子酸酯,EGCG,Epigallocatechol Gallate
Target: Ferroptosis, Autophagy, Endogenous Metabolite, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism
Taspine
TN5100
synonym:
Target: Akt, ERK, EGFR, MAPK, VEGFR, BCL
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