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Targets Recommended: EGFR

48

抑制剂 & 化合物

3

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302

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Cat. No. Product Name
L9410 共价抑制剂库

1920 compounds
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发;
L2191 抗乳腺癌化合物库

1939 compounds
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究;

化合物库

共价抑制剂库
Cat.No: L9410
Compounds: 1920
抗乳腺癌化合物库
Cat.No: L2191
Compounds: 1939
Cat. No. Product Name Target Signaling Pathways
T11159 EGFR-IN-2

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.
T12130 Mutated EGFR-IN-2

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.
T79393 ALK/EGFR-IN-2

Others Others
ALK/EGFR-IN-2 是一种高效的 ALK 和 EGFR 双重抑制剂,能够诱导癌细胞凋亡及 G0/G1 细胞周期停滞。此化合物在 H1975、PC9 和 Baf3-EML4-ALK 癌熙胞株的增殖抑制实验中,其 IC50 值分别为0.0034、0.0065 和 0.0018 μM,表明其对这些癌熙胞系具有显著的抑制作用。
T79727 EGFR/CDK2-IN-2

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR/CDK2-IN-2(compound 6a)是一种针对EGFR和CDK-2的双重抑制剂,具有19.6 nM和87.9 nM的IC50s。该化合物能在MCF-7细胞内诱导凋亡,并在S期引发细胞周期停滞。此外,EGFR/CDK2-IN-2展现出IC50为0.39 μM的显著抗癌活性,对MCF-7细胞具有强效的细胞毒性。
T78849 EGFR/BRAFV600E-IN-2

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
E07 aptamer是靶向人表皮生长因子受体(hEGFR)的适配体,能与EGF竞争性结合至EGFR的新表位。该适配体与表达hEGFR的细胞互作,阻断受体自磷酸化作用,抑制肿瘤细胞在三维基质中的增殖,适用于肿瘤病理研究。
T62776 EGFR/HER2-IN-2

Others Others
EGFR/HER2-IN-2 (Compound ZINC35560729) 是一种 EGFR 和 HER2 双重抑制剂,作用于 EGFR (IC50: 5.02 μM) 和 HER2 (IC50: 0.83 μM)。
T63357 EGFR/HER2/CDK9-IN-2

Others Others
EGFR/HER2/CDK9-IN-2EGFR/HER2/CDK9 的有效抑制剂,他们的 IC50s 值分别为 145.35、129.07 和 117.13 nM,表现出明显的抗肿瘤作用。
T74833 EGFR T790M/L858R-IN-2

Others Others
EGFRT790M/L858R-IN-2是一种有效选择性的EGFRT790M/L858R抑制剂,其对EGFRT790M/L858R和EGFRWT的IC50值分别为3.5nM和1290nM。该化合物能够降低p-EGFR、P-AKT、P-ERK1/2的表达,诱导细胞凋亡及细胞周期在G1期的停滞,显示出抗癌活性。
T63532 EGFR/HER2/TS-IN-2

Others Others
EGFR/HER2/TS-IN-2EGFR (IC50: 0.173 μM)、HER2 (IC50: 0.125 μM) 和 TS (IC50: 1.12 μM) 的有效抑制剂。EGFR/HER2/TS-IN-2 对 MDA-MB-231 癌细胞表现出细胞毒性作用 (IC50: 1.69 μM)。
T82493 EGFR/HER2/DHFR-IN-2

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR/HER2/DHFR-IN-2 (Compound 4b) 是针对EGFR、HER2和DHFR的三重抑制剂,IC50分别为0.248、0.156、0.138 μM。该化合物对包括Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7在内的多种癌细胞系展现出显著的抗癌活性(IC50分别为9.14、7.33、14.18、24.87、20.07、6.16 μM),并能有效减缓乳腺癌肿瘤的生长。
T6619 Desmethyl Erlotinib hydrochloride

OSI420,OSI-420,DesMethyl Erlotinib (CP-473420) HCl,去甲厄洛替尼,CP-473420,Desmethyl Erlotinib,OSI 420

EGFR; Drug Metabolite Angiogenesis; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
Desmethyl Erlotinib hydrochloride (OSI 420) 是 Erlotinib 的活性代谢物。Erlotinib 是 EGFR 酪氨酸激酶抑制剂。
T5475 ZD-4190

EGFR; VEGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
ZD-4190 是血管内皮细胞生长因子受体 2 (VEGFR2) 和表皮生长因子受体 (EGFR) 信号传导的抑制剂,用于治疗癌症。
T0373 Erlotinib

OSI-744,NSC 718781,CP358774,埃罗替尼,R1415

EGFR; Autophagy Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Erlotinib (CP358774) 是一种 EGFR 一代抑制剂,抑制 EGFR 19 Del 和 L858R 突变。Erlotinib 具有抗肿瘤活性,用于治疗 EGFR 突变的非小细胞肺癌。Erlotinib 用药会产生 EGFR C797S 耐药突变。
T34973 Tyrphostin 8

4-Hydroxybenzylidenemalononitrile

EGFR; GTPase Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) 是一种有效的 GTP 酶抑制剂,对 EGFR 激酶有抑制作用, IC50 值为 560 μM。Tyrphostin 8 可抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM),增强 Caco-2 细胞中转铁蛋白受体介导的转吞作用,并增加口服胰岛素 - 转铁蛋白的降血糖作用。
T16328 Nitroaspirin

2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016

Apoptosis; COX Apoptosis; Immunology/Inflammation; Neuroscience
Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物,与 Aspirin 结合可抑制环氧合酶=,可作为 COX-1 的直接和不可逆抑制剂。 它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白,显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡,具有抗血栓和抗血小板特性。
T2116 AEE788

NVP-AEE 788

Apoptosis; EGFR; c-Fms; FLT; Bcr-Abl Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors
AEE788 (NVP-AEE 788)是EGFR 和ErbB2的抑制剂,IC50值分别为2和6 nM。它已用于研究癌症、多形性胶质母细胞瘤以及脑和中枢神经系统肿瘤治疗的试验。
T78940 EGFR-IN-78

Apoptosis Apoptosis
EGFR-IN-78(compound A5)为2-氨基嘧啶衍生物,既是EGFRC797S-TK的可逆抑制剂,也能诱导细胞凋亡(apoptosis)。该化合物展现抗增殖能力,阻止EGFR磷酸化,导致细胞周期在G2/M期暂停。
T79729 EGFR/CDK2-IN-4

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR/CDK2-IN-4(化合物4c)是一种EGFR与CDK-2的双重抑制剂,其IC50值分别为89.6 nM和165.4 nM。该化合物在MCF-7细胞中能诱导(apoptosis)凋亡,并导致细胞周期在S期停滞。EGFR/CDK2-IN-4显示出显著的抗癌细胞毒性,对MCF-7细胞的IC50为2.74 μM。
T8525 EGFR-IN-16

AG473

EGFR; FGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR-IN-16 (AG473) 是一种EGFR 抑制剂,对 EGFR 和 HER-2 的pIC50分别为4.85和4.74。
T73627 Gefitinib N-oxide hydrochloride

Others Others
Gefitinib N-oxide hydrochloride 是 Gefitinib 的 N-oxide 衍生物。Gefitinib 是一种有效的 (EGFR) 抑制剂,在 NR6wtEGFR 细胞中 IC50值为 2-37 nM。
T11385 Gefitinib N-oxide

Others Others
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.
T61696 EGFR-IN-57

Others Others
EGFR-IN-57 (Compound 25a) 是一种有效的、具有口服活性的EGFR-TK 抑制剂,IC50值为 0.054 μM。EGFR-IN-57 也抑制VEGFR-2、CK2α、topoisomerase IIβ和tubulin polymerization,IC50值分别为 0.087、0.171、0.13 和 3.61 μM。EGFR-IN-57 诱导细胞 G2/M 和 pre-G1 期周期阻滞,诱导癌细胞凋亡 (apoptosis)。
T74561 JBJ-09-063 TFA

Others Others
JBJ-09-063 TFA 是一种突变选择性变构EGFR 抑制剂,对EGFRL858R、EGFR L858R/T790M、EGFR L858R/T790M/C797S 和 EGFRLT/L747S 的IC50分别为 0.147 nM、0.063 nM、0.083 nM 和 0.396 nM。JBJ-09-063 TFA 有效降低 EGFR、Akt 和 ERK1/2 磷酸化。JBJ-09-063 TFA 对EGFR 酪氨酸激酶抑制剂 (TKI) 敏感和耐药模型均有效。JBJ-09-063 TFA 可用于EGFR 突变型肺癌研究。
T63769 EGFR-IN-60

Others Others
EGFR-IN-60 是一种有效的、口服具有活力的、安全的抗肿瘤剂。EGFR-IN-60 能够明显抑制 EGFRWT (IC50: 83 nM)、EGFRT790M (IC50: 26 nM)、EGFRL858R (IC50: 53 nM) 和 JAK3 (IC50: 69 nM)。EGFR-IN-60 能够抑制携带 EGFRT790M 突变的 H1975 细胞 (IC50: 1.32 μM) ,并抑制过表达 EGFRWT 的 A431 细胞 (IC50: 4.96 μM)。EGFR-IN-60 能够提高 Bax/Bcl-2 比率,进而诱导细胞凋亡诱导并导致细胞死亡。
T63895 EGFR-IN-62

Others Others
EGFR-IN-62EGFR 激酶的有效抑制剂,对 L858R/T790 M、WT 和 L858R/T790 M/C797S 的 IC50 值分别为10 nM、29 nM 和2 42 nM。EGFR-IN-62 可将 A549 和/或 H1975细胞周期阻滞在 G1/G0 期,并诱导凋亡和运动抑制,有效的抑制 A549 细胞 (IC50: 2.53 μM) 和 H1975 细胞 (IC50: 1.56 μM) 的增殖。
T77073 Losatuxizumab

Losatuxizumab (ABT-806) 是一种抗EGFR 单克隆抗体。Losatuxizumab 可结合EGFREGFR 野生型 EC50为 0.96 nM,EGFRC271A, C283A 为 0.09 nM,EGFRvIII 为 0.12 nM,EGFR1-501 为 0.66 nM。Losatuxizumab 可用于研究表达EGFR 的癌症。
T72237 JBJ-09-063 hydrochloride

Others Others
JBJ-09-063 hydrochloride 是一种突变选择性变构EGFR 抑制剂,对EGFRL858R、EGFR L858R/T790M、EGFR L858R/T790M/C797S 和 EGFRLT/L747S 的IC50分别为 0.147 nM、0.063 nM、0.083 nM 和 0.396 nM。JBJ-09-063 hydrochloride 有效降低 EGFR、Akt 和 ERK1/2 磷酸化。JBJ-09-063 hydrochloride 对EGFR 酪氨酸激酶抑制剂 (TKI) 敏感和耐药模型均有效。JBJ-09-063 hydrochloride 可用于EGFR 突变型肺癌研究。
T76697 Panitumumab (anti-EGFR)

Panitumumab (anti-EGFR) 是一种全人源IgG2EGFR 单克隆抗体,具有抗肿瘤活性。Panitumumab (anti-EGFR) 抑制肿瘤细胞增殖、存活和血管生成。Panitumumab (anti-EGFR) 可用于癌症研究,例如结肠癌。
T63939 JBJ-09-063

Others Others
JBJ-09-063 是一种突变选择性变构 EGFR 抑制剂,对 EGFRL858R、EGFR L858R/T790M、EGFR L858R/T790M/C797S 和 EGFRLT/L747S 的 IC50分别为 0.147 nM、0.063 nM、0.083 nM 和 0.396 nM。JBJ-09-063 有效降低 EGFR、Akt 和 ERK1/2 磷酸化。JBJ-09-063 对EGFR 酪氨酸激酶抑制剂 (TKI) 敏感与耐药模型均有效。JBJ-09-063 可用于EGFR 突变型肺癌研究。
T74367 SC209

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
SC209 是个 ADC 细胞毒素, 用于合成抗 EGFR 抗体-活性分子偶联 ADC。SC209 是 STRO-002 的代谢物。
T1181L Gefitinib hydrochloride

Others Others
Gefitinib hydrochloride (ZD1839 hydrochloride) 是一种有效,选择性和具有口服活性的EGFR 酪氨酸激酶抑制剂,IC50为 33 nM。Gefitinib hydrochloride 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM),并阻断 EGF 刺激的肿瘤细胞中EGFR 自磷酸化。Gefitinib hydrochloride 也诱导细胞自噬 (autophagy),具有抗肿瘤活性。
T79728 EGFR/CDK2-IN-3

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EGFR/CDK2-IN-3(compound 4b)是一种针对EGFR与CDK-2的双重抑制剂,分别具有71.7 nM和113.7 nM的IC50s。该化合物在MCF-7细胞中能诱导凋亡,导致细胞周期在S期停滞,并显示出对癌细胞的明显毒性,其对MCF-7细胞的IC50值为3.16 μM。
T76812 Intetumumab

Intetumumab (CNTO 95) 是一种有效的抗EGFR 单克隆抗体,是糖工程增强抗体依赖性细胞毒性 (ADCC)。Intetumumab 可用于癌症的研究。
T69055 PD153035 nitrate

Others Others
PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also...
T14101 Acid-PEG3-C2-Boc

Others Others
Acid-PEG3-C2-Boc is a compound used as a linker in the synthesis of PROTACs to facilitate the degradation of EGFR and the inhibition of mTOR[1][2]. It is classified as a PEG- and alkyl/ether-based PROTAC linker.
T36102 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Others Others
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds.1,2,3It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.4,5
T62621 pan-HER-IN-2

Others Others
pan-HER-IN-2 (Compound C6) 是一种口服具有活力的、可逆的广谱 HER 抑制剂,能够作用于 EGFR (IC50: 0.72 nM)、HER4 (IC50: 2.0 nM)、EGFRT790M (IC50: 8.2 nM) / L858R (IC50: 75.1 nM)。pan-HER-IN-2 可以诱导细胞凋亡 (apoptosis),具有抗肿瘤作用。
T72890 VEGFR-2-IN-30

Others Others
VEGFR-2-IN-30为一种针对VEGFR-2的抑制剂(IC50:66 nM),同时对PDGFR、EGFR及FGFR1亦有一定抑制作用,其IC50s分别为180、98、82 nM。此外,VEGFR-2-IN-30能够阻止癌细胞在S期的进展并诱导早期以及晚期的细胞凋亡(apoptosis)。
T63205 HSP90-IN-13

Others Others
HSP90-IN-13(compound 5k)是一种有效的HSP90抑制剂,具有25.07 nM的IC50值,并对EGFR、VEGFR-2以及Topoisomerase-2展现出多靶点作用。此外,HSP90-IN-13能够在G2/M期阻滞MCF-7细胞周期,并通过线粒体途径诱导细胞凋亡(apoptosis)。
T9901A-024 Laprituximab emtansine

J2898A-SMCC-DM1,IMGN-289

Others Others
Laprituximab emtansine (IMGN-289) 为针对HER1的免疫毒素,属于EGFR抗体-药物偶联物(ADC),组成包括J2898A抗体、DM1(抗微管剂)及SMCC硫醚连接子。该化合物主要应用于癌症研究领域。
T79572 MAPK-IN-2

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
MAPK-IN-2 (化合物3h)是一种携带抗肿瘤活性的高效MAPK抑制剂。它在多个癌细胞系中有效抑制了细胞增殖,并对MAPK途径表现出强大的抑制效果(EGFRWT IC50=281 nM, c-MET IC50=205 nM, B-RAFWT IC50=112 nM, CDK4/6 IC50=95和184 nM),对突变型EGFR和B-RAF亦展现出高效力(EGFRT790M IC50=69 nM, B-RAFV600E IC50=83 nM)。
T35897 ASK120067

Others Others
ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...
T35855 AAA

Others Others
AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension...
T79714 HDAC3-IN-2

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
HDAC3-IN-2 (compound 4i) 是一种具有纳摩尔级效力的吡嗪酰肼基HDAC3抑制剂,IC50值为14 nM,针对三阴性乳腺癌细胞表现出高效抑制作用。该化合物在细胞内毒性测定中显示,对4T1细胞株的IC50为0.55 μM,对MDA-MB-231细胞株的IC50为0.74 μM。HDAC3-IN-2通过增加乙酰化水平(如H3K9、H3K27和H4K12),促进细胞凋亡(涉及caspase-3、caspase-7和细胞色素c的水平提升),并抑制细胞增殖相关蛋白(如Bcl-2、CD44、EGFR和Ki-67)的表达,从而在荷瘤小鼠模型中表现出显著的体内抗肿瘤作用。
T81739 Multi-target kinase inhibitor 2

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Multi-target kinase inhibitor 2 (compound 5K) 作为一种multi-targeted kinase抑制剂,对EGFR、Her2、VEGFR2和CDK2酶表现出强效活性,IC50值在40至204 nM之间。此化合物对包括HepG2、HeLa、MDA-MB-231 和 MCF-7在内的多种细胞系均显示出显著的细胞毒性,其IC50值分别为41、57、51 和 59 μM。此外,Multi-target kinase inhibitor 2 还能诱导HepG2细胞发生周期阻滞和凋亡 (apoptosis)。
T76721 Zalutumumab

Zalutumumab 是一种高亲和力的纯人类IgG1单克隆抗体,靶向EGFR。Zalutumumab 与表皮生长因子受体的结构域 III 结合,通过阻断表皮生长因子的结合和干扰受体的活性构象发挥作用。Zalutumumab 与IgG 及其 Fab 区段的EC50值分别为 7 和 19 nM。Zalutumumab 可用于癌症的研究。
T37594 Pericosine A

Others Others
Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable t...
T83911 CYY292

Others Others
CYY292是一种针对PDGFRα、PDGFRβ、FGFR1、-2和-3的抑制剂(IC50分别为5.35、4.6、28、28和78 nM)。该化合物对这些激酶的选择性高于FGFR4(IC50 > 1,000 nM),但也能抑制c-Kit、VEGFR2、VEGFR1和胰岛素样生长因子1受体(IGF-1R;IC50分别为67、33、36和75 nM),以及EGFR、布鲁顿酪氨酸激酶(BTK)、细胞周期依赖性激酶4(Cdk4)/cyclin D3和MET(IC50分别为128、198、214和396 nM)。CYY292抑制MG-63、U2OS、MNNG/HOS和Saos-2骨肉瘤细胞的增殖(IC50分别为0.84、0.76、1.36和0.72 µM)。在0.3和0.5 µM的浓度下,它抑制U87MG和LN-229胶质母细胞瘤细胞的迁移和侵袭。CYY292(30 mg/kg)在U87MG原位小鼠异种移植模型中降低肿瘤体积并增加生存率。

化合物

EGFR-IN-2
Cat.No: T11159
Synonym:
Target: EGFR
Mutated EGFR-IN-2
Cat.No: T12130
Synonym:
Target: EGFR
ALK/EGFR-IN-2
Cat.No: T79393
Synonym:
Target: Others
EGFR/CDK2-IN-2
Cat.No: T79727
Synonym:
Target: EGFR
EGFR/BRAFV600E-IN-2
Cat.No: T78849
Synonym:
Target: EGFR
EGFR/HER2-IN-2
Cat.No: T62776
Synonym:
Target: Others
EGFR/HER2/CDK9-IN-2
Cat.No: T63357
Synonym:
Target: Others
EGFR T790M/L858R-IN-2
Cat.No: T74833
Synonym:
Target: Others
EGFR/HER2/TS-IN-2
Cat.No: T63532
Synonym:
Target: Others
EGFR/HER2/DHFR-IN-2
Cat.No: T82493
Synonym:
Target: EGFR
Desmethyl Erlotinib hydrochloride
Cat.No: T6619
Synonym: OSI420,OSI-420,DesMethyl Erlotinib (CP-473420) HCl,去甲厄洛替尼,CP-473420,Desmethyl Erlotinib,OSI 420
Target: EGFR, Drug Metabolite
ZD-4190
Cat.No: T5475
Synonym:
Target: EGFR, VEGFR
Erlotinib
Cat.No: T0373
Synonym: OSI-744,NSC 718781,CP358774,埃罗替尼,R1415
Target: EGFR, Autophagy
Tyrphostin 8
Cat.No: T34973
Synonym: 4-Hydroxybenzylidenemalononitrile
Target: EGFR, GTPase
Nitroaspirin
Cat.No: T16328
Synonym: 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016
Target: Apoptosis, COX
AEE788
Cat.No: T2116
Synonym: NVP-AEE 788
Target: Apoptosis, EGFR, c-Fms, FLT, Bcr-Abl
EGFR-IN-78
Cat.No: T78940
Synonym:
Target: Apoptosis
EGFR/CDK2-IN-4
Cat.No: T79729
Synonym:
Target: EGFR
EGFR-IN-16
Cat.No: T8525
Synonym: AG473
Target: EGFR, FGFR
Gefitinib N-oxide hydrochloride
Cat.No: T73627
Synonym:
Target: Others
Gefitinib N-oxide
Cat.No: T11385
Synonym:
Target: Others
EGFR-IN-57
Cat.No: T61696
Synonym:
Target: Others
JBJ-09-063 TFA
Cat.No: T74561
Synonym:
Target: Others
EGFR-IN-60
Cat.No: T63769
Synonym:
Target: Others
EGFR-IN-62
Cat.No: T63895
Synonym:
Target: Others
Losatuxizumab
Cat.No: T77073
Synonym:
Target:
JBJ-09-063 hydrochloride
Cat.No: T72237
Synonym:
Target: Others
Panitumumab (anti-EGFR)
Cat.No: T76697
Synonym:
Target:
JBJ-09-063
Cat.No: T63939
Synonym:
Target: Others
SC209
Cat.No: T74367
Synonym:
Target: Others, ADC Cytotoxin
Gefitinib hydrochloride
Cat.No: T1181L
Synonym:
Target: Others
EGFR/CDK2-IN-3
Cat.No: T79728
Synonym:
Target: EGFR
Intetumumab
Cat.No: T76812
Synonym:
Target:
PD153035 nitrate
Cat.No: T69055
Synonym:
Target: Others
Acid-PEG3-C2-Boc
Cat.No: T14101
Synonym:
Target: Others
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
Cat.No: T36102
Synonym:
Target: Others
pan-HER-IN-2
Cat.No: T62621
Synonym:
Target: Others
VEGFR-2-IN-30
Cat.No: T72890
Synonym:
Target: Others
HSP90-IN-13
Cat.No: T63205
Synonym:
Target: Others
Laprituximab emtansine
Cat.No: T9901A-024
Synonym: J2898A-SMCC-DM1,IMGN-289
Target: Others
MAPK-IN-2
Cat.No: T79572
Synonym:
Target: EGFR
ASK120067
Cat.No: T35897
Synonym:
Target: Others
AAA
Cat.No: T35855
Synonym:
Target: Others
HDAC3-IN-2
Cat.No: T79714
Synonym:
Target: HDAC
Multi-target kinase inhibitor 2
Cat.No: T81739
Synonym:
Target: EGFR
Zalutumumab
Cat.No: T76721
Synonym:
Target:
Pericosine A
Cat.No: T37594
Synonym:
Target: Others
CYY292
Cat.No: T83911
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T4S0544 Furanodienone

呋喃二烯酮,莪术呋喃二烯酮

Apoptosis; HER Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Furanodienone 是来源于姜黄根茎的一种主要生物活性成分,可诱导细胞凋亡。
T2988 (-)-Epigallocatechin Gallate

Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG

Ferroptosis; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite; Autophagy Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
(-)-Epigallocatechin Gallate (EGCG) 属于茶类黄酮天然产物,可抑制 EGFR 信号传导,抑制 GLUD 1/2。(-)-Epigallocatechin Gallate 具有抗氧化、抗炎和抗肿瘤活性。(-)-Epigallocatechin Gallate 可以通过激活细胞色素 c 氧化酶来诱导氧化磷酸化。
TN5100 Taspine

ERK; EGFR; BCL; VEGFR; MAPK; Akt Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful angiogenesis activity. Taspine exhibi

天然产物

Furanodienone
Cat.No: T4S0544
Synonym: 呋喃二烯酮,莪术呋喃二烯酮
Target: Apoptosis, HER
(-)-Epigallocatechin Gallate
Cat.No: T2988
Synonym: Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG
Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy
Taspine
Cat.No: TN5100
Synonym:
Target: ERK, EGFR, BCL, VEGFR, MAPK, Akt
Cat. No. Product Name Species Expression System
TMPH-00963 Ataxin-2 Protein, Human, Recombinant (His)

TNRC13,ATX2,ATXN2,Ataxin-2

Human E. coli
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. Ataxin-2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.0 kDa and the accession number is Q99700.
TMPY-03125 SHP-2 Protein, Mouse, Recombinant (His)

SAP-2,Syp,PTP1D,SH-PTP2,SH-PTP3,SHP-2<...

Mouse HEK293 Cells
SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participat...
TMPK-00691 EGFRVIII Protein, Human, Recombinant (His & Avi)

EGFR,ErbB,mENA,HER1,LEGFR,EC 2.7....

Human HEK293 Cells
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi) is expressed in HEK2...
TMPK-00689 EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled

EC 2.7.10.1,EC 2.7.10,ERBB1,EGFR,...

Human HEK293 Cells
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled is expre...
TMPK-00690 EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled

LEGFR,ERBB1,EGFR,HER1,PIG61,NISBD2

Human HEK293 Cells
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled is exp...
TMPK-00692 EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated

EC 2.7.10.1,PIG61,NISBD2,HER1,mENA,LEG...

Human HEK293 Cells
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated is exp...
TMPH-02907 Sialidase-3 Protein, Mouse, Recombinant (His)

Neu3,Membrane sialidase,Ganglioside sialidase,N-acetyl-alpha...

Mouse E. coli
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with sig...
TMPH-01952 SPRY2 Protein, Human, Recombinant (His & Myc)

Protein sprouty homolog 2,SPRY2

Human E. coli
Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination. SPRY2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expressio...
TMPJ-01050 GRB2 Protein, Human, Recombinant (His)

Growth Factor Receptor-Bound Protein 2,SH<...

Human E. coli
As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted acti...
TMPJ-01286 proHB-EGF Protein, Human, Recombinant (His)

heparin-binding EGF-like growth f...

Human HEK293 Cells
Heparin-binding EGF-like growth factor (HB-EGF) is a 12­16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF­like domain, and a heparin-binding motif. Mature HB­EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB­EGF shows 76% and 73% aa sequence identity with rat and mouse HB­EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may b...
TMPY-00891 Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)

neuropilin 1,VEGF165R,CD304,NP1,Neuropilin...

Human HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2.
TMPY-02096 TACI Protein, Human, Recombinant (His)

RYZN,IGAD2,CVID,TACI,TNFRSF14B,CVID2,tumor...

Human HEK293 Cells
TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2.
TMPY-04113 KRAS Protein,Human,Recombinant(G12D & Q61H, His)

Kirsten rat sarcoma viral oncogene homolog,KRAS2,KI...

Human E. coli
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPY-02011 CD96 Protein, Human, Recombinant (His)

CD96 molecule,TACTILE

Human HEK293 Cells
CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2.
TMPY-01442 DMBT1 Protein, Human, Recombinant (His)

GP340,deleted in malignant brain tumors 1,...

Human HEK293 Cells
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo...
TMPY-01717 VEGF164 Protein, Mouse, Recombinant

vascular endothelial growth factor A,Vpf,Vegf,血管内皮生长因子

Mouse Baculovirus Insect Cells
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2.
TMPY-00341 FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

CEK2,HSFGFR3EX,fibroblast growth factor receptor 3,...

Human HEK293 Cells
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.
TMPY-01613 Periostin/OSF-2 Protein, Mouse, Recombinant (His)

A630052E07Rik,OSF-2,Osf2,PLF,AI74...

Mouse HEK293 Cells
Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2.
TMPJ-00850 ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)

Protein T1,suppression of tumorigenicity 2...

Mouse HEK293 Cells
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2.
TMPY-01691 Clusterin Protein, Human, Recombinant (CLU34, His)

SGP-2,AAG4,KUB1,CLI,CLU2,TRPM2,AP...

Human HEK293 Cells
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2.
TMPY-00751 TrkB Protein, Human, Recombinant (His)

trk-B,GP145-TrkB/GP95-TrkB,neurotrophic tyrosine k<...

Human HEK293 Cells
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
TMPY-05288 PLGF/PGF Protein, Human, Recombinant (aa 19-149)

PLGF,PGFL,placental growth factor,D12S1900,SHGC-107...

Human E. coli
PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2.
TMPY-04844 BTN3A1 Protein, Human, Recombinant (His)

BTN3.1,butyrophilin subfamily 3 member A1,BTF5,BT3....

Human HEK293 Cells
BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2.
TMPY-06056 KRAS Protein, Human, Recombinant (G12D, His)

KRAS1,K-RAS4B,Kirsten rat sarcoma viral oncogene homolog,RAL...

Human E. coli
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2.
TMPY-02820 SDF-1/CXCL12 Protein, Human, Recombinant (isoform a)

SDF1,chemokine (C-X-C motif) ligand 12,IRH...

Human E. coli
SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST)

v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosi...

Human Baculovirus Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...
TMPY-01935 c-Kit Protein, Human, Recombinant (His)

PBT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma vi...

Human HEK293 Cells
c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
TMPY-04644 PDGFB Protein, Human, Recombinant (His)

platelet-derived growth factor beta polypeptide,SSV,c-sis,SI...

Human P. pastoris (Yeast)
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted...
TMPY-04356 GSK3B Protein, Human, Recombinant (His)

glycogen synthase kinase 3 beta,glycogen synthase k...

Human Baculovirus Insect Cells
GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2.
TMPY-01985 CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated

FCGR2,FCGR21,CD32A,FCG2,...

Human HEK293 Cells
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2.
TMPY-02500 YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)

Gp39,AW208766,Brp39,chitinase 3 like 1

Mouse HEK293 Cells
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2.
TMPY-05414 NKG2D/CD314 Protein, Mouse, Recombinant (hFc)

D6H12S2489E,NKG2-D,killer cell le...

Mouse Baculovirus Insect Cells
NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2.
TMPY-01871 IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)

interleukin 5 receptor, alpha,IL5R,CD1...

Human HEK293 Cells
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2.
TMPY-02792 GDNF Protein, Human, Recombinant (HEK293)

HSCR3,ATF2,HFB1-GDNF,ATF1,glial cell derived neurot...

Human HEK293 Cells
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
TMPY-01359 ST2/IL-1 RL1 Protein, Human, Recombinant (His)

IL1RL1,IL‑1 R4,DER4,ST2,IL33R,interleuk

Human HEK293 Cells
ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2.
TMPY-01888 KRAS Protein,Human, Recombinant (Q61H, His)

KRAS2,C-K-RAS,Kirsten rat sarcoma viral oncogene ho...

Human E. coli
KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2.
TMPY-00747 Nectin-2 Protein, Human, Recombinant (His)

PVRR2,Nectin-2,poliovirus recepto...

Human HEK293 Cells
Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
TMPY-04051 c-Kit Protein, Human, Recombinant (hFc)

SCFR,v-kit Hardy-Zuckerman 4 feline sarcoma viral o...

Human HEK293 Cells
c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is P10721-2.
TMPY-05427 CD19 Protein, Human, Recombinant (hFc)

CVID3,B4,CD19 molecule

Human HEK293 Cells
CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2.
TMPJ-00335 TGFBR2 Protein, Mouse, Recombinant (His)

TGFR-2,TGF-beta type II receptor,Transformin

Mouse HEK293 Cells
TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
TMPY-00127 M-CSF/CSF1 Protein, Human, Recombinant

集落刺激因子,CSF-1,MCSF,M-CSF,colony stimulating factor 1...

Human HEK293 Cells
M-CSF/CSF1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.4 kDa and the accession number is P09603-2.
TMPY-04116 KRAS Protein,Human,Recombinant(G12C & Q61H, His)

NS,CFC2,K-RAS4B,C-K-RAS,KRAS2,K-RAS2

Human E. coli
KRAS Protein,Human,Recombinant(G12C & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPY-02231 TrkB Protein, Mouse, Recombinant (His)

trk-B,neurotrophic tyrosine kinase, recept...

Mouse HEK293 Cells
TrkB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is P15209-2.
TMPY-02432 VEGF164 Protein, Rat, Recombinant

血管内皮生长因子,vascular endothelial growth factor A

Rat Baculovirus Insect Cells
VEGF164 Protein, Rat, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is P16612-2.
TMPY-00850 ST2/IL-1 RL1 Protein, Human, Recombinant

ST2,IL1RL1,ST2L,IL33R,T1,DER4,ST2...

Human HEK293 Cells
ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2.
TMPY-02367 Neuropilin-1 Protein, Human, Recombinant (isoform b, His)

neuropilin 1,NRP,VEGF165R,BDCA4,Neuropilin...

Human HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2.
TMPY-00849 ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)

ST2V,FIT-1,DER4,interleukin 1 rec...

Human HEK293 Cells
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2.
TMPY-04829 G-CSF Protein, Human, Recombinant

G-CSF,colony stimulating factor 3 (granulocyte),集落刺...

Human HEK293 Cells
G-CSF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.7 kDa and the accession number is P09919-2.
TMPY-00871 LAYN Protein, Human, Recombinant (hFc)

layilin

Human HEK293 Cells
LAYN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.5 kDa and the accession number is Q6UX15-2.
TMPY-01199 CD74 Protein, Human, Recombinant (His)

II,DHLAG,Ia-GAMMA,CD74 molecule, major histocompatibility co...

Human HEK293 Cells
CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2.
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重组蛋白

Ataxin-2 Protein, Human, Recombinant (His)
Cat.No: TMPH-00963
Species: Human
Expression System: E. coli
SHP-2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03125
Species: Mouse
Expression System: HEK293 Cells
EGFRVIII Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00691
Species: Human
Expression System: HEK293 Cells
EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
Cat.No: TMPK-00689
Species: Human
Expression System: HEK293 Cells
EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled
Cat.No: TMPK-00690
Species: Human
Expression System: HEK293 Cells
EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00692
Species: Human
Expression System: HEK293 Cells
Sialidase-3 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02907
Species: Mouse
Expression System: E. coli
SPRY2 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01952
Species: Human
Expression System: E. coli
GRB2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01050
Species: Human
Expression System: E. coli
proHB-EGF Protein, Human, Recombinant (His)
Cat.No: TMPJ-01286
Species: Human
Expression System: HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
Cat.No: TMPY-00891
Species: Human
Expression System: HEK293 Cells
TACI Protein, Human, Recombinant (His)
Cat.No: TMPY-02096
Species: Human
Expression System: HEK293 Cells
KRAS Protein,Human,Recombinant(G12D & Q61H, His)
Cat.No: TMPY-04113
Species: Human
Expression System: E. coli
CD96 Protein, Human, Recombinant (His)
Cat.No: TMPY-02011
Species: Human
Expression System: HEK293 Cells
DMBT1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01442
Species: Human
Expression System: HEK293 Cells
VEGF164 Protein, Mouse, Recombinant
Cat.No: TMPY-01717
Species: Mouse
Expression System: Baculovirus Insect Cells
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
Cat.No: TMPY-00341
Species: Human
Expression System: HEK293 Cells
Periostin/OSF-2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01613
Species: Mouse
Expression System: HEK293 Cells
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
Cat.No: TMPJ-00850
Species: Mouse
Expression System: HEK293 Cells
Clusterin Protein, Human, Recombinant (CLU34, His)
Cat.No: TMPY-01691
Species: Human
Expression System: HEK293 Cells
TrkB Protein, Human, Recombinant (His)
Cat.No: TMPY-00751
Species: Human
Expression System: HEK293 Cells
PLGF/PGF Protein, Human, Recombinant (aa 19-149)
Cat.No: TMPY-05288
Species: Human
Expression System: E. coli
BTN3A1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04844
Species: Human
Expression System: HEK293 Cells
KRAS Protein, Human, Recombinant (G12D, His)
Cat.No: TMPY-06056
Species: Human
Expression System: E. coli
SDF-1/CXCL12 Protein, Human, Recombinant (isoform a)
Cat.No: TMPY-02820
Species: Human
Expression System: E. coli
C-ABL/ABL1 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04396
Species: Human
Expression System: Baculovirus Insect Cells
c-Kit Protein, Human, Recombinant (His)
Cat.No: TMPY-01935
Species: Human
Expression System: HEK293 Cells
PDGFB Protein, Human, Recombinant (His)
Cat.No: TMPY-04644
Species: Human
Expression System: P. pastoris (Yeast)
GSK3B Protein, Human, Recombinant (His)
Cat.No: TMPY-04356
Species: Human
Expression System: Baculovirus Insect Cells
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-01985
Species: Human
Expression System: HEK293 Cells
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02500
Species: Mouse
Expression System: HEK293 Cells
NKG2D/CD314 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-05414
Species: Mouse
Expression System: Baculovirus Insect Cells
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)
Cat.No: TMPY-01871
Species: Human
Expression System: HEK293 Cells
GDNF Protein, Human, Recombinant (HEK293)
Cat.No: TMPY-02792
Species: Human
Expression System: HEK293 Cells
ST2/IL-1 RL1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01359
Species: Human
Expression System: HEK293 Cells
KRAS Protein,Human, Recombinant (Q61H, His)
Cat.No: TMPY-01888
Species: Human
Expression System: E. coli
Nectin-2 Protein, Human, Recombinant (His)
Cat.No: TMPY-00747
Species: Human
Expression System: HEK293 Cells
c-Kit Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04051
Species: Human
Expression System: HEK293 Cells
CD19 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05427
Species: Human
Expression System: HEK293 Cells
TGFBR2 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00335
Species: Mouse
Expression System: HEK293 Cells
M-CSF/CSF1 Protein, Human, Recombinant
Cat.No: TMPY-00127
Species: Human
Expression System: HEK293 Cells
KRAS Protein,Human,Recombinant(G12C & Q61H, His)
Cat.No: TMPY-04116
Species: Human
Expression System: E. coli
TrkB Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02231
Species: Mouse
Expression System: HEK293 Cells
VEGF164 Protein, Rat, Recombinant
Cat.No: TMPY-02432
Species: Rat
Expression System: Baculovirus Insect Cells
ST2/IL-1 RL1 Protein, Human, Recombinant
Cat.No: TMPY-00850
Species: Human
Expression System: HEK293 Cells
Neuropilin-1 Protein, Human, Recombinant (isoform b, His)
Cat.No: TMPY-02367
Species: Human
Expression System: HEK293 Cells
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00849
Species: Human
Expression System: HEK293 Cells
G-CSF Protein, Human, Recombinant
Cat.No: TMPY-04829
Species: Human
Expression System: HEK293 Cells
LAYN Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00871
Species: Human
Expression System: HEK293 Cells
CD74 Protein, Human, Recombinant (His)
Cat.No: TMPY-01199
Species: Human
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
T35915 Erlotinib-13C6

Erlotinib-13C6

Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...
T11384 Gefitinib-d8

ZD1839 D8,Gefitinib D8

Others Others
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.

同位素

Erlotinib-13C6
Cat.No: T35915
Synonym: Erlotinib-13C6
Target:
Gefitinib-d8
Cat.No: T11384
Synonym: ZD1839 D8,Gefitinib D8
Target: Others
TargetMol Loading
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