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别名 抗DCBLD2/ESDN抗体 (FA19-1), FA19-1
Anti-DCBLD2/ESDN Antibody (FA19-1) 是一种靶向DCBLD2/ESDN的人源化单克隆抗体。DCBLD2在多种恶性肿瘤中高表达,是EGFR等生长因子信号的关键中继蛋白。该抗体通过特异性结合DCBLD2的胞外域,可用于在体外和体内模型中阻断其介导的下游信号(如AKT活化和EMT),是研究DCBLD2在肿瘤迁移、侵袭及转移中作用的关键药理学工具。
Anti-DCBLD2/ESDN Antibody (FA19-1) 是一种靶向DCBLD2/ESDN的人源化单克隆抗体。DCBLD2在多种恶性肿瘤中高表达,是EGFR等生长因子信号的关键中继蛋白。该抗体通过特异性结合DCBLD2的胞外域,可用于在体外和体内模型中阻断其介导的下游信号(如AKT活化和EMT),是研究DCBLD2在肿瘤迁移、侵袭及转移中作用的关键药理学工具。

| 产品描述 | Anti-DCBLD2/ESDN Antibody (FA19-1) is a humanized monoclonal antibody targeting Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2/ESDN/CLCP1). DCBLD2 is a type I transmembrane protein overexpressed in various malignancies (e.g., lung adenocarcinoma, glioma) and acts as a signal relay for growth factor signaling like EGFR. FA19-1 specifically binds to the extracellular domain of DCBLD2, blocking its mediated signaling—such as AKT activation or cisplatin-induced EMT—thereby inhibiting tumor cell migration, invasion, and distant metastasis. |
| 别名 | 抗DCBLD2/ESDN抗体 (FA19-1), FA19-1 |
| 克隆号 | FA19-1 |
| 反应种属 | Human |
| 应用 | ELISA FACS Functional assay |
| 抗体种类 | Monoclonal |
| 缓冲液 | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| 内毒素 | <1.0 EU/mg |
| 同型 | IgG1 kappa |
| 推荐同型对照 |
| 偶联 | Unconjugated |
| Uniprot ID | |
| 靶点 | DCBLD2/ESDN |
| 存储 |
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