follicular

Cladribine (2CdA) 是一种嘌呤核苷类似物，是具有口服活性的腺苷脱氨酶抑制剂。它能作为 DNA 合成的抑制剂，可阻断受损 DNA 的修复。它可抑制 DNA 甲基化，具有抗淋巴瘤活性，可研究血液恶性肿瘤和多发性硬化。

Human follicular gonadotropin releasing peptide (hF-GRP)是一种刺激垂体分泌促黄体激素(LH)及促卵泡激素(FSH)的激素类多肽，其作用可在体外实现。

Tazemetostat (EPZ6438) 是一种组蛋白甲基转移酶 EZH2 抑制剂 (IC50=11 nM)，具有口服活性、选择性和 SAM 竞争性。Tazemetostat 具有抗肿瘤活性，可以用于治疗上皮样肉瘤 滤泡性淋巴瘤。

Pregnant mare serum gonadotropin (PMSG) 是用于促进动物卵泡发育及排卵的促性腺激素。该激素可通过激活体内的血液激素、促性腺激素以及前脑垂体和下丘脑中的细胞质雌二醇受体，调节相关生理过程。在畜牧业中，Pregnant mare serum gonadotropin 用以增加繁殖效率；此外，它也被应用于研究发情周期的调节。

Coixol (MBOA) 是一种从薏苡仁中提取的多酚，有抗菌和抗肿瘤作用。

Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-54 (10-1,000 nM) inhibits insulin secretion from isolated mouse pancreatic β-cells in the presence of 2.8 mM, but not 11.1 mM, glucose.2 Kisspeptin-54 (1-5 nmol, i.c.v.) increases serum levels of luteinizing hormone (LH) and follicular stimulating hormone (FSH) in mice, an effect which is reversed by the gonadotropin releasing hormone (GNRH) antagonist acycline.3References1. Kotani, M., Detheux, M., Vandenbogaerde, A.L., et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276(37), 34631-34636 (2001).2. Vikman, J., and Ahrén, B. Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets. Diabetes Obes. Metab. 11(Suppl 4), 197-201 (2009).3. Gottsch, M.L., Cunningham, M.J., Smith, J.T., et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145(9), 4073-4077 (2004). Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-54 (10-1,000 nM) inhibits insulin secretion from isolated mouse pancreatic β-cells in the presence of 2.8 mM, but not 11.1 mM, glucose.2 Kisspeptin-54 (1-5 nmol, i.c.v.) increases serum levels of luteinizing hormone (LH) and follicular stimulating hormone (FSH) in mice, an effect which is reversed by the gonadotropin releasing hormone (GNRH) antagonist acycline.3 References1. Kotani, M., Detheux, M., Vandenbogaerde, A.L., et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276(37), 34631-34636 (2001).2. Vikman, J., and Ahrén, B. Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets. Diabetes Obes. Metab. 11(Suppl 4), 197-201 (2009).3. Gottsch, M.L., Cunningham, M.J., Smith, J.T., et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145(9), 4073-4077 (2004).

DM-01 是一种强效的、选择性的 EZH2 抑制剂。DM-01 能够用于研究弥漫性大 B 细胞淋巴瘤 (DLBCL)，滤泡性淋巴瘤 (FL) 和 SNF5 INI-1 SMARCB1 基因相关实体瘤。

Acyline is a novel GnRH antagonist found in animal studies to be a potent suppressor of circulating gonadotropin and testosterone (T) levels. Acyline inhibits basal and GnRH-stimulated serum testosterone concentrations in male dogs. Acyline prevented ovulation, but did not affect ovarian follicular development or gestational corpora lutea in the domestic cat. A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men.

PI3K-IN-36 是一种有效的 PI3K 抑制剂。PI3K-IN-36 可用于滤泡性淋巴瘤 (FL) 的研究。

FSHreceptor-binding inhibitor fragment(bi-10) 是一种有效的 FSH 拮抗剂。FSHreceptor-binding inhibitor fragment(bi-10) 阻断 FSH 与 FSHR 的结合，并在受体水平上改变 FSH 的作用。FSHreceptor-binding inhibitor fragment(bi-10) 导致小鼠排卵抑制和卵泡闭锁。FSHreceptor-binding inhibitor fragment(bi-10) 通过下调卵巢中 FSHR 和 ERβ的过度表达来抑制卵巢癌发生。

Mosunetuzumab (BTCT-4465A) 是一种基于免疫球蛋白 G1 且靶向 CD20 (B 细胞) 和 CD3 (T 细胞) 的人源化抗体。Mosunetuzumab 重定向 T 细胞以接合和消除恶性 B 细胞，可用于研究复发或难治性 (R R) B 细胞非霍奇金淋巴瘤 (B-NHL)和难治性滤泡性淋巴瘤。

Urelumab(BMS-66513) 是一种人源化的 IgG4 单克隆抗体，常被当作 CD137 激动剂使用。Urelumab 具有潜在的抗肿瘤活性，可增强 T 细胞和自然杀伤细胞对肿瘤细胞的杀伤作用，并增强 Rituximab 的细胞毒性。Urelumab 可用于研究弥漫性大B细胞淋巴瘤 (DLBCL)合滤泡性淋巴瘤 (FL) 等实体瘤相关疾病。

Palmitoyl tetrapeptide-20(PTP20)为具保护作用的生物活性肽，旨在维护滤泡黑素细胞，常用作化妆品配料。

Ethacridine 是聚 (ADP-核糖) 糖水解酶 (PARG) 的抑制剂，也是转录共激活因子的激活剂。它能够诱导甲状腺癌细胞凋亡 (apoptosis)，并促进甲状腺滤泡细胞分化。

Lecirelin is a synthetic GnRH (gonadotropin releasing hormone) analogue which shows a great efficacy in the treatment of bovine ovarian follicular cysts.

Lecirelin acetate(61012-19-9 free base) 是一种合成的 GnRH（促性腺激素释放激素）类似物，在治疗牛卵巢滤泡囊肿方面显示出很好的疗效。

CBP-1008 是一种与 MMAE 偶联的双配体多肽-药物共轭物 (PDC)，专注于靶向叶酸受体 (FRα) 和 TRPV6。它显示出对 FRα 的高亲和力和对 TRPV6 的低亲和力。CBP-1008 具有抗肿瘤活性，适用于晚期实体瘤的研究 (例如：结直肠癌、乳腺癌、非小细胞肺癌、卵巢癌、肾上腺皮质癌和滤泡树突状细胞肉瘤)。

Thyroglobulin 是一种由甲状腺滤泡细胞生成的 660 kDa 二聚体糖蛋白，专门在甲状腺使用。Thyroglobulin 可作为合成甲状腺激素 thyroxine (T4) 和 triiodothyronine (T3) 的底物，并在甲状腺滤泡的滤泡腔内以非活性形式储存甲状腺激素和 iodine。