drug development

(Z)-2-fluoro-1,3-bis(4-methoxyphenyl)prop-2-en-1-one 是一种筛选化合物，可用于新药研发相关研究。

Oxindole (Indolin-2-one) 是一种芳族杂环砌块，其衍生物是激酶抑制剂研究中的主要成分。

Boc-NH-PEG4-CH2COOH 是一种可切割的 ADC 接头，用作抗体-药物偶联物的接头。它也是基于 PEG 的 PROTAC 接头，可用于 PROTAC 的合成。

1-Methyl-1H-pyrazol-3-amine 是一种吡唑类化合物。它已被用于合成各种化合物，如药物、染料和聚合物。它也是合成某些药物的重要中间体。它还被用于新药的开发，以及酶抑制剂和受体调节剂的研究。

(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride (D-Mannosamine hydrochloride) 是内源性代谢产物的一种。

Istradefylline (KW-6002) 是选择性的可口服的腺苷 A2A 受体拮抗剂，可用于研究药物滥用、睡眠障碍、肝损伤、帕金森病和不安腿综合征等的治疗和基础科学的试验。

MFCD01917484 (ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE)是一种噻吩的衍生物，它具有多种性质，包括作为配体、催化剂和光敏剂的能力。它已被用作生化和生理研究以及药物发现和开发的模型化合物。

1,3,5-tris(pyridin-4-ylethynyl)benzene 是一种杂环化合物，具有广泛的性质，如荧光和电化学活性，具有相对较低的毒性。它已被用作合成各种材料的构建块，如聚合物、纳米材料和有机发光二极管（OLED）。它也是开发新型药物递送系统的一种有前途的材料。

Avarofloxacin (JNJ-Q2) is a broad-spectrum fluoroquinolone antibacterial drug being developed for the treatment of acute bacterial skin and community-acquired pneumonia and skin structure infections.

MMAE-d8是MMAE(Monomethyl auristatin)的氘代标记化合物，可用于同位素示踪。MMAE是一种tubulin微管抑制剂，抑制癌细胞有丝分裂,常用于抗体药物偶联物（ADC）开发。

Ald-Ph-amido-PEG4-C2-acid is a noncleavable linker utilized in the development of antibody-drug conjugates (ADC).

Azido-PEG4-CH2-Boc is a four-unit cleavable polyethylene glycol (PEG) linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. This linker is characterized by its azide functional group and PEG backbone, facilitating the conjugation of drugs to antibodies in ADC development and enabling the synthesis of PROTACs utilizing PEG and alkyl ether moieties.

Biotin-PEG3-acid 是一种属于 PEG 类的、生物素标记的 PROTAC linker，可用于 PROTAC 分子的合成。

Bis-PEG8-acid, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs)[1]. It serves as a cleavable ADC linker, facilitating the development of specialized compounds.

(2-Pyridyldithio)-PEG4 acid is a four-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. This linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. The PEG4 chain provides the necessary flexibility and biocompatibility for optimal drug release while maintaining stability throughout the circulation in the body. Ultimately, (2-Pyridyldithio)-PEG4 acid is instrumental in the development and advancement of ADCs, a promising approach in cancer therapy.

Ald-Ph-amido-PEG3-C-COOH is a noncleavable linker utilized in the formation of antibody-drug conjugates (ADCs).

Boc-Val-Ala-PAB-PNP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates the attachment of drugs to antibodies, allowing for targeted delivery and release of therapeutic agents within the body, making it an important component in ADC development.

DBCO-PEG4-Ahx-DM1 is a drug-linker conjugate that combines the microtubulin inhibitor DM1 (mertansine), which is an antibody-conjugatable maytansinoid designed to reduce systemic toxicity and improve tumor-specific delivery, with the linker DBCO-PEG4-Ahx, for the development of antibody drug conjugates (ADCs).

DM1-(PEG)4-DBCO is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (DM1) with the DBCO-PEG4-Ahx linker for the development of antibody-drug conjugates (ADCs). This conjugation aims to mitigate the systemic toxicity associated with maytansine while improving tumor-specific delivery, leveraging DM1’s capabilities as an antibody-conjugatable maytansinoid.

MMAE-SMCC is a drug-linker conjugate designed for antibody-drug conjugates (ADC). It consists of MMAE, a potent inhibitor of mitosis and tubulin, and SMCC, a linker that facilitates the development of ADCs.

PC Mal-NHS carbonate ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. This chemical compound plays a crucial role in facilitating the conjugation of drugs to antibodies, enabling targeted delivery and enhanced efficacy of therapeutic agents. Its unique carbonate ester structure allows for efficient cleavage in the targeted environment, ensuring the controlled release of the drug payload. Its application in ADC synthesis highlights its importance in the development of innovative and targeted cancer therapies.

Phe-Lys(Trt)-PAB 是一种组织蛋白酶可裂解的 ADC 接头，用于合成抗体-药物偶联物。

SNPB-sulfo-Me is a cleavable linker used in the development of antibody-drug conjugates (ADC).

SPDB-sulfo, a glutathione-cleavable linker, is utilized in the development of antibody-drug conjugates (ADCs) [1].