Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) 是线粒体氧化磷酸化的解偶联剂,可调节 amp 依赖性激酶 (ampk)-雷帕霉素 (mtor) 信号的哺乳动物靶点,并抑制 hepg2 肝癌细胞的增殖。它对白血病、黑色素瘤、乳腺癌和肺癌显示出强大的抗增殖活性。它是一种AMPK 活化剂,通过激活 AMPK 来抑制脂肪细胞分化,可用于肥胖及代谢紊乱相关的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 231 | 现货 | ||
25 mg | ¥ 417 | 现货 | ||
50 mg | ¥ 581 | 现货 | ||
100 mg | ¥ 987 | 现货 | ||
200 mg | ¥ 1,480 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 195 | 现货 |
产品描述 | COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proliferation of hepg2 hepatocarcinoma cells |
体内活性 | SR4 is a novel mitochondrial uncoupler with anti-obesity and anti-diabetic properties.?SR4 increased oxygen consumption, dissipated mitochondrial membrane potential, induced mitochondrial swelling, and decreased intracellular ATP in cultured cells and isolated liver mitochondria.?Oral feeding of SR4 significantly reduced body weight gain, improved glycemic control and insulin resistance, and prevented dyslipidemia in both high-fat-diet (HFD) induced obese and diabetic db/db mice.?SR4 treatment also decreased liver triglycerides and prevented hepatic steatosis in both animal models.?Mitochondrial uncoupling of SR4 results to activation of AMP-activated protein kinase (AMPK), leading to the phosphorylation and inhibition of acetyl-CoA carboxylase (ACC).?Gene analyses by RT-PCR showed SR4 significantly suppressed the mRNA expression of several lipogenic genes and gluconeogenic genes in the liver of HFD obese mice.?RNA sequencing analysis showed that 642 genes were differentially expressed in liver of db/db mice after SR4 treatment (217 upregulated, 425 down-regulated).?Gene ontology analysis by DAVID indicated SR4 upregulated amino acid metabolism and down-regulated lipid and fatty acid synthesis and glucose metabolism.?These studies demonstrate that SR4 may be a promising compound for treatment of T2DM and obesity |
别名 | COH-SR4 (Mitochondria uncoupler SR4) |
分子量 | 350.03 |
分子式 | C13H8Cl4N2O |
CAS No. | 73439-19-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4 mg/mL (11.43 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8569 mL | 14.2845 mL | 28.569 mL | 71.4224 mL |
5 mM | 0.5714 mL | 2.8569 mL | 5.7138 mL | 14.2845 mL | |
10 mM | 0.2857 mL | 1.4284 mL | 2.8569 mL | 7.1422 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
COH-SR4 73439-19-7 Chromatin/Epigenetic Others PI3K/Akt/mTOR signaling AMPK anticancer anti-proliferative kinase leukemia protein breast COH-SR4 (Mitochondria uncoupler SR4) cancers lung COH SR4 COHSR4 anti-adipogenic COH-SR-4 Inhibitor melanoma inhibit AMP-activated protein kinase Mitochondria uncoupler SR4 AMP-activated inhibitor