|
TMPY-00653
|
Complement C5 Protein, Human, Recombinant (Complement C5a)
C5D,C5b,CPAMD4,complement component 5,Complemen...
|
Human
|
E. coli
|
|
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity... |
|
TMPY-04902
|
Complement C5a Protein, Mouse, Recombinant
complement component 5
|
Mouse
|
E. coli
|
|
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity... |
|
TMPY-05732
|
Complement C3 Protein, Cynomolgus, Recombinant (His)
complement component 3
|
Cynomolgus
|
HEK293
|
|
Complement C3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 186.40 kDa. Accession number: XP_005587776.1 |
|
TMPY-05057
|
Complement C5 Protein, Human, Recombinant (His & FLAG)
C5b,ECLZB,C5a,CPAMD4,C5D,complement component 5,
|
Human
|
HEK293
|
|
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity... |
|
TMPY-00686
|
Complement C2 Protein, Human, Recombinant (His)
CO2,complement component 2,ARMD14
|
Human
|
HEK293
|
|
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in extrahepatic tissues. This pathway is triggered by a multimolecular complex C1, and subsequently the single-chain form of C2 is cleaved into two chains referred to C2a and C2b by activated C1. The second component of complement (C2) is a multi-domain serine protease that provides ca... |
|
TMPY-05731
|
Complement C3 Protein, Human, Recombinant (His)
HEL-S-62p,CPAMD1,ARMD9,C3b,ASP,C3a,AHUS5,complement...
|
Human
|
HEK293
|
|
Complement C3 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 186.43 kDa. Accession number: P01024 |
|
TMPY-04921
|
Complement factor B/CFB Protein, Human, Recombinant (His)
ARMD14,GBG,AHUS4,PBF2,complement factor B,FBI12,BF,...
|
Human
|
HEK293
|
|
Complement factor B/CFB Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 84.5 kDa. Accession number: AAH04143.1 |
|
TMPY-02892
|
Complement C7 Protein, Human, Recombinant (His)
Complement C7,complement component 7
|
Human
|
HEK293
|
|
Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. Complement component 7 serves as a membrane anchor. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. It is a constituent of MAC that plays a key role in the innate and adaptive im... |
|
TMPY-06538
|
Complement C5 Protein, Cynomolgus, Recombinant
complement component 5
|
Cynomolgus
|
HEK293
|
|
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity... |
|
TMPY-03012
|
Complement C7 Protein, Human, Recombinant (hFc)
complement component 7,Complement C7
|
Human
|
HEK293
|
|
Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. Complement component 7 serves as a membrane anchor. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. It is a constituent of MAC that plays a key role in the innate and adaptive im... |
|
TMPJ-00417
|
Complement C3a Protein, Human, Recombinant
Anaphylatoxin,C3a,Complement Component C3a
|
Human
|
E. coli
|
|
Complement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent point for all three major complement activation pathways: namely classical, alternative and mannose-binding lectin pathways. Complement activation leads to the formation of the C3 convertase, which cleaves C3 into the key effector molecules, C3a (anaphylatoxin) and C3b (opsonin)... |
|
TMPY-02641
|
Complement C6 Protein, Human, Recombinant (His)
complement component 6
|
Human
|
HEK293
|
|
Complement C6 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 104 kDa. Accession number: AAA59668.1 |
|
TMPY-06137
|
Complement C5 Protein, Cynomolgus, Recombinant (His)
complement component 5
|
Cynomolgus
|
HEK293
|
|
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity... |
|
TMPY-05459
|
Complement C5a Protein, Mouse, Recombinant, Biotinylated
complement component 5
|
Mouse
|
E. coli
|
|
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity... |
|
TMPY-03447
|
Complement C2 Protein, Mouse, Recombinant (His)
complement component 2
|
Mouse
|
HEK293
|
|
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in extrahepatic tissues. This pathway is triggered by a multimolecular complex C1, and subsequently the single-chain form of C2 is cleaved into two chains referred to C2a and C2b by activated C1. The second component of complement (C2) is a multi-domain serine protease that provides ca... |
|
TMPJ-00585
|
Complement C8 gamma Protein, Human, Recombinant (His)
C8 γ,Complement component C8 gamma chain,C8G,Co...
|
Human
|
E. coli
|
|
Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a... |
|
TMPJ-00416
|
Complement C3a Protein, Mouse, Recombinant
C3a,Complement Component C3a,Anaphylatoxin
|
Mouse
|
E. coli
|
|
Complement is defined as key part of innate immunity and as the first line of defense in the fight against invading pathogens. Complement 3 (C3) is the most abundant component of the complement cascade and the convergent point for all three major complement activation pathways: namely classical, alternative and mannose-binding lectin pathways. Complement activation leads to the formation of the C3 convertase, which cleaves C3 into the key effector molecules, C3a (anaphylatoxin) and C3b (opsonin)... |
|
TMPH-03270
|
Complement C5 Protein, Rat, Recombinant (His & Myc)
Complement C5,C5
|
Rat
|
E. coli
|
|
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction... |
|
TMPY-06814
|
Complement C5 Protein, Human, Recombinant (Flag)
C5a,CPAMD4,ECLZB,C5b,C5D,Complement C5,compleme...
|
Human
|
HEK293
|
|
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity... |
|
TMPH-01132
|
Complement C8a Protein, Human, Recombinant (His)
C8A,Complement component 8 subunit alpha,Comple...
|
Human
|
E. coli
|
|
Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli. |
|
TMPH-01134
|
Complement C8g Protein, Human, Recombinant (His)
C8G,Complement component C8 gamma chain
|
Human
|
E. coli
|
|
Complement C8g Protein, Human, Recombinant (His) is expressed in E. coli. |
|
TMPH-01133
|
Complement C8b Protein, Human, Recombinant (His)
Complement component C8 beta chain,C8B,Compleme...
|
Human
|
E. coli
|
|
Complement C8b Protein, Human, Recombinant (His) is expressed in E. coli. |
|
TMPH-03107
|
Complement C5a Protein, Pig, Recombinant (His)
Complement C5a anaphylatoxin,C5
|
Sus scrofa (Pig)
|
Yeast
|
|
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
|
TMPH-02604
|
Complement C3 Protein, Mouse, Recombinant (His & SUMO)
C3,Complement C3
|
Mouse
|
E. coli
|
|
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces t... |
|
TMPY-00687
|
Complement C2 Protein, Human, Recombinant (hFc)
ARMD14,complement component 2,CO2
|
Human
|
HEK293
|
|
Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in extrahepatic tissues. This pathway is triggered by a multimolecular complex C1, and subsequently the single-chain form of C2 is cleaved into two chains referred to C2a and C2b by activated C1. The second component of complement (C2) is a multi-domain serine protease that provides ca... |
|
TMPH-00231
|
Complement C3 Protein, Bovine, Recombinant (His & SUMO)
Complement C3,C3
|
Bovine
|
E. coli
|
|
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and... |
|
TMPY-06767
|
Complement C3 Protein, Mouse, Recombinant (His)
HSE-MSF,complement component 3,Plp,AI255234,ASP
|
Mouse
|
HEK293
|
|
Complement C3 Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 36.34 kDa. Accession number: NP_033908.2 |
|
TMPY-04141
|
Complement factor H/CFH Protein, Mouse, Recombinant (hFc)
complement factor H,Sas1,NOM,Mud-1,Sas-1
|
Mouse
|
HEK293
|
|
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and ... |
|
TMPK-01268
|
Complement C2 Protein, Cynomolgus, Recombinant (His)
C2,CO2,Complement C2,C3/C5 convertase,ARMD14
|
Cynomolgus
|
HEK293
|
|
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to healthy controls, and C2 was associated with TNM stages. Higher C2 expression was significantly associated with better prognosis, and multivariate analysis showed that C2 was also an independent factor for the prognosis of HCC. |
|
TMPH-03273
|
Complement factor I Protein, Rat, Recombinant (His & Myc)
If,Complement factor I,Cfi,C3B/C4B inactivator
|
Rat
|
Baculovirus
|
|
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degrada... |
|
TMPJ-00980
|
Complement Factor MASP3 Protein, Human, Recombinant (His)
PRSS5,CRARF,Serine Protease 5,MASP1,MASP-1,Mannose-Binding L...
|
Human
|
Human Cells
|
|
MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway. The MBL pathway is initiated by the binding of MBL to specific carbohydrate structures found on the surface of a variety of microorganisms. Activation of the complement pathway via MBL is initiated by specific MASPs. Three MASPs have been identified and all have domain structures similar to those of C1r and C1s with a heavy chain (chain A) and a light chain (chain B). Chain A is composed of CUB1, EGF, CUB2... |
|
TMPY-02183
|
Complement Factor D/CFD Protein, Human, Recombinant (His)
PFD,DF,complement factor D (adipsin),ADN,FACTOR D,A...
|
Human
|
HEK293
|
|
Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement factor D ( CFD / Adipsin ) is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Complement factor D ( CFD / Adipsin ) has a high level of expression in fat, suggesting a role for adipose tissue in immune sys... |
|
TMPY-04129
|
Complement factor H/CFH Protein, Mouse, Recombinant (His)
Sas-1,Mud-1,NOM,complement factor H,Sas1
|
Mouse
|
HEK293
|
|
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and ... |
|
TMPY-02167
|
Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293)
DF,Adn,complement factor D (adipsin)
|
Mouse
|
HEK293
|
|
Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement factor D ( CFD / Adipsin ) is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Complement factor D ( CFD / Adipsin ) has a high level of expression in fat, suggesting a role for adipose tissue in immune sys... |
|
TMPK-00776
|
Complement factor I Protein, Human, Recombinant (His)
FIC3b-INA,KAF,IF,CFI,I factor (complement),EC:3.4.2...
|
Human
|
HEK293
|
|
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. |
|
TMPH-02605
|
Complement C4-B Protein, Mouse, Recombinant (His)
C3 and PZP-like alpha-2-macroglobulin domain-containing prot...
|
Mouse
|
E. coli
|
|
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. |
|
TMPH-02607
|
Complement factor B Protein, Mouse, Recombinant (His)
C3/C5 convertase,Complement factor B,Cfb,Bf,H2-Bf
|
Mouse
|
E. coli
|
|
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. |
|
TMPK-01023
|
Complement factor I Protein, Mouse, Recombinant (His)
FIC3b-INA,I factor (complement),IF,C3B/C4B inactiva...
|
Mouse
|
HEK293
|
|
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. |
|
TMPH-01131
|
Complement C4-B Protein, Human, Recombinant (His & SUMO)
C4B,C3 and PZP-like alpha-2-macroglobulin domain-containing ...
|
Human
|
E. coli
|
|
Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. |
|
TMPJ-00149
|
Complement Factor D/CFD Protein, Mouse, Recombinant (His)
C3 convertase activator,28 kDa adipocyte protein,Cfd,Adipsin...
|
Mouse
|
Human Cells
|
|
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the... |
|
TMPH-03272
|
Complement factor D Protein, Rat, Recombinant (His)
Adipsin,Df,Adn,C3 convertase activator,Complement f...
|
Rat
|
Yeast
|
|
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. |
|
TMPK-00755
|
Complement Factor D/CFD Protein, Human, Recombinant (hFc)
C3 convertase activator,DF,AMBP-1,EC 3.4.21,EC 3.4.21.46,Adi...
|
Human
|
HEK293
|
|
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. |
|
TMPH-03271
|
Complement factor D Protein, Rat, Recombinant (His & Myc)
Adn,C3 convertase activator,Properdin factor D,Complemen...
|
Rat
|
HEK293
|
|
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. |
|
TMPK-00151
|
Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)
C3 convertase activator,AMBP-1,PFD,FACTOR D,CFD,ADN,EC 3.4.2...
|
Mouse
|
HEK293
|
|
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. |
|
TMPK-00671
|
Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)
Adipsin,CFD,ADN,Complement factor D,DF,AMBP-1,EC 3....
|
Rhesus macaque
|
HEK293
|
|
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. |
|
TMPK-00790
|
Complement factor H/CFH Protein, Human, Recombinant (His)
ARMD4,AHUS1,H factor 1,HF1,AMBP1,FH,FHL1,HUS,CFHL3,ARMS1,HF2...
|
Human
|
HEK293
|
|
Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self)... |
|
TMPJ-00809
|
CFH Protein, Human, Recombinant (His)
CFH,Complement factor H
|
Human
|
Human Cells
|
|
Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessi... |
|
TMPH-02603
|
C1SB Protein, Mouse, Recombinant (His & Myc)
C1sb,C1s,Gm5077,Complement C1s-1 subcomponent,C...
|
Mouse
|
E. coli
|
|
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. |
|
TMPH-02602
|
C1RA Protein, Mouse, Recombinant (His & Myc)
Complement component 1 subcomponent r-A,C1ra,C1r,
|
Mouse
|
E. coli
|
|
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. |
|
TMPH-02597
|
C1QA Protein, Mouse, Recombinant (His)
Complement C1q subcomponent subunit A,C1QA
|
Mouse
|
Yeast
|
|
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
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