Name: Crovalimab
Brand: TargetMol
SKU: T77190
Price: 2480 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,480

现货

5 mg

¥ 5,860

现货

10 mg

¥ 7,890

现货

25 mg

¥ 11,700

现货

50 mg

¥ 15,800

现货

生物活性

产品描述	Crovalimab (SKY59; RO7112689) is an Fc-engineered and pH-dependent humanised monoclonal antibody that binds to complement C5 and blocks its cleavage into C5a and C5b, thereby inhibiting MAC formation and intravascular haemolysis. It can rebind to the FcRn receptor under acidic pH conditions and return to the bloodstream, making it suitable for the treatment of paroxysmal nocturnal haemoglobinuria (PNH).
体内活性	方法：在食蟹猴中，评估单次静注 Crovalimab（20 mg/kg）及其衍生物 SG115 的药效与药代特性，并采用多次静注/皮下注射方案观察免疫与血清学变化。结果： Crovalimab 单剂量可抑制血浆 C5 积累并维持补体活性抑制达 8 周；SG115 清除较慢（1.87 mL/day/kg）。多次给药引起溶血活性升高、吞咽困难及 LDH、ALT 水平上升。[1]
别名	可伐利单抗, SKY59, SKY 59, RO7112689, RO 7112689
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	Human IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	~150 kDa
CAS No.	1917321-26-6

储存&溶解度

存储	-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Crovalimab