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Anti-Complement C2 Antibody-HRP (5P16)
还可以产品编号 TMAY-00364H
Anti-Complement C2 Antibody-HRP (5P16) 是一种 HRP-conjugated Mouse 抗体，靶向 Complement C2。Anti-Complement C2 Antibody-HRP (5P16) 可用于 ELISA。
Anti-Complement C2 Antibody-HRP (5P16)
Anti-Complement C2 Antibody-HRP (5P16)
还可以产品编号 TMAY-00364H
Anti-Complement C2 Antibody-HRP (5P16) 是一种 HRP-conjugated Mouse 抗体，靶向 Complement C2。Anti-Complement C2 Antibody-HRP (5P16) 可用于 ELISA。
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产品介绍
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抗原信息
| 产品描述 | Anti-Complement C2 Antibody-HRP (5P16) is a HRP-conjugated Mouse antibody targeting Complement C2. Anti-Complement C2 Antibody-HRP (5P16) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5P16 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Complement Component C2 (rh Complement Component C2; TMPY-00686; NP_000054.2; Met1-Leu752). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in extrahepatic tissues. This pathway is triggered by a multimolecular complex C1, and subsequently the single-chain form of C2 is cleaved into two chains referred to C2a and C2b by activated C1. The second component of complement (C2) is a multi-domain serine protease that provides catalytic activity for the C3 and C5 convertases of the classical and lectin pathways of human complement. C4b and C2 was investigated by surface plasmon resonance. C2a containing a serine protease domain combines with complement component C4b to form the C3 convertase C4b2a which is responsible for C3 activation, and leads to the stimulation of adaptive immune responses via Lectin pathway. C2 bound to C4b is cleaved by classical (C1s) or lectin (MASP2) proteases to produce C4bC2a. C2 has the same serine protease domain as C4bC2a but in an inactive zymogen-like conformation, requiring cofactor-induced conformational change for activity. Deficiency of C2 (C2D) is the most common genetic deficiency of the complement system, and two types of C2D have been recognized in the context of specific MHC haplotypes. C2D in human is reported to increase susceptibility to infection, and is associated with certain autoimmune diseases, such as rheumatological disorders. |
| 偶联 | HRP |
| 其他可选修饰符 | Unconjugated/Biotin |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human Complement Component C2 Protein (TMPY-00686) |
| 抗原种属 | Human |
| 研究领域 | Serine Proteases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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