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Anti-Complement factor H/CFH Antibody (5F716)
还可以产品编号 TMAY-01106
Anti-Complement factor H/CFH Antibody (5F716) 是一种 Mouse 抗体，靶向 Complement factor H/CFH。Anti-Complement factor H/CFH Antibody (5F716) 可用于 ELISA。
Anti-Complement factor H/CFH Antibody (5F716)
Anti-Complement factor H/CFH Antibody (5F716)
还可以产品编号 TMAY-01106
Anti-Complement factor H/CFH Antibody (5F716) 是一种 Mouse 抗体，靶向 Complement factor H/CFH。Anti-Complement factor H/CFH Antibody (5F716) 可用于 ELISA。
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抗原信息
| 产品描述 | Anti-Complement factor H/CFH Antibody (5F716) is a Mouse antibody targeting Complement factor H/CFH. Anti-Complement factor H/CFH Antibody (5F716) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5F716 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Complement Factor H / CFH (rh Complement Factor H / CFH; TMPY-01439; NP_000177.2; Ser 860-Arg 1231). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Complement Factor H / CFH Protein (TMPY-01439) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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