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Anti-Complement C3 Antibody (4V625)
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产品编号 TMAC-00505
别名 Complement Component C3a, C3a, Anaphylatoxin
Anti-Complement C3 Antibody (4V625) 是一种 Rabbit 抗体，靶向 Complement C3。Anti-Complement C3 Antibody (4V625) 可用于 WB,IHC,IP。
Anti-Complement C3 Antibody (4V625)
Anti-Complement C3 Antibody (4V625)
还可以产品编号 TMAC-00505 别名 Complement Component C3a, C3a, Anaphylatoxin
Anti-Complement C3 Antibody (4V625) 是一种 Rabbit 抗体，靶向 Complement C3。Anti-Complement C3 Antibody (4V625) 可用于 WB,IHC,IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-Complement C3 Antibody (4V625) is a Rabbit antibody targeting Complement C3. Anti-Complement C3 Antibody (4V625) can be used in WB,IHC,IP. |
| 别名 | Complement Component C3a, C3a, Anaphylatoxin |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of C3 on SiHa cell lysates using anti-C3 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-C3 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-C3 antibody. Counter stained with hematoxylin. |
| 应用 | |
| 推荐剂量 | WB: 1:500; IHC: 1:50-100; IP: 1:10-50 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Complement C3 precursor contains complement C3 beta chain, complement C3 alpha chain, C3a anaphylatoxin, complement C3b alpha chain, complement C3c fragment, complement C3dg fragment, complement C3g fragment, complement C3d fragment and complement C3f fragment. C3a, C4a, and C5a are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactions specific to cells of hematopoietic lineage that aids in the elimination of pathogens. C3a and C5a secretion correlates with pathophysiological phenotypes such as asthma and bacterial meningitis. Binding of these proteins to their respective G protein-coupled receptors (C3aR, C5aR), which are present on the surface of myeloid leukocytes, induces proinflammatory events such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3aR is expressed in brain and activated B-lymphocytes whereas C5aR is prevalent on the surface of hepatocyte, lung, smooth muscle, and endothelial cells. Upon activation, C3aR and C5aR are susceptible to rapid GRK-mediated phosphorylation and clathrin-coated vesicle targeting. C5aR utilizes the Ras-Raf-ERK1/2 cascade and couples to Gi/G16 proteins. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 187 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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