trazodone

Trazodone (AF-1161) 是一种 5-HT 2A 2C 受体拮抗剂，用作治疗主要焦虑症和抑郁症的抗抑郁药。

4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is selective for OAT3 over OAT1 (Ki= >200 μM).2 1.Yamato, C., Takahashi, T., Fujita, T., et al.Studies on metabolism of trazodone, II. Metabolic fate after intravenous administration and effects on liver microsomal drug-metabolizing enzymes in ratsXenobiotica4(12)765-777(1974) 2.Zou, L., Matsson, P., Stecula, A., et al.Drug metabolites potently inhibit renal organic anion transporters, OAT1 and OAT3J. Pharm. Sci.110(1)347-353(2021)

4-Chloro Trazodone hydrochloride 是 Trazodone hydrochloride 的异构体。Trazodone hydrochloride 是一种抗抑郁剂，属于血清素受体拮抗剂和再摄取抑制剂，用于研究焦虑症。

Trazodone-d6 hydrochloride 是 Trazodone hydrochloride 的氘代化合物。

Trazodone-d8 hydrochloride 是 Trazodone hydrochloride 的氘代化合物。Trazodone hydrochloride 的 CAS 号为 25332-39-2。Trazodone hydrochloride 是5 羟色胺受体拮抗剂和重吸收抑制剂，用作抗抑郁药，可治疗失眠和焦虑。

Trazodone hydrochloride (Trazodone HCl) 是5 羟色胺受体拮抗剂和重吸收抑制剂，用作抗抑郁药，可治疗失眠和焦虑。