Anti-p53 Antibody (7T648)

Name: Anti-p53 Antibody (7T648)
Brand: TargetMol
SKU: TMAB-01318
Rating: 4.5 (1 reviews)

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产品编号 TMAB-01318

Anti-p53 Antibody (7T648) 是一种 Mouse 抗体，靶向 p53。Anti-p53 Antibody (7T648) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-p53 Antibody (7T648)

还可以

产品编号 TMAB-01318

Anti-p53 Antibody (7T648) 是一种 Mouse 抗体，靶向 p53。Anti-p53 Antibody (7T648) 可用于 WB,IHC-P,IHC-Fr,IF。

规格	价格	库存	数量
50 μL	¥ 1,175	5日内发货
100 μL	¥ 1,960	5日内发货

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生物活性

产品描述	Anti-p53 Antibody (7T648) is a Mouse antibody targeting p53. Anti-p53 Antibody (7T648) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type	IgG
克隆号	7T648
交叉反应	Human
验证活性	1. Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (P53) Monoclonal Antibody, Unconjugated (TMAB-01318) at 1:500 overnight at 4°C, followed by operating according to SP Kit (Mouse) instructionsand DAB staining. 2. Paraformaldehyde-fixed, paraffin embedded (Human esophageal cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (P53) Monoclonal Antibody, Unconjugated (TMAB-01318) at 1:500 overnight at 4°C, followed by operating according to SP Kit (Mouse) instructionsand DAB staining.
应用	WB IHC-P IHC-Fr IF
推荐剂量	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类	Monoclonal
宿主来源	Mouse
亚细胞定位	Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4. Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm. Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells. Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress. Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm. Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli. Isoform 9: Cytoplasm.
构建方式	Hybridoma Monoclonal Antibody
纯化方式	Protein G purified
性状	Liquid
缓冲液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究背景	This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].

抗原信息

免疫原	KLH conjugated synthetic peptide: human p53
抗原种属	Human
基因ID	7157
Uniprot ID	P04637
研究领域	p53 pathway,p53 pathway,p53 Pathway,p53,p53,p53,Tumor Suppressors