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100

抑制剂 & 化合物

6

天然产物

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Cat. No. Product Name Target Signaling Pathways
T23383 SR11237

SR 11237

Others; RAR/RXR  Metabolism; Others
SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。
T22101 ML-031

S1P Receptor GPCR/G Protein
ML-031 是鞘氨醇 1-磷酸受体 2 (S1PR2)的选择性激动剂,其IC50=1.0 μM,EC50=1.03 μM。它可用于癌症疾病的研究。
T22818 GSK9027

GR agonist 23a,GSK 9027,GSK-9027

Glucocorticoid Receptor Endocrinology/Hormones
GSK9027 (GR agonist 23a) 是一种非甾体糖皮质激素受体 (GR) 激动剂。GSK9027 (GR agonist 23a) 在2×GRE报告基因上对比地塞米松的活性属于部分激动剂,活性较地塞米松活性较弱。
T14038L 4-Azido-L-phenylalanine hydrochloride

p-Azido-L-phenylalanine hydrochloride,p-Azidophenylalanine hydrochloride

Others Others
4-Azido-L-phenylalanine hydrochloride (p-Azido-L-phenylalanine hydrochloride) 是非天然氨基酸,可有效振动报道蛋白质环境。
T4043 ETC-159

ETC159,ETC-1922159,ETC 159

Wnt/beta-catenin; Porcupine Cytoskeletal Signaling; Stem Cells
ETC-159 (ETC-1922159) 是一种具有口服活性的,有效 PORCN 抑制剂。抑制β-catenin 报告基因活性的 IC50值为2.9 nM。
T15677 KY1220

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
KY1220 通过靶向 Wnt/β-连环蛋白通路,使 β-连环蛋白和 Ras 不稳定。 它在 HEK293 报告细胞中的 IC50 为 2.1 μM。
T4339 YU238259

DNA-PK; Others DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
YU238259 是一种新型的同源依赖性 DNA 修复 (HDR) 抑制剂,在基于细胞的 GFP 报告基因检测中不抑制非同源末端连接 (NHEJ),可研究癌症。
T4361 CBL0137 hydrochloride

CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride

Others; NF-κB; p53 Apoptosis; NF-κB; Others
CBL0137 hydrochloride (Curaxin-137 hydrochloride) 是一种组蛋白分子伴侣FACT 的抑制剂,也可激活p53并抑制NF-κB,对于它们的EC50值分别为 0.37 和 0.47 μM。
T19850 Semaglutide

索玛鲁肽,司美格鲁肽,索马鲁肽

Glucagon Receptor GPCR/G Protein
Semaglutide 是人胰高血糖素样肽-1受体激动剂,是一种人胰高血糖素样肽-1 的长效类似物。它有用于 2 型糖尿病研究的潜力。
T4684 ML241 hydrochloride

p97 Ubiquitination
ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂,IC50值为 100 nM。
T8752 BAR 501 impurity

GPCR19 GPCR/G Protein
BAR 501 impurity 在 BAR501 制剂中发现的一种杂质,可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。
T36527 IL-4-inhibitor-1

IL Receptor Immunology/Inflammation
IL-4-inhibitor-1 是 IL-4 的抑制剂 (EC50 = 1.81 µM)。
T4687 Ro5-3335

CBFβ-Runx1 inhibitor II,Ro 5-3335

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Ro5-3335 (CBFβ-Runx1 inhibitor II) 是苯二氮化合物,是RUNX1-CBFβ 相互作用抑制剂,可抑制 RUNX1/CBFB 依赖性反式激活,能作为核心结合因子 (CBF) 白血病抑制剂。
T37587 ML 209

ROR Metabolism
ML-209 是一种视黄酸相关的孤儿受体 RORγ 拮抗剂 (IC50= 1.1 μM)。ML-209 抑制 HEK293t 细胞中 RORγt 转录活性(IC50= 300 nM)。ML-209 不抑制细胞中 RORα。ML-209 对鼠 Th17 细胞分化具有选择性抑制,而不影响幼稚 CD4+ T 细胞分化为 Th1 和调节性 T 细胞。
T36587 8-Aminopyrene-1,3,6-trisulfonic Acid sodium salt

Others Others
8-Aminopyrene-1,3,6-trisulfonic Acid sodium salt 是一种阴离子荧光染料,用作葡萄糖传感和检测其他糖类的报告分子。激发/发射光谱为 425/503 nm。 它可以在溶液中使用,也可以通过还原胺化连接醛官能化单体来固定,而不会显著改变荧光强度。
T13067 TAK-828F

ROR Metabolism
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM).
T23970 DDD00015314

DDD-00015314,DDD 00015314

DDD00015314 is the GUS reporter activity activator that acts by specifically increasing stumpy reporter gene expression.
T71424 VT-102 free base

VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T13562 Atorvastatin methyl ester

Others Others
Atorvastatin methyl ester is a derivative of Atorvastatin. It inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin.
T68934 VT101 free base

VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T10403 Atorvastatin ethyl ester

Others Others
Atorvastatin ethyl ester, a derivative of Atorvastatin, exhibits potent inhibition of 9-cis-RA-induced Gal4 reporter activity.
T29347 2-Ethynyl Adenosine

2-Ethynyl-Ade,2 Ethynyl Adenosine,2-Ethynyl-Adenosine

2-Ethynyl Adenosine is an Adenosine derivative that is used to capture novel polyadenylated transcription and non-radiochemical reporter molecules of the protein AMPylation.
TD0086 ROX Reference Dye

ROX Reference Dye was designed to standardize fluorescent reporter gene signals in real-time quantitative PCR or RT-PCR
T37833 CAY10767

CAY10767 is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50= 37 nM in a reporter assay).1It is greater than 2,700-fold selective for PPARα over PPARγ or PPARδ.
T12916 Silvestrol aglycone

Others Others
Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity.
T40400 Enhanced Green Fluorescent Protein (EGFP) (200-208)

Enhanced Green Fluorescent Protein (EGFP) (200-208) is a reporter protein obtained from Aequorea Victoria jellyfish. EGFP is widely used as a marker gene product due to its strong fluorescence properties, making it easily detectable.
T39181 Cyanine 3 Tyramide

Cyanine 3 Tyramide,Tyramide-Cy3

Cyanine 3 Tyramide (Tyramide-Cy3), an orange fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition for signal amplification in immunoassays and in situ nucleic acid hybridization.
T10374 ARS-1323-alkyne

Ras GPCR/G Protein; MAPK
ARS-1323-alkyne 是switch-II pocket (S-IIP)抑制剂,能够特异性报告活体细胞中 KRASG12C 核苷酸的状态。
T38902 Cyanine 5 Tyramide

Tyramide-Cy5

Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification method employed in immunoassays and in situ hybridization of nucleic acids.
T37351 Desmethyl Bosentan

Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan .1Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay. 1.van Giersbergen, P.L.M., Gnerre, C., Treiber, A., et al.Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptorBr. J. Clin. Pharmacol.54(5)561-562(2002)
T27125 DBPR-110

MB110,MB 110,MB-110

DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9 ± 0.9 pM and >12,800,000, respectively. DBPR-110 reduced HCV2a replicon activity with
T38158 StA-IFN-1

StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective f...
T36365 KAPA (hydrochloride)

KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid

Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals. Biotin has a strong affinity for the protein avidin, a trait that has been utilized for many assay reporter applications. KAPA is a key intermediate in the biotin biosynthetic pathway.[1]
T77926 PROTAC KRAS G12C degrader-1

PROTACs PROTAC
PROTACKRAS G12C degrader-1是基于Cereblon的KRASG12C PROTAC降解剂,能诱导CRBN/KRASG12C二聚化,并在报告细胞中降解GFP-KRASG12C。
T71925 Isonanangenine B

Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.
T83878 Z-CITCO

Z-CITCO是构成型雄甾烷受体(CAR;在报告基因测定中,对人类受体的EC50 = 3.9 µM)的激动剂,同时也是CAR激动剂CITCO的顺式异构体。
T69408 GW590735 sodium

GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.
T38159 STING Agonist 12b

STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
T38223 N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxisome proliferator-activated receptor α (PPARα) in a luciferase reporter assay and, in rats, it decreases food intake. It does not inhibit fatty acid amide hydrolase (FAAH).
T37414 CAY10771

CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM. 1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Ch...
T29176 YKL-04-085

YKL 04085,YKL04-085,YKL 04-085,YKL-04085

YKL-04-085 is a potent inhibitor of viral translation. YKL-04-085 has cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition of translation of the DENV2(GVD) r
T62726 Phenylpyropene C

Phenylpyropene C (S14-95) 是一种 JAK/STAT 通路抑制剂,对 IFN-γ 介导的报告基因表达表现出抑制作用 (IC50:5.4~10.8 μM)。Phenylpyropene C 也是一种酰基辅酶 A 的抑制剂 (IC50: 16.0 μM)。
T37466 CAY10766

CAY10766 is an antiviral compound.1It inhibits entry of influenza virus-like particles pseudotyped with hemagglutinin A (HA) from H5N1 influenza A virus into A549 cells (EC50= 0.24 μM). CAY10766 (1 μM) reduces H1N1 and H5N1 influenza A viral titers in infected MDCK cells. It also exhibits synergy with oseltamivir carboxylate in MDCK cells infected with the influenza A reporter PR8-NS1-Gluc virus.
T36936 Prodan

Prodan 是一种溶剂化变色荧光团,已被用作微环境敏感膜报告剂。基于Prodan 的化学原理,设计并合成了荧光核苷。荧光核苷根据溶剂的取向极化率敏感地改变斯托克斯位移值。
T82397 Firefly Luciferase mRNA(N1-Me-Pseudo UTP)

Firefly luciferase mRNA可编码一种起源于Photinus pyralis(萤火虫)的荧光素酶。作为广泛运用于基因调控和功能研究的生物发光报告系统,Firefly luciferase适合进行基因表达、细胞活性以及活体成像等各类检测分析。
T37092 20-HEPE

20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter when used at a concentration of 10 μM. 20-HEPE also activates murine transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks antinociceptive activity in rats.
T36046 LH1306

LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 25 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 334 and 4,214 nM, respectively, in reporter assays). |1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibito...
T38160 STING Agonist 1a

STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based vir...
T77725 YAP-TEAD-IN-3

IAG933

YAP Stem Cells
YAP-TEAD-IN-3 是 YAP/TAZ-TEAD 相互作用的抑制剂,对于 Avi-人 TEAD4217-434 的 IC50 为 9 nM。 YAP-TEAD-IN-3 抑制 YAP 报告基因表达 (IC50 = 0.048 μM) 和 NCI-H2052 细胞增殖 (IC50 = 0.048 μM)。
T74073 Cyanine 5 Tyramide methyl indole

Cyanine 5 Tyramide (Tyramide-Cy5) methyl indole 为红色荧光染料,用于HRP催化沉积报告中作为荧光底物,应用于免疫测定及核酸原位杂交信号放大。储存须避光。

化合物

SR11237
Cat.No: T23383
Synonym: SR 11237
Target: Others, RAR/RXR 
ML-031
Cat.No: T22101
Synonym:
Target: S1P Receptor
GSK9027
Cat.No: T22818
Synonym: GR agonist 23a,GSK 9027,GSK-9027
Target: Glucocorticoid Receptor
4-Azido-L-phenylalanine hydrochloride
Cat.No: T14038L
Synonym: p-Azido-L-phenylalanine hydrochloride,p-Azidophenylalanine hydrochloride
Target: Others
ETC-159
Cat.No: T4043
Synonym: ETC159,ETC-1922159,ETC 159
Target: Wnt/beta-catenin, Porcupine
KY1220
Cat.No: T15677
Synonym:
Target: Wnt/beta-catenin
YU238259
Cat.No: T4339
Synonym:
Target: DNA-PK, Others
CBL0137 hydrochloride
Cat.No: T4361
Synonym: CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride
Target: Others, NF-κB, p53
Semaglutide
Cat.No: T19850
Synonym: 索玛鲁肽,司美格鲁肽,索马鲁肽
Target: Glucagon Receptor
ML241 hydrochloride
Cat.No: T4684
Synonym:
Target: p97
BAR 501 impurity
Cat.No: T8752
Synonym:
Target: GPCR19
IL-4-inhibitor-1
Cat.No: T36527
Synonym:
Target: IL Receptor
Ro5-3335
Cat.No: T4687
Synonym: CBFβ-Runx1 inhibitor II,Ro 5-3335
Target: DNA/RNA Synthesis
ML 209
Cat.No: T37587
Synonym:
Target: ROR
8-Aminopyrene-1,3,6-trisulfonic Acid sodium salt
Cat.No: T36587
Synonym:
Target: Others
TAK-828F
Cat.No: T13067
Synonym:
Target: ROR
DDD00015314
Cat.No: T23970
Synonym: DDD-00015314,DDD 00015314
Target:
VT-102 free base
Cat.No: T71424
Synonym:
Target:
Atorvastatin methyl ester
Cat.No: T13562
Synonym:
Target: Others
VT101 free base
Cat.No: T68934
Synonym:
Target:
Atorvastatin ethyl ester
Cat.No: T10403
Synonym:
Target: Others
2-Ethynyl Adenosine
Cat.No: T29347
Synonym: 2-Ethynyl-Ade,2 Ethynyl Adenosine,2-Ethynyl-Adenosine
Target:
ROX Reference Dye
Cat.No: TD0086
Synonym:
Target:
CAY10767
Cat.No: T37833
Synonym:
Target:
Silvestrol aglycone
Cat.No: T12916
Synonym:
Target: Others
Enhanced Green Fluorescent Protein (EGFP) (200-208)
Cat.No: T40400
Synonym:
Target:
Cyanine 3 Tyramide
Cat.No: T39181
Synonym: Cyanine 3 Tyramide,Tyramide-Cy3
Target:
ARS-1323-alkyne
Cat.No: T10374
Synonym:
Target: Ras
Cyanine 5 Tyramide
Cat.No: T38902
Synonym: Tyramide-Cy5
Target:
Desmethyl Bosentan
Cat.No: T37351
Synonym:
Target:
DBPR-110
Cat.No: T27125
Synonym: MB110,MB 110,MB-110
Target:
StA-IFN-1
Cat.No: T38158
Synonym:
Target:
KAPA (hydrochloride)
Cat.No: T36365
Synonym: KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid
Target:
PROTAC KRAS G12C degrader-1
Cat.No: T77926
Synonym:
Target: PROTACs
Isonanangenine B
Cat.No: T71925
Synonym:
Target:
Z-CITCO
Cat.No: T83878
Synonym:
Target:
GW590735 sodium
Cat.No: T69408
Synonym:
Target:
STING Agonist 12b
Cat.No: T38159
Synonym:
Target:
N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
Cat.No: T38223
Synonym:
Target:
CAY10771
Cat.No: T37414
Synonym:
Target:
YKL-04-085
Cat.No: T29176
Synonym: YKL 04085,YKL04-085,YKL 04-085,YKL-04085
Target:
Phenylpyropene C
Cat.No: T62726
Synonym:
Target:
CAY10766
Cat.No: T37466
Synonym:
Target:
Prodan
Cat.No: T36936
Synonym:
Target:
Firefly Luciferase mRNA(N1-Me-Pseudo UTP)
Cat.No: T82397
Synonym:
Target:
20-HEPE
Cat.No: T37092
Synonym:
Target:
LH1306
Cat.No: T36046
Synonym:
Target:
STING Agonist 1a
Cat.No: T38160
Synonym:
Target:
YAP-TEAD-IN-3
Cat.No: T77725
Synonym: IAG933
Target: YAP
Cyanine 5 Tyramide methyl indole
Cat.No: T74073
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T24729 Roseoflavin

Antibacterial Microbiology/Virology
Roseoflavin 是天然色素,起初分离自Streptomyces davawensis。Roseoflavin 是核黄素和黄素单核苷酸的抗代谢类似物,显示出抗菌活性。
TN7236 Cephalandole B

IL Receptor Immunology/Inflammation
cephalandole B 是一种从青黛中分离出两种吲哚生物碱,能明显地抑制了IL-17A 基因的表达,以剂量依赖的方式抑制了Jukat 细胞的IL-17A 荧光素酶报告。
T6808 Coelenterazine

Oplophorus luciferin,Coelenteramine,腔肠素

Others Others
Coelenterazine (Coelenteramine) 是一种 apoaequorin 和 Renilla 荧光素酶的发光酶底物。它是超氧阴离子敏感化学发光探针,可用于检测过氧亚硝酸盐的化学发光。其中 Renilla 荧光素酶和底物 coelenterazine 被用作生物发光共振能量转移中检测蛋白质-蛋白质相互作用的生物发光供体。
TN4383 Kazinol U

IL Receptor; IκB/IKK; NOS; NF-κB Immunology/Inflammation; NF-κB
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms.
TN3539 Broussonin A

ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c
T36749 Herboxidiene

Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo...

天然产物

Roseoflavin
Cat.No: T24729
Synonym:
Target: Antibacterial
Cephalandole B
Cat.No: TN7236
Synonym:
Target: IL Receptor
Coelenterazine
Cat.No: T6808
Synonym: Oplophorus luciferin,Coelenteramine,腔肠素
Target: Others
Kazinol U
Cat.No: TN4383
Synonym:
Target: IL Receptor, IκB/IKK, NOS, NF-κB
Broussonin A
Cat.No: TN3539
Synonym:
Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt
Herboxidiene
Cat.No: T36749
Synonym:
Target:
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