100
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23383 |
SR11237
SR 11237 |
Others; RAR/RXR | Metabolism; Others |
SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。 | |||
T22101 |
ML-031
|
S1P Receptor | GPCR/G Protein |
ML-031 是鞘氨醇 1-磷酸受体 2 (S1PR2)的选择性激动剂,其IC50=1.0 μM,EC50=1.03 μM。它可用于癌症疾病的研究。 | |||
T22818 |
GSK9027
GR agonist 23a,GSK 9027,GSK-9027 |
Glucocorticoid Receptor | Endocrinology/Hormones |
GSK9027 (GR agonist 23a) 是一种非甾体糖皮质激素受体 (GR) 激动剂。GSK9027 (GR agonist 23a) 在2×GRE报告基因上对比地塞米松的活性属于部分激动剂,活性较地塞米松活性较弱。 | |||
T14038L |
4-Azido-L-phenylalanine hydrochloride
p-Azido-L-phenylalanine hydrochloride,p-Azidophenylalanine hydrochloride |
Others | Others |
4-Azido-L-phenylalanine hydrochloride (p-Azido-L-phenylalanine hydrochloride) 是非天然氨基酸,可有效振动报道蛋白质环境。 | |||
T4043 |
ETC-159
ETC159,ETC-1922159,ETC 159 |
Wnt/beta-catenin; Porcupine | Cytoskeletal Signaling; Stem Cells |
ETC-159 (ETC-1922159) 是一种具有口服活性的,有效 PORCN 抑制剂。抑制β-catenin 报告基因活性的 IC50值为2.9 nM。 | |||
T15677 |
KY1220
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
KY1220 通过靶向 Wnt/β-连环蛋白通路,使 β-连环蛋白和 Ras 不稳定。 它在 HEK293 报告细胞中的 IC50 为 2.1 μM。 | |||
T4339 |
YU238259
|
DNA-PK; Others | DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling |
YU238259 是一种新型的同源依赖性 DNA 修复 (HDR) 抑制剂,在基于细胞的 GFP 报告基因检测中不抑制非同源末端连接 (NHEJ),可研究癌症。 | |||
T4361 |
CBL0137 hydrochloride
CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride |
Others; NF-κB; p53 | Apoptosis; NF-κB; Others |
CBL0137 hydrochloride (Curaxin-137 hydrochloride) 是一种组蛋白分子伴侣FACT 的抑制剂,也可激活p53并抑制NF-κB,对于它们的EC50值分别为 0.37 和 0.47 μM。 | |||
T19850 |
Semaglutide
索玛鲁肽,司美格鲁肽,索马鲁肽 |
Glucagon Receptor | GPCR/G Protein |
Semaglutide 是人胰高血糖素样肽-1受体激动剂,是一种人胰高血糖素样肽-1 的长效类似物。它有用于 2 型糖尿病研究的潜力。 | |||
T4684 |
ML241 hydrochloride
|
p97 | Ubiquitination |
ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂,IC50值为 100 nM。 | |||
T8752 |
BAR 501 impurity
|
GPCR19 | GPCR/G Protein |
BAR 501 impurity 在 BAR501 制剂中发现的一种杂质,可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。 | |||
T36527 |
IL-4-inhibitor-1
|
IL Receptor | Immunology/Inflammation |
IL-4-inhibitor-1 是 IL-4 的抑制剂 (EC50 = 1.81 µM)。 | |||
T4687 |
Ro5-3335
CBFβ-Runx1 inhibitor II,Ro 5-3335 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ro5-3335 (CBFβ-Runx1 inhibitor II) 是苯二氮化合物,是RUNX1-CBFβ 相互作用抑制剂,可抑制 RUNX1/CBFB 依赖性反式激活,能作为核心结合因子 (CBF) 白血病抑制剂。 | |||
T37587 |
ML 209
|
ROR | Metabolism |
ML-209 是一种视黄酸相关的孤儿受体 RORγ 拮抗剂 (IC50= 1.1 μM)。ML-209 抑制 HEK293t 细胞中 RORγt 转录活性(IC50= 300 nM)。ML-209 不抑制细胞中 RORα。ML-209 对鼠 Th17 细胞分化具有选择性抑制,而不影响幼稚 CD4+ T 细胞分化为 Th1 和调节性 T 细胞。 | |||
T36587 |
8-Aminopyrene-1,3,6-trisulfonic Acid sodium salt
|
Others | Others |
8-Aminopyrene-1,3,6-trisulfonic Acid sodium salt 是一种阴离子荧光染料,用作葡萄糖传感和检测其他糖类的报告分子。激发/发射光谱为 425/503 nm。 它可以在溶液中使用,也可以通过还原胺化连接醛官能化单体来固定,而不会显著改变荧光强度。 | |||
T13067 | TAK-828F | ROR | Metabolism |
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM). | |||
T23970 |
DDD00015314
DDD-00015314,DDD 00015314 |
||
DDD00015314 is the GUS reporter activity activator that acts by specifically increasing stumpy reporter gene expression. | |||
T71424 | VT-102 free base | ||
VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter. | |||
T13562 |
Atorvastatin methyl ester
|
Others | Others |
Atorvastatin methyl ester is a derivative of Atorvastatin. It inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin. | |||
T68934 | VT101 free base | ||
VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter. | |||
T10403 |
Atorvastatin ethyl ester
|
Others | Others |
Atorvastatin ethyl ester, a derivative of Atorvastatin, exhibits potent inhibition of 9-cis-RA-induced Gal4 reporter activity. | |||
T29347 |
2-Ethynyl Adenosine
2-Ethynyl-Ade,2 Ethynyl Adenosine,2-Ethynyl-Adenosine |
||
2-Ethynyl Adenosine is an Adenosine derivative that is used to capture novel polyadenylated transcription and non-radiochemical reporter molecules of the protein AMPylation. | |||
TD0086 |
ROX Reference Dye
|
||
ROX Reference Dye was designed to standardize fluorescent reporter gene signals in real-time quantitative PCR or RT-PCR | |||
T37833 |
CAY10767
|
||
CAY10767 is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50= 37 nM in a reporter assay).1It is greater than 2,700-fold selective for PPARα over PPARγ or PPARδ. | |||
T12916 |
Silvestrol aglycone
|
Others | Others |
Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity. | |||
T40400 |
Enhanced Green Fluorescent Protein (EGFP) (200-208)
|
||
Enhanced Green Fluorescent Protein (EGFP) (200-208) is a reporter protein obtained from Aequorea Victoria jellyfish. EGFP is widely used as a marker gene product due to its strong fluorescence properties, making it easily detectable. | |||
T39181 |
Cyanine 3 Tyramide
Cyanine 3 Tyramide,Tyramide-Cy3 |
||
Cyanine 3 Tyramide (Tyramide-Cy3), an orange fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition for signal amplification in immunoassays and in situ nucleic acid hybridization. | |||
T10374 | ARS-1323-alkyne | Ras | GPCR/G Protein; MAPK |
ARS-1323-alkyne 是switch-II pocket (S-IIP)抑制剂,能够特异性报告活体细胞中 KRASG12C 核苷酸的状态。 | |||
T38902 |
Cyanine 5 Tyramide
Tyramide-Cy5 |
||
Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification method employed in immunoassays and in situ hybridization of nucleic acids. | |||
T37351 |
Desmethyl Bosentan
|
||
Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan .1Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay. 1.van Giersbergen, P.L.M., Gnerre, C., Treiber, A., et al.Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptorBr. J. Clin. Pharmacol.54(5)561-562(2002) | |||
T27125 |
DBPR-110
MB110,MB 110,MB-110 |
||
DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9 ± 0.9 pM and >12,800,000, respectively. DBPR-110 reduced HCV2a replicon activity with | |||
T38158 |
StA-IFN-1
|
||
StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective f... | |||
T36365 |
KAPA (hydrochloride)
KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid |
||
Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals. Biotin has a strong affinity for the protein avidin, a trait that has been utilized for many assay reporter applications. KAPA is a key intermediate in the biotin biosynthetic pathway.[1] | |||
T77926 |
PROTAC KRAS G12C degrader-1
|
PROTACs | PROTAC |
PROTACKRAS G12C degrader-1是基于Cereblon的KRASG12C PROTAC降解剂,能诱导CRBN/KRASG12C二聚化,并在报告细胞中降解GFP-KRASG12C。 | |||
T71925 |
Isonanangenine B
|
||
Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells. | |||
T83878 |
Z-CITCO
|
||
Z-CITCO是构成型雄甾烷受体(CAR;在报告基因测定中,对人类受体的EC50 = 3.9 µM)的激动剂,同时也是CAR激动剂CITCO的顺式异构体。 | |||
T69408 | GW590735 sodium | ||
GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively. | |||
T38159 |
STING Agonist 12b
|
||
STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020) | |||
T38223 |
N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
|
||
N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxisome proliferator-activated receptor α (PPARα) in a luciferase reporter assay and, in rats, it decreases food intake. It does not inhibit fatty acid amide hydrolase (FAAH). | |||
T37414 |
CAY10771
|
||
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM. 1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Ch... | |||
T29176 |
YKL-04-085
YKL 04085,YKL04-085,YKL 04-085,YKL-04085 |
||
YKL-04-085 is a potent inhibitor of viral translation. YKL-04-085 has cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition of translation of the DENV2(GVD) r | |||
T62726 |
Phenylpyropene C
|
||
Phenylpyropene C (S14-95) 是一种 JAK/STAT 通路抑制剂,对 IFN-γ 介导的报告基因表达表现出抑制作用 (IC50:5.4~10.8 μM)。Phenylpyropene C 也是一种酰基辅酶 A 的抑制剂 (IC50: 16.0 μM)。 | |||
T37466 | CAY10766 | ||
CAY10766 is an antiviral compound.1It inhibits entry of influenza virus-like particles pseudotyped with hemagglutinin A (HA) from H5N1 influenza A virus into A549 cells (EC50= 0.24 μM). CAY10766 (1 μM) reduces H1N1 and H5N1 influenza A viral titers in infected MDCK cells. It also exhibits synergy with oseltamivir carboxylate in MDCK cells infected with the influenza A reporter PR8-NS1-Gluc virus. | |||
T36936 |
Prodan
|
||
Prodan 是一种溶剂化变色荧光团,已被用作微环境敏感膜报告剂。基于Prodan 的化学原理,设计并合成了荧光核苷。荧光核苷根据溶剂的取向极化率敏感地改变斯托克斯位移值。 | |||
T82397 |
Firefly Luciferase mRNA(N1-Me-Pseudo UTP)
|
||
Firefly luciferase mRNA可编码一种起源于Photinus pyralis(萤火虫)的荧光素酶。作为广泛运用于基因调控和功能研究的生物发光报告系统,Firefly luciferase适合进行基因表达、细胞活性以及活体成像等各类检测分析。 | |||
T37092 |
20-HEPE
|
||
20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter when used at a concentration of 10 μM. 20-HEPE also activates murine transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks antinociceptive activity in rats. | |||
T36046 |
LH1306
|
||
LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 25 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 334 and 4,214 nM, respectively, in reporter assays). |1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibito... | |||
T38160 |
STING Agonist 1a
|
||
STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based vir... | |||
T77725 |
YAP-TEAD-IN-3
IAG933 |
YAP | Stem Cells |
YAP-TEAD-IN-3 是 YAP/TAZ-TEAD 相互作用的抑制剂,对于 Avi-人 TEAD4217-434 的 IC50 为 9 nM。 YAP-TEAD-IN-3 抑制 YAP 报告基因表达 (IC50 = 0.048 μM) 和 NCI-H2052 细胞增殖 (IC50 = 0.048 μM)。 | |||
T74073 | Cyanine 5 Tyramide methyl indole | ||
Cyanine 5 Tyramide (Tyramide-Cy5) methyl indole 为红色荧光染料,用于HRP催化沉积报告中作为荧光底物,应用于免疫测定及核酸原位杂交信号放大。储存须避光。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24729 |
Roseoflavin
|
Antibacterial | Microbiology/Virology |
Roseoflavin 是天然色素,起初分离自Streptomyces davawensis。Roseoflavin 是核黄素和黄素单核苷酸的抗代谢类似物,显示出抗菌活性。 | |||
TN7236 |
Cephalandole B
|
IL Receptor | Immunology/Inflammation |
cephalandole B 是一种从青黛中分离出两种吲哚生物碱,能明显地抑制了IL-17A 基因的表达,以剂量依赖的方式抑制了Jukat 细胞的IL-17A 荧光素酶报告。 | |||
T6808 |
Coelenterazine
Oplophorus luciferin,Coelenteramine,腔肠素 |
Others | Others |
Coelenterazine (Coelenteramine) 是一种 apoaequorin 和 Renilla 荧光素酶的发光酶底物。它是超氧阴离子敏感化学发光探针,可用于检测过氧亚硝酸盐的化学发光。其中 Renilla 荧光素酶和底物 coelenterazine 被用作生物发光共振能量转移中检测蛋白质-蛋白质相互作用的生物发光供体。 | |||
TN4383 |
Kazinol U
|
IL Receptor; IκB/IKK; NOS; NF-κB | Immunology/Inflammation; NF-κB |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms. | |||
TN3539 | Broussonin A | ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt | Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c | |||
T36749 |
Herboxidiene
|
||
Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo... |