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GSK9027

Name: GSK9027
Brand: TargetMol
SKU: T22818
Price: 228 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: GSK-9027, GSK 9027, GR agonist 23a

货号 T22818Cas号 1229096-88-1 一键复制产品信息纯度: 99.31%

很棒

GSK9027 (GR agonist 23a) 是一种非甾体糖皮质激素受体 (GR) 激动剂。GSK9027 (GR agonist 23a) 在2×GRE报告基因上对比地塞米松的活性属于部分激动剂，活性较地塞米松活性较弱。

GSK9027

一键复制产品信息

很棒

纯度: 99.31%

货号 T22818Cas号 1229096-88-1

别名 GSK-9027, GSK 9027, GR agonist 23a

规格	价格	库存
1 mg	¥ 228	现货
5 mg	¥ 559	现货
10 mg	¥ 903	现货
25 mg	¥ 1,880	现货
50 mg	¥ 2,650	现货
100 mg	¥ 3,570	现货
200 mg	¥ 4,780	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.31%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

GSK9027 AI Summary

GSK9027 exhibits bioactivities related to glucocorticoid receptor (GR) modulation, including transrepression and transactivation activities in human A549 cells. It has notable anti-inflammatory properties, demonstrated by its inhibitory effect on IL1-induced IL6 release in mice at varying doses, and it inhibits IL1-induced release of IL6, IL8, and MMP1 in human primary synovial fibroblasts. Additionally, the compound shows significant antiviral activity against SARS-CoV-2, achieving 100.2% inhibition of virus-induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours, and 25.6% inhibition of cytotoxicity in VERO-6 cells under similar conditions. Furthermore, GSK9027 inhibits the SARS-CoV-2 3CL-Pro protease by 17.71% at a 20 µM concentration. The compound also demonstrates modest inhibitory activity on the human HDAC6 enzyme, with 8.14% inhibition using a commercial peptide substrate and 2.0% using a custom peptide substrate, suggesting a potential for GR-related and other therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	GSK9027 (GR agonist 23a) is a nonsteroidal glucocorticoid receptor (GR) agonist.GSK9027 is a partial agonist on the 2×GRE reporter gene compared to dexamethasone and is less active than dexamethasone activity.
别名	GSK-9027, GSK 9027, GR agonist 23a

化学信息

分子量	525.52
分子式	C₂₇H₁₉F₄N₃O₂S
CAS No.	1229096-88-1
Smiles	FC1=CC=C(N2C=3C(=CC(=CC3)C4=C(C(F)(F)F)C=C(NS(CC5=CC=CC=C5)(=O)=O)C=C4)C=N2)C=C1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (114.17 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9029 mL	9.5144 mL	19.0288 mL	95.1439 mL
5 mM	0.3806 mL	1.9029 mL	3.8058 mL	19.0288 mL
10 mM	0.1903 mL	0.9514 mL	1.9029 mL	9.5144 mL
20 mM	0.0951 mL	0.4757 mL	0.9514 mL	4.7572 mL
50 mM	0.0381 mL	0.1903 mL	0.3806 mL	1.9029 mL
100 mM	0.0190 mL	0.0951 mL	0.1903 mL	0.9514 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。