nav1.7

GNE-131 是有效的人类钠离子通道 NaV1.7(hNaV1.7)选择性抑制剂，IC50为 3 nM。

GNE-0439 is a novel Nav1.7-selective inhibitor (IC50: 0.34 uM) and inhibits Nav1.5 (IC50: 38.3 μM). GNE-0439 inhibits mutant N1742K channels (IC50: 0.37 uM) in membrane potential assays.

PF-05241328 is an effective and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (IC50: 31 nM).

Veratridine 是一种生物碱，来自百合科植物。Veratridine 是一种钠通道激动剂， 对 Nav1.7 的峰值电流具有抑制作用，IC50为 18.39 µM。

PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor.

Nav1.7 blocker 1 (example 41)，一种Na+通道 (Nav) 阻滞剂，具有0.037 μM的IC50值。此化合物主要应用于疼痛研究领域，包括神经性疼痛、术后疼痛、炎症性疼痛等。

Nav1.7 inhibitor 是一种 Nav1.7 抑制剂，可用于研究疼痛和麻醉领域。

NaV1.7 Blocker-801 is a potent NaV1.7 blocker.

NaV1.7 inhibitor-1 是有效的、选择性的电压门控钠通道 (Nav) 1.7 抑制剂，对于hNaV1.7的IC50为 0.6 nM，其选择性是 hNaV1.5 的 80 倍。

Nav1.7-IN-6, a selective inhibitor of Nav1.7.

Nav1.7-IN-3 is a selective and orally bioavailable inhibitor of voltage-gated sodium channel Nav1.7(IC50 of 8 nM).

Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP2C9 and CYP3A4, with IC50 values of 0.17 μM and 0.077 μM, respectively. Notably, Nav1.7-IN-8 demonstrates significant analgesic properties in rodent models of both acute and inflammatory pain.

Nav1.7-IN-2 is avoltage-gated sodium channels (Nav) inhibitor in particular Nav 1.7(IC50 of 80 nM).

Nav1.7-IN-18 (Compound 31) 是一种Nav1.7抑制剂，Ki值为4.9 nM，IC50为13 nM，并且在转基因小鼠的遗传性红斑肢痛症 (IEM) 模型中显示出镇痛效果。

(Rac)-AMG8379 ((Rac)-AMG8380) 是 AMG8379 的外消旋体，是一种具有口服活性和选择性的磺胺 NaV1.7 拮抗剂。

GX 201 是选择性的 NaV1.7 抑制剂，其对 hNaV1.7 的 IC50 值为 <3.2 nM。

GX-585 是一种磺胺类化合物，是一种Nav 1.7通道抑制剂，具有镇痛活性，可用于研究神经疼痛和炎症。

1-(2,4-difluorophenyl)guanidine hydrochloride 是一种化合物，是电压门控钠通道Nav1.7的强效选择性抑制剂，Nav1.7是疼痛信号传输的关键参与者，因此它能够减少疼痛信号的传递，从而产生镇痛作用。

TC-N 1752 是一种具有口服活性的 Nav1.7 通道抑制剂，IC50 为 0.17 μM。 TC-N 1752 显示镇痛活性。

Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inactivation on all channels. Increases

Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 also increases the activity of Nav1.2 and Nav1.5 channels but not of Nav1.4, Nav1.6 and Nav1.7 channels. Lu AE98134 can be used to analyze pathophysiological functions of the Nav1.1 channel in various central nervous system diseases, including cognitive restoring in schizophrenia, et al[1].

Potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM); also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal root ganglion neurons. Neuroprotective.

PF-05150122 is a novel potent and selective human Nav1.7 blocker.

ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) 是强效的、广谱的电压门控钠通道阻滞剂，对人 Nav1.1 和 Nav1.3 亚型具有等效选择性，IC50分别为 13 nM 和 23 nM。它对Nav1.2 的抑制作用较弱，IC50为240 nM，对 Nav1.4、Nav1.6、抗TTX 的人 Nav1.5、Nav1.8 通道表现出大于 1000 倍的选择性，IC50>10 μM。